Arimoclomol (BioDeep_00000176207)
human metabolite blood metabolite
代谢物信息卡片
化学式: C14H20ClN3O3 (313.11931200000004)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: OC(CON=C(Cl)C1=C[N+]([O-])=CC=C1)CN1CCCCC1
InChI: InChI=1S/C14H20ClN3O3/c15-14(12-5-4-8-18(20)9-12)16-21-11-13(19)10-17-6-2-1-3-7-17/h4-5,8-9,13,19H,1-3,6-7,10-11H2
数据库引用编号
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- James Gray, María E Fernández-Suárez, Maysa Falah, David Smith, Claire Smith, Ecem Kaya, Ashley M Palmer, Cathrine K Fog, Thomas Kirkegaard, Frances M Platt. Heat shock protein amplification improves cerebellar myelination in the Npc1nih mouse model.
EBioMedicine.
2022 Dec; 86(?):104374. doi:
10.1016/j.ebiom.2022.104374. [PMID: 36455410] - Benjamin N Atkinson, Hannah L Woodward, James Sipthorp, Paul V Fish. Regioselective and enantiospecific synthesis of the HSP co-inducer arimoclomol from chiral glycidyl derivatives.
Organic & biomolecular chemistry.
2017 Nov; 15(46):9794-9799. doi:
10.1039/c7ob02578e. [PMID: 29159344] - Ching-Hua Lu, Axel Petzold, Bernadett Kalmar, James Dick, Andrea Malaspina, Linda Greensmith. Plasma neurofilament heavy chain levels correlate to markers of late stage disease progression and treatment response in SOD1(G93A) mice that model ALS.
PloS one.
2012; 7(7):e40998. doi:
10.1371/journal.pone.0040998. [PMID: 22815892] - Merit E Cudkowicz, Jeremy M Shefner, Elizabeth Simpson, Daniela Grasso, Hong Yu, Hui Zhang, Amy Shui, David Schoenfeld, Robert H Brown, Scott Wieland, Jack R Barber. Arimoclomol at dosages up to 300 mg/day is well tolerated and safe in amyotrophic lateral sclerosis.
Muscle & nerve.
2008 Jul; 38(1):837-44. doi:
10.1002/mus.21059. [PMID: 18551622] - Zoltán Rakonczay, Béla Iványi, Ilona Varga, Imre Boros, Andrea Jednákovits, Ilona Németh, János Lonovics, Tamás Takács. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats.
Free radical biology & medicine.
2002 Jun; 32(12):1283-92. doi:
10.1016/s0891-5849(02)00833-x. [PMID: 12057766] - Elena Seböková, Maria Kürthy, T Mogyorosi, Karoly Nagy, Edita Demcáková, Jozef Ukropec, Laszlo Koranyi, Iwar Klimes. Comparison of the extrapancreatic action of BRX-220 and pioglitazone in the high-fat diet-induced insulin resistance.
Annals of the New York Academy of Sciences.
2002 Jun; 967(?):424-30. doi:
10.1111/j.1749-6632.2002.tb04298.x. [PMID: 12079870]