AUREOMYCIN (BioDeep_00000176314)
human metabolite blood metabolite
代谢物信息卡片
化学式: C22H23ClN2O8 (478.1142868)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C(C=CC(=C41)Cl)O)O)O)O)C(=O)N)N(C)C)O
InChI: InChI=1S/C22H23ClN2O8/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21/h4-5,7-8,15,26-27,30,32-33H,6H2,1-3H3,(H2,24,31)
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
同义名列表
23 个代谢物同义名
7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-3,4,4a,5,5a,6,12,12a-octahydrotetracene-2-carboximidic acid; 7-Chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-3,4,4a,5,5a,6,12,12a-octahydrotetracene-2-carboximidate; 7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboximidic acid; Monohydrochloride, chlortetracycline; Chlortetracycline monohydrochloride; Hydrochloride, chlortetracycline; Chlortetracycline sulfate (2:1); Chlortetracycline, calcium salt; Salt chlortetracycline, calcium; Chlortetracycline hydrochloride; Chlortetracycline sulfate (1:1); Calcium salt chlortetracycline; Bisulfate, chlortetracycline; Chlortetracycline bisulfate; Chlortetracycline, 4 epimer; Chlortetracycline, 4-epimer; 4-Epimer chlortetracycline; Chlorotetracycline; Chlortetracycline; Aureocyclin; Aureomycine; AUREOMYCIN; Biomycin
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 54677440
- HMDB: HMDB0248728
- ChEMBL: CHEMBL4782156
- MeSH: Chlortetracycline
- chemspider: 34560875
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Yuhu Tian, Jingyan Zhang, Fenghua Li, Anguo Wang, Zhiqiang Yang, Jianxi Li. Dietary supplementation with different alternative to in-feed antibiotic improves growth performance of broilers during specific phases.
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Journal of environmental management.
2023 May; 333(?):117468. doi:
10.1016/j.jenvman.2023.117468
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Environmental geochemistry and health.
2023 Jan; 45(1):7-17. doi:
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International journal of molecular sciences.
2022 Nov; 23(23):. doi:
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Poultry science.
2022 Aug; 101(8):101811. doi:
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Journal of applied microbiology.
2022 Mar; 132(3):1760-1767. doi:
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Chemosphere.
2022 Jan; 286(Pt 2):131770. doi:
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Dec; 263(?):120194. doi:
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. [PMID: 34303220] - Xin Ma, Zhiren Yang, Tingting Xu, Mengqi Qian, Xuemei Jiang, Xiuan Zhan, Xinyan Han. Chlortetracycline alters microbiota of gut or faeces in pigs and leads to accumulation and migration of antibiotic resistance genes.
The Science of the total environment.
2021 Nov; 796(?):148976. doi:
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Molecules (Basel, Switzerland).
2021 Feb; 26(4):. doi:
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Sheng wu gong cheng xue bao = Chinese journal of biotechnology.
2020 Dec; 36(12):2685-2694. doi:
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Poultry science.
2020 Oct; 99(10):4750-4757. doi:
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Poultry science.
2020 Sep; 99(9):4521-4529. doi:
10.1016/j.psj.2020.05.030
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Molecules (Basel, Switzerland).
2020 Jul; 25(14):. doi:
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Ecotoxicology and environmental safety.
2020 Jun; 196(?):110584. doi:
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Journal of environmental management.
2020 May; 262(?):110337. doi:
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Applied and environmental microbiology.
2020 03; 86(6):. doi:
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Journal of animal science.
2020 Mar; 98(3):. doi:
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International journal of molecular sciences.
2020 Jan; 21(2):. doi:
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Journal of environmental quality.
2020 Jan; 49(1):236-245. doi:
10.1002/jeq2.20034
. [PMID: 33016366] - Lei Meng, Chengwu Lan, Zhonghu Liu, Na Xu, Yuqing Wu. A novel ratiometric fluorescence probe for highly sensitive and specific detection of chlorotetracycline among tetracycline antibiotics.
Analytica chimica acta.
2019 Dec; 1089(?):144-151. doi:
10.1016/j.aca.2019.08.065
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Journal of environmental management.
2019 Nov; 250(?):109509. doi:
10.1016/j.jenvman.2019.109509
. [PMID: 31509789] - Manuel Conde-Cid, Gustavo Ferreira-Coelho, Avelino Núñez-Delgado, David Fernández-Calviño, Manuel Arias-Estévez, Esperanza Álvarez-Rodríguez, María J Fernández-Sanjurjo. Competitive adsorption of tetracycline, oxytetracycline and chlortetracycline on soils with different pH value and organic matter content.
Environmental research.
2019 11; 178(?):108669. doi:
10.1016/j.envres.2019.108669
. [PMID: 31450146] - Rui Yan, Aiping Hui, Yuru Kang, Yanming Zhou, Aiqin Wang. Effects of palygorskite composites on growth performance and antioxidant status in broiler chickens.
Poultry science.
2019 Jul; 98(7):2781-2789. doi:
10.3382/ps/pez070
. [PMID: 30778562] - Lei Meng, Chengwu Lan, Zhonghu Liu, Jian-Hang Yin, Na Xu. Nitrogen-terminated silicon nanoparticles obtained via chemical etching and passivation are specific fluorescent probes for creatinine.
Mikrochimica acta.
2019 05; 186(6):387. doi:
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Analytical chemistry.
2019 05; 91(9):5913-5921. doi:
10.1021/acs.analchem.9b00319
. [PMID: 30986040] - Devin B Holman, Bradley L Bearson, Heather K Allen, Daniel C Shippy, Crystal L Loving, Brian J Kerr, Shawn M D Bearson, Brian W Brunelle. Chlortetracycline Enhances Tonsil Colonization and Fecal Shedding of Multidrug-Resistant Salmonella enterica Serovar Typhimurium DT104 without Major Alterations to the Porcine Tonsillar and Intestinal Microbiota.
Applied and environmental microbiology.
2019 02; 85(4):. doi:
10.1128/aem.02354-18
. [PMID: 30530706] - Hui Shi, Cuihua Bai, Donglin Luo, Wei Wang, Changmin Zhou, Andrew A Meharg, Lixian Yao. Degradation of tetracyclines in manure-amended soil and their uptake by litchi (Litchi chinensis Sonn.).
Environmental science and pollution research international.
2019 Feb; 26(6):6209-6215. doi:
10.1007/s11356-018-04077-y
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PloS one.
2019; 14(12):e0225697. doi:
10.1371/journal.pone.0225697
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Journal of animal science.
2018 Dec; 96(12):5166-5178. doi:
10.1093/jas/sky370
. [PMID: 30358839] - Xuedong Wang, Yuansi Zheng, Yan Ma, Liyang Du, Fangyu Chu, Haidong Gu, Randy A Dahlgren, Yanyan Li, Huili Wang. Lipid metabolism disorder induced by up-regulation of miR-125b and miR-144 following β-diketone antibiotic exposure to F0-zebrafish (Danio rerio).
Ecotoxicology and environmental safety.
2018 Nov; 164(?):243-252. doi:
10.1016/j.ecoenv.2018.08.027
. [PMID: 30121499] - Eric Miller, Amit Vikram, Getahun E Agga, Terrance M Arthur, John W Schmidt. Effects of In-Feed Chlortetracycline Prophylaxis in Beef Cattle on Antimicrobial Resistance Genes.
Foodborne pathogens and disease.
2018 11; 15(11):689-697. doi:
10.1089/fpd.2018.2475
. [PMID: 30109957] - Bin Li, Jin-Qiu Zhang, Xian-Gan Han, Zheng-Lei Wang, Yuan-Yuan Xu, Jin-Feng Miao. Macleaya cordata helps improve the growth-promoting effect of chlortetracycline on broiler chickens.
Journal of Zhejiang University. Science. B.
2018 Oct; 19(10):776-784. doi:
10.1631/jzus.b1700435
. [PMID: 30269445] - Shanoy C Anderson, Seenivasan Subbiah, Angella Gentles, Darryll Oliver, Paul Stonum, Tiffanie A Brooks, Ernest E Smith. Qualitative and quantitative drug residue analyses: Chlortetracycline in white-tailed deer (Odocoileus virginianus) and supermarket meat by liquid chromatography tandem-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Aug; 1092(?):237-243. doi:
10.1016/j.jchromb.2018.05.027
. [PMID: 29913335] - M M Satorre, E Breininger, P D Cetica, M Córdoba. Relation between respiratory activity and sperm parameters in boar spermatozoa cryopreserved with alpha-tocopherol and selected by Sephadex.
Reproduction in domestic animals = Zuchthygiene.
2018 Aug; 53(4):979-985. doi:
10.1111/rda.13197
. [PMID: 29691903] - Hong-Lei Shi, Xiao-Chang Wang, Qian Li. [Removal of Typical Antibiotics During Aerobic Composting of Human Feces].
Huan jing ke xue= Huanjing kexue.
2018 Jul; 39(7):3434-3442. doi:
10.13227/j.hjkx.201711182
. [PMID: 29962171] - Margaret D Weinroth, H Morgan Scott, Bo Norby, Guy H Loneragan, Noelle R Noyes, Pablo Rovira, Enrique Doster, Xiang Yang, Dale R Woerner, Paul S Morley, Keith E Belk. Effects of Ceftiofur and Chlortetracycline on the Resistomes of Feedlot Cattle.
Applied and environmental microbiology.
2018 07; 84(13):. doi:
10.1128/aem.00610-18
. [PMID: 29728379] - Hongbo Yi, Li Wang, Yunxia Xiong, Xiaolu Wen, Zhilin Wang, Xuefen Yang, Kaiguo Gao, Zongyong Jiang. Effects of Lactobacillus reuteri LR1 on the growth performance, intestinal morphology, and intestinal barrier function in weaned pigs.
Journal of animal science.
2018 Jun; 96(6):2342-2351. doi:
10.1093/jas/sky129
. [PMID: 29659876] - Javiera Cornejo, Karina Yevenes, Constanza Avello, Ekaterina Pokrant, Aldo Maddaleno, Betty San Martin, Lisette Lapierre. Determination of Chlortetracycline Residues, Antimicrobial Activity and Presence of Resistance Genes in Droppings of Experimentally Treated Broiler Chickens.
Molecules (Basel, Switzerland).
2018 May; 23(6):. doi:
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. [PMID: 29799472] - K Washburn, V R Fajt, P Plummer, E Papastavros, J F Coetzee, L W Wulf, S Washburn. Pharmacokinetics of chlortetracycline in maternal plasma and in fetal tissues following oral administration to pregnant ewes.
Journal of veterinary pharmacology and therapeutics.
2018 Apr; 41(2):218-223. doi:
10.1111/jvp.12454
. [PMID: 28892152] - Yaning Mao, Yufeng Wu, Yongyin Nie, Jun Wang, Yuanyuan Liu, Shenghao Xu, Xiliang Luo. A two-wavelength fluorescence recovery method for the simultaneous determination of aureomycin and oxytetracycline by using gold nanocrystals modified with serine and 11-mercaptoundecanoic acid.
Mikrochimica acta.
2018 03; 185(4):222. doi:
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. [PMID: 29594841] - Wenguang Xiong, Yulin Wang, Yongxue Sun, Liping Ma, Qinglin Zeng, Xiaotao Jiang, Andong Li, Zhenling Zeng, Tong Zhang. Antibiotic-mediated changes in the fecal microbiome of broiler chickens define the incidence of antibiotic resistance genes.
Microbiome.
2018 02; 6(1):34. doi:
10.1186/s40168-018-0419-2
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Huan jing ke xue= Huanjing kexue.
2018 Feb; 39(2):935-943. doi:
10.13227/j.hjkx.201706250
. [PMID: 29964860] - Laura E J Peeters, Siska Croubels, Geertrui Rasschaert, Hein Imberechts, Els Daeseleire, Jeroen Dewulf, Marc Heyndrickx, Patrick Butaye, Freddy Haesebrouck, Annemieke Smet. Effect of residual doxycycline concentrations on resistance selection and transfer in porcine commensal Escherichia coli.
International journal of antimicrobial agents.
2018 Jan; 51(1):123-127. doi:
10.1016/j.ijantimicag.2017.04.018
. [PMID: 28668675] - Hyung Suk Chung, Young-Jun Lee, Md Musfiqur Rahman, A M Abd El-Aty, Han Sol Lee, Md Humayun Kabir, Sung Woo Kim, Byung-Jun Park, Jang-Eok Kim, Fazil Hacımüftüoğlu, Nilufar Nahar, Ho-Chul Shin, Jae-Han Shim. Uptake of the veterinary antibiotics chlortetracycline, enrofloxacin, and sulphathiazole from soil by radish.
The Science of the total environment.
2017 Dec; 605-606(?):322-331. doi:
10.1016/j.scitotenv.2017.06.231
. [PMID: 28668743] - Naomi Ohta, Keri N Norman, Bo Norby, Sara D Lawhon, Javier Vinasco, Henk den Bakker, Guy H Loneragan, H Morgan Scott. Population dynamics of enteric Salmonella in response to antimicrobial use in beef feedlot cattle.
Scientific reports.
2017 10; 7(1):14310. doi:
10.1038/s41598-017-14751-9
. [PMID: 29085049] - Xiao-Hui Dong, Cheng Peng, Yu-Yi Zhang, Yu-Long Tao, Xia Tao, Chuan Zhang, Alex F Chen, He-Hui Xie. Chronic Exposure to Subtherapeutic Antibiotics Aggravates Ischemic Stroke Outcome in Mice.
EBioMedicine.
2017 Oct; 24(?):116-126. doi:
10.1016/j.ebiom.2017.09.002
. [PMID: 28928014] - Daniel A Bair, Ina E Popova, Kenneth W Tate, Sanjai J Parikh. Transport of oxytetracycline, chlortetracycline, and ivermectin in surface runoff from irrigated pasture.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
2017 Sep; 52(9):631-640. doi:
10.1080/03601234.2017.1330069
. [PMID: 28898166] - Li Shenghe, Jin Erhui, Qiao Enmei, Wu Guozhong, Li Kui. Chitooligosaccharide promotes immune organ development in broiler chickens and reduces serum lipid levels.
Histology and histopathology.
2017 Sep; 32(9):951-961. doi:
10.14670/hh-11-860
. [PMID: 28008592] - Inna E Popova, Rosemarie D R Josue, Shiping Deng, Jeffory A Hattey. Tetracycline resistance in semi-arid agricultural soils under long-term swine effluent application.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
2017 May; 52(5):298-305. doi:
10.1080/03601234.2017.1281639
. [PMID: 28277084] - Michael E Hume, Curtis J Donskey. Effect of Vancomycin, Tylosin, and Chlortetracycline on Vancomycin-Resistant Enterococcus faecium Colonization of Broiler Chickens During Grow-Out.
Foodborne pathogens and disease.
2017 04; 14(4):231-237. doi:
10.1089/fpd.2016.2217
. [PMID: 28128649] - Song Yeob Kim, Saranya Kuppusamy, Jang Hwan Kim, Young-Eun Yoon, Kwon-Rae Kim, Yong Bok Lee. Occurrence and diversity of tetracycline resistance genes in the agricultural soils of South Korea.
Environmental science and pollution research international.
2016 Nov; 23(21):22190-22196. doi:
10.1007/s11356-016-7574-4
. [PMID: 27638788] - Laura E J Peeters, Els Daeseleire, Mathias Devreese, Geertrui Rasschaert, Annemieke Smet, Jeroen Dewulf, Marc Heyndrickx, Hein Imberechts, Freddy Haesebrouck, Patrick Butaye, Siska Croubels. Residues of chlortetracycline, doxycycline and sulfadiazine-trimethoprim in intestinal content and feces of pigs due to cross-contamination of feed.
BMC veterinary research.
2016 Sep; 12(?):209. doi:
10.1186/s12917-016-0803-8
. [PMID: 27645697] - Honglei Shi, Xiaochang C Wang, Qian Li, Shanqing Jiang. Degradation of typical antibiotics during human feces aerobic composting under different temperatures.
Environmental science and pollution research international.
2016 Aug; 23(15):15076-87. doi:
10.1007/s11356-016-6664-7
. [PMID: 27083910] - S Jahanbakhsh, A Letellier, J M Fairbrother. Circulating of CMY-2 β-lactamase gene in weaned pigs and their environment in a commercial farm and the effect of feed supplementation with a clay mineral.
Journal of applied microbiology.
2016 Jul; 121(1):136-48. doi:
10.1111/jam.13166
. [PMID: 27138244] - Martina Kyselková, Tomáš Chrudimský, Filip Husník, Alica Chroňáková, Holger Heuer, Kornelia Smalla, Dana Elhottová. Characterization of tet(Y)-carrying LowGC plasmids exogenously captured from cow manure at a conventional dairy farm.
FEMS microbiology ecology.
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