3-Azetidinecarboxylic acid (BioDeep_00000176375)

   

human metabolite blood metabolite natural product


代谢物信息卡片


Azetidine-2-carboxylic acid

化学式: C4H7NO2 (101.0476762)
中文名称: 3-羧基环丁胺
谱图信息: 最多检出来源 Homo sapiens(blood) 10.34%

分子结构信息

SMILES: C1C(CN1)C(=O)O
InChI: InChI=1S/C4H7NO2/c6-4(7)3-1-5-2-3/h3,5H,1-2H2,(H,6,7)

描述信息

同义名列表

8 个代谢物同义名

Azetidine-2-carboxylic acid; Azetidine 2 carboxylic Acid; Azetidine 3 carboxylic Acid; Azetidine-3-carboxylic Acid; 3-azetidinecarboxylic Acid; 3 azetidinecarboxylic Acid; Azetidinecarboxylic acid; 3-Azetidinecarboxylate



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

40 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xi Wu, Yafeng Jia, Qian Ma, Tingting Wang, Jiena Xu, Hongli Chen, Mingxia Wang, Hui Song, Shuqing Cao. The transcription factor bZIP44 cooperates with MYB10 and MYB72 to regulate the response of Arabidopsis thaliana to iron deficiency stress. The New phytologist. 2024 Jun; 242(6):2586-2603. doi: 10.1111/nph.19706. [PMID: 38523234]
  • Nicolas Kratena, Markus Draskovits, Nina Biedermann, Eva Oburger, Christian Stanetty. Total synthesis of [13 C2 ]-labeled phytosiderophores of the mugineic and avenic acid families. Journal of labelled compounds & radiopharmaceuticals. 2023 11; 66(13):428-434. doi: 10.1002/jlcr.4064. [PMID: 37755147]
  • Lijuan Han, Wangyu Zhao, Aijuan Li, Bo Zhou, Jiwen Zhang, Wenjun Wu. Antifungal activity of l-azetidine-2-carboxylic acid isolated from Disporopsis aspera rhizomes against Podosphaera xanthii. Pest management science. 2022 May; 78(5):1946-1952. doi: 10.1002/ps.6812. [PMID: 35085420]
  • Wentao Sun, Xiaojin J Zhou, Chen Chen, Xin Zhang, Xiaolong Tian, Ke Xiao, Chenxu Liu, Rumei Chen, Shaojiang Chen. Maize Interveinal Chlorosis 1 links the Yang Cycle and Fe homeostasis through Nicotianamine biosynthesis. Plant physiology. 2022 03; 188(4):2131-2145. doi: 10.1093/plphys/kiac009. [PMID: 35099564]
  • Jesse T Beasley, Julien P Bonneau, Laura T Moreno-Moyano, Damien L Callahan, Kate S Howell, Elad Tako, Julian Taylor, Raymond P Glahn, Rudi Appels, Alexander A T Johnson. Multi-year field evaluation of nicotianamine biofortified bread wheat. The Plant journal : for cell and molecular biology. 2022 03; 109(5):1168-1182. doi: 10.1111/tpj.15623. [PMID: 34902177]
  • S Gopika, Cyril Augustine. Theoretical studies on the coordination chemistry of phytosiderophores with special reference to Fe-nicotianamine complexes in graminaceous plants. Journal of molecular modeling. 2022 Feb; 28(3):71. doi: 10.1007/s00894-022-05065-3. [PMID: 35226207]
  • Xin Zhang, Ke Xiao, Suzhen Li, Jie Li, Jiaxing Huang, Rumei Chen, Sen Pang, Xiaojin Zhou. Genome-wide analysis of the NAAT, DMAS, TOM, and ENA gene families in maize suggests their roles in mediating iron homeostasis. BMC plant biology. 2022 Jan; 22(1):37. doi: 10.1186/s12870-021-03422-7. [PMID: 35039017]
  • Ada Biratsi, Alexandros Athanasopoulos, Vassili N Kouvelis, Christos Gournas, Vicky Sophianopoulou. A highly conserved mechanism for the detoxification and assimilation of the toxic phytoproduct L-azetidine-2-carboxylic acid in Aspergillus nidulans. Scientific reports. 2021 04; 11(1):7391. doi: 10.1038/s41598-021-86622-3. [PMID: 33795709]
  • Fumiaki Nasu, Yutaro Obara, Yosuke Okamoto, Hiroaki Yamaguchi, Kazuya Kurakami, Ikuo Norota, Kuniaki Ishii. Azelnidipine treatment reduces the expression of Cav1.2 protein. Life sciences. 2021 Mar; 269(?):119043. doi: 10.1016/j.lfs.2021.119043. [PMID: 33453240]
  • Motofumi Suzuki, Atsumi Urabe, Sayaka Sasaki, Ryo Tsugawa, Satoshi Nishio, Haruka Mukaiyama, Yoshiko Murata, Hiroshi Masuda, May Sann Aung, Akane Mera, Masaki Takeuchi, Keijo Fukushima, Michika Kanaki, Kaori Kobayashi, Yuichi Chiba, Binod Babu Shrestha, Hiromi Nakanishi, Takehiro Watanabe, Atsushi Nakayama, Hiromichi Fujino, Takanori Kobayashi, Keiji Tanino, Naoko K Nishizawa, Kosuke Namba. Development of a mugineic acid family phytosiderophore analog as an iron fertilizer. Nature communications. 2021 03; 12(1):1558. doi: 10.1038/s41467-021-21837-6. [PMID: 33692352]
  • Ghaya Alchoubassi, Katarzyna Kińska, Katarzyna Bierla, Ryszard Lobinski, Joanna Szpunar. Speciation of essential nutrient trace elements in coconut water. Food chemistry. 2021 Mar; 339(?):127680. doi: 10.1016/j.foodchem.2020.127680. [PMID: 32860999]
  • Yoshiko Murata, Masami Yoshida, Naho Sakamoto, Shiho Morimoto, Takehiro Watanabe, Kosuke Namba. Iron uptake mediated by the plant-derived chelator nicotianamine in the small intestine. The Journal of biological chemistry. 2021 Jan; 296(?):100195. doi: 10.1074/jbc.ra120.015861. [PMID: 33334885]
  • James F Collins. Iron chelates hitch a ride on PAT1. The Journal of biological chemistry. 2021 Jan; 296(?):100418. doi: 10.1016/j.jbc.2021.100418. [PMID: 33837730]
  • Laura Marastoni, Luigi Lucini, Begoña Miras-Moreno, Marco Trevisan, Davide Sega, Anita Zamboni, Zeno Varanini. Changes in physiological activities and root exudation profile of two grapevine rootstocks reveal common and specific strategies for Fe acquisition. Scientific reports. 2020 11; 10(1):18839. doi: 10.1038/s41598-020-75317-w. [PMID: 33139754]
  • Clémentine Laffont, Pascal Arnoux. The ancient roots of nicotianamine: diversity, role, regulation and evolution of nicotianamine-like metallophores. Metallomics : integrated biometal science. 2020 10; 12(10):1480-1493. doi: 10.1039/d0mt00150c. [PMID: 33084706]
  • Yuta Kawakami, Navreet K Bhullar. Potential Implications of Interactions between Fe and S on Cereal Fe Biofortification. International journal of molecular sciences. 2020 Apr; 21(8):. doi: 10.3390/ijms21082827. [PMID: 32325653]
  • Huimin Zhang, Yang Li, Mengna Pu, Peng Xu, Gang Liang, Diqiu Yu. Oryza sativa POSITIVE REGULATOR OF IRON DEFICIENCY RESPONSE 2 (OsPRI2) and OsPRI3 are involved in the maintenance of Fe homeostasis. Plant, cell & environment. 2020 01; 43(1):261-274. doi: 10.1111/pce.13655. [PMID: 31674679]
  • Qian Li, Lei Chen, An Yang. The Molecular Mechanisms Underlying Iron Deficiency Responses in Rice. International journal of molecular sciences. 2019 Dec; 21(1):. doi: 10.3390/ijms21010043. [PMID: 31861687]
  • Ruohan Xie, Jianqi Zhao, Lingli Lu, Jun Ge, Patrick H Brown, Shuai Wei, Runze Wang, Yabei Qiao, Samuel M Webb, Shengke Tian. Efficient phloem remobilization of Zn protects apple trees during the early stages of Zn deficiency. Plant, cell & environment. 2019 12; 42(12):3167-3181. doi: 10.1111/pce.13621. [PMID: 31325325]
  • Houqing Zeng, Xin Zhang, Ming Ding, Xiajun Zhang, Yiyong Zhu. Transcriptome profiles of soybean leaves and roots in response to zinc deficiency. Physiologia plantarum. 2019 Nov; 167(3):330-351. doi: 10.1111/ppl.12894. [PMID: 30536844]
  • Shaopei Gao, Yunhua Xiao, Fan Xu, Xiaokai Gao, Shouyun Cao, Fengxia Zhang, Guodong Wang, Dale Sanders, Chengcai Chu. Cytokinin-dependent regulatory module underlies the maintenance of zinc nutrition in rice. The New phytologist. 2019 10; 224(1):202-215. doi: 10.1111/nph.15962. [PMID: 31131881]
  • Raviraj Banakar, Ana Alvarez Fernandez, Changfu Zhu, Javier Abadia, Teresa Capell, Paul Christou. The ratio of phytosiderophores nicotianamine to deoxymugenic acid controls metal homeostasis in rice. Planta. 2019 Oct; 250(4):1339-1354. doi: 10.1007/s00425-019-03230-2. [PMID: 31278466]
  • Jing Che, Kengo Yokosho, Naoki Yamaji, Jian Feng Ma. A Vacuolar Phytosiderophore Transporter Alters Iron and Zinc Accumulation in Polished Rice Grains. Plant physiology. 2019 09; 181(1):276-288. doi: 10.1104/pp.19.00598. [PMID: 31331995]
  • Jesse T Beasley, Julien P Bonneau, Jose T Sánchez-Palacios, Laura T Moreno-Moyano, Damien L Callahan, Elad Tako, Raymond P Glahn, Enzo Lombi, Alexander A T Johnson. Metabolic engineering of bread wheat improves grain iron concentration and bioavailability. Plant biotechnology journal. 2019 08; 17(8):1514-1526. doi: 10.1111/pbi.13074. [PMID: 30623558]
  • Jesse T Beasley, Jonathan J Hart, Elad Tako, Raymond P Glahn, Alexander A T Johnson. Investigation of Nicotianamine and 2' Deoxymugineic Acid as Enhancers of Iron Bioavailability in Caco-2 Cells. Nutrients. 2019 Jun; 11(7):. doi: 10.3390/nu11071502. [PMID: 31262064]
  • Shimpei Uraguchi, Michael Weber, Stephan Clemens. Elevated root nicotianamine concentrations are critical for Zn hyperaccumulation across diverse edaphic environments. Plant, cell & environment. 2019 06; 42(6):2003-2014. doi: 10.1111/pce.13541. [PMID: 30809818]
  • Xinxin Zhang, Di Zhang, Wei Sun, Tianzuo Wang. The Adaptive Mechanism of Plants to Iron Deficiency via Iron Uptake, Transport, and Homeostasis. International journal of molecular sciences. 2019 May; 20(10):. doi: 10.3390/ijms20102424. [PMID: 31100819]
  • Brigitta Müller, Krisztina Kovács, Hong-Diep Pham, Yusuf Kavak, Jiři Pechoušek, Libor Machala, Radek Zbořil, Kálmán Szenthe, Javier Abadía, Ferenc Fodor, Zoltán Klencsár, Ádám Solti. Chloroplasts preferentially take up ferric-citrate over iron-nicotianamine complexes in Brassica napus. Planta. 2019 Mar; 249(3):751-763. doi: 10.1007/s00425-018-3037-0. [PMID: 30382344]
  • Alessio Aprile, Erika Sabella, Marzia Vergine, Alessandra Genga, Maria Siciliano, Eliana Nutricati, Patrizia Rampino, Mariarosaria De Pascali, Andrea Luvisi, Antonio Miceli, Carmine Negro, Luigi De Bellis. Activation of a gene network in durum wheat roots exposed to cadmium. BMC plant biology. 2018 Oct; 18(1):238. doi: 10.1186/s12870-018-1473-4. [PMID: 30326849]
  • Maria Garnica, Eva Bacaicoa, Veronica Mora, Sara San Francisco, Roberto Baigorri, Angel Mari Zamarreño, Jose Maria Garcia-Mina. Shoot iron status and auxin are involved in iron deficiency-induced phytosiderophores release in wheat. BMC plant biology. 2018 Jun; 18(1):105. doi: 10.1186/s12870-018-1324-3. [PMID: 29866051]
  • Noura A Hassan, Hany M El Bassossy, Ahmed Fahmy, Mona F Mahmoud. Limonin alleviates macro- and micro-vascular complications of metabolic syndrome in rats: A comparative study with azelnidipine. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Apr; 43(?):92-102. doi: 10.1016/j.phymed.2018.03.044. [PMID: 29747759]
  • Kosuke Namba, Yoshiko Murata. Organic Chemistry Research on the Mechanistic Elucidation of Iron Acquisition in Barley. Biological & pharmaceutical bulletin. 2018; 41(10):1502-1507. doi: 10.1248/bpb.b18-00070. [PMID: 30270318]
  • Rakesh K Kumar, Heng-Hsuan Chu, Celina Abundis, Kenneth Vasques, David Chan Rodriguez, Ju-Chen Chia, Rong Huang, Olena K Vatamaniuk, Elsbeth L Walker. Iron-Nicotianamine Transporters Are Required for Proper Long Distance Iron Signaling. Plant physiology. 2017 Nov; 175(3):1254-1268. doi: 10.1104/pp.17.00821. [PMID: 28894019]
  • Takeshi Senoura, Emi Sakashita, Takanori Kobayashi, Michiko Takahashi, May Sann Aung, Hiroshi Masuda, Hiromi Nakanishi, Naoko K Nishizawa. The iron-chelate transporter OsYSL9 plays a role in iron distribution in developing rice grains. Plant molecular biology. 2017 Nov; 95(4-5):375-387. doi: 10.1007/s11103-017-0656-y. [PMID: 28871478]
  • Raviraj Banakar, Ana Alvarez Fernandez, Pablo Díaz-Benito, Javier Abadia, Teresa Capell, Paul Christou. Phytosiderophores determine thresholds for iron and zinc accumulation in biofortified rice endosperm while inhibiting the accumulation of cadmium. Journal of experimental botany. 2017 10; 68(17):4983-4995. doi: 10.1093/jxb/erx304. [PMID: 29048564]
  • Dong-Keun Lee, Pil Joong Chung, Jin Seo Jeong, Geupil Jang, Seung Woon Bang, Harin Jung, Youn Shic Kim, Sun-Hwa Ha, Yang Do Choi, Ju-Kon Kim. The rice OsNAC6 transcription factor orchestrates multiple molecular mechanisms involving root structural adaptions and nicotianamine biosynthesis for drought tolerance. Plant biotechnology journal. 2017 Jun; 15(6):754-764. doi: 10.1111/pbi.12673. [PMID: 27892643]
  • Chandan Kumar Gupta, Bhupinder Singh. Uninhibited biosynthesis and release of phytosiderophores in the presence of heavy metal (HM) favors HM remediation. Environmental science and pollution research international. 2017 Apr; 24(10):9407-9416. doi: 10.1007/s11356-017-8636-y. [PMID: 28233213]
  • Khurram Bashir, Tomoko Nozoye, Seiji Nagasaka, Sultana Rasheed, Nanako Miyauchi, Motoaki Seki, Hiromi Nakanishi, Naoko K Nishizawa. Paralogs and mutants show that one DMA synthase functions in iron homeostasis in rice. Journal of experimental botany. 2017 03; 68(7):1785-1795. doi: 10.1093/jxb/erx065. [PMID: 28369596]
  • Weilin Zhang, Chengqi Yan, Mei Li, Ling Yang, Bojun Ma, Hongyu Meng, Li Xie, Jianping Chen. Transcriptome Analysis Reveals the Response of Iron Homeostasis to Early Feeding by Small Brown Planthopper in Rice. Journal of agricultural and food chemistry. 2017 Feb; 65(6):1093-1101. doi: 10.1021/acs.jafc.6b04674. [PMID: 28112511]
  • Jesse T Beasley, Julien P Bonneau, Alexander A T Johnson. Characterisation of the nicotianamine aminotransferase and deoxymugineic acid synthase genes essential to Strategy II iron uptake in bread wheat (Triticum aestivum L.). PloS one. 2017; 12(5):e0177061. doi: 10.1371/journal.pone.0177061. [PMID: 28475636]
  • Jiyeon Lee, Naveen Joshi, Rita Pasini, Renwick C J Dobson, Jane Allison, Thomas Leustek. Inhibition of Arabidopsis growth by the allelopathic compound azetidine-2-carboxylate is due to the low amino acid specificity of cytosolic prolyl-tRNA synthetase. The Plant journal : for cell and molecular biology. 2016 10; 88(2):236-246. doi: 10.1111/tpj.13246. [PMID: 27332880]
  • Priyabrata Das, Soma Mukhopadhyay, Nirmal Kumar Sarkar, Suvra Mandal, Manoj Kar, Ashis Mukhopadhyay. Mugineic acid, active ingredient of wheat grass: an oral novel hexadentate iron chelator in iron overloaded diseases. Journal of biochemistry. 2016 Sep; 160(3):163-76. doi: 10.1093/jb/mvw023. [PMID: 27008864]
  • Jelena Pavlovic, Jelena Samardzic, Ljiljana Kostic, Kristian H Laursen, Maja Natic, Gordana Timotijevic, Jan K Schjoerring, Miroslav Nikolic. Silicon enhances leaf remobilization of iron in cucumber under limited iron conditions. Annals of botany. 2016 08; 118(2):271-80. doi: 10.1093/aob/mcw105. [PMID: 27371693]
  • Zhao-hua Yin, Yan Li, Chun-qing Zhang, Cui-cui Yang, Cheng-lai Wu, Xiang-pan Liu, Ming-ming Wang. Cloning and promoter activity analyses of the promoter of 2'-deoxymugineic acid (DMA) secretion channel gene YS3 in maize. Yi chuan = Hereditas. 2016 06; 38(6):560-568. doi: 10.16288/j.yczz.15-174. [PMID: 27655317]
  • Ghassan Ghssein, Catherine Brutesco, Laurent Ouerdane, Clémentine Fojcik, Amélie Izaute, Shuanglong Wang, Christine Hajjar, Ryszard Lobinski, David Lemaire, Pierre Richaud, Romé Voulhoux, Akbar Espaillat, Felipe Cava, David Pignol, Elise Borezée-Durant, Pascal Arnoux. Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus. Science (New York, N.Y.). 2016 May; 352(6289):1105-9. doi: 10.1126/science.aaf1018. [PMID: 27230378]
  • Michio Fukuda, Yoshiaki Ogiyama, Ryo Sato, Toshiyuki Miura, Hidekatsu Fukuta, Masashi Mizuno, Ken Kiyono, Yoshiharu Yamamoto, Junichiro Hayano, Nobuyuki Ohte. L/T-type calcium channel blocker reduces non-Gaussianity of heart rate variability in chronic kidney disease patients under preceding treatment with ARB. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2016 Apr; 17(2):1470320316643905. doi: 10.1177/1470320316643905. [PMID: 27094219]
  • Tomoko Ariga, Yuki Imura, Michio Suzuki, Etsuro Yoshimura. Determination of ferric iron chelators by high-performance liquid chromatography using luminol chemiluminescence detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Mar; 1014(?):75-82. doi: 10.1016/j.jchromb.2016.01.048. [PMID: 26874881]
  • Norio Susa, Yayoi Nishida, Yoichi Yada, Tomohiro Nakayama, Satoshi Asai, Yasuo Takahashi. Comparative effect of fixed-dose combination tablets of candesartan cilexetil/amlodipine versus olmesartan medoxomil/azelnidipine on laboratory parameters in patients with hypertension: a retrospective cohort study. Clinical and experimental hypertension (New York, N.Y. : 1993). 2016; 38(2):173-9. doi: 10.3109/10641963.2015.1081214. [PMID: 26453437]
  • Adrian D Hobson, Christopher M Harris, Elizabeth L van der Kam, Sean C Turner, Ayome Abibi, Ana L Aguirre, Peter Bousquet, Tegest Kebede, Donald B Konopacki, Gary Gintant, Youngjae Kim, Kelly Larson, John W Maull, Nigel S Moore, Dan Shi, Anurupa Shrestha, Xiubo Tang, Peng Zhang, Kathy K Sarris. Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders. Journal of medicinal chemistry. 2015 Dec; 58(23):9154-70. doi: 10.1021/acs.jmedchem.5b00928. [PMID: 26509640]
  • Tomoko Nozoye, Seiji Nagasaka, Takanori Kobayashi, Yuki Sato, Nobuyuki Uozumi, Hiromi Nakanishi, Naoko K Nishizawa. The Phytosiderophore Efflux Transporter TOM2 Is Involved in Metal Transport in Rice. The Journal of biological chemistry. 2015 Nov; 290(46):27688-99. doi: 10.1074/jbc.m114.635193. [PMID: 26432636]
  • Tadakatsu Yoneyama, Satoru Ishikawa, Shu Fujimaki. Route and Regulation of Zinc, Cadmium, and Iron Transport in Rice Plants (Oryza sativa L.) during Vegetative Growth and Grain Filling: Metal Transporters, Metal Speciation, Grain Cd Reduction and Zn and Fe Biofortification. International journal of molecular sciences. 2015 Aug; 16(8):19111-29. doi: 10.3390/ijms160819111. [PMID: 26287170]
  • Yanhui Gao, Baoqiu Li, Baomeng Zhu, Dongming Liu, Hengli Zhao, Zengjun Fang, Haisheng Wang, Hongxiang Lou. A liquid chromatography-tandem mass spectrometric assay for the antihypertensive agent azelnidipine in human plasma with application to clinical pharmacokinetics studies. Biomedical chromatography : BMC. 2015 Jul; 29(7):970-4. doi: 10.1002/bmc.3399. [PMID: 25472837]
  • Kenji Hazama, Shinji Nagata, Tamaki Fujimori, Shuichi Yanagisawa, Tadakatsu Yoneyama. Concentrations of metals and potential metal-binding compounds and speciation of Cd, Zn and Cu in phloem and xylem saps from castor bean plants (Ricinus communis) treated with four levels of cadmium. Physiologia plantarum. 2015 Jun; 154(2):243-55. doi: 10.1111/ppl.12309. [PMID: 25403762]
  • Hideki Kato, Takeshi Shiraishi, Shuko Ueda, Eiji Kubo, Tomoko Shima, Michito Nagura, Hirofumi Yano, Yuh Izumikawa, Masaru Shimada, Satoru Tomioka, Hitonari Nosaka, Kenichiro Kojima, Masayuki Tanemoto, Shunya Uchida. Blood pressure control and satisfaction of hypertensive patients following a switch to combined drugs of an angiotensin receptor blocker and a calcium channel blocker in clinical practice of nephrology. Clinical and experimental nephrology. 2015 Jun; 19(3):465-73. doi: 10.1007/s10157-014-1017-7. [PMID: 25135635]
  • Jean-Yves Cornu, Ulrich Deinlein, Stephan Höreth, Manuel Braun, Holger Schmidt, Michael Weber, Daniel P Persson, Søren Husted, Jan K Schjoerring, Stephan Clemens. Contrasting effects of nicotianamine synthase knockdown on zinc and nickel tolerance and accumulation in the zinc/cadmium hyperaccumulator Arabidopsis halleri. The New phytologist. 2015 Apr; 206(2):738-50. doi: 10.1111/nph.13237. [PMID: 25545296]
  • Saori Takahashi, Taku Yoshiya, Kumiko Yoshizawa-Kumagaye, Toshihiro Sugiyama. Nicotianamine is a novel angiotensin-converting enzyme 2 inhibitor in soybean. Biomedical research (Tokyo, Japan). 2015; 36(3):219-24. doi: 10.2220/biomedres.36.219. [PMID: 26106051]
  • Ryoichi Araki, Kosuke Namba, Yoshiko Murata, Jun Murata. Phytosiderophores revisited: 2'-deoxymugineic acid-mediated iron uptake triggers nitrogen assimilation in rice (Oryza sativa L.) seedlings. Plant signaling & behavior. 2015; 10(6):e1031940. doi: 10.1080/15592324.2015.1031940. [PMID: 26023724]
  • Ryoichi Araki, Kayoko Kousaka, Kosuke Namba, Yoshiko Murata, Jun Murata. 2'-Deoxymugineic acid promotes growth of rice (Oryza sativa L.) by orchestrating iron and nitrate uptake processes under high pH conditions. The Plant journal : for cell and molecular biology. 2015 Jan; 81(2):233-46. doi: 10.1111/tpj.12722. [PMID: 25393516]
  • Zhao-Xia Ma, Ya-Jun Leng, Guang-Xia Chen, Peng-Min Zhou, De Ye, Li-Qun Chen. The THERMOSENSITIVE MALE STERILE 1 Interacts with the BiPs via DnaJ Domain and Stimulates Their ATPase Enzyme Activities in Arabidopsis. PloS one. 2015; 10(7):e0132500. doi: 10.1371/journal.pone.0132500. [PMID: 26186593]
  • Martin R Walter, Daniel Artner, Christian Stanetty. Synthesis of [13C4]-labeled 2'-deoxymugineic acid. Journal of labelled compounds & radiopharmaceuticals. 2014 Nov; 57(13):710-4. doi: 10.1002/jlcr.3242. [PMID: 25385205]
  • Mark G M Aarts. Nicotianamine secretion for zinc excess tolerance. Plant physiology. 2014 Oct; 166(2):751-2. doi: 10.1104/pp.114.249490. [PMID: 25288637]
  • Munkhtsetseg Tsednee, Shun-Chung Yang, Der-Chuen Lee, Kuo-Chen Yeh. Root-secreted nicotianamine from Arabidopsis halleri facilitates zinc hypertolerance by regulating zinc bioavailability. Plant physiology. 2014 Oct; 166(2):839-52. doi: 10.1104/pp.114.241224. [PMID: 25118254]
  • Eva Oburger, Barbara Gruber, Yvonne Schindlegger, Walter D C Schenkeveld, Stephan Hann, Stephan M Kraemer, Walter W Wenzel, Markus Puschenreiter. Root exudation of phytosiderophores from soil-grown wheat. The New phytologist. 2014 Sep; 203(4):1161-1174. doi: 10.1111/nph.12868. [PMID: 24890330]
  • Stephan Clemens. Zn and Fe biofortification: the right chemical environment for human bioavailability. Plant science : an international journal of experimental plant biology. 2014 Aug; 225(?):52-7. doi: 10.1016/j.plantsci.2014.05.014. [PMID: 25017159]
  • Hiroyasu Uzui, Tetsuji Morishita, Akira Nakano, Naoki Amaya, Yoshitomo Fukuoka, Kentaro Ishida, Kenichiro Arakawa, Jong-Dae Lee, Hiroshi Tada. Effects of combination therapy with olmesartan and azelnidipine on serum osteoprotegerin in patients with hypertension. Journal of cardiovascular pharmacology and therapeutics. 2014 May; 19(3):304-9. doi: 10.1177/1074248413511692. [PMID: 24288395]
  • Yvonne Schindlegger, Eva Oburger, Barbara Gruber, Walter D C Schenkeveld, Stephan M Kraemer, Markus Puschenreiter, Gunda Koellensperger, Stephan Hann. Accurate LC-ESI-MS/MS quantification of 2'-deoxymugineic acid in soil and root related samples employing porous graphitic carbon as stationary phase and a ¹³C₄-labeled internal standard. Electrophoresis. 2014 May; 35(9):1375-85. doi: 10.1002/elps.201300551. [PMID: 24464840]
  • Kazi Rafiq, Akira Nishiyama, Yoshio Konishi, Takashi Morikawa, Chizuko Kitabayashi, Masakazu Kohno, Tsutomu Masaki, Hirohito Mori, Hiroyuki Kobori, Masahito Imanishi. Regression of glomerular and tubulointerstitial injuries by dietary salt reduction with combination therapy of angiotensin II receptor blocker and calcium channel blocker in Dahl salt-sensitive rats. PloS one. 2014; 9(9):e107853. doi: 10.1371/journal.pone.0107853. [PMID: 25233358]
  • Satoshi Miyazaki, Toshihiro Hamada, Shigemasa Hirata, Akira Ohtahara, Einosuke Mizuta, Yasutaka Yamamoto, Masanari Kuwabara, Yoshihito Nosaka, Osamu Igawa, Kazuhide Ogino, Masahiko Kato, Akio Yoshida, Haruaki Ninomiya, Jidong Cheng, Yuji Moriwaki, Kazuhiro Yamamoto, Ichiro Hisatome. Effects of azelnidipine on uric acid metabolism in patients with essential hypertension. Clinical and experimental hypertension (New York, N.Y. : 1993). 2014; 36(7):447-53. doi: 10.3109/10641963.2013.846359. [PMID: 24433018]
  • Hongchun Xiong, Yusuke Kakei, Takanori Kobayashi, Xiaotong Guo, Mikio Nakazono, Hirokazu Takahashi, Hiromi Nakanishi, Hongyun Shen, Fusuo Zhang, Naoko K Nishizawa, Yuanmei Zuo. Molecular evidence for phytosiderophore-induced improvement of iron nutrition of peanut intercropped with maize in calcareous soil. Plant, cell & environment. 2013 Oct; 36(10):1888-902. doi: 10.1111/pce.12097. [PMID: 23496756]
  • Ge Gao, Xiao-Cheng Liu, Wen-Bin Jing, Qin Yang, Guo-Wei He. Vasorelaxation induced by new third-generation dihydropyridine calcium antagonist azelnidipine in human internal mammary artery. The Annals of thoracic surgery. 2013 Oct; 96(4):1316-1321. doi: 10.1016/j.athoracsur.2013.05.020. [PMID: 23895889]
  • Emmanuel Koen, Angélique Besson-Bard, Céline Duc, Jérémy Astier, Antoine Gravot, Pierre Richaud, Olivier Lamotte, Jossia Boucherez, Frédéric Gaymard, David Wendehenne. Arabidopsis thaliana nicotianamine synthase 4 is required for proper response to iron deficiency and to cadmium exposure. Plant science : an international journal of experimental plant biology. 2013 Aug; 209(?):1-11. doi: 10.1016/j.plantsci.2013.04.006. [PMID: 23759098]
  • Stephan Clemens, Ulrich Deinlein, Hassan Ahmadi, Stephan Höreth, Shimpei Uraguchi. Nicotianamine is a major player in plant Zn homeostasis. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2013 Aug; 26(4):623-32. doi: 10.1007/s10534-013-9643-1. [PMID: 23775667]
  • Masayoshi Kojima, Setsuya Okubo, Ryuichi Mizubayashi, Naoki Isaka, Hirofumi Machida, Shinya Okamoto, Hisayoshi Hirota, Misao Takeuchi, Takuya Kato, Kaname Nakatani, Osamu Mizuno, Koichi Miyagawa, Katsutoshi Makino, Takanobu Okura, Yasuaki Dohi, Masaaki Ito, Genjiro Kimura. Kidney-protective effects of azelnidipine versus a diuretic in combination with olmesartan in hypertensive patients with diabetes and albuminuria: a randomized study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2013 Jul; 28(7):1802-10. doi: 10.1093/ndt/gft034. [PMID: 23535223]
  • Matsuda Sanae, Aoyagi Yasuo. Green asparagus (Asparagus officinalis) prevented hypertension by an inhibitory effect on angiotensin-converting enzyme activity in the kidney of spontaneously hypertensive rats. Journal of agricultural and food chemistry. 2013 Jun; 61(23):5520-5. doi: 10.1021/jf3041066. [PMID: 23647085]
  • Roberto Terzano, Tanja Mimmo, Bart Vekemans, Laszlo Vincze, Gerald Falkenberg, Nicola Tomasi, Magali Schnell Ramos, Roberto Pinton, Stefano Cesco. Iron (Fe) speciation in xylem sap by XANES at a high brilliant synchrotron X-ray source: opportunities and limitations. Analytical and bioanalytical chemistry. 2013 Jun; 405(16):5411-9. doi: 10.1007/s00216-013-6959-1. [PMID: 23609785]
  • Allison R Hayward, Kahlan E Coates, Amy L Galer, Thomas C Hutchinson, R J Neil Emery. Chelator profiling in Deschampsia cespitosa (L.) Beauv. Reveals a Ni reaction, which is distinct from the ABA and cytokinin associated response to Cd. Plant physiology and biochemistry : PPB. 2013 Mar; 64(?):84-91. doi: 10.1016/j.plaphy.2012.12.018. [PMID: 23399533]
  • Ahmad H Kabir, Nicholas G Paltridge, Ute Roessner, James C R Stangoulis. Mechanisms associated with Fe-deficiency tolerance and signaling in shoots of Pisum sativum. Physiologia plantarum. 2013 Mar; 147(3):381-95. doi: 10.1111/j.1399-3054.2012.01682.x. [PMID: 22913816]
  • Tadashi Uramatsu, Tomoya Nishino, Yoko Obata, Yohei Sato, Akira Furusu, Takehiko Koji, Toru Miyazaki, Shigeru Kohno. Involvement of apoptosis inhibitor of macrophages in a rat hypertension model with nephrosclerosis: possible mechanisms of action of olmesartan and azelnidipine. Biological & pharmaceutical bulletin. 2013; 36(8):1271-7. doi: 10.1248/bpb.b12-00965. [PMID: 23902971]
  • Ling Yuan, Lianghuan Wu, Chunlei Yang, Qian Lv. Effects of iron and zinc foliar applications on rice plants and their grain accumulation and grain nutritional quality. Journal of the science of food and agriculture. 2013 Jan; 93(2):254-61. doi: 10.1002/jsfa.5749. [PMID: 22740351]
  • Kazuki Noda, Maki Hosoya, Sota Nakajima, Junko Ohashi, Yoshihiro Fukumoto, Hiroaki Shimokawa. Anti-atherogenic effects of the combination therapy with olmesartan and azelnidipine in diabetic apolipoprotein E-deficient mice. The Tohoku journal of experimental medicine. 2012 12; 228(4):305-15. doi: 10.1620/tjem.228.305. [PMID: 23124103]
  • Hitomi Yamaguchi, Riichiro Uchida. Determination of nicotianamine in soy sauce and other plant-based foods by LC-MS/MS. Journal of agricultural and food chemistry. 2012 Oct; 60(40):10000-6. doi: 10.1021/jf3035868. [PMID: 23025624]
  • Luqing Zheng, Naoki Yamaji, Kengo Yokosho, Jian Feng Ma. YSL16 is a phloem-localized transporter of the copper-nicotianamine complex that is responsible for copper distribution in rice. The Plant cell. 2012 Sep; 24(9):3767-82. doi: 10.1105/tpc.112.103820. [PMID: 23012434]
  • Ikuo Saito, Toshio Kushiro, Natsuko Zenimura, Yasuyuki Matsushita, Kei Sagawa, Katsutoshi Hiramatsu, Fumie Yamaguchi. Olmesartan medoxomil and azelnidipine therapy in patients with hypertension and chronic kidney disease in Japan. Journal of nephrology. 2012 Sep; 25(5):699-708. doi: 10.5301/jn.5000043. [PMID: 22020401]
  • Scott Aleksander Sinclair, Ute Krämer. The zinc homeostasis network of land plants. Biochimica et biophysica acta. 2012 Sep; 1823(9):1553-67. doi: 10.1016/j.bbamcr.2012.05.016. [PMID: 22626733]
  • Maria N Hindt, Mary Lou Guerinot. Getting a sense for signals: regulation of the plant iron deficiency response. Biochimica et biophysica acta. 2012 Sep; 1823(9):1521-30. doi: 10.1016/j.bbamcr.2012.03.010. [PMID: 22483849]
  • Rongli Shi, Günther Weber, Jessica Köster, Mohammad Reza-Hajirezaei, Chunqin Zou, Fusuo Zhang, Nicolaus von Wirén. Senescence-induced iron mobilization in source leaves of barley (Hordeum vulgare) plants. The New phytologist. 2012 Jul; 195(2):372-383. doi: 10.1111/j.1469-8137.2012.04165.x. [PMID: 22591276]
  • Mara Schuler, Rubén Rellán-Álvarez, Claudia Fink-Straube, Javier Abadía, Petra Bauer. Nicotianamine functions in the Phloem-based transport of iron to sink organs, in pollen development and pollen tube growth in Arabidopsis. The Plant cell. 2012 Jun; 24(6):2380-400. doi: 10.1105/tpc.112.099077. [PMID: 22706286]
  • Ishari Waduwara-Jayabahu, Yasmin Oppermann, Markus Wirtz, Zachary T Hull, Sarah Schoor, Alexander N Plotnikov, Rüdiger Hell, Margret Sauter, Barbara A Moffatt. Recycling of methylthioadenosine is essential for normal vascular development and reproduction in Arabidopsis. Plant physiology. 2012 Apr; 158(4):1728-44. doi: 10.1104/pp.111.191072. [PMID: 22345506]
  • Hajime Nagasu, Minoru Satoh, Sohachi Fujimoto, Naruya Tomita, Tamaki Sasaki, Naoki Kashihara. Azelnidipine attenuates glomerular damage in Dahl salt-sensitive rats by suppressing sympathetic nerve activity. Hypertension research : official journal of the Japanese Society of Hypertension. 2012 Mar; 35(3):348-55. doi: 10.1038/hr.2011.184. [PMID: 22072106]
  • Ulrich Deinlein, Michael Weber, Holger Schmidt, Stefan Rensch, Aleksandra Trampczynska, Thomas H Hansen, Søren Husted, Jan K Schjoerring, Ina N Talke, Ute Krämer, Stephan Clemens. Elevated nicotianamine levels in Arabidopsis halleri roots play a key role in zinc hyperaccumulation. The Plant cell. 2012 Feb; 24(2):708-23. doi: 10.1105/tpc.111.095000. [PMID: 22374395]
  • Michael J Haydon, Miki Kawachi, Markus Wirtz, Stefan Hillmer, Rüdiger Hell, Ute Krämer. Vacuolar nicotianamine has critical and distinct roles under iron deficiency and for zinc sequestration in Arabidopsis. The Plant cell. 2012 Feb; 24(2):724-37. doi: 10.1105/tpc.111.095042. [PMID: 22374397]
  • T Ohyama, K Sato, K Kishimoto, Y Yamazaki, N Horiguchi, T Ichikawa, S Kakizaki, H Takagi, T Izumi, M Mori. Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence. British journal of pharmacology. 2012 Feb; 165(4b):1173-87. doi: 10.1111/j.1476-5381.2011.01599.x. [PMID: 21790536]
  • Nancy R Hofmann. Nicotianamine in zinc and iron homeostasis. The Plant cell. 2012 Feb; 24(2):373. doi: 10.1105/tpc.112.240212. [PMID: 22374391]
  • Reiko Nishiyama, Mariyo Kato, Shinji Nagata, Shuichi Yanagisawa, Tadakatsu Yoneyama. Identification of Zn-nicotianamine and Fe-2'-Deoxymugineic acid in the phloem sap from rice plants (Oryza sativa L.). Plant & cell physiology. 2012 Feb; 53(2):381-90. doi: 10.1093/pcp/pcr188. [PMID: 22218421]
  • Tsuneo Takenaka, Takeru Seto, Mika Okayama, Eriko Kojima, Yuka Nodaira, Keita Sueyoshi, Tomohiro Kikuta, Yusuke Watanabe, Tsutomu Inoue, Hiroshi Takane, Yoichi Ohno, Hiromichi Suzuki. Long-term effects of calcium antagonists on augmentation index in hypertensive patients with chronic kidney disease: a randomized controlled study. American journal of nephrology. 2012; 35(5):416-23. doi: 10.1159/000338132. [PMID: 22517217]
  • Sarah S Conte, Elsbeth L Walker. Genetic and biochemical approaches for studying the yellow stripe-like transporter family in plants. Current topics in membranes. 2012; 69(?):295-322. doi: 10.1016/b978-0-12-394390-3.00011-2. [PMID: 23046655]
  • Akimasa Sasaki, Naoki Yamaji, Jixing Xia, Jian Feng Ma. OsYSL6 is involved in the detoxification of excess manganese in rice. Plant physiology. 2011 Dec; 157(4):1832-40. doi: 10.1104/pp.111.186031. [PMID: 21969384]
  • Sichul Lee, Daniel P Persson, Thomas H Hansen, Søren Husted, Jan K Schjoerring, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Yusuke Kakei, Hiroshi Masuda, Naoko K Nishizawa, Gynheung An. Bio-available zinc in rice seeds is increased by activation tagging of nicotianamine synthase. Plant biotechnology journal. 2011 Oct; 9(8):865-73. doi: 10.1111/j.1467-7652.2011.00606.x. [PMID: 21426477]
  • Kosuke Fukao, Kazunori Shimada, Makoto Hiki, Takashi Kiyanagi, Kuniaki Hirose, Atsumi Kume, Hiromichi Ohsaka, Rie Matsumori, Takeshi Kurata, Tetsuro Miyazaki, Hiroyuki Daida. Effects of calcium channel blockers on glucose tolerance, inflammatory state, and circulating progenitor cells in non-diabetic patients with essential hypertension: a comparative study between azelnidipine and amlodipine on glucose tolerance and endothelial function--a crossover trial (AGENT). Cardiovascular diabetology. 2011 Sep; 10(?):79. doi: 10.1186/1475-2840-10-79. [PMID: 21906391]