Batrachotoxinin A 20-alpha-benzoate (BioDeep_00000176447)

   

human metabolite blood metabolite


代谢物信息卡片


1-{9,12-dihydroxy-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.1^{5,9}.0^{1,14}.0^{2,11}.0^{6,11}]tricosa-2,21-dien-22-yl}ethyl benzoate

化学式: C31H39NO6 (521.2777234)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C1=CCC23C1(CC(C45C2=CCC6C4(CCC(C6)(O5)O)C)O)CN(CCO3)C)OC(=O)C7=CC=CC=C7
InChI: InChI=1S/C31H39NO6/c1-20(37-26(34)21-7-5-4-6-8-21)23-11-12-30-24-10-9-22-17-29(35)14-13-27(22,2)31(24,38-29)25(33)18-28(23,30)19-32(3)15-16-36-30/h4-8,10-11,20,22,25,33,35H,9,12-19H2,1-3H3

描述信息

D009676 - Noxae > D011042 - Poisons > D014688 - Venoms

同义名列表

9 个代谢物同义名

1-{9,12-dihydroxy-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.1^{5,9}.0^{1,14}.0^{2,11}.0^{6,11}]tricosa-2,21-dien-22-yl}ethyl benzoate; 1-(9,12-Dihydroxy-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-dien-22-yl)ethyl benzoate; 1-{9,12-dihydroxy-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.1,.0,.0,.0,]tricosa-2,21-dien-22-yl}ethyl benzoic acid; Batrachotoxinin a 20-alpha-benzoic acid; Batrachotoxinin A 20-alpha-benzoate; Batrachotoxinin a 20-a-benzoic acid; Batrachotoxinin a 20-α-benzoic acid; Batrachotoxinin a 20-a-benzoate; Batrachotoxinin a 20-α-benzoate



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yin Duan, Chengyong Liao, Saurabh Jain, Russell A Nicholson. The cannabinoid receptor agonist CP-55,940 and ethyl arachidonate interfere with [(3)H]batrachotoxinin A 20 alpha-benzoate binding to sodium channels and inhibit sodium channel function. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2008 Sep; 148(3):244-9. doi: 10.1016/j.cbpc.2008.06.002. [PMID: 18599378]
  • Yin Duan, Jian Zheng, Russell A Nicholson. Inhibition of [3H]batrachotoxinin A-20alpha-benzoate binding to sodium channels and sodium channel function by endocannabinoids. Neurochemistry international. 2008 Feb; 52(3):438-46. doi: 10.1016/j.neuint.2007.08.004. [PMID: 17888543]
  • Yin Duan, Jian Zheng, Vanessa Law, Russell Nicholson. Natural products from ginseng inhibit [3H]batrachotoxinin A 20-alpha-benzoate binding to Na+ channels in mammalian brain. European journal of pharmacology. 2006 Jan; 530(1-2):9-14. doi: 10.1016/j.ejphar.2005.11.022. [PMID: 16359658]
  • R A Nicholson, C Liao, J Zheng, L S David, L Coyne, A C Errington, G Singh, G Lees. Sodium channel inhibition by anandamide and synthetic cannabimimetics in brain. Brain research. 2003 Jul; 978(1-2):194-204. doi: 10.1016/s0006-8993(03)02808-7. [PMID: 12834914]
  • R A Nicholson, J Zheng, C R Ganellin , B Verdon, G Lees. Anesthetic-like interaction of the sleep-inducing lipid oleamide with voltage-gated sodium channels in mammalian brain. Anesthesiology. 2001 Jan; 94(1):120-8. doi: 10.1097/00000542-200101000-00022. [PMID: 11135731]
  • M L Brown, G B Brown, W J Brouillette. Effects of log P and phenyl ring conformation on the binding of 5-phenylhydantoins to the voltage-dependent sodium channel. Journal of medicinal chemistry. 1997 Feb; 40(4):602-7. doi: 10.1021/jm960692v. [PMID: 9046351]
  • J X Kang, A Leaf. Evidence that free polyunsaturated fatty acids modify Na+ channels by directly binding to the channel proteins. Proceedings of the National Academy of Sciences of the United States of America. 1996 Apr; 93(8):3542-6. doi: 10.1073/pnas.93.8.3542. [PMID: 8622972]
  • K R Scott, G O Rankin, J P Stables, M S Alexander, I O Edafiogho, V A Farrar, K R Kolen, J A Moore, L D Sims, A D Tonnu. Synthesis and anticonvulsant activity of enaminones. 3. Investigations on 4'-, 3'-, and 2'-substituted and polysubstituted anilino compounds, sodium channel binding studies, and toxicity evaluations. Journal of medicinal chemistry. 1995 Sep; 38(20):4033-43. doi: 10.1021/jm00020a019. [PMID: 7562939]
  • T L Casebolt, G B Brown. Batrachotoxinin-A-ortho-azidobenzoate: a photoaffinity probe of the batrachotoxin binding site of voltage-sensitive sodium channels. Toxicon : official journal of the International Society on Toxinology. 1993 Sep; 31(9):1113-22. doi: 10.1016/0041-0101(93)90126-4. [PMID: 8266344]
  • M E Reith, A E Jacobson, K C Rice, M Benuck, I Zimanyi. Effect of metaphit on dopaminergic neurotransmission in rat striatal slices: involvement of the dopamine transporter and voltage-dependent sodium channel. The Journal of pharmacology and experimental therapeutics. 1991 Dec; 259(3):1188-96. doi: . [PMID: 1662274]
  • F Gusovsky, Y Nishizawa, W Padgett, E T McNeal, K Rice, C H Kim, C R Creveling, J W Daly. Voltage-dependent sodium channels in synaptoneurosomes: studies with 22Na+ influx and [3H]saxitoxin and [3H]batrachotoxinin-A 20-alpha-benzoate binding. Effects of proparacaine isothiocyanate. Brain research. 1990 Jun; 518(1-2):101-6. doi: 10.1016/0006-8993(90)90959-f. [PMID: 1697206]
  • C R Creveling, M E Bell, T R Burke, E Chang, G A Lewandowski-Lovenberg, C H Kim, K C Rice, J W Daly. Procaine isothiocyanate: an irreversible inhibitor of the specific binding of [3H]batrachotoxinin-A benzoate to sodium channels. Neurochemical research. 1990 Apr; 15(4):441-8. doi: 10.1007/bf00969931. [PMID: 2167458]
  • R S Sheldon, R J Hill, N J Cannon, H J Duff. Amiodarone: biochemical evidence for binding to a receptor for class I drugs associated with the rat cardiac sodium channel. Circulation research. 1989 Aug; 65(2):477-82. doi: 10.1161/01.res.65.2.477. [PMID: 2546697]
  • R S Sheldon, N J Cannon, H J Duff. A receptor for type I antiarrhythmic drugs associated with rat cardiac sodium channels. Circulation research. 1987 Oct; 61(4):492-7. doi: 10.1161/01.res.61.4.492. [PMID: 2443266]
  • M J Mullin, T K Dalton, W A Hunt, R A Harris, E Majchrowicz. Actions of ethanol on voltage-sensitive sodium channels: effects of acute and chronic ethanol treatment. The Journal of pharmacology and experimental therapeutics. 1987 Aug; 242(2):541-7. doi: NULL. [PMID: 2441033]