Amotosalen (BioDeep_00000176015)
human metabolite blood metabolite
代谢物信息卡片
3-[(2-aminoethoxy)methyl]-2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one
化学式: C17H19NO4 (301.1314014)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 1.32%
分子结构信息
SMILES: CC1=C(COCCN)C2=C(O1)C(C)=C1OC(=O)C=C(C)C1=C2
InChI: InChI=1S/C17H19NO4/c1-9-6-15(19)22-16-10(2)17-13(7-12(9)16)14(11(3)21-17)8-20-5-4-18/h6-7H,4-5,8,18H2,1-3H3
描述信息
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents > D011564 - Furocoumarins
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D003879 - Dermatologic Agents
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 159599
- HMDB: HMDB0248350
- ChEMBL: CHEMBL2110621
- chemspider: 140326
- CAS: 161262-29-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Anil Bagri, Rafael R de Assis, Cheng-Ting Tsai, Graham Simmons, Zhen W Mei, Melissa Von Goetz, Michelle Gatmaitan, Mars Stone, Clara Di Germanio, Rachel Martinelli, Orsolya Darst, Jowin Rioveros, Peter V Robinson, Dawn Ward, Alyssa Ziman, David Seftel, Saahir Khan, Michael P Busch, Philip L Felgner, Laurence M Corash. Antibody profiles in COVID-19 convalescent plasma prepared with amotosalen/UVA pathogen reduction treatment.
Transfusion.
2022 03; 62(3):570-583. doi:
10.1111/trf.16819. [PMID: 35128658] - S I Hindawi, S A El-Kafrawy, A M Hassan, M A Badawi, M M Bayoumi, A A Almalki, H M Zowawi, A M Tolah, T A Alandijany, Q Abunada, M Picard-Maureau, G A Damanhouri, E I Azhar. Efficient inactivation of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in human apheresis platelet concentrates with amotosalen and ultraviolet A light.
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine.
2022 Feb; 29(1):31-36. doi:
10.1016/j.tracli.2021.08.005. [PMID: 34411748] - Esam I Azhar, Salwa I Hindawi, Sherif A El-Kafrawy, Ahmed M Hassan, Ahmed M Tolah, Thamir A Alandijany, Leena H Bajrai, Ghazi A Damanhouri. Amotosalen and ultraviolet A light treatment efficiently inactivates severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human plasma.
Vox sanguinis.
2021 Jul; 116(6):673-681. doi:
10.1111/vox.13043. [PMID: 33277935] - Alexander I Kostin, Maria N Lundgren, Andrey Y Bulanov, Elena A Ladygina, Karina S Chirkova, Alexander L Gintsburg, Denis Y Logunov, Inna V Dolzhikova, Dmitry V Shcheblyakov, Natalia V Borovkova, Mikhail A Godkov, Alexey I Bazhenov, Valeriy V Shustov, Alina S Bogdanova, Alina R Kamalova, Vladimir V Ganchin, Eugene A Dombrovskiy, Stanislav E Volkov, Nataliya E Drozdova, Sergey S Petrikov. Impact of pathogen reduction methods on immunological properties of the COVID-19 convalescent plasma.
Vox sanguinis.
2021 Jul; 116(6):665-672. doi:
10.1111/vox.13056. [PMID: 33734455] - Michal Bubinski, Agnieszka Gronowska, Pawel Szykula, Kamila Kluska, Ilona Kuleta, Emilia Ciesielska, Marcus Picard-Maureau, Elzbieta Lachert. Plasma pooling in combination with amotosalen/UVA pathogen inactivation to increase standardisation and safety of therapeutic plasma units.
Transfusion medicine (Oxford, England).
2021 Apr; 31(2):136-141. doi:
10.1111/tme.12763. [PMID: 33686720] - Emmanuel A Fadeyi, Stephen J Wagner, Corinne Goldberg, Thea Lu, Pampee Young, Peter W Bringmann, Nathaniel M Meier, Andrew M Namen, Richard J Benjamin, Elizabeth Palavecino. Fatal sepsis associated with a storage container leak permitting platelet contamination with environmental bacteria after pathogen reduction.
Transfusion.
2021 02; 61(2):641-648. doi:
10.1111/trf.16210. [PMID: 33616945] - Alisa Agey, Kristin Reddoch-Cardenas, Colby McIntosh, Umang Sharma, Carolina Cantu, Andrew Cap, James Bynum. Effects of Intercept pathogen reduction treatment on extended cold storage of apheresis platelets.
Transfusion.
2021 01; 61(1):167-177. doi:
10.1111/trf.16096. [PMID: 33295030] - Reed W Kamyszek, Matthew W Foster, Brooke A Evans, Keaton Stoner, Jessica Poisson, Amudan J Srinivasan, J Will Thompson, M Arthur Moseley, Micah J Mooberry, Ian J Welsby. The effect of pathogen inactivation on cryoprecipitate: a functional and quantitative evaluation.
Blood transfusion = Trasfusione del sangue.
2020 11; 18(6):454-464. doi:
10.2450/2020.0077-20. [PMID: 33000752] - Marion C Lanteri, Felicia Santa-Maria, Andrew Laughhunn, Yvette A Girard, Marcus Picard-Maureau, Jean-Marc Payrat, Johannes Irsch, Adonis Stassinopoulos, Peter Bringmann. Inactivation of a broad spectrum of viruses and parasites by photochemical treatment of plasma and platelets using amotosalen and ultraviolet A light.
Transfusion.
2020 06; 60(6):1319-1331. doi:
10.1111/trf.15807. [PMID: 32333396] - Yvette A Girard, Felicia Santa Maria, Marion C Lanteri. Inactivation of yellow fever virus with amotosalen and ultraviolet A light pathogen-reduction technology.
Transfusion.
2020 03; 60(3):622-627. doi:
10.1111/trf.15673. [PMID: 31957887] - Paul M Mertes, Charles Tacquard, Georges Andreu, Daniel Kientz, Sylvie Gross, Lucile Malard, Christian Drouet, Monique Carlier, Christian Gachet, Imad Sandid, Karim Boudjedir. Hypersensitivity transfusion reactions to platelet concentrate: a retrospective analysis of the French hemovigilance network.
Transfusion.
2020 03; 60(3):507-512. doi:
10.1111/trf.15275. [PMID: 30907010] - Olivier Garraud, Sandrine Malot, Raoul Herbrecht, Mario Ojeda-Uribe, Jin-Sying Lin, Agnès Veyradier, Jean-Marc Payrat, Kathy Liu, Laurence Corash, Paul Coppo. Amotosalen-inactivated fresh frozen plasma is comparable to solvent-detergent inactivated plasma to treat thrombotic thrombocytopenic purpura.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.
2019 Dec; 58(6):102665. doi:
10.1016/j.transci.2019.10.007. [PMID: 31740165] - Niels Arni Arnason, Freyr Johannson, Ragna Landrö, Björn Hardarsson, Johannes Irsch, Sveinn Gudmundsson, Ottar Rolfsson, Olafur E Sigurjonsson. Pathogen inactivation with amotosalen plus UVA illumination minimally impacts microRNA expression in platelets during storage under standard blood banking conditions.
Transfusion.
2019 12; 59(12):3727-3735. doi:
10.1111/trf.15575. [PMID: 31674051] - A M Hashem, A M Hassan, A M Tolah, M A Alsaadi, Q Abunada, G A Damanhouri, S A El-Kafrawy, M Picard-Maureau, E I Azhar, S I Hindawi. Amotosalen and ultraviolet A light efficiently inactivate MERS-coronavirus in human platelet concentrates.
Transfusion medicine (Oxford, England).
2019 Dec; 29(6):434-441. doi:
10.1111/tme.12638. [PMID: 31696565] - Ouada Nebie, David Devos, Valérie Vingtdeux, Lassina Barro, Jean-Christophe Devedjian, Aurélie Jonneaux, Ming-Li Chou, Régis Bordet, Luc Buée, Folke Knutson, David Blum, Thierry Burnouf. The neuroprotective activity of heat-treated human platelet lysate biomaterials manufactured from outdated pathogen-reduced (amotosalen/UVA) platelet concentrates.
Journal of biomedical science.
2019 Oct; 26(1):89. doi:
10.1186/s12929-019-0579-9. [PMID: 31666073] - O Garraud, C Martinaud. The plasma supply in France.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.
2019 Aug; 58(4):358-362. doi:
10.1016/j.transci.2019.06.004. [PMID: 31253561] - Stephan Meinke, Agneta Wikman, Gunilla Gryfelt, Kjell Hultenby, Michael Uhlin, Petter Höglund, Per Sandgren. Cryopreservation of buffy coat-derived platelet concentrates photochemically treated with amotosalen and UVA light.
Transfusion.
2018 11; 58(11):2657-2668. doi:
10.1111/trf.14905. [PMID: 30281156] - Catherine Ravanat, Arnaud Dupuis, Nadine Marpaux, Christian Naegelen, Guillaume Mourey, Herve Isola, Michel Laforêt, Pascal Morel, Christian Gachet. In vitro quality of amotosalen-UVA pathogen-inactivated mini-pool plasma prepared from whole blood stored overnight.
Vox sanguinis.
2018 Oct; 113(7):622-631. doi:
10.1111/vox.12697. [PMID: 30079963] - Grace Castro, Patricia A Merkel, Hannah E Giclas, Andrew Gibula, Gillian E Andersen, Laurence M Corash, Jin Sying Lin, Jennifer Green, Vijaya Knight, Adonis Stassinopoulos. Amotosalen/UVA treatment inactivates T cells more effectively than the recommended gamma dose for prevention of transfusion-associated graft-versus-host disease.
Transfusion.
2018 06; 58(6):1506-1515. doi:
10.1111/trf.14589. [PMID: 29607502] - Andrew Laughhunn, Yan-Jang S Huang, Dana L Vanlandingham, Marion C Lanteri, Adonis Stassinopoulos. Inactivation of chikungunya virus in blood components treated with amotosalen/ultraviolet A light or amustaline/glutathione.
Transfusion.
2018 03; 58(3):748-757. doi:
10.1111/trf.14442. [PMID: 29322519] - C Guignier, A Benamara, P Oriol, P Coppo, C Mariat, O Garraud. Amotosalen-inactivated plasma is as equally well tolerated as quarantine plasma in patients undergoing large volume therapeutic plasma exchange.
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine.
2018 Feb; 25(1):73-77. doi:
10.1016/j.tracli.2017.10.002. [PMID: 29102655] - Salwa I Hindawi, Anwar M Hashem, Ghazi A Damanhouri, Sherif A El-Kafrawy, Ahmed M Tolah, Ahmed M Hassan, Esam I Azhar. Inactivation of Middle East respiratory syndrome-coronavirus in human plasma using amotosalen and ultraviolet A light.
Transfusion.
2018 01; 58(1):52-59. doi:
10.1111/trf.14422. [PMID: 29239484] - Simona Stivala, Sara Gobbato, Laura Infanti, Martin F Reiner, Nicole Bonetti, Sara C Meyer, Giovanni G Camici, Thomas F Lüscher, Andreas Buser, Jürg H Beer. Amotosalen/ultraviolet A pathogen inactivation technology reduces platelet activatability, induces apoptosis and accelerates clearance.
Haematologica.
2017 10; 102(10):1650-1660. doi:
10.3324/haematol.2017.164137. [PMID: 28729303] - Laura Tonnetti, Andrew Laughhunn, Aaron M Thorp, Irina Vasilyeva, Kent Dupuis, Adonis Stassinopoulos, Susan L Stramer. Inactivation of Babesia microti in red blood cells and platelet concentrates.
Transfusion.
2017 10; 57(10):2404-2412. doi:
10.1111/trf.14280. [PMID: 28872685] - Nicholas H Saadah, Fabienne M A van Hout, Martin R Schipperus, Saskia le Cessie, Rutger A Middelburg, Johanna C Wiersum-Osselton, Johanna G van der Bom. Comparing transfusion reaction rates for various plasma types: a systematic review and meta-analysis/regression.
Transfusion.
2017 09; 57(9):2104-2114. doi:
10.1111/trf.14245. [PMID: 28766723] - Felicia Santa Maria, Andrew Laughhunn, Marion C Lanteri, Maite Aubry, Didier Musso, Adonis Stassinopoulos. Inactivation of Zika virus in platelet components using amotosalen and ultraviolet A illumination.
Transfusion.
2017 08; 57(8):2016-2025. doi:
10.1111/trf.14161. [PMID: 28671343] - Anna Erickson, Katie Waldhaus, Tovo David, Norman Huang, Salvador Rico, Laurence Corash, Nina Mufti, Richard J Benjamin. Plasma treated with amotosalen and ultraviolet A light retains activity for hemostasis after 5 days post-thaw storage at 1 to 6o C.
Transfusion.
2017 04; 57(4):997-1006. doi:
10.1111/trf.13973. [PMID: 28150310] - W Nussbaumer, M Amato, H Schennach, M Astl, C Y Chen, J-S Lin, L Corash, R J Benjamin. Patient outcomes and amotosalen/UVA-treated platelet utilization in massively transfused patients.
Vox sanguinis.
2017 Apr; 112(3):249-256. doi:
10.1111/vox.12489. [PMID: 28198023] - M Amato, H Schennach, M Astl, C Y Chen, J-S Lin, R J Benjamin, W Nussbaumer. Impact of platelet pathogen inactivation on blood component utilization and patient safety in a large Austrian Regional Medical Centre.
Vox sanguinis.
2017 Jan; 112(1):47-55. doi:
10.1111/vox.12456. [PMID: 28001297] - Richard J Benjamin, Kent L Carter, Laurence Corash. Amotosalen and ultraviolet-A treated platelets and plasma are safe and efficacious in active hemorrhage.
Transfusion.
2016 10; 56(10):2649-2650. doi:
10.1111/trf.13786. [PMID: 27739155] - Philippe Ohlmann, Béatrice Hechler, Philippe Chafey, Catherine Ravanat, Hervé Isola, Marie-Louise Wiesel, Jean-Pierre Cazenave, Christian Gachet. Hemostatic properties and protein expression profile of therapeutic apheresis plasma treated with amotosalen and ultraviolet A for pathogen inactivation.
Transfusion.
2016 09; 56(9):2239-47. doi:
10.1111/trf.13670. [PMID: 27250038] - Mélanie Abonnenc, David Crettaz, Philippe Tacchini, Luciana Di Vincenzo, Giona Sonego, Michel Prudent, Jean-Daniel Tissot, Niels Lion. Antioxidant power as a quality control marker for completeness of amotosalen and ultraviolet A photochemical treatments in platelet concentrates and plasma units.
Transfusion.
2016 07; 56(7):1819-27. doi:
10.1111/trf.13638. [PMID: 27184608] - L Backholer, M Wiltshire, S Proffitt, P Cookson, R Cardigan. Paired comparison of methylene blue- and amotosalen-treated plasma and cryoprecipitate.
Vox sanguinis.
2016 May; 110(4):352-61. doi:
10.1111/vox.12368. [PMID: 26757252] - C Geisen, G Kann, T Strecker, T Wolf, G Schüttfort, M van Kraaij, S MacLennan, S Rummler, C Weinigel, M Eickmann, S K Fehling, V Krähling, C Seidl, E Seifried, M Schmidt, R Schäfer. Pathogen-reduced Ebola virus convalescent plasma: first steps towards standardization of manufacturing and quality control including assessment of Ebola-specific neutralizing antibodies.
Vox sanguinis.
2016 May; 110(4):329-35. doi:
10.1111/vox.12376. [PMID: 26766162] - Laurence Corash, Richard J Benjamin. The role of hemovigilance and postmarketing studies when introducing innovation into transfusion medicine practice: the amotosalen-ultraviolet A pathogen reduction treatment model.
Transfusion.
2016 Mar; 56 Suppl 1(?):S29-38. doi:
10.1111/trf.13530. [PMID: 27001358] - Sonia Bakkour, Daniel M Chafets, Li Wen, Kent Dupuis, Grace Castro, Jennifer M Green, Adonis Stassinopoulos, Michael P Busch, Tzong-Hae Lee. Assessment of nucleic acid modification induced by amotosalen and ultraviolet A light treatment of platelets and plasma using real-time polymerase chain reaction amplification of variable length fragments of mitochondrial DNA.
Transfusion.
2016 Feb; 56(2):410-20. doi:
10.1111/trf.13360. [PMID: 26446053] - Maite Aubry, Vaea Richard, Jennifer Green, Julien Broult, Didier Musso. Inactivation of Zika virus in plasma with amotosalen and ultraviolet A illumination.
Transfusion.
2016 Jan; 56(1):33-40. doi:
10.1111/trf.13271. [PMID: 26283013] - Thomas Hubbard, Lucy Backholer, Michael Wiltshire, Rebecca Cardigan, Robert A S Ariëns. Effects of riboflavin and amotosalen photoactivation systems for pathogen inactivation of fresh-frozen plasma on fibrin clot structure.
Transfusion.
2016 Jan; 56(1):41-8. doi:
10.1111/trf.13261. [PMID: 26358662] - V Bost, P Chavarin, F Boussoulade, P Fabrigli, C Chabre, H Benamara, H Odent-Malaure, D Legrand, F Cognasse, O Garraud. Independent evaluation of tolerance of therapeutic plasma inactivated by amotosalen-HCl-UVA (Intercept ™) over a 5-year period of extensive delivery.
Vox sanguinis.
2015 Nov; 109(4):414-6. doi:
10.1111/vox.12300. [PMID: 26031441] - Jacques Cinqualbre, Daniel Kientz, Emilie Remy, Norman Huang, Laurence Corash, Jean Pierre Cazenave. Comparative effectiveness of plasma prepared with amotosalen-UVA pathogen inactivation and conventional plasma for support of liver transplantation.
Transfusion.
2015 Jul; 55(7):1710-20. doi:
10.1111/trf.13100. [PMID: 25857325] - Johannes Irsch, Jerard Seghatchian. Update on pathogen inactivation treatment of plasma, with the INTERCEPT Blood System: Current position on methodological, clinical and regulatory aspects.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.
2015 Apr; 52(2):240-4. doi:
10.1016/j.transci.2015.02.013. [PMID: 25824703] - Didier Musso, Vaea Richard, Julien Broult, Van-Mai Cao-Lormeau. Inactivation of dengue virus in plasma with amotosalen and ultraviolet A illumination.
Transfusion.
2014 Nov; 54(11):2924-30. doi:
10.1111/trf.12713. [PMID: 24845685] - Janna M Mundt, Lindsay Rouse, Jeroen Van den Bossche, Raymond P Goodrich. Chemical and biological mechanisms of pathogen reduction technologies.
Photochemistry and photobiology.
2014 Sep; 90(5):957-64. doi:
10.1111/php.12311. [PMID: 25041351] - Axel Seltsam, Thomas H Müller. Update on the use of pathogen-reduced human plasma and platelet concentrates.
British journal of haematology.
2013 Aug; 162(4):442-54. doi:
10.1111/bjh.12403. [PMID: 23710899] - Joerg-Peter Sigle, Laura Infanti, Jan-Dirk Studt, Maria Martinez, Martin Stern, Alois Gratwohl, Jakob Passweg, André Tichelli, Andreas S Buser. Comparison of transfusion efficacy of amotosalen-based pathogen-reduced platelet components and gamma-irradiated platelet components.
Transfusion.
2013 Aug; 53(8):1788-97. doi:
10.1111/j.1537-2995.2012.03959.x. [PMID: 23176347] - Konstantin A Tsetsarkin, Adam Sampson-Johannes, Lynette Sawyer, John Kinsey, Stephen Higgs, Dana L Vanlandingham. Photochemical inactivation of chikungunya virus in human apheresis platelet components by amotosalen and UVA light.
The American journal of tropical medicine and hygiene.
2013 Jun; 88(6):1163-9. doi:
10.4269/ajtmh.12-0603. [PMID: 23530077] - C Martinaud, A Cauet, A Sailliol. [Therapeutic plasmas available worldwide].
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine.
2013 May; 20(2):255-60. doi:
10.1016/j.tracli.2013.02.009. [PMID: 23522688] - P Morel, C Naegelen, M Deschaseaux, L Bardiaux. [Prevention of bacterial risk: pathogen inactivation/detection of bacteria].
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine.
2013 May; 20(2):109-14. doi:
10.1016/j.tracli.2013.03.006. [PMID: 23622837] - L Johnson, Y S Loh, M Kwok, D C Marks. In vitro assessment of buffy-coat derived platelet components suspended in SSP+ treated with the INTERCEPT Blood system.
Transfusion medicine (Oxford, England).
2013 Apr; 23(2):121-9. doi:
10.1111/tme.12020. [PMID: 23480103] - Joan Cid, Carolina Caballo, Marc Pino, Ana M Galan, Nuria Martínez, Ginés Escolar, Maribel Diaz-Ricart. Quantitative and qualitative analysis of coagulation factors in cryoprecipitate prepared from fresh-frozen plasma inactivated with amotosalen and ultraviolet A light.
Transfusion.
2013 Mar; 53(3):600-5. doi:
10.1111/j.1537-2995.2012.03763.x. [PMID: 22738354] - Patricia Marial Sobral, Artur Emilio de Lima Barros, Ayla Maritcha Alves Silva Gomes, Cristine Vieira do Bonfim. Viral inactivation in hemotherapy: systematic review on inactivators with action on nucleic acids.
Revista brasileira de hematologia e hemoterapia.
2012; 34(3):231-5. doi:
10.5581/1516-8484.20120056. [PMID: 23049426] - J-P Cazenave. [Photochemical inactivation of pathogens in platelets and plasma: five years of clinical use in routine and hemovigilance. Towards a change of paradigm in transfusion safety].
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine.
2011 Apr; 18(2):53-61. doi:
10.1016/j.tracli.2011.02.023. [PMID: 21474358] - G Rock. A comparison of methods of pathogen inactivation of FFP.
Vox sanguinis.
2011 Feb; 100(2):169-78. doi:
10.1111/j.1423-0410.2010.01374.x. [PMID: 20667071] - P Chavarin, F Cognasse, C Argaud, M Vidal, C De Putter, F Boussoulade, C Ripaud, S Acquart, L Lin, O Garraud. In vitro assessment of apheresis and pooled buffy coat platelet components suspended in plasma and SSP+ photochemically treated with amotosalen and UVA for pathogen inactivation (INTERCEPT Blood System™).
Vox sanguinis.
2011 Feb; 100(2):247-9. doi:
10.1111/j.1423-0410.2010.01389.x. [PMID: 20735811] - Weiqun Liu, George D Cimino, Laurence Corash, Lily Lin. The extent of amotosalen photodegradation during photochemical treatment of platelet components correlates with the level of pathogen inactivation.
Transfusion.
2011 Jan; 51(1):52-61. doi:
10.1111/j.1537-2995.2010.02786.x. [PMID: 20663111] - Chandana Tekkatte, Gency Ponrose Gunasingh, K M Cherian, Kavitha Sankaranarayanan. 'Humanized' stem cell culture techniques: the animal serum controversy.
Stem cells international.
2011; 2011(?):504723. doi:
10.4061/2011/504723. [PMID: 21603148] - Mark H Yazer. The how's and why's of evidence based plasma therapy.
The Korean journal of hematology.
2010 Sep; 45(3):152-7. doi:
10.5045/kjh.2010.45.3.152. [PMID: 21120202] - Jean-Louis H Kerkhoffs, Wim L J van Putten, Viera M J Novotny, Peter A W Te Boekhorst, Martin R Schipperus, Jaap Jan Zwaginga, Lizzy C M van Pampus, Georgine E de Greef, Marleen Luten, Peter C Huijgens, Anneke Brand, Dick J van Rhenen. Clinical effectiveness of leucoreduced, pooled donor platelet concentrates, stored in plasma or additive solution with and without pathogen reduction.
British journal of haematology.
2010 Jul; 150(2):209-17. doi:
10.1111/j.1365-2141.2010.08227.x. [PMID: 20507310] - Jean-Pierre Cazenave, Chantal Waller, Daniel Kientz, Isabelle Mendel, Lily Lin, Michele Jacquet, Meisa Propst, Weiqun Liu, Laurence Corash, David Sundin, Laurence Defoin, Nathalie Messe, Jean-Claude Osselaer. An active hemovigilance program characterizing the safety profile of 7483 transfusions with plasma components prepared with amotosalen and UVA photochemical treatment.
Transfusion.
2010 Jun; 50(6):1210-9. doi:
10.1111/j.1537-2995.2009.02579.x. [PMID: 20113450] - M Ståhle, B Carlsson, K Le Blanc, O Korsgren, F Knutson. Photochemical pathogen inactivation of human serum enables its large-scale application in clinical cell transplantation.
Vox sanguinis.
2010 Apr; 98(3 Pt 1):e364-5. doi:
10.1111/j.1423-0410.2009.01257.x. [PMID: 20412169] - J Irsch, L Pinkoski, L Corash, L Lin. INTERCEPT plasma: comparability with conventional fresh-frozen plasma based on coagulation function--an in vitro analysis.
Vox sanguinis.
2010 Jan; 98(1):47-55. doi:
10.1111/j.1423-0410.2009.01224.x. [PMID: 19719461] - Vic Ciaravino, Jessica Hanover, Lily Lin, Theresa Sullivan, Laurence Corash. Assessment of safety in neonates for transfusion of platelets and plasma prepared with amotosalen photochemical pathogen inactivation treatment by a 1-month intravenous toxicity study in neonatal rats.
Transfusion.
2009 May; 49(5):985-94. doi:
10.1111/j.1537-2995.2008.02076.x. [PMID: 19175545] - N de Valensart, A Rapaille, E Goossenaerts, D Sondag-Thull, V Deneys. Study of coagulation function in thawed apheresis plasma for photochemical treatment by amotosalen and UVA.
Vox sanguinis.
2009 Apr; 96(3):213-8. doi:
10.1111/j.1423-0410.2008.001147.x. [PMID: 19207170] - Stephen J Wagner, Andrey Skripchenko, Andrew Myrup, Helen Awatefe, Dedeene Thompson-Montgomery, Gary Moroff, Patrick Carmichael, Lily Lin. Evaluation of in vitro storage properties of prestorage pooled whole blood-derived platelets suspended in 100 percent plasma and treated with amotosalen and long-wavelength ultraviolet light.
Transfusion.
2009 Apr; 49(4):704-10. doi:
10.1111/j.1537-2995.2008.02040.x. [PMID: 19171001] - Joan Cid, Laia Ramiro, Nuria Martínez, Marta Palomo, Olga Magallon, Montse Claparols, Pilar Ortiz, Lluis Puig, Ramon Pau Pla. Quantitative and qualitative analysis of proteins in fresh frozen plasma obtained from whole blood donations and prepared with two photochemical treatments.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.
2008 Oct; 39(2):115-21. doi:
10.1016/j.transci.2008.07.009. [PMID: 18710822] - Philippe Grellier, Jorge Benach, Mehdi Labaied, Sébastien Charneau, Horacio Gil, Gloria Monsalve, Ryan Alfonso, Lynette Sawyer, Lily Lin, Matthias Steiert, Kent Dupuis. Photochemical inactivation with amotosalen and long-wavelength ultraviolet light of Plasmodium and Babesia in platelet and plasma components.
Transfusion.
2008 Aug; 48(8):1676-84. doi:
10.1111/j.1537-2995.2007.01762.x. [PMID: 18503613] - Susanne M Picker, Alexander Steisel, Birgit S Gathof. Effects of Mirasol PRT treatment on storage lesion development in plasma-stored apheresis-derived platelets compared to untreated and irradiated units.
Transfusion.
2008 Aug; 48(8):1685-92. doi:
10.1111/j.1537-2995.2008.01778.x. [PMID: 18513255] - Jean C Osselaer, Nathalie Messe, Tor Hervig, Jose Bueno, Emma Castro, Aurora Espinosa, Patrizia Accorsi, Klaus Junge, Michele Jacquet, Jocelyne Flament, Laurence Corash. A prospective observational cohort safety study of 5106 platelet transfusions with components prepared with photochemical pathogen inactivation treatment.
Transfusion.
2008 Jun; 48(6):1061-71. doi:
10.1111/j.1537-2995.2008.01643.x. [PMID: 18346019] - Peter Schlenke, Tor Hervig, Hervé Isola, Marie-Louise Wiesel, Daniel Kientz, Linda Pinkoski, Yasmin Singh, Lily Lin, Laurence Corash, Jean-Pierre Cazenave. Photochemical treatment of plasma with amotosalen and UVA light: process validation in three European blood centers.
Transfusion.
2008 Apr; 48(4):697-705. doi:
10.1111/j.1537-2995.2007.01594.x. [PMID: 18194378] - Nahreen Tynngård, Britt Marie Johansson, Tomas L Lindahl, Gösta Berlin, Mona Hansson. Effects of intercept pathogen inactivation on platelet function as analysed by free oscillation rheometry.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.
2008 Feb; 38(1):85-8. doi:
10.1016/j.transci.2007.12.012. [PMID: 18294916] - Jean-Claude Osselaer, Cécile Debry, Maite Goffaux, Jacqueline Pineau, Genevieve Calomme, Eric Dubuc, Bernard Chatelain, Marie-Claire Vandendaele, Jocelyn Hsu, Margaret Rheinschmidt, Lily Lin. Coagulation function in fresh-frozen plasma prepared with two photochemical treatment methods: methylene blue and amotosalen.
Transfusion.
2008 Jan; 48(1):108-17. doi:
10.1111/j.1537-2995.2007.01488.x. [PMID: 17900283] - Jeffrey McCullough. Pathogen inactivation: a new paradigm for preventing transfusion-transmitted infections.
American journal of clinical pathology.
2007 Dec; 128(6):945-55. doi:
10.1309/rapq3nxg3mv9al94. [PMID: 18024320] - Mark E Brecher, Shauna Hay, Laurence Corash, Jocelyn Hsu, Lily Lin. Evaluation of bacterial inactivation in prestorage pooled, leukoreduced, whole blood-derived platelet concentrates suspended in plasma prepared with photochemical treatment.
Transfusion.
2007 Oct; 47(10):1896-901. doi:
10.1111/j.1537-2995.2007.01413.x. [PMID: 17880617] - Raymond R Tice, David Gatehouse, David Kirkland, Günter Speit. The pathogen reduction treatment of platelets with S-59 HCl (Amotosalen) plus ultraviolet A light: genotoxicity profile and hazard assessment.
Mutation research.
2007 Jun; 630(1-2):50-68. doi:
10.1016/j.mrgentox.2007.02.008. [PMID: 17433761] - Lynette Sawyer, Deborah Hanson, Grace Castro, William Luckett, Thomas W Dubensky, Adonis Stassinopoulos. Inactivation of parvovirus B19 in human platelet concentrates by treatment with amotosalen and ultraviolet A illumination.
Transfusion.
2007 Jun; 47(6):1062-70. doi:
10.1111/j.1537-2995.2007.01237.x. [PMID: 17524098] - Jean-Pierre Allain, Jocelyn Hsu, Manisha Pranmeth, Deborah Hanson, Adonis Stassinopoulos, Lucia Fischetti, Laurence Corash, Lily Lin. Quantification of viral inactivation by photochemical treatment with amotosalen and UV A light, using a novel polymerase chain reaction inhibition method with preamplification.
The Journal of infectious diseases.
2006 Dec; 194(12):1737-44. doi:
10.1086/509260. [PMID: 17109347] - Paul D Mintz, Anne Neff, Malcolm MacKenzie, Lawrence T Goodnough, Christopher Hillyer, Craig Kessler, Keith McCrae, Jay E Menitove, Barry S Skikne, Lloyd Damon, Ileana Lopez-Plaza, Charles Rouault, Kendall P Crookston, Richard J Benjamin, James George, Jin-Sying Lin, Laurence Corash, Maureen G Conlan. A randomized, controlled Phase III trial of therapeutic plasma exchange with fresh-frozen plasma (FFP) prepared with amotosalen and ultraviolet A light compared to untreated FFP in thrombotic thrombocytopenic purpura.
Transfusion.
2006 Oct; 46(10):1693-704. doi:
10.1111/j.1537-2995.2006.00959.x. [PMID: 17002625] - Joseph E Kiss. Randomized clinical trials in thrombotic thrombocytopenic purpura: where do we go from here?.
Transfusion.
2006 Oct; 46(10):1659-62. doi:
10.1111/j.1537-2995.2006.00986.x. [PMID: 17002620] - Yasmin Singh, Lynette S Sawyer, Linda S Pinkoski, Kent W Dupuis, Jocelyn C Hsu, Lily Lin, Laurence Corash. Photochemical treatment of plasma with amotosalen and long-wavelength ultraviolet light inactivates pathogens while retaining coagulation function.
Transfusion.
2006 Jul; 46(7):1168-77. doi:
10.1111/j.1537-2995.2006.00867.x. [PMID: 16836564] - Sheila MacLennan, Lorna M Williamson. Risks of fresh frozen plasma and platelets.
The Journal of trauma.
2006 Jun; 60(6 Suppl):S46-50. doi:
NULL. [PMID: 16763481] - Alvaro Pineda, Jeffrey McCullough, Richard J Benjamin, Ritchard Cable, Ronald G Strauss, Edwin Burgstaler, Seth Porter, Lily Lin, Peyton Metzel, Maureen G Conlan. Pathogen inactivation of platelets with a photochemical treatment with amotosalen HCl and ultraviolet light: process used in the SPRINT trial.
Transfusion.
2006 Apr; 46(4):562-71. doi:
10.1111/j.1537-2995.2006.00761.x. [PMID: 16584432] - H Isola, D Kientz, B Aleil, P Laeuffer, J Weil, M-L Wiesel, M Laforêt, L Lin, V Mayaudon, J-P Cazenave. In vitro evaluation of Haemonetics MCS+ apheresis platelet concentrates treated with photochemical pathogen inactivation following plasma volume reduction using the INTERCEPT Preparation Set.
Vox sanguinis.
2006 Feb; 90(2):128-30. doi:
10.1111/j.1423-0410.2005.00723.x. [PMID: 16430671] - J P R Pelletier, S Transue, E L Snyder. Pathogen inactivation techniques.
Best practice & research. Clinical haematology.
2006; 19(1):205-42. doi:
10.1016/j.beha.2005.04.001. [PMID: 16377551] - Lily Lin, Maureen G Conlan, John Tessman, George Cimino, Seth Porter. Amotosalen interactions with platelet and plasma components: absence of neoantigen formation after photochemical treatment.
Transfusion.
2005 Oct; 45(10):1610-20. doi:
10.1111/j.1537-2995.2005.00554.x. [PMID: 16181212] - Helen Yarranton, Andrew S Lawrie, Ian J Mackie, Linda Pinkoski, Laurence Corash, Samuel J Machin. Coagulation factor levels in cryosupernatant prepared from plasma treated with amotosalen hydrochloride (S-59) and ultraviolet A light.
Transfusion.
2005 Sep; 45(9):1453-8. doi:
10.1111/j.1537-2995.2005.00551.x. [PMID: 16131377] - Pedro de Alarcon, Richard Benjamin, Marion Dugdale, Craig Kessler, Rinah Shopnick, Peter Smith, Thomas Abshire, Julie Hambleton, Prasad Matthew, Idith Ortiz, Alice Cohen, Barbara A Konkle, Michael Streiff, Martin Lee, David Wages, Laurence Corash. Fresh frozen plasma prepared with amotosalen HCl (S-59) photochemical pathogen inactivation: transfusion of patients with congenital coagulation factor deficiencies.
Transfusion.
2005 Aug; 45(8):1362-72. doi:
10.1111/j.1537-2995.2005.00216.x. [PMID: 16078927] - Valérie Jauvin, Ryan D Alfonso, Bernard Guillemain, Kent Dupuis, Hervé J A Fleury. In vitro photochemical inactivation of cell-associated human T-cell leukemia virus Type I and II in human platelet concentrates and plasma by use of amotosalen.
Transfusion.
2005 Jul; 45(7):1151-9. doi:
10.1111/j.1537-2995.2005.04400.x. [PMID: 15987361] - Lily Lin, Carl V Hanson, Harvey J Alter, Valérie Jauvin, Kristen A Bernard, Krishna K Murthy, Peyton Metzel, Laurence Corash. Inactivation of viruses in platelet concentrates by photochemical treatment with amotosalen and long-wavelength ultraviolet light.
Transfusion.
2005 Apr; 45(4):580-90. doi:
10.1111/j.0041-1132.2005.04316.x. [PMID: 15819680] - Jean Pierre Allain, Celso Bianco, Morris A Blajchman, Mark E Brecher, Michael Busch, David Leiby, Lily Lin, Susan Stramer. Protecting the blood supply from emerging pathogens: the role of pathogen inactivation.
Transfusion medicine reviews.
2005 Apr; 19(2):110-26. doi:
10.1016/j.tmrv.2004.11.005. [PMID: 15852240] - Edmund K Waller, Cynthia R Giver, Hilary Rosenthal, Jyoti Somani, Amelia A Langston, Sagar Lonial, John D Roback, Jian-Ming Li, Mohammad S Hossain, Istvan Redei. Facilitating T-cell immune reconstitution after haploidentical transplantation in adults.
Blood cells, molecules & diseases.
2004 Nov; 33(3):233-7. doi:
10.1016/j.bcmd.2004.08.009. [PMID: 15528137] - Lily Lin, Roberta Dikeman, Barbara Molini, Sheila A Lukehart, Robert Lane, Kent Dupuis, Peyton Metzel, Laurence Corash. Photochemical treatment of platelet concentrates with amotosalen and long-wavelength ultraviolet light inactivates a broad spectrum of pathogenic bacteria.
Transfusion.
2004 Oct; 44(10):1496-504. doi:
10.1111/j.1537-2995.2004.04125.x. [PMID: 15383024] - Cetherine T Jordan, Natia Saakadze, James L Newman, Levan J Lezhava, Tanya T Maiers, Whitney M Hillyer, John D Roback, Christopher D Hillyer. Photochemical treatment of platelet concentrates with amotosalen hydrochloride and ultraviolet A light inactivates free and latent cytomegalovirus in a murine transfusion model.
Transfusion.
2004 Aug; 44(8):1159-65. doi:
10.1111/j.1537-2995.2004.03351.x. [PMID: 15265119] - K Janetzko, L Lin, H Eichler, V Mayaudon, J Flament, H Klüter. Implementation of the INTERCEPT Blood System for Platelets into routine blood bank manufacturing procedures: evaluation of apheresis platelets.
Vox sanguinis.
2004 May; 86(4):239-45. doi:
10.1111/j.0042-9007.2004.00419.x. [PMID: 15144528] - Gerard A J Jansen, Huub H D M van Vliet, Hans Vermeij, Erik A M Beckers, Frank W G Leebeek, Pieter Sonneveld, Dick J van Rhenen. Functional characteristics of photochemically treated platelets.
Transfusion.
2004 Mar; 44(3):313-9. doi:
10.1111/j.1537-2995.2003.00588.x. [PMID: 14996186] - R Moog, A Fröhlich, V Mayaudon, L Lin. In vitro evaluation of COM.TEC apheresis platelet concentrates using a preparation set and pathogen inactivation over a storage period of five days.
Journal of clinical apheresis.
2004; 19(4):185-91. doi:
10.1002/jca.20025. [PMID: 15597347] - V Ciaravino, T McCullough, G Cimino, T Sullivan. Preclinical safety profile of plasma prepared using the INTERCEPT Blood System.
Vox sanguinis.
2003 Oct; 85(3):171-82. doi:
10.1046/j.1423-0410.2003.00351.x. [PMID: 14516447] - Yan Yun Wu, Edward L Snyder. Safety of the blood supply: role of pathogen reduction.
Blood reviews.
2003 Jun; 17(2):111-22. doi:
10.1016/s0268-960x(02)00063-2. [PMID: 12642123] - Wesley C Van Voorhis, Lynn K Barrett, Richard T Eastman, Ryan Alfonso, Kent Dupuis. Trypanosoma cruzi inactivation in human platelet concentrates and plasma by a psoralen (amotosalen HCl) and long-wavelength UV.
Antimicrobial agents and chemotherapy.
2003 Feb; 47(2):475-9. doi:
10.1128/aac.47.2.475-479.2003. [PMID: 12543646] - NULL. Amotosalen: Allogeneic Cellular Immunotherapies system, INTERCEPT Plasma System, INTERCEPT Platelet System, S 59.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy.
2003; 17(1):66-8. doi:
10.2165/00063030-200317010-00006. [PMID: 12534321]