Physalin F (BioDeep_00000017629)

human metabolite PANOMIX_OTCML-2023 Endogenous

代谢物信息卡片

15-hydroxy-11,18,21-trimethyl-5,17,24,28,29-pentaoxanonacyclo[17.9.1.1¹,²⁰.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁵,¹⁹.0¹⁸,²³.0²¹,²⁶]triacont-8-ene-10,16,25,30-tetrone

化学式: C28H30O10 (526.183888)
中文名称: 酸浆苦味素F
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC12CC3C4(C56C1C(=O)C(O5)(C7CC8C9(O8)CC=CC(=O)C9(C7CCC6(C(=O)O4)O)C)OCC2C(=O)O3)C
InChI: InChI=1S/C28H30O10/c1-22-10-17-24(3)28-18(22)19(30)27(38-28,34-11-14(22)20(31)35-17)13-9-16-26(36-16)7-4-5-15(29)23(26,2)12(13)6-8-25(28,33)21(32)37-24/h4-5,12-14,16-18,33H,6-11H2,1-3H3

描述信息

Constituent of the famine food Physalis angulata (cutleaf ground cherry). Physalin J is found in herbs and spices and fruits.
Physalin F is a natural product found in Physalis angulata, Physalis lagascae, and Physalis minima with data available.
Physalin J is found in fruits. Physalin J is a constituent of the famine food Physalis angulata (cutleaf ground cherry)

同义名列表

10 个代谢物同义名

15-hydroxy-11,18,21-trimethyl-5,17,24,28,29-pentaoxanonacyclo[17.9.1.1¹,²⁰.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁵,¹⁹.0¹⁸,²³.0²¹,²⁶]triacont-8-ene-10,16,25,30-tetrone; 5.alpha.,6.alpha.-Epoxyphysalin B; 5.beta.,6.beta.-epoxyphysalin B; 5beta,6beta-epoxyphysalin B; 5,6-Epoxide of Physalin B; PHYSALIN B 5,6-EPOXIDE; 5,6-epxoyphysalin B; EPOXYPHYSALIN,6A-; Physalin F; Physalin J

数据库引用编号

10 个数据库交叉引用编号

PubChem: 433531
HMDB: HMDB0034092
ChEMBL: CHEMBL1979392
MeSH: physalin F
KNApSAcK: C00040001
foodb: FDB012720
chemspider: 383390
CAS: 57423-71-9
medchemexpress: HY-N7696
PMhub: MS000103367

分类词条

Physalins and derivatives

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

J C C Arruda, N C Rocha, E G Santos, L G B Ferreira, M L Bello, C Penido, T E M M Costa, J A A Santos, I M Ribeiro, T C B Tomassini, R X Faria. Physalin pool from Physalis angulata L. leaves and physalin D inhibit P2X7 receptor function in vitro and acute lung injury in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Oct; 142(?):112006. doi: 10.1016/j.biopha.2021.112006. [PMID: 34392085]
Kheng Leong Ooi, Tengku Sifzizul Tengku Muhammad, Shaida Fariza Sulaiman. Physalin F from Physalis minima L. triggers apoptosis-based cytotoxic mechanism in T-47D cells through the activation caspase-3- and c-myc-dependent pathways. Journal of ethnopharmacology. 2013 Oct; 150(1):382-8. doi: 10.1016/j.jep.2013.09.014. [PMID: 24051023]
Szu-Ying Wu, Yann-Lii Leu, Ya-Ling Chang, Tian-Shung Wu, Ping-Chung Kuo, Yu-Ren Liao, Che-Ming Teng, Shiow-Lin Pan. Physalin F induces cell apoptosis in human renal carcinoma cells by targeting NF-kappaB and generating reactive oxygen species. PloS one. 2012; 7(7):e40727. doi: 10.1371/journal.pone.0040727. [PMID: 22815798]
Nadia J Jacobo-Herrera, Paul Bremner, Nieves Marquez, Mahabir P Gupta, Simon Gibbons, Eduardo Muñoz, Michael Heinrich. Physalins from Witheringia solanacea as modulators of the NF-kappaB cascade. Journal of natural products. 2006 Mar; 69(3):328-31. doi: 10.1021/np050225t. [PMID: 16562828]
Angélica T Vieira, Vanessa Pinho, Lucilia B Lepsch, Cristóforo Scavone, Ivone M Ribeiro, Therezinha Tomassini, Ricardo Ribeiro-dos-Santos, Milena B P Soares, Mauro M Teixeira, Danielle G Souza. Mechanisms of the anti-inflammatory effects of the natural secosteroids physalins in a model of intestinal ischaemia and reperfusion injury. British journal of pharmacology. 2005 Sep; 146(2):244-51. doi: 10.1038/sj.bjp.0706321. [PMID: 16025143]
Liqiong Fang, Hee-Byung Chai, Juan J Castillo, Djaja D Soejarto, Norman R Farnsworth, Geoffrey A Cordell, John M Pezzuto, A Douglas Kinghorn. Cytotoxic constituents of Brachistus stramoniifolius. Phytotherapy research : PTR. 2003 May; 17(5):520-3. doi: 10.1002/ptr.1315. [PMID: 12748990]
Milena B P Soares, Moema C Bellintani, Ivone M Ribeiro, Therezinha C B Tomassini, Ricardo Ribeiro dos Santos. Inhibition of macrophage activation and lipopolysaccaride-induced death by seco-steroids purified from Physalis angulata L. European journal of pharmacology. 2003 Jan; 459(1):107-12. doi: 10.1016/s0014-2999(02)02829-7. [PMID: 12505539]
A H Januário, E Rodrigues Filho, R C L R Pietro, S Kashima, D N Sato, S C França. Antimycobacterial physalins from Physalis angulata L. (Solanaceae). Phytotherapy research : PTR. 2002 Aug; 16(5):445-8. doi: 10.1002/ptr.939. [PMID: 12203265]
H C Chiang, S M Jaw, P M Chen. Inhibitory effects of physalin B and physalin F on various human leukemia cells in vitro. Anticancer research. 1992 Jul; 12(4):1155-62. doi: ". [PMID: 1503404]
H C Chiang, S M Jaw, C F Chen, W S Kan. Antitumor agent, physalin F from Physalis angulata L. Anticancer research. 1992 May; 12(3):837-43. doi: ". [PMID: 1622143]