Belinostat (BioDeep_00000176493)
human metabolite blood metabolite
代谢物信息卡片
化学式: C15H14N2O4S (318.0674)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: ONC(=O)C=CC1=CC(=CC=C1)S(=O)(=O)NC1=CC=CC=C1
InChI: InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Mi Joung Kim, Dong Eun Kim, In Gab Jeong, Jene Choi, Sejin Jang, Je-Hwan Lee, Seonggu Ro, Jung Jin Hwang, Choung-Soo Kim. HDAC inhibitors synergize antiproliferative effect of sorafenib in renal cell carcinoma cells.
Anticancer research.
2012 Aug; 32(8):3161-8. doi:
NULL. [PMID: 22843888] - Marina Barreto Felisbino, Wirla M S C Tamashiro, Maria Luiza S Mello. Chromatin remodeling, cell proliferation and cell death in valproic acid-treated HeLa cells.
PloS one.
2011; 6(12):e29144. doi:
10.1371/journal.pone.0029144. [PMID: 22206001] - Enrique M Ocio, Jesús F San Miguel. The DAC system and associations with multiple myeloma.
Investigational new drugs.
2010 Dec; 28 Suppl 1(?):S28-35. doi:
10.1007/s10637-010-9589-x. [PMID: 21120582] - Ling-Zhi Wang, Daniel Chan, Winnie Yeo, Seow-Ching Wan, Stephen Chan, Anthony Chan, Soo-Chin Lee, How-Sung Lee, Boon-Cher Goh. A sensitive and specific liquid chromatography-tandem mass spectrometric method for determination of belinostat in plasma from liver cancer patients.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Sep; 878(26):2409-14. doi:
10.1016/j.jchromb.2010.07.015. [PMID: 20724229] - C Dive, R A Smith, E Garner, T Ward, S St George-Smith, F Campbell, W Greenhalf, P Ghaneh, J P Neoptolemos. Considerations for the use of plasma cytokeratin 18 as a biomarker in pancreatic cancer.
British journal of cancer.
2010 Feb; 102(3):577-82. doi:
10.1038/sj.bjc.6605494. [PMID: 20051949] - L C Scott, T R J Evans, J Cassidy, S Harden, J Paul, R Ullah, V O'Brien, R Brown. Cytokeratin 18 in plasma of patients with gastrointestinal adenocarcinoma as a biomarker of tumour response.
British journal of cancer.
2009 Aug; 101(3):410-7. doi:
10.1038/sj.bjc.6605175. [PMID: 19603019] - Katherine E Warren, Cindy McCully, Henrik Dvinge, Jette Tjørnelund, Maxwell Sehested, Henri S Lichenstein, Frank M Balis. Plasma and cerebrospinal fluid pharmacokinetics of the histone deacetylase inhibitor, belinostat (PXD101), in non-human primates.
Cancer chemotherapy and pharmacology.
2008 Aug; 62(3):433-7. doi:
10.1007/s00280-007-0622-5. [PMID: 17960383] - Lena Marquard, Kamille Dumong Petersen, Morten Persson, Kirsten Damgaard Hoff, Peter Buhl Jensen, Maxwell Sehested. Monitoring the effect of belinostat in solid tumors by H4 acetylation.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.
2008 May; 116(5):382-92. doi:
10.1111/j.1600-0463.2008.00957.x. [PMID: 18452428]
