Befunolol (BioDeep_00000176491)

   

human metabolite blood metabolite


代谢物信息卡片


1-(7-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}-1-benzofuran-2-yl)ethan-1-one

化学式: C16H21NO4 (291.1470506)
中文名称: 苯呋洛尔
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)NCC(COC1=CC=CC2=C1OC(=C2)C(=O)C)O
InChI: InChI=1S/C16H21NO4/c1-10(2)17-8-13(19)9-20-14-6-4-5-12-7-15(11(3)18)21-16(12)14/h4-7,10,13,17,19H,8-9H2,1-3H3

描述信息

S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics > S01ED - Beta blocking agents
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
C78283 - Agent Affecting Organs of Special Senses > C29705 - Anti-glaucoma Agent

同义名列表

9 个代谢物同义名

1-(7-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}-1-benzofuran-2-yl)ethan-1-one; 2-Acetyl-7-(2-hydroxy-3-isopropylamino)propoxybenzofuran; Befunolol hydrochloride; Befunolol HCL; (±)-Befunolol; Befunolol; Glauconex; Bentos; BFE 60



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Maryam Malmir, Katelene Lima, Sérgio Póvoas Camões, Vera Manageiro, Maria Paula Duarte, Joana Paiva Miranda, Rita Serrano, Isabel Moreira da Silva, Beatriz Silva Lima, Manuela Caniça, Olga Silva. Identification of Marker Compounds and In Vitro Toxicity Evaluation of Two Portuguese Asphodelus Leaf Extracts. Molecules (Basel, Switzerland). 2023 Mar; 28(5):. doi: 10.3390/molecules28052372. [PMID: 36903618]
  • Stéphanie Proulx, Jeanne d'Arc Uwamaliya, Patrick Carrier, Alexandre Deschambeault, Caroline Audet, Claude J Giasson, Sylvain L Guérin, François A Auger, Lucie Germain. Reconstruction of a human cornea by the self-assembly approach of tissue engineering using the three native cell types. Molecular vision. 2010 Oct; 16(?):2192-201. doi: NULL. [PMID: 21139684]
  • Takahiro Horinouchi, Shigeru Morishima, Yoshio Tanaka, Katsuo Koike, Soichi Miwa, Ikunobu Muramatsu. Pharmacological evaluation of ocular beta-adrenoceptors in rabbit by tissue segment binding method. Life sciences. 2009 Jan; 84(5-6):181-7. doi: 10.1016/j.lfs.2008.11.016. [PMID: 19087880]
  • Małgorzata Latalska, Marek Gerkowicz, Małgorzata Pietraś-Trzpiel, Maria Kozioł-Montewka, Ewa Kosior-Jarecka. [Levels of antiphospholipid antibodies in the serum and aqueous humor of glaucoma patients]. Klinika oczna. 2004; 106(3 Suppl):419-20. doi: NULL. [PMID: 15636221]
  • R Braakman, P van der Linden, P Sipkema. Effects of topical beta-blockers on the diameter of the isolated porcine short posterior ciliary artery. Investigative ophthalmology & visual science. 1999 Feb; 40(2):370-7. doi: NULL. [PMID: 9950595]
  • Y Imamura, T Koga, T Higuchi, M Otagiri, E Sugino, S Hibino. Inhibitory effect of drugs with a ketone group on reduction of acetohexamide catalyzed by carbonyl reductase from rabbit kidney. Journal of enzyme inhibition. 1997 Feb; 11(4):285-92. doi: 10.3109/14756369709027657. [PMID: 9208371]
  • T Higuchi, Y Imamura, M Otagiri. Kinetic studies on the reduction of acetohexamide catalyzed by carbonyl reductase from rabbit kidney. Biochimica et biophysica acta. 1993 Aug; 1158(1):23-8. doi: 10.1016/0304-4165(93)90091-l. [PMID: 8353128]
  • Y Maruyama, T Awaji, M Inoue, S Takeo. Metabolic profile of beta-adrenoceptor-blocking action of befunolol. Archives internationales de pharmacodynamie et de therapie. 1991 May; 311(?):73-88. doi: NULL. [PMID: 1686392]
  • Y Imamura, Y Nozaki, T Imai, M Otagiri. Studies on metabolic reduction of befunolol in rabbit liver and kidney. Chemical & pharmaceutical bulletin. 1988 Feb; 36(2):708-12. doi: 10.1248/cpb.36.708. [PMID: 2900698]
  • K Kawahara, T Ofuji. Gas chromatographic determination of the glucuronide of 2-(1-hydroxy-ethyl)-7-(2-hydroxy-3-isopropyl-aminopropoxy)-benzofuran, a metabolite of befunolol, in human urine. Journal of chromatography. 1983 Jan; 272(1):187-92. doi: 10.1016/s0378-4347(00)86117-4. [PMID: 6841539]
  • S Sato, I Yamamoto. Enzyme immunoassays for beta-adrenoreceptor blocking agent, befunolol and its main metabolite, M1. Journal of immunoassay. 1983; 4(4):351-71. doi: 10.1080/15321818308057015. [PMID: 6142059]
  • A Ebihara, K Tawara, T Oka, T Ofuji, K Kawahara. Clinical pharmacology of a new beta-adrenoceptor blocking drug, befunolol. Cross-over comparison with propranolol on repeated administration. European journal of clinical pharmacology. 1982; 23(3):189-95. doi: 10.1007/bf00547552. [PMID: 6129139]
  • N Miki, Y Furusho, K Itaya, K Midorikawa, E Kumagai, M Terasawa, S Ihara, T Matoba, H Toshima. Effects of oral befunolol on heart rate and systolic blood pressure during submaximal exercise in man. Japanese circulation journal. 1980 Oct; 44(10):783-93. doi: 10.1253/jcj.44.783. [PMID: 6107392]
  • M Tohno, K Kimura, M Nagahara, Y Sakai, T Ofuji, T Nadai. [Identification of urinary metabolites of befunolol in dog and man principally by mass spectrometry (author's transl)]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1979 Sep; 99(9):944-57. doi: 10.1248/yakushi1947.99.9_944. [PMID: 44723]
  • K Kawahara, T Ofuji. Simultaneous determination of befunolol, a beta-blocking agent, and its metabolite in human plasma by gas chromatography with electron-caputre detection. Journal of chromatography. 1979 Jan; 168(1):266-72. doi: 10.1016/s0021-9673(00)80723-2. [PMID: 33199]