2-[(4S)-4-Amino-5-oxopentyl]guanidine (BioDeep_00000176196)
human metabolite blood metabolite
代谢物信息卡片
2-[(4S)-4-Amino-5-oxopentyl]guanidine
化学式: C6H14N4O (158.1167554)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 66.67%
分子结构信息
SMILES: C(CC(C=O)N)CN=C(N)N
InChI: InChI=1S/C6H14N4O/c7-5(4-11)2-1-3-10-6(8)9/h4-5H,1-3,7H2,(H4,8,9,10)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lali V Shanshiashvili, Irina V Kalandadze, Jeremy J Ramsden, David G Mikeladze. Adhesive properties and inflammatory potential of citrullinated myelin basic protein peptide 45-89.
Neurochemical research.
2012 Sep; 37(9):1959-66. doi:
10.1007/s11064-012-0816-z. [PMID: 22678722] - Tomoyuki Konishi, Mayumi Ohnishi-Kameyama, Kazumi Funane, Yasumasa Miyazaki, Teruko Konishi, Tadashi Ishii. An arginyl residue in rice UDP-arabinopyranose mutase is required for catalytic activity and autoglycosylation.
Carbohydrate research.
2010 Apr; 345(6):787-91. doi:
10.1016/j.carres.2010.01.008. [PMID: 20149347] - Madeleine Singwe-Ngandeu, Axel Finckh, Sylvette Bas, Jean-Marie Tiercy, Cem Gabay. Diagnostic value of anti-cyclic citrullinated peptides and association with HLA-DRB1 shared epitope alleles in African rheumatoid arthritis patients.
Arthritis research & therapy.
2010; 12(2):R36. doi:
10.1186/ar2945. [PMID: 20196860] - Marieangela C Wilson, David Meredith, Chotirote Bunnun, Richard B Sessions, Andrew P Halestrap. Studies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle.
The Journal of biological chemistry.
2009 Jul; 284(30):20011-21. doi:
10.1074/jbc.m109.014217. [PMID: 19473976] - L Zambotti-Villela, S C Yamasaki, J S Villarroel, R F Alponti, P F Silveira. Prospective evaluation of aminopeptidase activities in plasma and peripheral organs of streptozotocin-induced diabetic rats.
Journal of endocrinological investigation.
2008 Jun; 31(6):492-8. doi:
10.1007/bf03346396. [PMID: 18591879] - Eugenia Polverini, Godha Rangaraj, David S Libich, Joan M Boggs, George Harauz. Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications.
Biochemistry.
2008 Jan; 47(1):267-82. doi:
10.1021/bi701336n. [PMID: 18067320] - Mario A Moscarello, Fabrizio G Mastronardi, D Denise Wood. The role of citrullinated proteins suggests a novel mechanism in the pathogenesis of multiple sclerosis.
Neurochemical research.
2007 Feb; 32(2):251-6. doi:
10.1007/s11064-006-9144-5. [PMID: 17031564] - V Duplan, C Foulquier, C Clavel, R Al Badine, G Serre, A Saoudi, M Sebbag. In the rat, citrullinated autologous fibrinogen is immunogenic but the induced autoimmune response is not arthritogenic.
Clinical and experimental immunology.
2006 Sep; 145(3):502-12. doi:
10.1111/j.1365-2249.2006.03168.x. [PMID: 16907920] - Mireille Sebbag, Sabine Chapuy-Regaud, Isabelle Auger, Elisabeth Petit-Texeira, Cyril Clavel, Leonor Nogueira, Christian Vincent, François Cornélis, Jean Roudier, Guy Serre. Clinical and pathophysiological significance of the autoimmune response to citrullinated proteins in rheumatoid arthritis.
Joint bone spine.
2004 Nov; 71(6):493-502. doi:
10.1016/j.jbspin.2004.07.004. [PMID: 15589429] - Anna Biró, Zoltán Hérincs, Erzsébet Fellinger, László Szilágyi, Zsuzsa Barad, János Gergely, László Gráf, Gabriella Sármay. Characterization of a trypsin-like serine protease of activated B cells mediating the cleavage of surface proteins.
Biochimica et biophysica acta.
2003 Dec; 1624(1-3):60-9. doi:
10.1016/j.bbagen.2003.09.010. [PMID: 14642814] - J M Lord, E Deeks, C J Marsden, K Moore, C Pateman, D C Smith, R A Spooner, P Watson, L M Roberts. Retrograde transport of toxins across the endoplasmic reticulum membrane.
Biochemical Society transactions.
2003 Dec; 31(Pt 6):1260-2. doi:
10.1042/bst0311260. [PMID: 14641038] - Alimjan Idiris, Ken-ichi Ohtsubo, Koh-ichi Yoza, Toshiya Osada, Noboru Nakamichi, Toshiharu Matsumura, Atsushi Ikai. Molecular cloning and structural characterization of the hagfish proteinase inhibitor of the alpha-2-macroglobulin family.
Journal of protein chemistry.
2003 Jan; 22(1):89-98. doi:
10.1023/a:1023076029496. [PMID: 12739901] - Ian R Bates, David S Libich, D Denise Wood, Mario A Moscarello, George Harauz. An Arg/Lys-->Gln mutant of recombinant murine myelin basic protein as a mimic of the deiminated form implicated in multiple sclerosis.
Protein expression and purification.
2002 Jul; 25(2):330-41. doi:
10.1016/s1046-5928(02)00017-7. [PMID: 12135568] - N Ishiyama, I R Bates, C M Hill, D D Wood, P Matharu, N J Viner, M A Moscarello, G Harauz. The effects of deimination of myelin basic protein on structures formed by its interaction with phosphoinositide-containing lipid monolayers.
Journal of structural biology.
2001 Oct; 136(1):30-45. doi:
10.1006/jsbi.2001.4421. [PMID: 11858705] - M D Mayas, M J Ramírez-Expósito, M J García, M Ramírez, J M Martínez-Martos. [Influence of alcohol on brain aminopeptidases. An in vitro study].
Revista de neurologia.
2001 Jun; 32(11):1031-40. doi:
". [PMID: 11562824] - T Zima, V Tesar, P J Richardson, D Mantle, V R Preedy. Effects of Doxorubicin (Adriamycin) and [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)]propane (ICRF-187) on skeletal muscle protease activities.
Toxicology and applied pharmacology.
2001 Mar; 171(3):135-40. doi:
10.1006/taap.2000.9084. [PMID: 11243912] - I Lorenc-Kubis, J Kowalska, B Pochroń, A Zuzło, T Wilusz. Isolation and amino acid sequence of a serine proteinase inhibitor from common flax (Linum usitatissimum) seeds.
Chembiochem : a European journal of chemical biology.
2001 Jan; 2(1):45-51. doi:
10.1002/1439-7633(20010105)2:1<45::aid-cbic45>3.0.co;2-\%23. [PMID: 11828426]