Banoxantrone (BioDeep_00000176425)

   

human metabolite blood metabolite


代谢物信息卡片


2-[(4-{[2-(dimethyl-oxo-$l^{5}-azanyl)ethyl]amino}-5,8-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-1-yl)amino]-N,N-dimethylethanamine oxide

化学式: C22H28N4O6 (444.2008748)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C[N+](C)(CCNC1=C2C(=C(C=C1)NCC[N+](C)(C)[O-])C(=O)C3=C(C=CC(=C3C2=O)O)O)[O-]
InChI: InChI=1S/C22H28N4O6/c1-25(2,31)11-9-23-13-5-6-14(24-10-12-26(3,4)32)18-17(13)21(29)19-15(27)7-8-16(28)20(19)22(18)30/h5-8,23-24,27-28H,9-12H2,1-4H3

描述信息

C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D000970 - Antineoplastic Agents

同义名列表

7 个代谢物同义名

2-[(4-{[2-(dimethyl-oxo-$l^{5}-azanyl)ethyl]amino}-5,8-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-1-yl)amino]-N,N-dimethylethanamine oxide; 2-[(4-{[2-(dimethyl-oxo-$l^{5}-azanyl)ethyl]amino}-5,8-dihydroxy-9,10-dioxoanthracen-1-yl)amino]-N,N-dimethylethanamine oxide; 1,4-Bis-((2-(dimethylamino-N-oxide)ethyl)amino)-5,8-dihydroxyanthracene-9,10-dione; 1,4-Bis-((2-(dimethylamino)ethyl)amino)-5,8-dihydroxyanthracene-9,10-dione; Banoxantrone dihydrochloride; Banoxantrone; AQ4n



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiaoqiu Li, Yangyang Zhao, Wei Jiang, Shuya Li, Meixiao Zhan, Hao Liu, Congjun Zhang, Hui Liang, Hang Liu, Ligong Lu, Yucai Wang. Ultralong circulating choline phosphate liposomal nanomedicines for cascaded chemo-radiotherapy. Biomaterials science. 2019 Mar; 7(4):1335-1344. doi: 10.1039/c9bm00051h. [PMID: 30816393]
  • W P Steward, M Middleton, A Benghiat, P M Loadman, C Hayward, S Waller, S Ford, G Halbert, L H Patterson, D Talbot. The use of pharmacokinetic and pharmacodynamic end points to determine the dose of AQ4N, a novel hypoxic cell cytotoxin, given with fractionated radiotherapy in a phase I study. Annals of oncology : official journal of the European Society for Medical Oncology. 2007 Jun; 18(6):1098-103. doi: 10.1093/annonc/mdm120. [PMID: 17442658]
  • Alshad S Lalani, Susan E Alters, Alvin Wong, Mark R Albertella, Jeffrey L Cleland, William David Henner. Selective tumor targeting by the hypoxia-activated prodrug AQ4N blocks tumor growth and metastasis in preclinical models of pancreatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007 Apr; 13(7):2216-25. doi: 10.1158/1078-0432.ccr-06-2427. [PMID: 17404106]
  • P M Loadman, D J Swaine, M C Bibby, K J Welham, L H Patterson. A preclinical pharmacokinetic study of the bioreductive drug AQ4N. Drug metabolism and disposition: the biological fate of chemicals. 2001 Apr; 29(4 Pt 1):422-6. doi: NULL. [PMID: 11259326]
  • D J Swaine, P M Loadman, M C Bibby, M A Graham, L H Patterson. High-performance liquid chromatographic analysis of AQ4N, an alkylaminoanthraquinone N-oxide. Journal of chromatography. B, Biomedical sciences and applications. 2000 Jun; 742(2):239-45. doi: 10.1016/s0378-4347(00)00160-2. [PMID: 10901128]