Bendamustine (BioDeep_00000176501)
human metabolite blood metabolite
代谢物信息卡片
4-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1,3-benzodiazol-2-yl}butanoic acid
化学式: C16H21Cl2N3O2 (357.1010746)
中文名称: 宾达氮芥
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C(CCCC(O)=O)=NC2=CC(=CC=C12)N(CCCl)CCCl
InChI: InChI=1S/C16H21Cl2N3O2/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23/h5-6,11H,2-4,7-10H2,1H3,(H,22,23)
描述信息
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01A - Alkylating agents > L01AA - Nitrogen mustard analogues
D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D009676 - Noxae > D000477 - Alkylating Agents
同义名列表
11 个代谢物同义名
4-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1,3-benzodiazol-2-yl}butanoic acid; 4-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1,3-benzodiazol-2-yl}butanoate; Hydrochloride, bendamustine; Bendamustine Hydrochloride; Bendamustine; Bendamustin; Cytostasan; Ribomustin; Zimet 3393; IMET 3393; Treanda
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:135515
- PubChem: 65628
- HMDB: HMDB0248945
- DrugBank: DB06769
- ChEMBL: CHEMBL487253
- Wikipedia: Bendamustine
- MeSH: Bendamustine Hydrochloride
- chemspider: 59069
- CAS: 16506-27-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Akie Hirata, Kaname Miyashita, Takafumi Tanaka, Kiyoko Hirata, Taisuke Narazaki, Hayato Utsunomiya, Hirofumi Ohno, Eriko Nakashima, Yoshimichi Tachikawa, Ilseung Choi, Kenichi Taguchi, Youko Suehiro. Serum immunoglobulin G as a discriminator of infection in follicular lymphoma patients undergoing chemotherapy with bendamustine in combination with rituximab.
Hematology (Amsterdam, Netherlands).
2022 Dec; 27(1):384-395. doi:
10.1080/16078454.2022.2051863. [PMID: 35344477] - Honglu Yin, Yuepeng Chen, Qiu Zhong, Shilong Zheng, Guangdi Wang, Ling He. Design, synthesis, and antitumor study of a series of novel 1-Oxa-4-azaspironenone derivatives.
Bioorganic & medicinal chemistry letters.
2022 10; 74(?):128925. doi:
10.1016/j.bmcl.2022.128925. [PMID: 35944852] - Harsha K Tripathy, S V Nair Manju, Rama Murthy Bestha, Vinay Kiran, Sreekanth Dittakavi, Ramesh Mullangi. Validated liquid chromatography-tandem mass spectrometry method for simultaneous quantitation of bendamustine and copanlisib in mouse plasma: Application to a pharmacokinetic study in mice.
Biomedical chromatography : BMC.
2022 Aug; 36(8):e5387. doi:
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International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2022 Aug; 121(?):85-88. doi:
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European journal of medicinal chemistry.
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Journal of clinical and experimental hematopathology : JCEH.
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Bone marrow transplantation.
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The British journal of dermatology.
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10.1002/ajh.25413. [PMID: 30663798] - Matthew Ettleson, Kale S Bongers, Kaitlyn Vitale, Anthony J Perissinotti, Tycel Phillips, Bernard L Marini. Successful use of cytarabine and bendamustine in a patient with mantle cell lymphoma and acute renal failure using intermittent hemodialysis: A case report.
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BMC cancer.
2018 Jul; 18(1):729. doi:
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Leukemia & lymphoma.
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European journal of medicinal chemistry.
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Leukemia & lymphoma.
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American journal of physiology. Renal physiology.
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Journal of pharmaceutical and biomedical analysis.
2015 Feb; 104(?):137-43. doi:
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Leukemia & lymphoma.
2015 Feb; 56(2):347-52. doi:
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British journal of haematology.
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Terapevticheskii arkhiv.
2015; 87(12):85-88. doi:
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Pharmacological research.
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Current medical research and opinion.
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Journal of neuro-oncology.
2014 Sep; 119(2):413-20. doi:
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Deutsche medizinische Wochenschrift (1946).
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Leukemia & lymphoma.
2014 Jun; 55(6):1266-73. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Jun; 960(?):98-104. doi:
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
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International journal of laboratory hematology.
2014 Feb; 36(1):20-8. doi:
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Terapevticheskii arkhiv.
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Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2013 Oct; 18(4):996-1005. doi:
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BMJ case reports.
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Cellular signalling.
2013 May; 25(5):1108-17. doi:
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Drugs in R&D.
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Investigational new drugs.
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Drug metabolism and disposition: the biological fate of chemicals.
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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Kidney international.
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British journal of haematology.
2011 Dec; 155(5):632-4. doi:
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Cancer science.
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Journal of cancer research and clinical oncology.
2008 Feb; 134(2):245-53. doi:
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Journal of chemotherapy (Florence, Italy).
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Drug metabolism and disposition: the biological fate of chemicals.
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Anti-cancer drugs.
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British journal of cancer.
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Anti-cancer drugs.
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Cancer chemotherapy and pharmacology.
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European journal of haematology.
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Drug metabolism and disposition: the biological fate of chemicals.
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