Auda (BioDeep_00000176309)
human metabolite blood metabolite
代谢物信息卡片
化学式: C23H40N2O3 (392.30387700000006)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 99.44%
分子结构信息
SMILES: C1C2CC3CC1CC(C2)(C3)NC(=O)NCCCCCCCCCCCC(=O)O
InChI: InChI=1S/C23H40N2O3/c26-21(27)10-8-6-4-2-1-3-5-7-9-11-24-22(28)25-23-15-18-12-19(16-23)14-20(13-18)17-23/h18-20H,1-17H2,(H,26,27)(H2,24,25,28)
数据库引用编号
7 个数据库交叉引用编号
- PubChem: 10069117
- HMDB: HMDB0248721
- ChEMBL: CHEMBL215387
- Wikipedia: .au Domain Administration
- KNApSAcK: C00000247
- chemspider: 8244657
- CAS: 479413-70-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Khong Trong Quan, InWha Park, Chung Sub Kim, Wesley Yoshida, Daneel Ferreira, Phuong Thien Thuong, Young Ho Kim, MinKyun Na, Joonseok Oh. Configurational Assignment of a Flexible Benzo[g]isochromene Stereodiad from Rubia philippinensis and Inhibition of Soluble Epoxide Hydrolase Activity.
Journal of natural products.
2021 09; 84(9):2594-2599. doi:
10.1021/acs.jnatprod.1c00037
. [PMID: 34427436] - Alessandra Ammazzalorso, Cristina Maccallini, Pasquale Amoia, Rosa Amoroso. Multitarget PPARγ agonists as innovative modulators of the metabolic syndrome.
European journal of medicinal chemistry.
2019 Jul; 173(?):261-273. doi:
10.1016/j.ejmech.2019.04.030
. [PMID: 31009912] - Nguyen Phuong Thao, Bui Thi Thuy Luyen, Ji Sun Lee, Jang Hoon Kim, Nguyen Tien Dat, Young Ho Kim. Inhibition Potential of Cycloartane-Type Glycosides from the Roots of Cimicifuga dahurica against Soluble Epoxide Hydrolase.
Journal of natural products.
2017 06; 80(6):1867-1875. doi:
10.1021/acs.jnatprod.7b00166
. [PMID: 28558206] - Bui Thi Thuy Luyen, Bui Huu Tai, Nguyen Phuong Thao, Kim Ji Eun, Ji Yun Cha, Ming Jie Xin, Young Mi Lee, Young Ho Kim. Anti-inflammatory components of Euphorbia humifusa Willd.
Bioorganic & medicinal chemistry letters.
2014 Apr; 24(8):1895-900. doi:
10.1016/j.bmcl.2014.03.014
. [PMID: 24679441] - Nassiba Merabet, Jeremy Bellien, Etienne Glevarec, Lionel Nicol, Daniele Lucas, Isabelle Remy-Jouet, Frederic Bounoure, Yvonne Dreano, Didier Wecker, Christian Thuillez, Paul Mulder. Soluble epoxide hydrolase inhibition improves myocardial perfusion and function in experimental heart failure.
Journal of molecular and cellular cardiology.
2012 Mar; 52(3):660-6. doi:
10.1016/j.yjmcc.2011.11.015
. [PMID: 22155238] - Jung Pyo Lee, Seung Hee Yang, Hee-Yoon Lee, Bora Kim, Joo-Youn Cho, Jin Ho Paik, Yun Jung Oh, Dong Ki Kim, Chun Soo Lim, Yon Su Kim. Soluble epoxide hydrolase activity determines the severity of ischemia-reperfusion injury in kidney.
PloS one.
2012; 7(5):e37075. doi:
10.1371/journal.pone.0037075
. [PMID: 22590647] - Stéphanie Corriveau, Maryse Berthiaume, Eric Rousseau, Jean-Charles Pasquier. Inhibition of epoxy-eicosanoid degradation improves the tocolytic effects of indomethacin in the uterus from pregnant women.
Prostaglandins & other lipid mediators.
2011 Nov; 96(1-4):84-9. doi:
10.1016/j.prostaglandins.2011.07.004
. [PMID: 21821146] - Ji Gao, Jeremy Bellien, Elodie Gomez, Jean-Paul Henry, Brigitte Dautreaux, Frederic Bounoure, Mohamed Skiba, Christian Thuillez, Vincent Richard. Soluble epoxide hydrolase inhibition prevents coronary endothelial dysfunction in mice with renovascular hypertension.
Journal of hypertension.
2011 Jun; 29(6):1128-35. doi:
10.1097/hjh.0b013e328345ef7b
. [PMID: 21451419] - Joe Liu, Daniel Obando, Vivian Liao, Tulip Lifa, Rachel Codd. The many faces of the adamantyl group in drug design.
European journal of medicinal chemistry.
2011 Jun; 46(6):1949-63. doi:
10.1016/j.ejmech.2011.01.047
. [PMID: 21354674] - Annette Cronin, Martina Decker, Michael Arand. Mammalian soluble epoxide hydrolase is identical to liver hepoxilin hydrolase.
Journal of lipid research.
2011 Apr; 52(4):712-9. doi:
10.1194/jlr.m009639
. [PMID: 21217101] - Oliver Jung, Felix Jansen, Anja Mieth, Eduardo Barbosa-Sicard, Rainer U Pliquett, Andrea Babelova, Christophe Morisseau, Sung H Hwang, Cindy Tsai, Bruce D Hammock, Liliana Schaefer, Gerd Geisslinger, Kerstin Amann, Ralf P Brandes. Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease.
PloS one.
2010 Aug; 5(8):e11979. doi:
10.1371/journal.pone.0011979
. [PMID: 20694143] - Marc Revermann, Manuel Schloss, Eduardo Barbosa-Sicard, Anja Mieth, Stefan Liebner, Christophe Morisseau, Gerd Geisslinger, Ralph T Schermuly, Ingrid Fleming, Bruce D Hammock, Ralf P Brandes. Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice.
Arteriosclerosis, thrombosis, and vascular biology.
2010 May; 30(5):909-14. doi:
10.1161/atvbaha.110.204099
. [PMID: 20224052] - Hong C Shen, Fa-Xiang Ding, Siyi Wang, Qiaolin Deng, Xiaoping Zhang, Yuli Chen, Gaochao Zhou, Suoyu Xu, Hsuan-Shen Chen, Xinchun Tong, Vincent Tong, Kaushik Mitra, Sanjeev Kumar, Christine Tsai, Andra S Stevenson, Lee-Yuh Pai, Magdalena Alonso-Galicia, Xiaoli Chen, Stephen M Soisson, Sophie Roy, Bei Zhang, James R Tata, Joel P Berger, Steven L Colletti. Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement.
Journal of medicinal chemistry.
2009 Aug; 52(16):5009-12. doi:
10.1021/jm900725r
. [PMID: 19645482] - Alan R Parrish, Gang Chen, Robert C Burghardt, Takaho Watanabe, Christophe Morisseau, Bruce D Hammock. Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase.
Cell biology and toxicology.
2009 Jun; 25(3):217-25. doi:
10.1007/s10565-008-9071-0
. [PMID: 18386137] - Marc Revermann, Eduardo Barbosa-Sicard, Eva Dony, Ralph T Schermuly, Christophe Morisseau, Gerd Geisslinger, Ingrid Fleming, Bruce D Hammock, Ralf P Brandes. Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats.
Journal of hypertension.
2009 Feb; 27(2):322-31. doi:
10.1097/hjh.0b013e32831aedfa
. [PMID: 19226702] - Jun-Yan Liu, Hsing-Ju Tsai, Sung Hee Hwang, Paul D Jones, Christophe Morisseau, Bruce D Hammock. Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation.
British journal of pharmacology.
2009 Jan; 156(2):284-96. doi:
10.1111/j.1476-5381.2008.00009.x
. [PMID: 19154430] - Jeffrey J Olearczyk, Jeffrey E Quigley, Bradford C Mitchell, Tatsuo Yamamoto, In-Hae Kim, John W Newman, Ayala Luria, Bruce D Hammock, John D Imig. Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats.
Clinical science (London, England : 1979).
2009 Jan; 116(1):61-70. doi:
10.1042/cs20080039
. [PMID: 18459944] - Kimberly L Fife, Yingmei Liu, Kara R Schmelzer, Hsing-Ju Tsai, In-Hae Kim, Christophe Morisseau, Bruce D Hammock, Deanna L Kroetz. Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation.
The Journal of pharmacology and experimental therapeutics.
2008 Dec; 327(3):707-15. doi:
10.1124/jpet.108.142398
. [PMID: 18815352] - Jing Li, Mairead A Carroll, Praveen N Chander, John R Falck, Bhavani Sangras, Charles T Stier. Soluble epoxide hydrolase inhibitor, AUDA, prevents early salt-sensitive hypertension.
Frontiers in bioscience : a journal and virtual library.
2008 May; 13(?):3480-7. doi:
10.2741/2942
. [PMID: 18508449] - Hui Huang, Christophe Morisseau, JingFeng Wang, Tianxin Yang, John R Falck, Bruce D Hammock, Mong-Heng Wang. Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats.
American journal of physiology. Renal physiology.
2007 Jul; 293(1):F342-9. doi:
10.1152/ajprenal.00004.2007
. [PMID: 17442729] - Anne M Dorrance, Nicole Rupp, David M Pollock, John W Newman, Bruce D Hammock, John D Imig. An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats.
Journal of cardiovascular pharmacology.
2005 Dec; 46(6):842-8. doi:
10.1097/01.fjc.0000189600.74157.6d
. [PMID: 16306811] - John D Imig, Xueying Zhao, Constantine Z Zaharis, Jeffrey J Olearczyk, David M Pollock, John W Newman, In-Hae Kim, Takaho Watanabe, Bruce D Hammock. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension.
Hypertension (Dallas, Tex. : 1979).
2005 Oct; 46(4):975-81. doi:
10.1161/01.hyp.0000176237.74820.75
. [PMID: 16157792] - Oliver Jung, Ralf P Brandes, In-Hae Kim, Frank Schweda, Ronald Schmidt, Bruce D Hammock, Rudi Busse, Ingrid Fleming. Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension.
Hypertension (Dallas, Tex. : 1979).
2005 Apr; 45(4):759-65. doi:
10.1161/01.hyp.0000153792.29478.1d
. [PMID: 15699457]