2-({6-Amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl}sulfanyl)acetamide (BioDeep_00000176456)

   

human metabolite blood metabolite


代谢物信息卡片


2-({6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl}sulphanyl)acetamide

化学式: C19H17N5O2S (379.1102902)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC1COC2=CC=C(C=C2)C3=C(C(=NC(=C3C#N)SCC(=O)N)N)C#N
InChI: InChI=1S/C19H17N5O2S/c20-7-14-17(12-3-5-13(6-4-12)26-9-11-1-2-11)15(8-21)19(24-18(14)23)27-10-16(22)25/h3-6,11H,1-2,9-10H2,(H2,22,25)(H2,23,24)

描述信息

D018377 - Neurotransmitter Agents > D058905 - Purinergic Agents > D058913 - Purinergic Agonists
BAY 60-6583 is a potent and high-affinity agonist of adenosine A2B receptor (EC50?= 3 nM) over A1, A2A, and A3 receptors. BAY 60-6583 binds to mouse, rabbit, and dog A2BAR with Ki values of 750 nM, 340 nM and 330 nM, respectively. BAY 60-6583 has a cardioprotective effect in a myocardial ischemia model[1][5].

同义名列表

4 个代谢物同义名

2-({6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl}sulphanyl)acetamide; 2-((6-Amino-3,5-dicyano-4-(4-(cyclopropylmethoxy)phenyl)pyridin-2-yl)sulfanyl)acetamide; 2-({6-Amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl}sulfanyl)acetamide; BAY 60-6583



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Samantha L Cooper, Edward S Wragg, Patrizia Pannucci, Mark Soave, Stephen J Hill, Jeanette Woolard. Regionally selective cardiovascular responses to adenosine A2A and A2B receptor activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022 04; 36(4):e22214. doi: 10.1096/fj.202101945r. [PMID: 35230706]
  • Elisabetta Coppi, Federica Cherchi, Irene Fusco, Ilaria Dettori, Lisa Gaviano, Giada Magni, Daniela Catarzi, Vittoria Colotta, Flavia Varano, Francesca Rossi, Caterina Bernacchioni, Chiara Donati, Paola Bruni, Felicita Pedata, Francesca Cencetti, Anna Maria Pugliese. Adenosine A2B receptors inhibit K+ currents and cell differentiation in cultured oligodendrocyte precursor cells and modulate sphingosine-1-phosphate signaling pathway. Biochemical pharmacology. 2020 07; 177(?):113956. doi: 10.1016/j.bcp.2020.113956. [PMID: 32251679]
  • Sonja Hinz, Wessam M Alnouri, Ulrich Pleiss, Christa E Müller. Tritium-labeled agonists as tools for studying adenosine A2B receptors. Purinergic signalling. 2018 09; 14(3):223-233. doi: 10.1007/s11302-018-9608-5. [PMID: 29752618]
  • Jessica M Wilson, Ellen Lorimer, Michael D Tyburski, Carol L Williams. β-Adrenergic receptors suppress Rap1B prenylation and promote the metastatic phenotype in breast cancer cells. Cancer biology & therapy. 2015; 16(9):1364-74. doi: 10.1080/15384047.2015.1070988. [PMID: 26209110]
  • Tomomi E Kimura, Aparna Duggirala, Charles C T Hindmarch, Richard C Hewer, Mei-Zhen Cui, Andrew C Newby, Mark Bond. Inhibition of Egr1 expression underlies the anti-mitogenic effects of cAMP in vascular smooth muscle cells. Journal of molecular and cellular cardiology. 2014 Jul; 72(?):9-19. doi: 10.1016/j.yjmcc.2014.02.001. [PMID: 24534707]
  • Sonja Hinz, Svenja K Lacher, Benjamin F Seibt, Christa E Müller. BAY60-6583 acts as a partial agonist at adenosine A2B receptors. The Journal of pharmacology and experimental therapeutics. 2014 Jun; 349(3):427-36. doi: 10.1124/jpet.113.210849. [PMID: 24633424]
  • Balázs Koscsó, Alexey Trepakov, Balázs Csóka, Zoltán H Németh, Pál Pacher, Holger K Eltzschig, György Haskó. Stimulation of A2B adenosine receptors protects against trauma-hemorrhagic shock-induced lung injury. Purinergic signalling. 2013 Sep; 9(3):427-32. doi: 10.1007/s11302-013-9362-7. [PMID: 23584760]
  • Almut Grenz, Hartmut Osswald, Tobias Eckle, Dan Yang, Hua Zhang, Zung Vu Tran, Karin Klingel, Katya Ravid, Holger K Eltzschig. The reno-vascular A2B adenosine receptor protects the kidney from ischemia. PLoS medicine. 2008 Jun; 5(6):e137. doi: 10.1371/journal.pmed.0050137. [PMID: 18578565]