Aminooxyacetic acid (BioDeep_00000175995)
Secondary id: BioDeep_00000279186
human metabolite PANOMIX_OTCML-2023 blood metabolite
代谢物信息卡片
(O-Carboxymethyl)hydroxylamine
化学式: C2H5NO3 (91.026942)
中文名称: 2-(氨基氧基)乙酸
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 4.76%
分子结构信息
SMILES: C(C(=O)O)ON
InChI: InChI=1S/C2H5NO3/c3-6-1-2(4)5/h1,3H2,(H,4,5)
描述信息
D018377 - Neurotransmitter Agents > D018682 - GABA Agents
D004791 - Enzyme Inhibitors
同义名列表
16 个代谢物同义名
(O-Carboxymethyl)hydroxylamine; 2-Aminooxyethanoic acid; 2-(Aminooxy)acetic acid; (aminooxy)acetic acid; (Carboxymethoxy)amine; Aminooxy-acetic acid; Acid, aminooxyacetic; 2-Aminooxyethanoate; Aminooxyacetic acid; Carboxymethoxyamine; 2-(Aminooxy)acetate; Aminooxy-acetate; Aminooxyacetate; U-7524; AOAA; AOA
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:40823
- PubChem: 286
- HMDB: HMDB0248327
- DrugBank: DB02079
- ChEMBL: CHEMBL347862
- Wikipedia: Aminooxyacetic_acid
- MeSH: Aminooxyacetic Acid
- MetaCyc: CARBOXYMETHOXYLAMINE
- chemspider: 280
- CAS: 645-88-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ahmet Hatipoglu, Deepak Menon, Talia Levy, Maria A Frias, David A Foster. Inhibiting glutamine utilization creates a synthetic lethality for suppression of ATP citrate lyase in KRas-driven cancer cells.
PloS one.
2022; 17(10):e0276579. doi:
10.1371/journal.pone.0276579. [PMID: 36269753] - Monika Kijewska, Tomasz Koch, Mateusz Waliczek, Andrzej Konieczny, Piotr Stefanowicz, Zbigniew Szewczuk. Selective ESI-MS detection of carbonyl containing compounds by aminooxyacetic acid immobilized on a resin.
Analytica chimica acta.
2021 Sep; 1176(?):338767. doi:
10.1016/j.aca.2021.338767. [PMID: 34399903] - Mark R Hellmich, Celia Chao, Katalin Módis, Ye Ding, John R Zatarain, Ketan Thanki, Manjit Maskey, Nadiya Druzhyna, Ashley A Untereiner, Akbar Ahmad, Yu Xue, Haiying Chen, William K Russell, Jianmei Wang, Jia Zhou, Csaba Szabo. Efficacy of Novel Aminooxyacetic Acid Prodrugs in Colon Cancer Models: Towards Clinical Translation of the Cystathionine β-Synthase Inhibition Concept.
Biomolecules.
2021 07; 11(8):. doi:
10.3390/biom11081073. [PMID: 34439739] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Anthony L Su, Lawrence H Lash, Ingrid L Bergin, Faith Bjork, Rita Loch-Caruso. N-Acetyl-L-cysteine and aminooxyacetic acid differentially modulate trichloroethylene reproductive toxicity via metabolism in Wistar rats.
Archives of toxicology.
2021 04; 95(4):1303-1321. doi:
10.1007/s00204-021-02991-8. [PMID: 33599830] - Maria Romerowicz-Misielak, Katarzyna Kozioł, Sławomir Nowak, Anna Lewińska, Marek Koziorowski. Altered dynamics in the circadian oscillation of clock genes in serum-shocked NIH-3T3 cells by the treatment of GYY4137 or AOAA.
Archives of biochemistry and biophysics.
2020 02; 680(?):108237. doi:
10.1016/j.abb.2019.108237. [PMID: 31881188] - L V Kovaleva, E V Zakharova, G V Timofeeva, I M Andreev, Ya Yu Golivanov, L R Bogoutdinova, E N Baranova, M R Khaliluev. Aminooxyacetic acid (АОА), inhibitor of 1-aminocyclopropane-1-carboxilic acid (AСС) synthesis, suppresses self-incompatibility-induced programmed cell death in self-incompatible Petunia hybrida L. pollen tubes.
Protoplasma.
2020 Jan; 257(1):213-227. doi:
10.1007/s00709-019-01430-x. [PMID: 31410589] - Renfei Luo, Shan Hu, Qiaojuan Liu, Mengke Han, Feifei Wang, Miaojuan Qiu, Suchun Li, Xiaosa Li, Tianxin Yang, Xiaodong Fu, Weidong Wang, Chunling Li. Hydrogen sulfide upregulates renal AQP-2 protein expression and promotes urine concentration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 01; 33(1):469-483. doi:
10.1096/fj.201800436r. [PMID: 30036087] - L V Kovaleva, E V Zakharova, A S Voronkov, G V Timofeeva. [Auxin Abolishes Inhibitory Effects of Methylcyclopropen and Amino Oxyacetic Acid on Pollen Grain Germination, Pollen Tube Growth, and the Synthesis of ACC in Petunia].
Ontogenez.
2017 Mar; 48(2):140-8. doi:
". [PMID: 30277364] - Akbar Ahmad, Csaba Szabo. Both the H2S biosynthesis inhibitor aminooxyacetic acid and the mitochondrially targeted H2S donor AP39 exert protective effects in a mouse model of burn injury.
Pharmacological research.
2016 11; 113(Pt A):348-355. doi:
10.1016/j.phrs.2016.09.013. [PMID: 27639598] - Laura Blancquaert, Shahid P Baba, Sebastian Kwiatkowski, Jan Stautemas, Sanne Stegen, Silvia Barbaresi, Weiliang Chung, Adjoa A Boakye, J David Hoetker, Aruni Bhatnagar, Joris Delanghe, Bert Vanheel, Maria Veiga-da-Cunha, Wim Derave, Inge Everaert. Carnosine and anserine homeostasis in skeletal muscle and heart is controlled by β-alanine transamination.
The Journal of physiology.
2016 09; 594(17):4849-63. doi:
10.1113/jp272050. [PMID: 27062388] - Yan-Min Zhang, Zi-Hui Liu, Rui-Juan Yang, Guo-Liang Li, Xiu-Lin Guo, Hua-Ning Zhang, Hong-Mei Zhang, Rui Di, Qing-Song Zhao, Meng-Chen Zhang. Improvement of soybean transformation via Agrobacterium tumefaciens methods involving α-aminooxyacetic acid and sonication treatments enlightened by gene expression profile analysis.
Plant cell reports.
2016 Jun; 35(6):1259-71. doi:
10.1007/s00299-016-1958-2. [PMID: 26960402] - George J Dugbartey, Fatemeh Talaei, Martin C Houwertjes, Maaike Goris, Anne H Epema, Hjalmar R Bouma, Robert H Henning. Dopamine treatment attenuates acute kidney injury in a rat model of deep hypothermia and rewarming - The role of renal H2S-producing enzymes.
European journal of pharmacology.
2015 Dec; 769(?):225-33. doi:
10.1016/j.ejphar.2015.11.022. [PMID: 26593431] - Xiaolei Liang, Huahua Wang, Yanfeng Hu, Lina Mao, Lili Sun, Tian Dong, Wenbin Nan, Yurong Bi. Silicon does not mitigate cell death in cultured tobacco BY-2 cells subjected to salinity without ethylene emission.
Plant cell reports.
2015 Feb; 34(2):331-43. doi:
10.1007/s00299-014-1712-6. [PMID: 25477205] - Aya Koshio, Tomomi Hasegawa, Rieko Okada, Kiyotoshi Takeno. Endogenous factors regulating poor-nutrition stress-induced flowering in pharbitis: The involvement of metabolic pathways regulated by aminooxyacetic acid.
Journal of plant physiology.
2015 Jan; 173(?):82-8. doi:
10.1016/j.jplph.2014.09.004. [PMID: 25462081] - George J Dugbartey, Hjalmar R Bouma, Arjen M Strijkstra, Ate S Boerema, Robert H Henning. Induction of a Torpor-Like State by 5'-AMP Does Not Depend on H2S Production.
PloS one.
2015; 10(8):e0136113. doi:
10.1371/journal.pone.0136113. [PMID: 26295351] - Erika Segear Johnson, Kelly R Lindblom, Alexander Robeson, Robert D Stevens, Olga R Ilkayeva, Christopher B Newgard, Sally Kornbluth, Joshua L Andersen. Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis.
The Journal of biological chemistry.
2013 May; 288(20):14463-14475. doi:
10.1074/jbc.m112.437210. [PMID: 23553630] - Barbara Baragatti, Enrica Ciofini, Daria Sodini, Stefano Luin, Francesca Scebba, Flavio Coceani. Hydrogen sulfide in the mouse ductus arteriosus: a naturally occurring relaxant with potential EDHF function.
American journal of physiology. Heart and circulatory physiology.
2013 Apr; 304(7):H927-34. doi:
10.1152/ajpheart.00718.2012. [PMID: 23376828] - Kirill Tsirulnikov, Natalia Abuladze, Anatol Bragin, Kym Faull, Duilio Cascio, Robert Damoiseaux, Matthew J Schibler, Alexander Pushkin. Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal.
Toxicology and applied pharmacology.
2012 Sep; 263(3):303-14. doi:
10.1016/j.taap.2012.07.002. [PMID: 22819785] - Aya Shimakawa, Takeshi Shiraya, Yuta Ishizuka, Kaede C Wada, Toshiaki Mitsui, Kiyotoshi Takeno. Salicylic acid is involved in the regulation of starvation stress-induced flowering in Lemna paucicostata.
Journal of plant physiology.
2012 Jul; 169(10):987-91. doi:
10.1016/j.jplph.2012.02.009. [PMID: 22429781] - Sang-Ho Cha, Sung-Hee Kim, Karyn Bischoff, Hyun-Jeong Kim, Seong-Wan Son, Hwan-Goo Kang. Production of a highly group-specific monoclonal antibody against zearalenone and its application in an enzyme-linked immunosorbent assay.
Journal of veterinary science.
2012 Jun; 13(2):119-25. doi:
10.4142/jvs.2012.13.2.119. [PMID: 22705733] - Atsushi Takeda, Haruka Iwaki, Kazuki Ide, Haruna Tamano, Naoto Oku. Therapeutic effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient and pair-fed mice.
Brain research bulletin.
2012 Apr; 87(6):551-5. doi:
10.1016/j.brainresbull.2012.02.003. [PMID: 22373913] - Markus Niessen, Katrin Krause, Ina Horst, Norma Staebler, Stephanie Klaus, Stefanie Gaertner, Rashad Kebeish, Wagner L Araujo, Alisdair R Fernie, Christoph Peterhansel. Two alanine aminotranferases link mitochondrial glycolate oxidation to the major photorespiratory pathway in Arabidopsis and rice.
Journal of experimental botany.
2012 Apr; 63(7):2705-16. doi:
10.1093/jxb/err453. [PMID: 22268146] - Mojtaba Bagheri, Michael Beyermann, Margitta Dathe. Mode of action of cationic antimicrobial peptides defines the tethering position and the efficacy of biocidal surfaces.
Bioconjugate chemistry.
2012 Jan; 23(1):66-74. doi:
10.1021/bc200367f. [PMID: 22148269] - Antonio Ferrante, Alice Trivellini, Eva Borghesi, Paolo Vernieri. Chlorophyll a fluorescence as a tool in evaluating the effects of ABA content and ethylene inhibitors on quality of flowering potted Bougainvillea.
TheScientificWorldJournal.
2012; 2012(?):684747. doi:
10.1100/2012/684747. [PMID: 22272178] - Gerile, Chiharu Sogawa, Kazumi Ohyama, Takashi Masuko, Tadashi Kusama, Katsuya Morita, Norio Sogawa, Shigeo Kitayama. Inhibitory action of antidepressants on mouse Betaine/GABA transporter (BGT1) heterologously expressed in cell cultures.
International journal of molecular sciences.
2012; 13(3):2578-2589. doi:
10.3390/ijms13032578. [PMID: 22489112] - W Gordon Frankle, Raymond Y Cho, N Scott Mason, Chi-Min Chen, Michael Himes, Christopher Walker, David A Lewis, Chester A Mathis, Rajesh Narendran. [11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels.
PloS one.
2012; 7(2):e32443. doi:
10.1371/journal.pone.0032443. [PMID: 22384252] - Huahua Wang, Junjun Huang, Xiaolei Liang, Yurong Bi. Involvement of hydrogen peroxide, calcium, and ethylene in the induction of the alternative pathway in chilling-stressed Arabidopsis callus.
Planta.
2012 Jan; 235(1):53-67. doi:
10.1007/s00425-011-1488-7. [PMID: 21814799] - Alexander Roy, Abdul H Khan, Mohammed T Islam, Minolfa C Prieto, Dewan S A Majid. Interdependency of cystathione γ-lyase and cystathione β-synthase in hydrogen sulfide-induced blood pressure regulation in rats.
American journal of hypertension.
2012 Jan; 25(1):74-81. doi:
10.1038/ajh.2011.149. [PMID: 21866187] - Rieko Katayama, Saori Nagata, Hiroko Iida, Norio Yamagishi, Tetsuro Yamashita, Kazuhisa Furuhama. Possible role of cysteine-S-conjugate β-lyase in species differences in cisplatin nephrotoxicity.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2011 Sep; 49(9):2053-9. doi:
10.1016/j.fct.2011.05.017. [PMID: 21640784] - Maria C Parra-Lobato, Maria C Gomez-Jimenez. Polyamine-induced modulation of genes involved in ethylene biosynthesis and signalling pathways and nitric oxide production during olive mature fruit abscission.
Journal of experimental botany.
2011 Aug; 62(13):4447-65. doi:
10.1093/jxb/err124. [PMID: 21633085] - Joshua P Gray, Timothy Eisen, Gary W Cline, Peter J S Smith, Emma Heart. Plasma membrane electron transport in pancreatic β-cells is mediated in part by NQO1.
American journal of physiology. Endocrinology and metabolism.
2011 Jul; 301(1):E113-21. doi:
10.1152/ajpendo.00673.2010. [PMID: 21505151] - E A Bulantseva, M A Protsenko, A S Toropkina, N P Korableva. [The effect of physiologically active compounds on the production of ethylene and the activity of polygalacturonase inhibiting protein in fruits].
Prikladnaia biokhimiia i mikrobiologiia.
2011 Mar; 47(2):201-8. doi:
. [PMID: 22808745] - Shigemi Seo, Ichiro Mitsuhara, Jiao Feng, Takayoshi Iwai, Morifumi Hasegawa, Yuko Ohashi. Cyanide, a coproduct of plant hormone ethylene biosynthesis, contributes to the resistance of rice to blast fungus.
Plant physiology.
2011 Jan; 155(1):502-14. doi:
10.1104/pp.110.162412. [PMID: 21075959] - Jiaojiao Wu, Chuang Wang, Luqing Zheng, Lu Wang, Yunlong Chen, James Whelan, Huixia Shou. Ethylene is involved in the regulation of iron homeostasis by regulating the expression of iron-acquisition-related genes in Oryza sativa.
Journal of experimental botany.
2011 Jan; 62(2):667-74. doi:
10.1093/jxb/erq301. [PMID: 21112958] - Joanna K Polko, Laurentius A C J Voesenek, Anton J M Peeters, Ronald Pierik. Petiole hyponasty: an ethylene-driven, adaptive response to changes in the environment.
AoB PLANTS.
2011; 2011(?):plr031. doi:
10.1093/aobpla/plr031. [PMID: 22476501] - Takashi Kadono, Daniel Tran, Rafik Errakhi, Takuya Hiramatsu, Patrice Meimoun, Joël Briand, Mari Iwaya-Inoue, Tomonori Kawano, François Bouteau. Increased anion channel activity is an unavoidable event in ozone-induced programmed cell death.
PloS one.
2010 Oct; 5(10):e13373. doi:
10.1371/journal.pone.0013373. [PMID: 20967217] - Huahua Wang, Xiaolei Liang, Junjun Huang, Dongkai Zhang, Hongxia Lu, Zhongjuan Liu, Yurong Bi. Involvement of ethylene and hydrogen peroxide in induction of alternative respiratory pathway in salt-treated Arabidopsis calluses.
Plant & cell physiology.
2010 Oct; 51(10):1754-65. doi:
10.1093/pcp/pcq134. [PMID: 20801923] - Alexandre Benedetto, Catherine Au, Daiana Silva Avila, Dejan Milatovic, Michael Aschner. Extracellular dopamine potentiates mn-induced oxidative stress, lifespan reduction, and dopaminergic neurodegeneration in a BLI-3-dependent manner in Caenorhabditis elegans.
PLoS genetics.
2010 Aug; 6(8):. doi:
10.1371/journal.pgen.1001084. [PMID: 20865164] - Leonid E Fridlyand, Louis H Philipson. Glucose sensing in the pancreatic beta cell: a computational systems analysis.
Theoretical biology & medical modelling.
2010 May; 7(?):15. doi:
10.1186/1742-4682-7-15. [PMID: 20497556] - Kaede C Wada, Mizuki Yamada, Takeshi Shiraya, Kiyotoshi Takeno. Salicylic acid and the flowering gene FLOWERING LOCUS T homolog are involved in poor-nutrition stress-induced flowering of Pharbitis nil.
Journal of plant physiology.
2010 Apr; 167(6):447-52. doi:
10.1016/j.jplph.2009.10.006. [PMID: 19906461] - David De Vleesschauwer, Yinong Yang, Casiana Vera Cruz, Monica Höfte. Abscisic acid-induced resistance against the brown spot pathogen Cochliobolus miyabeanus in rice involves MAP kinase-mediated repression of ethylene signaling.
Plant physiology.
2010 Apr; 152(4):2036-52. doi:
10.1104/pp.109.152702. [PMID: 20130100] - Takahiro Ishii, Kazuo Soeno, Tadao Asami, Shozo Fujioka, Yukihisa Shimada. Arabidopsis seedlings over-accumulated indole-3-acetic acid in response to aminooxyacetic acid.
Bioscience, biotechnology, and biochemistry.
2010; 74(11):2345-7. doi:
10.1271/bbb.100463. [PMID: 21071851] - Soraya Labboun, Thérèse Tercé-Laforgue, Albrecht Roscher, Magali Bedu, Francesco M Restivo, Christos N Velanis, Damianos S Skopelitis, Panagiotis N Moschou, Panagiotis N Moshou, Kalliopi A Roubelakis-Angelakis, Akira Suzuki, Bertrand Hirel. Resolving the role of plant glutamate dehydrogenase. I. In vivo real time nuclear magnetic resonance spectroscopy experiments.
Plant & cell physiology.
2009 Oct; 50(10):1761-73. doi:
10.1093/pcp/pcp118. [PMID: 19690000] - Debabrata Sircar, Adinpunya Mitra. Accumulation of p-hydroxybenzoic acid in hairy roots of Daucus carota 2: confirming biosynthetic steps through feeding of inhibitors and precursors.
Journal of plant physiology.
2009 Sep; 166(13):1370-80. doi:
10.1016/j.jplph.2009.02.006. [PMID: 19342120] - Steve F Perry, Brian McNeill, Eshay Elia, Ashish Nagpal, Branka Vulesevic. Hydrogen sulfide stimulates catecholamine secretion in rainbow trout (Oncorhynchus mykiss).
American journal of physiology. Regulatory, integrative and comparative physiology.
2009 Jan; 296(1):R133-40. doi:
10.1152/ajpregu.00185.2008. [PMID: 18987290] - Kwok Wai Lai, Chi Ping Yau, Yu Chung Tse, Liwen Jiang, Wing Kin Yip. Heterologous expression analyses of rice OsCAS in Arabidopsis and in yeast provide evidence for its roles in cyanide detoxification rather than in cysteine synthesis in vivo.
Journal of experimental botany.
2009; 60(3):993-1008. doi:
10.1093/jxb/ern343. [PMID: 19181864] - Anouk Dirksen, Philip E Dawson. Rapid oxime and hydrazone ligations with aromatic aldehydes for biomolecular labeling.
Bioconjugate chemistry.
2008 Dec; 19(12):2543-8. doi:
10.1021/bc800310p. [PMID: 19053314] - Erin D Hopper, Adrianne M C Pittman, Michael C Fitzgerald, Chandra L Tucker. In vivo and in vitro examination of stability of primary hyperoxaluria-associated human alanine:glyoxylate aminotransferase.
The Journal of biological chemistry.
2008 Nov; 283(45):30493-502. doi:
10.1074/jbc.m803525200. [PMID: 18782763] - Dipjyoti Chakraborty, Debabrata Sircar, Adinpunya Mitra. Phenylalanine ammonia-lyase-mediated biosynthesis of 2-hydroxy-4-methoxybenzaldehyde in roots of Hemidesmus indicus.
Journal of plant physiology.
2008 Jul; 165(10):1033-40. doi:
10.1016/j.jplph.2007.09.002. [PMID: 18023917] - Maria Kendziorek, Andrzej Paszkowski. Properties of serine:glyoxylate aminotransferase purified from Arabidopsis thaliana leaves.
Acta biochimica et biophysica Sinica.
2008 Feb; 40(2):102-10. doi:
10.1111/j.1745-7270.2008.00383.x. [PMID: 18235971] - Hiroyuki Tanaka, Atsushi Yamamoto, Tetsuo Ishida, Kihachiro Horiike. D-Serine dehydratase from chicken kidney: a vertebral homologue of the cryptic enzyme from Burkholderia cepacia.
Journal of biochemistry.
2008 Jan; 143(1):49-57. doi:
10.1093/jb/mvm203. [PMID: 17977854] - N I Fedotcheva, E G Litvinova, Z G Amerkhanov, S V Kamzolova, I G Morgunov, M N Kondrashova. Increase in the contribution of transamination to the respiration of mitochondria during arousal.
Cryo letters.
2008 Jan; 29(1):35-42. doi:
". [PMID: 18392288] - Julia Koehl, Alma Djulic, Veronika Kirner, Tach Thao Nguyen, Ingrid Heiser. Ethylene is required for elicitin-induced oxidative burst but not for cell death induction in tobacco cell suspension cultures.
Journal of plant physiology.
2007 Dec; 164(12):1555-63. doi:
10.1016/j.jplph.2007.05.012. [PMID: 17913292] - Adnan A Elfarra, Renee J Krause. S-(1,2,2-trichlorovinyl)-L-cysteine sulfoxide, a reactive metabolite of S-(1,2,2-Trichlorovinyl)-L-cysteine formed in rat liver and kidney microsomes, is a potent nephrotoxicant.
The Journal of pharmacology and experimental therapeutics.
2007 Jun; 321(3):1095-101. doi:
10.1124/jpet.107.120444. [PMID: 17347324] - L Qin, J He, S K Lee, I C Dodd. An assessment of the role of ethylene in mediating lettuce (Lactuca sativa) root growth at high temperatures.
Journal of experimental botany.
2007; 58(11):3017-24. doi:
10.1093/jxb/erm156. [PMID: 17728295] - Takayoshi Iwai, Atsushi Miyasaka, Shigemi Seo, Yuko Ohashi. Contribution of ethylene biosynthesis for resistance to blast fungus infection in young rice plants.
Plant physiology.
2006 Nov; 142(3):1202-15. doi:
10.1104/pp.106.085258. [PMID: 17012402] - Lei Zhang, Arthur J L Cooper, Boris F Krasnikov, Hui Xu, Parvesh Bubber, John T Pinto, Gary E Gibson, Marie H Hanigan. Cisplatin-induced toxicity is associated with platinum deposition in mouse kidney mitochondria in vivo and with selective inactivation of the alpha-ketoglutarate dehydrogenase complex in LLC-PK1 cells.
Biochemistry.
2006 Jul; 45(29):8959-71. doi:
10.1021/bi060027g. [PMID: 16846239] - Peter T H Wong, Kun Qu, Ghislain N Chimon, Alvin B H Seah, Hui Meng Chang, Meng Cheong Wong, Yee Kong Ng, Helmut Rumpel, Barry Halliwell, Christopher P L H Chen. High plasma cyst(e)ine level may indicate poor clinical outcome in patients with acute stroke: possible involvement of hydrogen sulfide.
Journal of neuropathology and experimental neurology.
2006 Feb; 65(2):109-15. doi:
10.1097/01.jnen.0000199571.96472.c7. [PMID: 16462202] - Ryosuke Tatsunami, Tadao Yoshioka. Enzymatic and mechanistic studies on the formation of N-phenylglycolohydroxamic acid from nitrosobenzene and pyruvate in spinach leaf homogenate.
Journal of agricultural and food chemistry.
2006 Jan; 54(2):590-6. doi:
10.1021/jf051969f. [PMID: 16417326] - Donghui Cui, Gary O Rankin, Peter J Harvison. Transamination in the metabolism of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide in rats.
Drug metabolism and disposition: the biological fate of chemicals.
2005 Dec; 33(12):1765-70. doi:
10.1124/dmd.105.006593. [PMID: 16174804] - Hsiao-Ping Peng, Ter-Yun Lin, Ning-Ning Wang, Ming-Che Shih. Differential expression of genes encoding 1-aminocyclopropane-1-carboxylate synthase in Arabidopsis during hypoxia.
Plant molecular biology.
2005 May; 58(1):15-25. doi:
10.1007/s11103-005-3573-4. [PMID: 16028113] - Kensuke Miyamoto, Tomoki Hoshino, Masamichi Yamashita, Junichi Ueda. Automorphosis of etiolated pea seedlings in space is simulated by a three-dimensional clinostat and the application of inhibitors of auxin polar transport.
Physiologia plantarum.
2005 Apr; 123(4):467-74. doi:
10.1111/j.1399-3054.2005.00472.x. [PMID: 15844285] - Kirsten Bagh, Toshifumi Hiraoki, Trevor A Thorpe, Hans J Vogel. Nitrogen-15 NMR studies of nitrogen metabolism in Picea glauca buds.
Plant physiology and biochemistry : PPB.
2004 Dec; 42(10):803-9. doi:
10.1016/j.plaphy.2004.09.006. [PMID: 15596100] - Andrzej Kaźmierczak. Aminooxyacetic acid inhibits antheridiogenesis and development of Anemia phyllitidis gametophytes.
Plant cell reports.
2004 Oct; 23(4):203-10. doi:
10.1007/s00299-004-0829-4. [PMID: 15480681] - Johanna C Mader. Differential in vitro development of inflorescences in long and short day Lemna spp.: involvement of ethylene and polyamines.
Journal of plant physiology.
2004 Jun; 161(6):653-63. doi:
10.1078/0176-1617-01079. [PMID: 15266712] - John P M Wood, Glyn Chidlow, Mark Graham, Neville N Osborne. Energy substrate requirements of rat retinal pigmented epithelial cells in culture: relative importance of glucose, amino acids, and monocarboxylates.
Investigative ophthalmology & visual science.
2004 Apr; 45(4):1272-80. doi:
10.1167/iovs.03-0693. [PMID: 15037596] - Katarzyna Wejksza, Wojciech Rzeski, Jolanta Parada-Turska, Barbara Zdzisinska, Robert Rejdak, Tomasz Kocki, Etsuo Okuno, Martyna Kandefer-Szerszen, Eberhart Zrenner, Waldemar A Turski. Kynurenic acid production in cultured bovine aortic endothelial cells. Homocysteine is a potent inhibitor.
Naunyn-Schmiedeberg's archives of pharmacology.
2004 Mar; 369(3):300-4. doi:
10.1007/s00210-004-0872-2. [PMID: 14770276] - Hyung Gon Mang, Eun Ok Kang, Jung Hye Shim, So-yeon Kim, Ky Young Park, Yu Sam Kim, Young Yil Bahk, Woo Taek Kim. A proteomic analysis identifies glutathione S-transferase isoforms whose abundance is differentially regulated by ethylene during the formation of early root epidermis in Arabidopsis seedlings.
Biochimica et biophysica acta.
2004 Feb; 1676(3):231-9. doi:
10.1016/j.bbaexp.2003.12.005. [PMID: 14984929] - Ineta Steinite, Agnese Gailite, Gederts Ievinsh. Reactive oxygen and ethylene are involved in the regulation of regurgitant-induced responses in bean plants.
Journal of plant physiology.
2004 Feb; 161(2):191-6. doi:
10.1078/0176-1617-01098. [PMID: 15022833] - An S Tan, Michael V Berridge. Distinct trans-plasma membrane redox pathways reduce cell-impermeable dyes in HeLa cells.
Redox report : communications in free radical research.
2004; 9(6):302-6. doi:
10.1179/135100004225006777. [PMID: 15720822] - H Zaid, R El Morabet, H G Diem, M Arahou. Does ethylene mediate cluster root formation under iron deficiency?.
Annals of botany.
2003 Nov; 92(5):673-7. doi:
10.1093/aob/mcg186. [PMID: 12967908] - Tetsuya Yamada, Wataru Marubashi. Overproduced ethylene causes programmed cell death leading to temperature-sensitive lethality in hybrid seedlings from the cross Nicotiana suaveolens x N. tabacum.
Planta.
2003 Sep; 217(5):690-8. doi:
10.1007/s00425-003-1035-2. [PMID: 12728318] - Trevor A McGoldrick, Edward A Lock, Vicente Rodilla, Gabrielle M Hawksworth. Renal cysteine conjugate C-S lyase mediated toxicity of halogenated alkenes in primary cultures of human and rat proximal tubular cells.
Archives of toxicology.
2003 Jul; 77(7):365-70. doi:
10.1007/s00204-003-0459-6. [PMID: 12700887] - Jorma Vahala, Raili Ruonala, Markku Keinänen, Hannele Tuominen, Jaakko Kangasjärvi. Ethylene insensitivity modulates ozone-induced cell death in birch.
Plant physiology.
2003 May; 132(1):185-95. doi:
10.1104/pp.102.018887. [PMID: 12746524] - Tomomi Hatayama, Kiyotoshi Takeno. The metabolic pathway of salicylic acid rather than of chlorogenic acid is involved in the stress-induced flowering of Pharbitis nil.
Journal of plant physiology.
2003 May; 160(5):461-7. doi:
10.1078/0176-1617-01041. [PMID: 12806773] - Fatma Ouaked, Wilfried Rozhon, David Lecourieux, Heribert Hirt. A MAPK pathway mediates ethylene signaling in plants.
The EMBO journal.
2003 Mar; 22(6):1282-8. doi:
10.1093/emboj/cdg131. [PMID: 12628921] - Danyelle M Townsend, Mei Deng, Lei Zhang, Maia G Lapus, Marie H Hanigan. Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells.
Journal of the American Society of Nephrology : JASN.
2003 Jan; 14(1):1-10. doi:
10.1097/01.asn.0000042803.28024.92. [PMID: 12506132] - Michelle C Brincat, Donna M Gibson, Michael L Shuler. Alterations in Taxol production in plant cell culture via manipulation of the phenylalanine ammonia lyase pathway.
Biotechnology progress.
2002 Nov; 18(6):1149-56. doi:
10.1021/bp0256115. [PMID: 12467445] - Renee J Krause, Steven C Glocke, Adnan A Elfarra. Sulfoxides as urinary metabolites of S-allyl-L-cysteine in rats: evidence for the involvement of flavin-containing monooxygenases.
Drug metabolism and disposition: the biological fate of chemicals.
2002 Oct; 30(10):1137-42. doi:
10.1124/dmd.30.10.1137. [PMID: 12228191] - Jörgen Persson, Torgny Näsholm. Regulation of amino acid uptake in conifers by exogenous and endogenous nitrogen.
Planta.
2002 Aug; 215(4):639-44. doi:
10.1007/s00425-002-0786-5. [PMID: 12172847] - Martijn Rooseboom, Gerben Schaaf, Jan N M Commandeur, Nico P E Vermeulen, Johanna Fink-Gremmels. Beta-lyase-dependent attenuation of cisplatin-mediated toxicity by selenocysteine Se-conjugates in renal tubular cell lines.
The Journal of pharmacology and experimental therapeutics.
2002 Jun; 301(3):884-92. doi:
10.1124/jpet.301.3.884. [PMID: 12023515] - Danyelle M Townsend, Marie H Hanigan. Inhibition of gamma-glutamyl transpeptidase or cysteine S-conjugate beta-lyase activity blocks the nephrotoxicity of cisplatin in mice.
The Journal of pharmacology and experimental therapeutics.
2002 Jan; 300(1):142-8. doi:
10.1124/jpet.300.1.142. [PMID: 11752109] - J H Kim, W T Kim, B G Kang. IAA and N(6)-benzyladenine inhibit ethylene-regulated expression of ACC oxidase and ACC synthase genes in mungbean hypocotyls.
Plant & cell physiology.
2001 Oct; 42(10):1056-61. doi:
10.1093/pcp/pce133. [PMID: 11673620] - N Bughio, H Nakanishi, S Kiyomiya, S Matsuhashi, N S Ishioka, S Watanabe, H Uchida, A Tsuji, A Osa, T Kume, S Hashimoto, T Sekine, S Mori. Real-time [11C]methionine translocation in barley in relation to mugineic acid phytosiderophore biosynthesis.
Planta.
2001 Sep; 213(5):708-15. doi:
10.1007/s004250100552. [PMID: 11678274] - T Yamada, W Marubashi, T Nakamura, M Niwa. Possible involvement of auxin-induced ethylene in an apoptotic cell death during temperature-sensitive lethality expressed by hybrid between Nicotiana glutinosa and N. repanda.
Plant & cell physiology.
2001 Sep; 42(9):923-30. doi:
10.1093/pcp/pce114. [PMID: 11577186] - M Rooseboom, N P Vermeulen, N van Hemert, J N Commandeur. Bioactivation of chemopreventive selenocysteine Se-conjugates and related amino acids by amino acid oxidases novel route of metabolism of selenoamino acids.
Chemical research in toxicology.
2001 Aug; 14(8):996-1005. doi:
10.1021/tx000265r. [PMID: 11511173] - J J Kornblatt, D R Grattan. Lactation alters gamma-aminobutyric acid neuronal activity in the hypothalamus and cerebral cortex in the rat.
Neuroendocrinology.
2001 Mar; 73(3):175-84. doi:
10.1159/000054634. [PMID: 11307036] - Y Chen, J Cai, M W Anders, J L Stevens, D P Jones. Role of mitochondrial dysfunction in S-(1,2-dichlorovinyl)-l-cysteine-induced apoptosis.
Toxicology and applied pharmacology.
2001 Feb; 170(3):172-80. doi:
10.1006/taap.2000.9107. [PMID: 11162782] - K Kishida, N Saida, N Yamamura, Y Iwai, T Sasabe. Cysteine conjugate of methazolamide is metabolized by beta-lyase.
Journal of pharmaceutical sciences.
2001 Feb; 90(2):224-33. doi:
10.1002/1520-6017(200102)90:2<224::aid-jps13>3.0.co;2-0. [PMID: 11169539] - B S Cummings, L H Lash. Metabolism and toxicity of trichloroethylene and S-(1,2-dichlorovinyl)-L-cysteine in freshly isolated human proximal tubular cells.
Toxicological sciences : an official journal of the Society of Toxicology.
2000 Feb; 53(2):458-66. doi:
10.1093/toxsci/53.2.458. [PMID: 10696794] - S C Hood, N B Schwartz. Sex difference in serum luteinizing hormone postgonadectomy in the rat: role of gamma-aminobutyric acid-ergic inhibition.
Endocrine.
2000 Feb; 12(1):35-40. doi:
10.1385/endo:12:1:35. [PMID: 10855688] - C Feleder, M Guinzburg, W Wuttke, J A Moguilevsky, P Arias. [Effect prolonged GABAergic activation on the pubertal development of female rats].
Medicina.
2000; 60(2):229-32. doi:
NULL. [PMID: 10962814] - J L VanSteenhouse, J S Prescott, S A Barker. Identification of the 1-cyano-3,4-epithiobutane-derived urinary mercapturic acid N-acetyl-S-(4-cyano-2-thio-1-butyl)-cysteine in male Fischer 344 rats.
Journal of applied toxicology : JAT.
2000 Jan; 20(1):1-10. doi:
10.1002/(sici)1099-1263(200001/02)20:1<1::aid-jat599>3.0.co;2-4. [PMID: 10641011] - C Feleder, M Ginzburg, W Wuttke, J A Moguilevsky, P Arias. GABAergic activation inhibits the hypothalamic-pituitary-ovaric axis and sexual development in the immature female rat. Associated changes in hypothalamic glutamatergic and taurinergic systems.
Brain research. Developmental brain research.
1999 Sep; 116(2):151-7. doi:
10.1016/s0165-3806(99)00087-5. [PMID: 10521559] - K Eto, S Suga, M Wakui, Y Tsubamoto, Y Terauchi, J Taka, S Aizawa, M Noda, S Kimura, H Kasai, T Kadowaki. NADH shuttle system regulates K(ATP) channel-dependent pathway and steps distal to cytosolic Ca(2+) concentration elevation in glucose-induced insulin secretion.
The Journal of biological chemistry.
1999 Sep; 274(36):25386-92. doi:
10.1074/jbc.274.36.25386. [PMID: 10464266] - S Gunnarsdottir, A A Elfarra. Glutathione-dependent metabolism of cis-3-(9H-purin-6-ylthio)acrylic acid to yield the chemotherapeutic drug 6-mercaptopurine: evidence for two distinct mechanisms in rats.
The Journal of pharmacology and experimental therapeutics.
1999 Sep; 290(3):950-7. doi:
NULL. [PMID: 10454464] - R Gomez, N Asnis, S L Tannhauser, H M Barros. GABA agonists differentially modify blood glucose levels of diabetic rats.
Japanese journal of pharmacology.
1999 Aug; 80(4):327-31. doi:
10.1254/jjp.80.327. [PMID: 10496333] - J L VanSteenhouse, J S Prescott, D H Swenson. Protection from 1-cyano-3,4-epithiobutane nephrotoxicity by aminooxyacetic acid and effect on xenobiotic-metabolizing enzymes in male Fischer 344 rats.
Journal of applied toxicology : JAT.
1999 Jul; 19(4):237-49. doi:
10.1002/(sici)1099-1263(199907/08)19:4<237::aid-jat569>3.0.co;2-7. [PMID: 10439337]