Bay-41-8543 (BioDeep_00000176459)

   

human metabolite blood metabolite


代谢物信息卡片


4,6-Pyrimidinediamine, 2-(1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)-5-(4-morpholinyl)-

化学式: C21H21FN8O (420.18222679999997)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 90.48%

分子结构信息

SMILES: C1COCCN1C2=C(N=C(N=C2N)C3=NN(C4=C3C=CC=N4)CC5=CC=CC=C5F)N
InChI: InChI=1S/C21H21FN8O/c22-15-6-2-1-4-13(15)12-30-21-14(5-3-7-25-21)16(28-30)20-26-18(23)17(19(24)27-20)29-8-10-31-11-9-29/h1-7H,8-12H2,(H4,23,24,26,27)

描述信息

同义名列表

4 个代谢物同义名

4,6-Pyrimidinediamine, 2-(1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)-5-(4-morpholinyl)-; 2-{1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}-5-(morpholin-4-yl)pyrimidine-4,6-diamine; 2-{1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl}-5-(morpholin-4-yl)pyrimidine-4,6-diamine; BAY-41-8543



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Bianca Stancu, Stephanie Krämer, Tanja Loof, Alice Mika, Kerstin Amann, Hans-H Neumayer, Harm Peters. Soluble guanylate cyclase stimulator BAY 41-8543 and female sex ameliorate uremic aortic remodeling in a rat model of mild uremia. Journal of hypertension. 2015 Sep; 33(9):1907-20; discussion 1921. doi: 10.1097/hjh.0000000000000648. [PMID: 26176653]
  • Linda S Hoffmann, Jennifer Etzrodt, Lena Willkomm, Abhishek Sanyal, Ludger Scheja, Alexander W C Fischer, Johannes-Peter Stasch, Wilhelm Bloch, Andreas Friebe, Joerg Heeren, Alexander Pfeifer. Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue. Nature communications. 2015 May; 6(?):7235. doi: 10.1038/ncomms8235. [PMID: 26011238]
  • Johannes-Peter Stasch, Jens Schlossmann, Berthold Hocher. Renal effects of soluble guanylate cyclase stimulators and activators: a review of the preclinical evidence. Current opinion in pharmacology. 2015 Apr; 21(?):95-104. doi: 10.1016/j.coph.2014.12.014. [PMID: 25645316]
  • Nicolaas J H Raat, D Marcela Tabima, Patricia A C Specht, Jesús Tejero, Hunter C Champion, Daniel B Kim-Shapiro, Jeff Baust, Egbert G Mik, Mariana Hildesheim, Johannes-Peter Stasch, Eva-Maria Becker, Hubert Truebel, Mark T Gladwin. Direct sGC activation bypasses NO scavenging reactions of intravascular free oxy-hemoglobin and limits vasoconstriction. Antioxidants & redox signaling. 2013 Dec; 19(18):2232-43. doi: 10.1089/ars.2013.5181. [PMID: 23697678]
  • Yingrui Wang-Rosenke, Alice Mika, Dymtro Khadzhynov, Tanja Loof, Hans-Hellmut Neumayer, Harm Peters. Impact of biological gender and soluble guanylate cyclase stimulation on renal recovery after relief of unilateral ureteral obstruction. The Journal of urology. 2012 Jul; 188(1):316-23. doi: 10.1016/j.juro.2012.02.2552. [PMID: 22608751]
  • John A Watts, Michael A Gellar, Mary-Beth K Fulkerson, Jeffrey A Kline. Pulmonary vascular reserve during experimental pulmonary embolism: effects of a soluble guanylate cyclase stimulator, BAY 41-8543. Critical care medicine. 2011 Dec; 39(12):2700-4. doi: 10.1097/ccm.0b013e318226678e. [PMID: 21705882]
  • Yingrui Wang-Rosenke, Alice Mika, Dymtro Khadzhynov, Tanja Loof, Hans-H Neumayer, Harm Peters. Stimulation of soluble guanylate cyclase improves renal recovery after relief of unilateral ureteral obstruction. The Journal of urology. 2011 Sep; 186(3):1142-9. doi: 10.1016/j.juro.2011.04.108. [PMID: 21784461]
  • Johannes-Peter Stasch, Cristina Alonso-Alija, Heiner Apeler, Klaus Dembowsky, Achim Feurer, Torsten Minuth, Elisabeth Perzborn, Matthias Schramm, Alexander Straub. Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies. British journal of pharmacology. 2002 Jan; 135(2):333-43. doi: 10.1038/sj.bjp.0704484. [PMID: 11815368]
  • Johannes-Peter Stasch, Klaus Dembowsky, Elisabeth Perzborn, Elke Stahl, Matthias Schramm. Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vivo studies. British journal of pharmacology. 2002 Jan; 135(2):344-55. doi: 10.1038/sj.bjp.0704483. [PMID: 11815369]