5-[[4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl]methyl]-4-hydroxy-3H-1,3-thiazol-2-one (BioDeep_00000176472)
human metabolite blood metabolite
代谢物信息卡片
5-({4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}methyl)-4-hydroxy-2,3-dihydro-1,3-thiazol-2-one
化学式: C19H20N2O3S (356.1195)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 5.93%
分子结构信息
SMILES: CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3=C(NC(=O)S3)O
InChI: InChI=1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,22H,2,9-11H2,1H3,(H,21,23)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
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Chinese medical journal.
2012 May; 125(9):1633-7. doi:
NULL. [PMID: 22800834] - Atsuko Nakatsuka, Jun Wada, Kazuyuki Hida, Aya Hida, Jun Eguchi, Sanae Teshigawara, Kazutoshi Murakami, Motoko Kanzaki, Kentaro Inoue, Takahiro Terami, Akihiro Katayama, Daisuke Ogawa, Hiroyuki Kagechika, Hirofumi Makino. RXR antagonism induces G0 /G1 cell cycle arrest and ameliorates obesity by up-regulating the p53-p21(Cip1) pathway in adipocytes.
The Journal of pathology.
2012 Apr; 226(5):784-95. doi:
10.1002/path.3001. [PMID: 21956786] - Tongwei Yew, Sue-Anne Toh, John S Millar. Selective peroxisome proliferator-activated receptor-γ modulation to reduce cardiovascular risk in patients with insulin resistance.
Recent patents on cardiovascular drug discovery.
2012 Apr; 7(1):33-41. doi:
10.2174/157489012799362359. [PMID: 22044303] - Adriana M Hung, Christianne L Roumie, Robert A Greevy, Xulei Liu, Carlos G Grijalva, Harvey J Murff, T Alp Ikizler, Marie R Griffin. Comparative effectiveness of incident oral antidiabetic drugs on kidney function.
Kidney international.
2012 Apr; 81(7):698-706. doi:
10.1038/ki.2011.444. [PMID: 22258320] - G Musso, M Cassader, F Rosina, R Gambino. Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials.
Diabetologia.
2012 Apr; 55(4):885-904. doi:
10.1007/s00125-011-2446-4. [PMID: 22278337] - E Tsirella, T Mavrakanas, O Rager, S Tsartsalis, K Kallaras, B Kokkas, M Mironidou-Tzouveleki. Low dose pioglitazone does not affect bone formation and resorption markers or bone mineral density in streptozocin-induced diabetic rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2012 Apr; 63(2):201-4. doi:
NULL. [PMID: 22653908] - Mona F Schaalan. Effects of pioglitazone and/or simvastatin on circulating TNFα and adiponectin levels in insulin resistance.
Journal of immunotoxicology.
2012 Apr; 9(2):201-9. doi:
10.3109/1547691x.2012.660998. [PMID: 22428554] - Hui Huang, Hong Xin, Xinhua Liu, Yajun Xu, Danyi Wen, Yahua Zhang, Yi Zhun Zhu. Novel anti-diabetic effect of SCM-198 via inhibiting the hepatic NF-κB pathway in db/db mice.
Bioscience reports.
2012 Apr; 32(2):185-95. doi:
10.1042/bsr20110017. [PMID: 21859425] - A H van Lierop, N A T Hamdy, R W van der Meer, J T Jonker, H J Lamb, L J Rijzewijk, M Diamant, J A Romijn, J W A Smit, S E Papapoulos. Distinct effects of pioglitazone and metformin on circulating sclerostin and biochemical markers of bone turnover in men with type 2 diabetes mellitus.
European journal of endocrinology.
2012 Apr; 166(4):711-6. doi:
10.1530/eje-11-1061. [PMID: 22267280] - Wijtske Annema, Uwe Jf Tietge. Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies.
Nutrition & metabolism.
2012 Mar; 9(1):25. doi:
10.1186/1743-7075-9-25. [PMID: 22458435] - Thomas Karagiannis, Paschalis Paschos, Konstantinos Paletas, David R Matthews, Apostolos Tsapas. Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis.
BMJ (Clinical research ed.).
2012 Mar; 344(?):e1369. doi:
10.1136/bmj.e1369. [PMID: 22411919] - Chia Ju Chang, Thing-Fong Tzeng, Yuan-Shiun Chang, I-Min Liu. Beneficial impact of Zingiber zerumbet on insulin sensitivity in fructose-fed rats.
Planta medica.
2012 Mar; 78(4):317-25. doi:
10.1055/s-0031-1298136. [PMID: 22234408] - Emily Borsting, Vicki Pei-Chun Cheng, Chris K Glass, Volker Vallon, Robyn Cunard. Peroxisome proliferator-activated receptor-γ agonists repress epithelial sodium channel expression in the kidney.
American journal of physiology. Renal physiology.
2012 Mar; 302(5):F540-51. doi:
10.1152/ajprenal.00306.2011. [PMID: 22169011] - Yan-Ling He. Clinical pharmacokinetics and pharmacodynamics of vildagliptin.
Clinical pharmacokinetics.
2012 Mar; 51(3):147-62. doi:
10.2165/11598080-000000000-00000. [PMID: 22339447] - Joanna Karbowska, Zdzislaw Kochan. Intermittent fasting up-regulates Fsp27/Cidec gene expression in white adipose tissue.
Nutrition (Burbank, Los Angeles County, Calif.).
2012 Mar; 28(3):294-9. doi:
10.1016/j.nut.2011.06.009. [PMID: 21996045] - H-B Yang, X-Y Zhao, J-Y Zhang, Y-Y Du, X-F Wang. Pioglitazone induces regression and stabilization of coronary atherosclerotic plaques in patients with impaired glucose tolerance.
Diabetic medicine : a journal of the British Diabetic Association.
2012 Mar; 29(3):359-65. doi:
10.1111/j.1464-5491.2011.03458.x. [PMID: 21950726] - Maki Hasegawa, Harunobu Tahara, Ryo Inoue, Masakazu Kakuni, Chise Tateno, Junko Ushiki. Investigation of drug-drug interactions caused by human pregnane X receptor-mediated induction of CYP3A4 and CYP2C subfamilies in chimeric mice with a humanized liver.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Mar; 40(3):474-80. doi:
10.1124/dmd.111.042754. [PMID: 22126990] - Paresh Ved, Samrat Shah. Evaluation of vildagliptin and fixed dose combination of vildagliptin and metformin on glycemic control and insulin dose over 3 months in patients with type 2 diabetes mellitus.
Indian journal of endocrinology and metabolism.
2012 Mar; 16 Suppl 1(?):S110-3. doi:
10.4103/2230-8210.94258. [PMID: 22701828] - Ajay Chaudhuri, Julio Rosenstock, Andres DiGenio, Luigi Meneghini, Priscilla Hollander, Janet B McGill, Paresh Dandona, John Ilgenfritz, Matthew Riddle. Comparing the effects of insulin glargine and thiazolidinediones on plasma lipids in type 2 diabetes: a patient-level pooled analysis.
Diabetes/metabolism research and reviews.
2012 Mar; 28(3):258-67. doi:
10.1002/dmrr.1305. [PMID: 22081557] - J Pita, A Panadero, L Soriano-Guillén, E Rodríguez, A Rovira. The insulin sensitizing effects of PPAR-γ agonist are associated to changes in adiponectin index and adiponectin receptors in Zucker fatty rats.
Regulatory peptides.
2012 Feb; 174(1-3):18-25. doi:
10.1016/j.regpep.2011.11.004. [PMID: 22120832] - Dongzhu Xu, Nobuyuki Murakoshi, Miyako Igarashi, Aki Hirayama, Yoko Ito, Yoshihiro Seo, Hiroshi Tada, Kazutaka Aonuma. PPAR-γ activator pioglitazone prevents age-related atrial fibrillation susceptibility by improving antioxidant capacity and reducing apoptosis in a rat model.
Journal of cardiovascular electrophysiology.
2012 Feb; 23(2):209-17. doi:
10.1111/j.1540-8167.2011.02186.x. [PMID: 21954843] - Yang Yu, Zhi-Hua Zhang, Shun-Guang Wei, Robert M Weiss, Robert B Felder. Peroxisome proliferator-activated receptor-γ regulates inflammation and renin-angiotensin system activity in the hypothalamic paraventricular nucleus and ameliorates peripheral manifestations of heart failure.
Hypertension (Dallas, Tex. : 1979).
2012 Feb; 59(2):477-84. doi:
10.1161/hypertensionaha.111.182345. [PMID: 22083161] - Pinaki Sengupta, Utpal Nandi, Tapan Kumar Pal. Development of safety profile evaluating pharmacokinetics, pharmacodynamics and toxicity of a combination of pioglitazone and olmesartan medoxomil in Wistar albino rats.
Regulatory toxicology and pharmacology : RTP.
2012 Feb; 62(1):7-15. doi:
10.1016/j.yrtph.2011.12.008. [PMID: 22203042] - Angela Martín, José V Pérez-Girón, Raquel Hernanz, Roberto Palacios, Ana M Briones, Ana Fortuño, Guillermo Zalba, Mercedes Salaices, María J Alonso. Peroxisome proliferator-activated receptor-γ activation reduces cyclooxygenase-2 expression in vascular smooth muscle cells from hypertensive rats by interfering with oxidative stress.
Journal of hypertension.
2012 Feb; 30(2):315-26. doi:
10.1097/hjh.0b013e32834f043b. [PMID: 22179086] - Ming-Feng Xia, Hong-Mei Yan, Wan-Yuan He, Xiao-Ming Li, Chao-Lun Li, Xiu-Zhong Yao, Ruo-Kun Li, Meng-Su Zeng, Xin Gao. Standardized ultrasound hepatic/renal ratio and hepatic attenuation rate to quantify liver fat content: an improvement method.
Obesity (Silver Spring, Md.).
2012 Feb; 20(2):444-52. doi:
10.1038/oby.2011.302. [PMID: 22016092] - Hiroki Fujita, Hiromi Fujishima, Tsukasa Morii, Takuya Sakamoto, Koga Komatsu, Mihoko Hosoba, Takuma Narita, Keiko Takahashi, Takamune Takahashi, Yuichiro Yamada. Modulation of renal superoxide dismutase by telmisartan therapy in C57BL/6-Ins2(Akita) diabetic mice.
Hypertension research : official journal of the Japanese Society of Hypertension.
2012 Feb; 35(2):213-20. doi:
10.1038/hr.2011.176. [PMID: 22072110] - David Russell-Jones, Robert M Cuddihy, Markolf Hanefeld, Ajay Kumar, Jose G González, Melanie Chan, Anne M Wolka, Marilyn K Boardman. Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study.
Diabetes care.
2012 Feb; 35(2):252-8. doi:
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The Journal of endocrinology.
2012 Feb; 212(2):179-86. doi:
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Chemistry Central journal.
2012 Jan; 6(1):9. doi:
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Nutrition & metabolism.
2012 Jan; 9(1):4. doi:
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Cardiovascular diabetology.
2012 Jan; 11(?):6. doi:
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BMJ (Clinical research ed.).
2012 Jan; 344(?):d7771. doi:
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Regulatory peptides.
2012 Jan; 173(1-3):60-3. doi:
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Biochemistry research international.
2012; 2012(?):398697. doi:
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Lupus.
2012 Jan; 21(1):27-35. doi:
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ISRN endocrinology.
2012; 2012(?):798146. doi:
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