5-[4-(4-Cyanobut-1-yn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxo-1lambda~6~,4-thiazinan-4-yl)-4-methyl-1H-pyrazole-3-carboxamide (BioDeep_00000175946)

   

human metabolite blood metabolite


代谢物信息卡片


5-[4-(4-cyanobut-1-yn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-4-methyl-1H-pyrazole-3-carboxamide

化学式: C26H23Cl2N5O3S (555.0898588)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(N(N=C1C(=O)NN1CCS(=O)(=O)CC1)C1=C(Cl)C=C(Cl)C=C1)C1=CC=C(C=C1)C#CCCC#N
InChI: InChI=1S/C26H23Cl2N5O3S/c1-18-24(26(34)31-32-13-15-37(35,36)16-14-32)30-33(23-11-10-21(27)17-22(23)28)25(18)20-8-6-19(7-9-20)5-3-2-4-12-29/h6-11,17H,2,4,13-16H2,1H3,(H,31,34)

描述信息

同义名列表

4 个代谢物同义名

5-[4-(4-cyanobut-1-yn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-4-methyl-1H-pyrazole-3-carboxamide; 5-[4-(4-Cyanobut-1-yn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxo-1lambda~6~,4-thiazinan-4-yl)-4-methyl-1H-pyrazole-3-carboxamide; 5-[4-(4-cyanobut-1-yn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-4-methylpyrazole-3-carboxamide; 5-(4-(4-Cyanobut-1-ynyl)phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Basma G Eid, Thikryat Neamatallah, Lenah S Binmahfouz, Amina M Bagher, Abdulmohsin J Alamoudi, Hibah Mubarak Aldawsari, Abeer Hanafy, Atif Hasan, Hany M El-Bassossy, Ashraf B Abdel-Naim, Kiran Vemuri, Alexandros Makriyannis. Effects of the CB1 receptor antagonists AM6545 and AM4113 on metabolic syndrome-induced prostatic hyperplasia in rats. Biomolecules and biomedicine. 2023 May; ?(?):. doi: 10.17305/bb.2023.9173. [PMID: 37212036]
  • Mark B Wiley, Sarah D Bobardt, Tara M Nordgren, Meera G Nair, Nicholas V DiPatrizio. Cannabinoid Receptor Subtype-1 Regulates Allergic Airway Eosinophilia During Lung Helminth Infection. Cannabis and cannabinoid research. 2021 06; 6(3):242-252. doi: 10.1089/can.2020.0167. [PMID: 33998896]
  • Basma G Eid, Thikryat Neamatallah, Abeer Hanafy, Hany M El-Bassossy, Lenah Binmahfouz, Hibah M Aldawsari, Atif Hasan, Gamal Abd El-Aziz, Kiran Vemuri, Alexandros Makriyannis. Interference with TGFβ1-Mediated Inflammation and Fibrosis Underlies Reno-Protective Effects of the CB1 Receptor Neutral Antagonists AM6545 and AM4113 in a Rat Model of Metabolic Syndrome. Molecules (Basel, Switzerland). 2021 Feb; 26(4):. doi: 10.3390/molecules26040866. [PMID: 33562080]
  • Basma G Eid, Thikryat Neamatallah, Abeer Hanafy, Hany M El-Bassossy, Hibah M Aldawsari, Kiran Vemuri, Alexandros Makriyannis. Effects of the CB1 Receptor Antagonists AM6545 and AM4113 on Insulin Resistance in a High-Fructose High-Salt Rat Model of Metabolic Syndrome. Medicina (Kaunas, Lithuania). 2020 Oct; 56(11):. doi: 10.3390/medicina56110573. [PMID: 33138155]
  • Donovan A Argueta, Nicholas V DiPatrizio. Peripheral endocannabinoid signaling controls hyperphagia in western diet-induced obesity. Physiology & behavior. 2017 03; 171(?):32-39. doi: 10.1016/j.physbeh.2016.12.044. [PMID: 28065722]
  • Nicholas V DiPatrizio, Miki Igarashi, Vidya Narayanaswami, Conor Murray, Joseph Gancayco, Amy Russell, Kwang-Mook Jung, Daniele Piomelli. Fasting stimulates 2-AG biosynthesis in the small intestine: role of cholinergic pathways. American journal of physiology. Regulatory, integrative and comparative physiology. 2015 Oct; 309(8):R805-13. doi: 10.1152/ajpregu.00239.2015. [PMID: 26290104]
  • Nicole P Bowles, Ilia N Karatsoreos, Xiaosong Li, V Kiran Vemuri, Jodi-Anne Wood, Zhiying Li, Kellie L K Tamashiro, Gary J Schwartz, Alexandros M Makriyannis, George Kunos, Cecilia J Hillard, Bruce S McEwen, Matthew N Hill. A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome. Proceedings of the National Academy of Sciences of the United States of America. 2015 Jan; 112(1):285-90. doi: 10.1073/pnas.1421420112. [PMID: 25535367]
  • Joseph Tam, V Kiran Vemuri, Jie Liu, Sándor Bátkai, Bani Mukhopadhyay, Grzegorz Godlewski, Douglas Osei-Hyiaman, Shinobu Ohnuma, Suresh V Ambudkar, James Pickel, Alexandros Makriyannis, George Kunos. Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. The Journal of clinical investigation. 2010 Aug; 120(8):2953-66. doi: 10.1172/jci42551. [PMID: 20664173]