Amtolmetin guacil (BioDeep_00000176030)

   

human metabolite blood metabolite


代谢物信息卡片


2-methoxyphenyl 2-{2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetamido}acetate

化学式: C24H24N2O5 (420.1685134)
中文名称: 氨苄青霉素
谱图信息: 最多检出来源 Homo sapiens(blood) 66.67%

分子结构信息

SMILES: CC1=CC=C(C=C1)C(=O)C2=CC=C(N2C)CC(=O)NCC(=O)OC3=CC=CC=C3OC
InChI: InChI=1S/C24H24N2O5/c1-16-8-10-17(11-9-16)24(29)19-13-12-18(26(19)2)14-22(27)25-15-23(28)31-21-7-5-4-6-20(21)30-3/h4-13H,14-15H2,1-3H3,(H,25,27)

描述信息

C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents

同义名列表

10 个代谢物同义名

2-methoxyphenyl 2-{2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetamido}acetate; 2-methoxyphenyl {2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetamido}acetate; 2-Methoxyphenyl 1-methyl-5-(4-methylbenzoylpyrrol)-2-acetamidoacetate; Amtolmetineguacil; Amtolmetin guacyl; Amtolmetin guacil; Artromed; MED 15; MED-15; MED15



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • I Z Gaydukova, E V Khondkaryan, A V Aparkina, A P Rebrov. [Changes in the serum concentrations of adhesion molecules and vascular endothelial growth factor in active ankylosing spondylitis patients taking amtolmetin guacil: Results of a 56-week prospective ореn-label controlled observational study]. Terapevticheskii arkhiv. 2017 ; 89(5):38-45. doi: 10.17116/terarkh201789538-45. [PMID: 28631697]
  • Malini Nagulapalli, Sourobh Maji, Nidhi Dwivedi, Pradeep Dahiya, Jitendra K Thakur. Evolution of disorder in Mediator complex and its functional relevance. Nucleic acids research. 2016 Feb; 44(4):1591-612. doi: 10.1093/nar/gkv1135. [PMID: 26590257]
  • Zhihui Rong, Yanjiao Xu, Chengliang Zhang, Daochun Xiang, Xiping Li, Dong Liu. Evaluation of intestinal absorption of amtolmetin guacyl in rats: breast cancer resistant protein as a primary barrier of oral bioavailability. Life sciences. 2013 Feb; 92(3):245-51. doi: 10.1016/j.lfs.2012.12.010. [PMID: 23333829]
  • Kishore Kumar Hotha, D Vijaya Bharathi, S Sirish Kumar, Y Narsimha Reddy, Pankaj Chatki, L K Ravindranath, K N Jaya Veera, Ramesh Mullangi. Validation and clinical application of an LC-ESI-MS/MS method for simultaneous determination of tolmetin and MED5, the metabolites of amtolmetin guacil in human plasma. Biomedical chromatography : BMC. 2010 Oct; 24(10):1100-7. doi: 10.1002/bmc.1411. [PMID: 20853464]
  • Kishore Kumar Hotha, Vijaya Bharathi Dasari, Abdul Naveed Shaik, Muzeeb Syed, Vittal Shivva, Ravindranath Krishnarao Lakshmanarao, Jayaveera Narasimhulu Korlakunta, Ramesh Mullangi. Species difference in the in vitro and in vivo metabolism of amtolmetin guacil. Arzneimittel-Forschung. 2010; 60(11):667-74. doi: 10.1055/s-0031-1296345. [PMID: 21175039]
  • M Kirkova, A Alexandova, M Kesiova, S Todorov. In vivo effects of amtolmetin guacyl on lipid peroxidation and antioxidant defence systems. Comparison with non-selective and COX-2 selective NSAIDs. Autonomic & autacoid pharmacology. 2007 Apr; 27(2):99-104. doi: 10.1111/j.1474-8673.2007.00395.x. [PMID: 17391279]
  • M Kirkova, A Alexandova, M Kesiova, E Tsvetanova, A Georgieva, S Todorov. Potential antioxidant activity of celecoxib and amtolmetin guacyl: in vitro studies. Autonomic & autacoid pharmacology. 2007 Jan; 27(1):13-8. doi: 10.1111/j.1474-8673.2006.00391.x. [PMID: 17199871]
  • M Kirkova, M Kesiova, S Konstantinova, A Alexandrova, L Petrov, E Tsvetanova, S Todorov. In vivo effects of amtolmetin guacyl on lipid peroxidation and antioxidant defence systems in different models of gastrointestinal injury. Autonomic & autacoid pharmacology. 2007 Jan; 27(1):63-70. doi: 10.1111/j.1474-8673.2006.00390.x. [PMID: 17199877]
  • Z Jajić, M Malaise, K Nekam, E Koó, K Dankó, M Kovacs, C Scarpignato. Gastrointestinal safety of amtolmetin guacyl in comparison with celecoxib in patients with rheumatoid arthritis. Clinical and experimental rheumatology. 2005 Nov; 23(6):809-18. doi: NULL. [PMID: 16396699]
  • L Niccoli, S Bellino, F Cantini. Renal tolerability of three commonly employed non-steroidal anti-inflammatory drugs in elderly patients with osteoarthritis. Clinical and experimental rheumatology. 2002 Mar; 20(2):201-7. doi: NULL. [PMID: 12051399]
  • M Lingetti, M Ciarimboli, F A Porfido, L Imparato, G P Sorrentino, G Garzya, G Saraceni, G Donati, G Nolfe. [An evaluation of the therapeutic activity and tolerance of ST-679 in patients with osteoarthritis at different sites. A controlled double-blind study vs tolmetin]. La Clinica terapeutica. 1993 Jan; 142(1 Pt 2):29-40. doi: NULL. [PMID: 8472518]
  • A Mancinelli, G Bruno, G Cardace, E Morabito, A Marzo, E Arrigoni Martelli. High-performance liquid chromatographic evaluation of Med 15 and its metabolites Med 5 and tolmetin in rat plasma. Journal of chromatography. 1991 Aug; 553(1-2):81-6. doi: 10.1016/s0021-9673(01)88475-2. [PMID: 1787172]