Bamifylline (BioDeep_00000176424)

   

human metabolite blood metabolite


代谢物信息卡片


8-benzyl-7-{2-[ethyl(2-hydroxyethyl)amino]ethyl}-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione

化学式: C20H27N5O3 (385.2113792)
中文名称: 苄乙醇胺嘌呤
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN(CCN1C(=NC2=C1C(=O)N(C(=O)N2C)C)CC3=CC=CC=C3)CCO
InChI: InChI=1S/C20H27N5O3/c1-4-24(12-13-26)10-11-25-16(14-15-8-6-5-7-9-15)21-18-17(25)19(27)23(3)20(28)22(18)2/h5-9,26H,4,10-14H2,1-3H3

描述信息

R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03D - Other systemic drugs for obstructive airway diseases > R03DA - Xanthines
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents

同义名列表

6 个代谢物同义名

8-benzyl-7-{2-[ethyl(2-hydroxyethyl)amino]ethyl}-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione; bamifylline hydrochloride; Benzetamophylline; Bamiphylline; BAMIFYLLINE; Trentadil



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Katarzyna Choma, Piotr Bednarczyk, Izabela Koszela-Piotrowska, Bogusz Kulawiak, Alexei Kudin, Wolfram S Kunz, Krzysztof Dołowy, Adam Szewczyk. Single channel studies of the ATP-regulated potassium channel in brain mitochondria. Journal of bioenergetics and biomembranes. 2009 Aug; 41(4):323-34. doi: 10.1007/s10863-009-9233-7. [PMID: 19821034]
  • F Belliardo, C Lucarelli. Micro-scale liquid chromatographic method for the determination of bamifylline and its major metabolite in human plasma. Journal of chromatography. 1990 Dec; 535(1-2):305-9. doi: 10.1016/s0021-9673(01)88956-1. [PMID: 2089060]
  • G Segre, D Cerretani, L Moltoni, R Urso, M Fusillo. Pharmacokinetics of bamifylline during chronic therapy. Arzneimittel-Forschung. 1990 Apr; 40(4):450-2. doi: NULL. [PMID: 2357245]
  • P Schiantarelli, D Acerbi, G C Botta, L Bonati, P Capelli, I Rondelli. Evidence of pulmonary tropism of bamifylline and its main active metabolite. Arzneimittel-Forschung. 1989 Feb; 39(2):215-9. doi: NULL. [PMID: 2730690]
  • E Pulido, F Pupita, C Battistoni. Treatment of patients with chronic airways obstruction: a controlled study with bamyphylline. Pharmatherapeutica. 1989; 5(6):416-22. doi: NULL. [PMID: 2687897]
  • E Gerlo, V Maes. HPLC method for assay of bamifylline in plasma from neonates. Clinical chemistry. 1988 Aug; 34(8):1657. doi: NULL. [PMID: 3402076]
  • L D Makoeva, T F Belinskaia, E D Li, A G Margarian, V V Sabaev. [Effect of beta-adrenergic blockaders and trental on plasma levels of renin and aldosterone in healthy persons during antiorthostatic hypokinesia]. Kardiologiia. 1985 Jun; 25(6):40-2. doi: NULL. [PMID: 3900526]
  • G Nicot, G Lachatre, C Gonnet, J L Rocca, J P Valette, L Merle, Y Nouaille. High-performance liquid chromatographic method for the determination of bamifylline and its three metabolites in human plasma. Journal of chromatography. 1983 Oct; 277(?):239-49. doi: 10.1016/s0378-4347(00)84841-0. [PMID: 6643609]
  • L I Mazur, V V Nikolaĭchik, V G Astapenko, V A Ostapenko. [Complications of extracorporeal hemosorption and their prevention]. Vestnik khirurgii imeni I. I. Grekova. 1983 Jun; 130(6):114-9. doi: NULL. [PMID: 6612925]
  • J B Fourtillan, A M Brisson, M A Lefebvre. [Technique for the assay of bamifylline and some of its metabolites in plasma by high-performance liquid chromatography]. Annales pharmaceutiques francaises. 1983; 41(1):37-43. doi: NULL. [PMID: 6625476]
  • L Dodion, M Aylward. Metabolic and pharmacokinetic studies on Bamifylline. A review. Revue de l'Institut d'hygiene des mines. 1978; 33(4):204-10. doi: NULL. [PMID: 552145]
  • J MILLASANTOS, A DARNELLTEY. [RESULTS OF CLINICAL EXPERIMENTATION WITH AC 3810 (TRENTADIL)]. Medicina. 1964 Aug; 32(?):397-401. doi: NULL. [PMID: 14204002]