Asp-Asp-Asp-Asp-Lys (BioDeep_00000176256)
human metabolite blood metabolite
代谢物信息卡片
6-amino-2-(2-{2-[2-(2-amino-3-carboxypropanamido)-3-carboxypropanamido]-3-carboxypropanamido}-3-carboxypropanamido)hexanoic acid
化学式: C22H34N6O14 (606.2132904)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: C(CCN)CC(C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CC(=O)O)N
InChI: InChI=1S/C22H34N6O14/c23-4-2-1-3-10(22(41)42)25-19(38)12(7-16(33)34)27-21(40)13(8-17(35)36)28-20(39)11(6-15(31)32)26-18(37)9(24)5-14(29)30/h9-13H,1-8,23-24H2,(H,25,38)(H,26,37)(H,27,40)(H,28,39)(H,29,30)(H,31,32)(H,33,34)(H,35,36)(H,41,42)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
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PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hiroaki Yasuda, Keisho Kataoka, Yoshifumi Takeyama, Kazunori Takeda, Tetsuhide Ito, Toshihiko Mayumi, Shuji Isaji, Tetsuya Mine, Motoji Kitagawa, Seiki Kiriyama, Junichi Sakagami, Atsushi Masamune, Kazuo Inui, Kenji Hirano, Ryukichi Akashi, Masamichi Yokoe, Yoshio Sogame, Kazuichi Okazaki, Chie Morioka, Yasuyuki Kihara, Shigeyuki Kawa, Masao Tanaka, Akira Andoh, Wataru Kimura, Isao Nishimori, Junji Furuse, Isao Yokota, Tooru Shimosegawa. Usefulness of urinary trypsinogen-2 and trypsinogen activation peptide in acute pancreatitis: A multicenter study in Japan.
World journal of gastroenterology.
2019 Jan; 25(1):107-117. doi:
10.3748/wjg.v25.i1.107. [PMID: 30643362] - Wei Huang, Kiran Altaf, Tao Jin, Jun-Jie Xiong, Li Wen, Muhammad A Javed, Marianne Johnstone, Ping Xue, Christopher M Halloran, Qing Xia. Prediction of the severity of acute pancreatitis on admission by urinary trypsinogen activation peptide: a meta-analysis.
World journal of gastroenterology.
2013 Jul; 19(28):4607-15. doi:
10.3748/wjg.v19.i28.4607. [PMID: 23901239] - Ke Meng, Qingsen Liu, Yan Dou, Qiyang Huang. Prior peritoneal lavage with hot 0.9 \% saline induces HSP70 expression and protects against cerulein-induced acute pancreatitis in rats.
Molecular biology reports.
2013 Feb; 40(2):1443-9. doi:
10.1007/s11033-012-2187-6. [PMID: 23096089] - Shuli Yang, Men Bing, Fengmei Chen, Ying Sun, Huang Chen, Weichang Chen. Autophagy regulation by the nuclear factor κB signal axis in acute pancreatitis.
Pancreas.
2012 Apr; 41(3):367-73. doi:
10.1097/mpa.0b013e31822a9b05. [PMID: 21926933] - Gao Jun, Tian Zhi-jun, Qiu Bao-liang, Li Fei, Sun Jia-bang. Significance of trypsinogen activation peptides and interleukin-6 in experimental acute pancreatitis.
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.
2011 Apr; 33(2):205-9. doi:
10.3881/j.issn.1000-503x.2011.02.021. [PMID: 21529452] - Ana Maria Mendonça Coelho, José Jukemura, Sandra N Sampietre, Joilson O Martins, Nilza A T Molan, Rosely A Patzina, Björn Lindkvist, Sonia Jancar, José Eduardo M Cunha, Luiz A Carneiro D'Albuquerque, Marcel Cerqueira Cesar Machado. Mechanisms of the beneficial effect of hypertonic saline solution in acute pancreatitis.
Shock (Augusta, Ga.).
2010 Nov; 34(5):502-7. doi:
10.1097/shk.0b013e3181defaa1. [PMID: 20351627] - Qiu-Lin Huang, Zhao-Xin Qian, Hao Li. A comparative study of the urinary trypsinogen-2, trypsinogen activation peptide, and the computed tomography severity index as early predictors of the severity of acute pancreatitis.
Hepato-gastroenterology.
2010 Sep; 57(102-103):1295-9. doi:
NULL. [PMID: 21410075] - Bhupendra S Kaphalia, Kamlesh K Bhopale, Shakuntala Kondraganti, Hai Wu, Paul J Boor, G A Shakeel Ansari. Pancreatic injury in hepatic alcohol dehydrogenase-deficient deer mice after subchronic exposure to ethanol.
Toxicology and applied pharmacology.
2010 Aug; 246(3):154-62. doi:
10.1016/j.taap.2010.05.002. [PMID: 20478324] - Raffaele Pezzilli, Alberto Mariani, Armando Gabbrielli, Antonio M Morselli-Labate, Alessandra Barassi. Serum and urine trypsinogen activation peptide in assessing post-endoscopic retrograde cholangiopancreatography pancreatitis.
Pancreas.
2010 Jan; 39(1):108-10. doi:
10.1097/mpa.0b013e3181bab5fb. [PMID: 20019567] - Oliver Mann, Wolf-Jonas Tiefenbacher, Jussuf Kaifi, Claus Schneider, Dirk Kluth, Christian Bloechle, Emre Yekebas, Jakob R Izbicki, Tim Strate. Effect of platelet-activating factor antagonist WEB 2086 on microcirculatory disorders in acute experimental pancreatitis of graded severity.
Pancreas.
2009 Jan; 38(1):58-64. doi:
10.1097/mpa.0b013e3181841845. [PMID: 18695628] - Jonathan M Buscaglia, Brian W Simons, Brent J Prosser, Dawn S Ruben, Samuel A Giday, Priscilla Magno, John O Clarke, Eun Ji Shin, Anthony N Kalloo, Sergey V Kantsevoy, Kathleen L Gabrielson, Sanjay B Jagannath. Etanercept, a TNF-alpha binding agent, is ineffective in the prevention of post-ERCP pancreatitis in canines.
JOP : Journal of the pancreas.
2008 Jul; 9(4):456-67. doi:
NULL. [PMID: 18648137] - C A Muller, O Belyaev, S Appelros, M Buchler, W Uhl, A Borgstrom. Dexamethasone affects inflammation but not trypsinogen activation in experimental acute pancreatitis.
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes.
2008; 40(4):317-24. doi:
10.1159/000118027. [PMID: 18303267] - Stefan Wildi, Jörg Kleeff, Julia Mayerle, Arthur Zimmermann, Erwin P Böttinger, Lalage Wakefield, Markus W Büchler, Helmut Friess, Murray Korc. Suppression of transforming growth factor beta signalling aborts caerulein induced pancreatitis and eliminates restricted stimulation at high caerulein concentrations.
Gut.
2007 May; 56(5):685-92. doi:
10.1136/gut.2006.105833. [PMID: 17135311] - Heidi S Allen, Jörg Steiner, John Broussard, Caroline Mansfield, David A Williams, Boyd Jones. Serum and urine concentrations of trypsinogen-activation peptide as markers for acute pancreatitis in cats.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
2006 Oct; 70(4):313-6. doi:
NULL. [PMID: 17042387] - Ping Chen, Yaozong Yuan, Shiwen Wang, Leheng Zhan, Jiayu Xu. Captopril, an Angiotensin-converting enzyme inhibitor, attenuates the severity of acute pancreatitis in rats by reducing expression of matrix metalloproteinase 9.
The Tohoku journal of experimental medicine.
2006 Jun; 209(2):99-107. doi:
10.1620/tjem.209.99. [PMID: 16707851] - Ulf Petersson, Anders Borgström. Characterization of immunoreactive trypsinogen activation peptide in urine in acute pancreatitis.
JOP : Journal of the pancreas.
2006 May; 7(3):274-82. doi:
NULL. [PMID: 16685108] - Jesús Sáez, Juan Martínez, Celia Trigo, José Sánchez-Payá, Luis Compañy, Raquel Laveda, Pilar Griñó, Cristina García, Miguel Pérez-Mateo. Clinical value of rapid urine trypsinogen-2 test strip, urinary trypsinogen activation peptide, and serum and urinary activation peptide of carboxypeptidase B in acute pancreatitis.
World journal of gastroenterology.
2005 Dec; 11(46):7261-5. doi:
10.3748/wjg.v11.i46.7261. [PMID: 16437625] - Jaimie D Nathan, Joelle Romac, Ruth Y Peng, Michael Peyton, Raymond J Macdonald, Rodger A Liddle. Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice.
Gastroenterology.
2005 Mar; 128(3):717-27. doi:
10.1053/j.gastro.2004.11.052. [PMID: 15765407] - M Lempinen, P Puolakkainen, E Kemppainen. Clinical value of severity markers in acute pancreatitis.
Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society.
2005; 94(2):118-23. doi:
10.1177/145749690509400207. [PMID: 16111093] - Satoru Naruse. [Urinary trypsinogen activation peptide (TAP)].
Nihon rinsho. Japanese journal of clinical medicine.
2004 Nov; 62 Suppl 11(?):131-2. doi:
NULL. [PMID: 15628355] - Seiki Kiriyama, Takashi Kumada, Makoto Tanikawa. [Recent advances in biochemical diagnosis and assessment of severity in acute pancreatitis].
Nihon rinsho. Japanese journal of clinical medicine.
2004 Nov; 62(11):2035-9. doi:
NULL. [PMID: 15552886] - R Pezzilli, M Venturi, A M Morselli-Labate, R Ceciliato, M G Lamparelli, A Rossi, D Moneta, L Piscitelli, R Corinaldesi. Serum trypsinogen activation peptide in the assessment of the diagnosis and severity of acute pancreatic damage: a pilot study using a new determination technique.
Pancreas.
2004 Nov; 29(4):298-305. doi:
10.1097/00006676-200411000-00009. [PMID: 15502646] - C D Johnson, M Lempinen, C W Imrie, P Puolakkainen, E Kemppainen, R Carter, C McKay. Urinary trypsinogen activation peptide as a marker of severe acute pancreatitis.
The British journal of surgery.
2004 Aug; 91(8):1027-33. doi:
10.1002/bjs.4612. [PMID: 15286966] - J Sáez, J Martínez, C Trigo, J Sánchez-Payá, P Griñó, L Compañy, R Laveda, J C Penalva, C García, M Pérez-Mateo. A comparative study of the activation peptide of carboxypeptidase B and trypsinogen as early predictors of the severity of acute pancreatitis.
Pancreas.
2004 Jul; 29(1):e9-14. doi:
10.1097/00006676-200407000-00062. [PMID: 15211118] - Xia Xu, Hui Wang. [Preparation and application of monoclonal antibodies against trypsinogen activation peptide].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2004 Jul; 20(4):425-8. doi:
NULL. [PMID: 15207086] - B Rau, M K Schilling, H G Beger. Laboratory markers of severe acute pancreatitis.
Digestive diseases (Basel, Switzerland).
2004; 22(3):247-57. doi:
10.1159/000082796. [PMID: 15753607] - S Benz, M Busing, B Kruger, J M Mayer, R Obermaier, T Keck, F Pfeffer, U T Hopt. Pancreas graft thrombosis: is there a role for trypsin.
Pancreas.
2004 Jan; 28(1):75-9. doi:
10.1097/00006676-200401000-00012. [PMID: 14707734] - Yukio Mikami, Kazunori Takeda, Kazuhiko Shibuya, Huang Qiu-Feng, Hiromune Shimamura, Junichiro Yamauchi, Shinichi Egawa, Makoto Sunamura, Hideki Yagi, Yasuo Endo, Seiki Matsuno. Do peritoneal macrophages play an essential role in the progression of acute pancreatitis in rats?.
Pancreas.
2003 Oct; 27(3):253-60. doi:
10.1097/00006676-200310000-00011. [PMID: 14508132] - M Lempinen, U H Stenman, P Puolakkainen, A Hietaranta, R Haapiainen, E Kemppainen. Sequential changes in pancreatic markers in acute pancreatitis.
Scandinavian journal of gastroenterology.
2003 Jun; 38(6):666-75. doi:
10.1080/00365520310000357. [PMID: 12825877] - Marko Lempinen, Ulf-Håkan Stenman, Patrik Finne, Pauli Puolakkainen, Reijo Haapiainen, Esko Kemppainen. Trypsinogen-2 and trypsinogen activation peptide (TAP) in urine of patients with acute pancreatitis.
The Journal of surgical research.
2003 May; 111(2):267-73. doi:
10.1016/s0022-4804(03)00044-1. [PMID: 12850473] - Ana Maria de Mendonça Coelho, Marcel Cerqueira Cesar Machado, José Eduardo Monteiro Cunha, Sandra Nassa Sampietre, Emilio Elias Abdo. Influence of pancreatic enzyme content on experimental acute pancreatitis.
Pancreas.
2003 Apr; 26(3):230-4. doi:
10.1097/00006676-200304000-00004. [PMID: 12657947] - Carlos A Rettally, Shayne Skarda, Mario A Garza, Steven Schenker. The usefulness of laboratory tests in the early assessment of severity of acute pancreatitis.
Critical reviews in clinical laboratory sciences.
2003 Apr; 40(2):117-49. doi:
10.1080/713609331. [PMID: 12755453] - Caroline S Mansfield, Boyd R Jones, T Spillman. Assessing the severity of canine pancreatitis.
Research in veterinary science.
2003 Apr; 74(2):137-44. doi:
10.1016/s0034-5288(02)00181-9. [PMID: 12589738] - Zoltán Rakonczay, Erno Duda, József Kaszaki, Béla Iványi, Imre Boros, János Lonovics, Tamás Takács. The anti-inflammatory effect of methylprednisolone occurs down-stream of nuclear factor-kappaB DNA binding in acute pancreatitis.
European journal of pharmacology.
2003 Mar; 464(2-3):217-27. doi:
10.1016/s0014-2999(03)01380-3. [PMID: 12620516] - Shahnaz Sultan, John Baillie. What are the predictors of post-ERCP pancreatitis, and how useful are they?.
JOP : Journal of the pancreas.
2002 Nov; 3(6):188-94. doi:
NULL. [PMID: 12432185] - Emre F Yekebas, Tim Strate, Sharam Zolmajd, Claus F Eisenberger, Andreas Erbersdobler, Armin Saalmüller, Katharina Steffani, Christoph Busch, Holger-Andreas Elsner, Madelaine Engelhardt, Andrea Gillesen, Jan Meins, Marcel The, Wolfram T Knoefel, Jakob R Izbicki. Impact of different modalities of continuous venovenous hemofiltration on sepsis-induced alterations in experimental pancreatitis.
Kidney international.
2002 Nov; 62(5):1806-18. doi:
10.1046/j.1523-1755.2002.00607.x. [PMID: 12371983] - Zia Khan, Jane Vlodov, Joel Horovitz, Rose Mary Jose, K Iswara, Joseph Smotkin, Alphonso Brown, Scott Tenner. Urinary trypsinogen activation peptide is more accurate than hematocrit in determining severity in patients with acute pancreatitis: a prospective study.
The American journal of gastroenterology.
2002 Aug; 97(8):1973-7. doi:
10.1111/j.1572-0241.2002.05953.x. [PMID: 12190163] - Dirk Uhlmann, Barbara Armann, Stefan Ludwig, Evelyn Escher, Uta-Carolin Pietsch, Andrea Tannapfel, Daniel Teupser, Johann Hauss, Helmut Witzigmann. Comparison of Celsior and UW solution in experimental pancreas preservation.
The Journal of surgical research.
2002 Jun; 105(2):173-80. doi:
10.1006/jsre.2002.6408. [PMID: 12121704] - Metin Piri, Etem Alhan, Uzer Küçüktülü, Cengiz Erçin, Orhan Deger, Kadir Yücel, Ramazan Cicek. The effects of somatostatin on the microperfusion of the pancreas during acute necrotizing pancreatitis in rats.
Hepato-gastroenterology.
2002 May; 49(45):833-7. doi:
NULL. [PMID: 12064001] - Zhi-Su Liu, Cong-Qing Jiang, Qun Qian, Quan Sun, Li-Fang Fan, Zhong-Li Ai. Early prediction of severe acute pancreatitis by urinary trypsinogen activation peptide.
Hepatobiliary & pancreatic diseases international : HBPD INT.
2002 May; 1(2):285-9. doi:
NULL. [PMID: 14612286] - Jens M Mayer, Michael Raraty, John Slavin, Esko Kemppainen, John Fitzpatrick, Antti Hietaranta, Pauli Puolakkainen, Hans G Beger, John P Neoptolemos. Severe acute pancreatitis is related to increased early urinary levels of the activation Peptide of pancreatic phospholipase A(2).
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].
2002; 2(6):535-42. doi:
10.1159/000066098. [PMID: 12435866] - E Kemppainen, J Mayer, P Puolakkainen, M Raraty, J Slavin, J P Neoptolemos. Plasma trypsinogen activation peptide in patients with acute pancreatitis.
The British journal of surgery.
2001 May; 88(5):679-80. doi:
10.1046/j.1365-2168.2001.01747.x. [PMID: 11350439] - Y Wang, S Naruse, M Kitagawa, H Ishiguro, Y Nakae, T Hayakawa. Urinary excretion of trypsinogen activation peptide (TAP) in taurocholate-induced pancreatitis in rats.
Pancreas.
2001 Jan; 22(1):24-7. doi:
10.1097/00006676-200101000-00004. [PMID: 11138966] - J L Frossard. Trypsinogen activation peptide in acute pancreatitis.
Lancet (London, England).
2000 Aug; 356(9231):766-7. doi:
10.1016/s0140-6736(05)73665-5. [PMID: 11085712] - J A Windsor. Search for prognostic markers for acute pancreatitis.
Lancet (London, England).
2000 Jun; 355(9219):1924-5. doi:
10.1016/s0140-6736(00)02317-5. [PMID: 10859031] - J P Neoptolemos, E A Kemppainen, J M Mayer, J M Fitzpatrick, M G Raraty, J Slavin, H G Beger, A J Hietaranta, P A Puolakkainen. Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: a multicentre study.
Lancet (London, England).
2000 Jun; 355(9219):1955-60. doi:
10.1016/s0140-6736(00)02327-8. [PMID: 10859041] - C S Mansfield, B R Jones. Plasma and urinary trypsinogen activation peptide in healthy dogs, dogs with pancreatitis and dogs with other systemic diseases.
Australian veterinary journal.
2000 Jun; 78(6):416-22. doi:
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The Journal of trauma.
2000 Apr; 48(4):689-94. doi:
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Digestion.
2000; 62(2-3):164-70. doi:
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Pancreas.
1999 Jul; 19(1):62-8. doi:
10.1097/00006676-199907000-00010. [PMID: 10416694] - J Schmidt, E Ryschich, H P Sinn, S Maksan, C Herfarth, E Klar. Trypsinogen activation peptides (TAP) in peritoneal fluid as predictors of late histopathologic injury in necrotizing pancreatitis of the rat.
Digestive diseases and sciences.
1999 Apr; 44(4):823-9. doi:
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Pancreas.
1998 Oct; 17(3):289-94. doi:
10.1097/00006676-199810000-00011. [PMID: 9788544] - U Petersson, R Källén, A Montgomery, A Borgström. Role of oxygen-derived free radicals in protease activation after pancreas transplantation in the pig.
Transplantation.
1998 Feb; 65(3):421-6. doi:
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Gut.
1998 Jan; 42(1):8-9. doi:
10.1136/gut.42.1.8. [PMID: 9505874] - C W Imrie. Classification of acute pancreatitis and the role of prognostic factors in assessing severity of disease.
Schweizerische medizinische Wochenschrift.
1997 May; 127(19):798-804. doi:
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International journal of pancreatology : official journal of the International Association of Pancreatology.
1997 Apr; 21(2):105-10. doi:
10.1007/bf02822381. [PMID: 9209951] - P A Banks, D L Carr-Locke, A Slivka, J Van Dam, D R Lichtenstein, M Hughes. Urinary trypsinogen activation peptides (TAP) are not increased in mild ERCP-induced pancreatitis.
Pancreas.
1996 Apr; 12(3):294-7. doi:
10.1097/00006676-199604000-00013. [PMID: 8830337] - L T Merriam, D Wilcockson, I Samuel, R J Joehl. Ligation-induced acute pancreatitis increases pancreatic circulating trypsinogen activation peptides.
The Journal of surgical research.
1996 Feb; 60(2):417-21. doi:
10.1006/jsre.1996.0068. [PMID: 8598679] - T Foitzik, H G Hotz, J Schmidt, E Klar, A L Warshaw, H J Buhr. Effect of microcirculatory perfusion on distribution of trypsinogen activation peptides in acute experimental pancreatitis.
Digestive diseases and sciences.
1995 Oct; 40(10):2184-8. doi:
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Digestive diseases and sciences.
1995 Oct; 40(10):2152-61. doi:
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Scandinavian journal of gastroenterology.
1995 Aug; 30(8):812-6. doi:
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Gastroenterology.
1995 Jul; 109(1):239-46. doi:
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Pancreas.
1995 May; 10(4):347-53. doi:
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Pancreas.
1995 Apr; 10(3):306-13. doi:
10.1097/00006676-199504000-00014. [PMID: 7542773] - C W Imrie. Prognosis of acute pancreatitis.
Annali italiani di chirurgia.
1995 Mar; 66(2):187-9. doi:
NULL. [PMID: 7668494] - C Fernández-del Castillo, J Schmidt, A L Warshaw, D W Rattner. Interstitial protease activation is the central event in progression to necrotizing pancreatitis.
Surgery.
1994 Sep; 116(3):497-504. doi:
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Surgery.
1994 Jun; 115(6):698-702. doi:
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Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen.
1994 Mar; 65(3):186-9. doi:
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Pancreas.
1993 Mar; 8(2):189-95. doi:
10.1097/00006676-199303000-00009. [PMID: 8460094]