Amenamevir (BioDeep_00000175957)

   

human metabolite blood metabolite


代谢物信息卡片


2-[N-(2,6-dimethylphenyl)-1-(1,1-dioxo-1lambda6-thian-4-yl)formamido]-N-[4-(1,2,4-oxadiazol-3-yl)phenyl]acetamide

化学式: C24H26N4O5S (482.16238260000006)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C(=CC=C1)C)N(CC(=O)NC2=CC=C(C=C2)C3=NOC=N3)C(=O)C4CCS(=O)(=O)CC4
InChI: InChI=1S/C24H26N4O5S/c1-16-4-3-5-17(2)22(16)28(24(30)19-10-12-34(31,32)13-11-19)14-21(29)26-20-8-6-18(7-9-20)23-25-15-33-27-23/h3-9,15,19H,10-14H2,1-2H3,(H,26,29)

描述信息

J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals
C254 - Anti-Infective Agent > C281 - Antiviral Agent

同义名列表

2 个代谢物同义名

2-[N-(2,6-dimethylphenyl)-1-(1,1-dioxo-1lambda6-thian-4-yl)formamido]-N-[4-(1,2,4-oxadiazol-3-yl)phenyl]acetamide; Amenamevir



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Naoko Shoji, Keiji Tanese, Ayano Sasaki, Taishi Horiuchi, Yuji Utsuno, Koichi Fukuda, Yukiko Hoshino, Shinichi Noda, Hirofumi Minami, Wataru Asakura. Pharmaceuticals and Medical Device Agency approval summary: Amenamevir for the treatment of herpes zoster. The Journal of dermatology. 2020 Jul; 47(7):683-688. doi: 10.1111/1346-8138.15393. [PMID: 32424854]
  • Kota Kato, Martin den Adel, Dorien Groenendaal-van de Meent, Yoshiaki Ohtsu, Akitsugu Takada, Masataka Katashima. An Open-Label, Single-Dose, Human Mass Balance Study of Amenamevir in Healthy Male Adults. Clinical pharmacology in drug development. 2019 07; 8(5):595-602. doi: 10.1002/cpdd.630. [PMID: 30412362]
  • Hiromi Maeda, Hideki Nakamura, Yoshinobu Kikukawa. [Pharmacological profiles and clinical effects of amenamevir tablet as treatments for herpes zoster]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 2019 ; 153(1):35-43. doi: 10.1254/fpj.153.35. [PMID: 30643090]
  • Yoshiaki Ohtsu, Yoko Susaki, Kiyoshi Noguchi. Absorption, Distribution, Metabolism, and Excretion of the Novel Helicase-Primase Inhibitor, Amenamevir (ASP2151), in Rodents. European journal of drug metabolism and pharmacokinetics. 2018 Dec; 43(6):693-706. doi: 10.1007/s13318-018-0481-y. [PMID: 29748821]
  • Jeremy Dennison, Adeep Puri, Steven Warrington, Takamasa Endo, Temitope Adeloye, Atholl Johnston. Amenamevir: Studies of Potential CYP2C8- and CYP2B6-Mediated Pharmacokinetic Interactions With Montelukast and Bupropion in Healthy Volunteers. Clinical pharmacology in drug development. 2018 11; 7(8):860-870. doi: 10.1002/cpdd.578. [PMID: 29870591]
  • Temitope Adeloye, Omair Sahgal, Adeep Puri, Steve Warrington, Takamasa Endo, Jeremy Dennison, Atholl Johnston. Amenamevir: Studies of Potential CYP3A-Mediated Pharmacokinetic Interactions With Midazolam, Cyclosporine, and Ritonavir in Healthy Volunteers. Clinical pharmacology in drug development. 2018 11; 7(8):844-859. doi: 10.1002/cpdd.586. [PMID: 30044899]
  • Tomohiro Kusawake, James J Keirns, Donna Kowalski, Martin den Adel, Dorien Groenendaal-van de Meent, Akitsugu Takada, Yoshiaki Ohtsu, Masataka Katashima. Pharmacokinetics and Safety of Amenamevir in Healthy Subjects: Analysis of Four Randomized Phase 1 Studies. Advances in therapy. 2017 12; 34(12):2625-2637. doi: 10.1007/s12325-017-0642-4. [PMID: 29134426]
  • Tomohiro Kusawake, Martin den Adel, Dorien Groenendaal-van de Meent, Alberto Garcia-Hernandez, Akitsugu Takada, Kota Kato, Yoshiaki Ohtsu, Masataka Katashima. Pharmacokinetic Evaluation of the Interactions of Amenamevir (ASP2151) with Ketoconazole, Rifampicin, Midazolam, and Warfarin in Healthy Adults. Advances in therapy. 2017 11; 34(11):2466-2480. doi: 10.1007/s12325-017-0634-4. [PMID: 29076107]
  • Yoshiaki Ohtsu, Shohei Otsuka, Takeshi Nakamura, Kiyoshi Noguchi. Regulated bioanalysis of conformers - A case study with ASP2151 in dog plasma and urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Aug; 997(?):56-63. doi: 10.1016/j.jchromb.2015.05.028. [PMID: 26093120]
  • Kiyomitsu Katsumata, Koji Chono, Kota Kato, Yoshiaki Ohtsu, Shoji Takakura, Toru Kontani, Hiroshi Suzuki. Pharmacokinetics and pharmacodynamics of ASP2151, a helicase-primase inhibitor, in a murine model of herpes simplex virus infection. Antimicrobial agents and chemotherapy. 2013 Mar; 57(3):1339-46. doi: 10.1128/aac.01803-12. [PMID: 23274658]