Ataluren (BioDeep_00000176282)
human metabolite blood metabolite
代谢物信息卡片
3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid
化学式: C15H9FN2O3 (284.0597)
中文名称: ATALUREN
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: C1=CC=C(C(=C1)C2=NC(=NO2)C3=CC(=CC=C3)C(=O)O)F
InChI: InChI=1S/C15H9FN2O3/c16-12-7-2-1-6-11(12)14-17-13(18-21-14)9-4-3-5-10(8-9)15(19)20/h1-8H,(H,19,20)
描述信息
C78281 - Agent Affecting Musculoskeletal System
M - Musculo-skeletal system
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:94805
- PubChem: 11219835
- HMDB: HMDB0248691
- DrugBank: DB05016
- ChEMBL: CHEMBL256997
- Wikipedia: Ataluren
- chemspider: 9394889
- CAS: 775304-57-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jiyuan Ma, Nicole Risher, Valerie Northcutt, Young-Choon Moon, Marla Weetall, Ellen Welch, Joseph Colacino, Neil Almstead, Ronald Kong. Ataluren metabolism: Ataluren-O-1β-acyl glucuronide is a stable circulating metabolite in mouse, rat, dog and human.
Drug metabolism and pharmacokinetics.
2021 Jun; 38(?):100393. doi:
10.1016/j.dmpk.2021.100393. [PMID: 33872944] - Rachida Amzal, Alice Thébaut, Martine Lapalus, Marion Almes, Brigitte Grosse, Elodie Mareux, Mauricette Collado-Hilly, Anne Davit-Spraul, Laure Bidou, Olivier Namy, Emmanuel Jacquemin, Emmanuel Gonzales. Pharmacological Premature Termination Codon Readthrough of ABCB11 in Bile Salt Export Pump Deficiency: An In Vitro Study.
Hepatology (Baltimore, Md.).
2021 04; 73(4):1449-1463. doi:
10.1002/hep.31476. [PMID: 32702170] - Diksha Kaushik, Jiyuan Ma, Guodong Gu, Seongwoo Hwang, Young-Choon Moon, Ronald Kong. LC-MS/MS quantification of ataluren and ataluren acyl glucuronide in human plasma/urine: application in clinical studies.
Bioanalysis.
2020 Nov; 12(21):1545-1555. doi:
10.4155/bio-2020-0214. [PMID: 33064028] - Ronald Kong, Jiyuan Ma, Seongwoo Hwang, Elizabeth Goodwin, Valerie Northcutt, John Babiak, Neil Almstead, Joseph McIntosh. Metabolism and Disposition of Ataluren after Oral Administration to Mice, Rats, Dogs, and Humans.
Drug metabolism and disposition: the biological fate of chemicals.
2020 04; 48(4):317-325. doi:
10.1124/dmd.119.089391. [PMID: 31980502] - Ronald Kong, Jiyuan Ma, Seongwoo Hwang, Young-Choon Moon, Ellen M Welch, Marla Weetall, Joseph M Colacino, Neil Almstead, John Babiak, Elizabeth Goodwin. In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren.
Pharmacology research & perspectives.
2020 04; 8(2):e00576. doi:
10.1002/prp2.576. [PMID: 32196986] - Ronald Kong, Oscar L Laskin, Diksha Kaushik, Fengbin Jin, Jiyuan Ma, Joseph McIntosh, Marcio Souza, Neil Almstead. Ataluren Pharmacokinetics in Healthy Japanese and Caucasian Subjects.
Clinical pharmacology in drug development.
2019 02; 8(2):172-178. doi:
10.1002/cpdd.645. [PMID: 30629861] - Georgios Kosmidis, Christiaan C Veerman, Simona Casini, Arie O Verkerk, Simone van de Pas, Milena Bellin, Arthur A M Wilde, Christine L Mummery, Connie R Bezzina. Readthrough-Promoting Drugs Gentamicin and PTC124 Fail to Rescue Nav1.5 Function of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Carrying Nonsense Mutations in the Sodium Channel Gene SCN5A.
Circulation. Arrhythmia and electrophysiology.
2016 11; 9(11):. doi:
10.1161/circep.116.004227. [PMID: 27784737] - Y-W Fang, S-S Yang, T Chau, M Nakamura, O Yamazaki, G Seki, H Yamada, H-M Hsu, C-J Cheng, S-H Lin. Therapeutic effect of prenatal alkalization and PTC124 in Na(+)/HCO3(-) cotransporter 1 p.W516* knock-in mice.
Gene therapy.
2015 May; 22(5):374-81. doi:
10.1038/gt.2015.7. [PMID: 25716530] - John Karijolich, Yi-Tao Yu. Therapeutic suppression of premature termination codons: mechanisms and clinical considerations (review).
International journal of molecular medicine.
2014 Aug; 34(2):355-62. doi:
10.3892/ijmm.2014.1809. [PMID: 24939317] - Eitan Kerem, Michael W Konstan, Kris De Boeck, Frank J Accurso, Isabelle Sermet-Gaudelus, Michael Wilschanski, J Stuart Elborn, Paola Melotti, Inez Bronsveld, Isabelle Fajac, Anne Malfroot, Daniel B Rosenbluth, Patricia A Walker, Susanna A McColley, Christiane Knoop, Serena Quattrucci, Ernst Rietschel, Pamela L Zeitlin, Jay Barth, Gary L Elfring, Ellen M Welch, Arthur Branstrom, Robert J Spiegel, Stuart W Peltz, Temitayo Ajayi, Steven M Rowe. Ataluren for the treatment of nonsense-mutation cystic fibrosis: a randomised, double-blind, placebo-controlled phase 3 trial.
The Lancet. Respiratory medicine.
2014 Jul; 2(7):539-47. doi:
10.1016/s2213-2600(14)70100-6. [PMID: 24836205] - Jan Johansson, Marzia Vezzalini, Genny Verzè, Sara Caldrer, Silvia Bolognin, Mario Buffelli, Giuseppe Bellisola, Gloria Tridello, Baroukh Maurice Assael, Paola Melotti, Claudio Sorio. Detection of CFTR protein in human leukocytes by flow cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology.
2014 Jul; 85(7):611-20. doi:
10.1002/cyto.a.22456. [PMID: 24623386] - Richard S Finkel, Kevin M Flanigan, Brenda Wong, Carsten Bönnemann, Jacinda Sampson, H Lee Sweeney, Allen Reha, Valerie J Northcutt, Gary Elfring, Jay Barth, Stuart W Peltz. Phase 2a study of ataluren-mediated dystrophin production in patients with nonsense mutation Duchenne muscular dystrophy.
PloS one.
2013; 8(12):e81302. doi:
10.1371/journal.pone.0081302. [PMID: 24349052] - Patricia K Dranchak, Erminia Di Pietro, Ann Snowden, Nathan Oesch, Nancy E Braverman, Steven J Steinberg, Joseph G Hacia. Nonsense suppressor therapies rescue peroxisome lipid metabolism and assembly in cells from patients with specific PEX gene mutations.
Journal of cellular biochemistry.
2011 May; 112(5):1250-8. doi:
10.1002/jcb.22979. [PMID: 21465523] - Roser Torra, Joao Paulo Oliveira, Alberto Ortiz. UGA hopping: a sport for nephrologists too?.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2010 Aug; 25(8):2391-5. doi:
10.1093/ndt/gfq301. [PMID: 20501459] - Ellen M Welch, Elisabeth R Barton, Jin Zhuo, Yuki Tomizawa, Westley J Friesen, Panayiota Trifillis, Sergey Paushkin, Meenal Patel, Christopher R Trotta, Seongwoo Hwang, Richard G Wilde, Gary Karp, James Takasugi, Guangming Chen, Stephen Jones, Hongyu Ren, Young-Choon Moon, Donald Corson, Anthony A Turpoff, Jeffrey A Campbell, M Morgan Conn, Atiyya Khan, Neil G Almstead, Jean Hedrick, Anna Mollin, Nicole Risher, Marla Weetall, Shirley Yeh, Arthur A Branstrom, Joseph M Colacino, John Babiak, William D Ju, Samit Hirawat, Valerie J Northcutt, Langdon L Miller, Phyllis Spatrick, Feng He, Masataka Kawana, Huisheng Feng, Allan Jacobson, Stuart W Peltz, H Lee Sweeney. PTC124 targets genetic disorders caused by nonsense mutations.
Nature.
2007 May; 447(7140):87-91. doi:
10.1038/nature05756. [PMID: 17450125] - Samit Hirawat, Ellen M Welch, Gary L Elfring, Valerie J Northcutt, Sergey Paushkin, Seongwoo Hwang, Eileen M Leonard, Neil G Almstead, William Ju, Stuart W Peltz, Langdon L Miller. Safety, tolerability, and pharmacokinetics of PTC124, a nonaminoglycoside nonsense mutation suppressor, following single- and multiple-dose administration to healthy male and female adult volunteers.
Journal of clinical pharmacology.
2007 Apr; 47(4):430-44. doi:
10.1177/0091270006297140. [PMID: 17389552]
