Atglistatin (BioDeep_00000176289)
human metabolite blood metabolite
代谢物信息卡片
化学式: C17H21N3O (283.1685)
中文名称: Atglistatin
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: CN(C)C(=O)NC1=CC=CC(=C1)C1=CC=C(C=C1)N(C)C
InChI: InChI=1S/C17H21N3O/c1-19(2)16-10-8-13(9-11-16)14-6-5-7-15(12-14)18-17(21)20(3)4/h5-12H,1-4H3,(H,18,21)
描述信息
Atglistatin is a selective adipose triglyceride lipase (ATGL) inhibitor which inhibits lipolysis with an IC50 of 0.7 μM in vitro.
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 71699712
- HMDB: HMDB0248698
- ChEMBL: CHEMBL3823931
- chemspider: 30646765
- CAS: 1469924-27-3
- medchemexpress: HY-15859
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Huiya Li, Pinyi Liu, Shiji Deng, Liwen Zhu, Xiang Cao, Xinyu Bao, Shengnan Xia, Yun Xu, Bing Zhang. Pharmacological Upregulation of Microglial Lipid Droplet Alleviates Neuroinflammation and Acute Ischemic Brain Injury.
Inflammation.
2023 Oct; 46(5):1832-1848. doi:
10.1007/s10753-023-01844-z. [PMID: 37450211] - Dianne Lumaquin, Eleanor Johns, Emily Montal, Joshua M Weiss, David Ola, Abderhman Abuhashem, Richard M White. An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish.
eLife.
2021 06; 10(?):. doi:
10.7554/elife.64744. [PMID: 34114952] - Si-Lan Han, Yan Liu, Samwel M Limbu, Li-Qiao Chen, Mei-Ling Zhang, Zhen-Yu Du. The reduction of lipid-sourced energy production caused by ATGL inhibition cannot be compensated by activation of HSL, autophagy, and utilization of other nutrients in fish.
Fish physiology and biochemistry.
2021 Feb; 47(1):173-188. doi:
10.1007/s10695-020-00904-7. [PMID: 33245450] - Marta Z Pacia, Magdalena Sternak, Lukasz Mateuszuk, Marta Stojak, Agnieszka Kaczor, Stefan Chlopicki. Heterogeneity of chemical composition of lipid droplets in endothelial inflammation and apoptosis.
Biochimica et biophysica acta. Molecular cell research.
2020 06; 1867(6):118681. doi:
10.1016/j.bbamcr.2020.118681. [PMID: 32084444] - Martina Schweiger, Matthias Romauch, Renate Schreiber, Gernot F Grabner, Sabrina Hütter, Petra Kotzbeck, Pia Benedikt, Thomas O Eichmann, Sohsuke Yamada, Oskar Knittelfelder, Clemens Diwoky, Carina Doler, Nicole Mayer, Werner De Cecco, Rolf Breinbauer, Robert Zimmermann, Rudolf Zechner. Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice.
Nature communications.
2017 03; 8(?):14859. doi:
10.1038/ncomms14859. [PMID: 28327588] - Pierre-Philippe Roy, Kenneth D'Souza, Miroslava Cuperlovic-Culf, Petra C Kienesberger, Mohamed Touaibia. New Atglistatin closely related analogues: Synthesis and structure-activity relationship towards adipose triglyceride lipase inhibition.
European journal of medicinal chemistry.
2016 Aug; 118(?):290-8. doi:
10.1016/j.ejmech.2016.04.021. [PMID: 27155760] - Maidina Tuohetahuntila, Martijn R Molenaar, Bart Spee, Jos F Brouwers, Martin Houweling, Arie B Vaandrager, J Bernd Helms. ATGL and DGAT1 are involved in the turnover of newly synthesized triacylglycerols in hepatic stellate cells.
Journal of lipid research.
2016 07; 57(7):1162-74. doi:
10.1194/jlr.m066415. [PMID: 27179362] - Hiroki Kobayashi, Haruna Nishimura, Ken Matsumoto, Minoru Yoshida. Identification of the determinants of 2-deoxyglucose sensitivity in cancer cells by shRNA library screening.
Biochemical and biophysical research communications.
2015 Nov; 467(1):121-7. doi:
10.1016/j.bbrc.2015.09.106. [PMID: 26403972] - Rachid Zagani, Wissal El-Assaad, Isabelle Gamache, Jose G Teodoro. Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells.
Oncotarget.
2015 Sep; 6(29):28282-95. doi:
10.18632/oncotarget.5061. [PMID: 26318046]
