1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide (BioDeep_00000175943)

   

human metabolite blood metabolite


代谢物信息卡片


1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(morpholin-4-yl)-1H-pyrazole-3-carboxamide

化学式: C21H19Cl2IN4O2 (555.9929764)
中文名称: 1-(2,4-二氯苯基)-5-(4-碘苯基)-4-甲基-N-吗啉-1H-吡唑-3-甲酰胺
谱图信息: 最多检出来源 Rattus norvegicus(blood) 70%

分子结构信息

SMILES: CC1=C(N(N=C1C(=O)NN1CCOCC1)C1=C(Cl)C=C(Cl)C=C1)C1=CC=C(I)C=C1
InChI: InChI=1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29)

描述信息

同义名列表

6 个代谢物同义名

1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(morpholin-4-yl)-1H-pyrazole-3-carboxamide; N-(Morpholin-4-yl)-5-(4-iodophenyl)-1-(2,4-dichlorphenyl)-4-methyl-1H-pyrazole-3-carboxamide; 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide; 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(morpholin-4-yl)pyrazole-3-carboxamide; AM281 CPD; AM281



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Marisol Maya-López, Leonardo C Rubio-López, Ivana V Rodríguez-Alvarez, Julián Orduño-Piceno, Yuliza Flores-Valdivia, Aline Colonnello, Edgar Rangel-López, Isaac Túnez, Oscar Prospéro-García, Abel Santamaría. A Cannabinoid Receptor-Mediated Mechanism Participates in the Neuroprotective Effects of Oleamide Against Excitotoxic Damage in Rat Brain Synaptosomes and Cortical Slices. Neurotoxicity research. 2020 Jan; 37(1):126-135. doi: 10.1007/s12640-019-00083-1. [PMID: 31286434]
  • Cintia Folgueira, Silvia Barja-Fernandez, Laura Prado, Omar Al-Massadi, Cecilia Castelao, Veronica Pena-Leon, Patricia Gonzalez-Saenz, Javier Baltar, Ivan Baamonde, Rosaura Leis, Carlos Dieguez, Uberto Pagotto, Felipe F Casanueva, Sulay A Tovar, Ruben Nogueiras, Luisa M Seoane. Pharmacological inhibition of cannabinoid receptor 1 stimulates gastric release of nesfatin-1 via the mTOR pathway. World journal of gastroenterology. 2017 Sep; 23(35):6403-6411. doi: 10.3748/wjg.v23.i35.6403. [PMID: 29085189]
  • Filippo Molica, Fabienne Burger, Aurélien Thomas, Christian Staub, Anne Tailleux, Bart Staels, Graziano Pelli, Andreas Zimmer, Benjamin Cravatt, Christian M Matter, Pal Pacher, Sabine Steffens. Endogenous cannabinoid receptor CB1 activation promotes vascular smooth-muscle cell proliferation and neointima formation. Journal of lipid research. 2013 May; 54(5):1360-8. doi: 10.1194/jlr.m035147. [PMID: 23479425]
  • Rachel Ribeiro, Jie Wen, Shihe Li, Yumin Zhang. Involvement of ERK1/2, cPLA2 and NF-κB in microglia suppression by cannabinoid receptor agonists and antagonists. Prostaglandins & other lipid mediators. 2013 Jan; 100-101(?):1-14. doi: 10.1016/j.prostaglandins.2012.11.003. [PMID: 23219970]
  • C Dean. Endocannabinoid modulation of sympathetic and cardiovascular responses to acute stress in the periaqueductal gray of the rat. American journal of physiology. Regulatory, integrative and comparative physiology. 2011 Mar; 300(3):R771-9. doi: 10.1152/ajpregu.00391.2010. [PMID: 21228344]
  • Partha Mukhopadhyay, Hao Pan, Mohanraj Rajesh, Sándor Bátkai, Vivek Patel, Judith Harvey-White, Bani Mukhopadhyay, György Haskó, Bin Gao, Ken Mackie, Pál Pacher. CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model. British journal of pharmacology. 2010 Jun; 160(3):657-68. doi: 10.1111/j.1476-5381.2010.00769.x. [PMID: 20590569]
  • Julie A Przybyla, Val J Watts. Ligand-induced regulation and localization of cannabinoid CB1 and dopamine D2L receptor heterodimers. The Journal of pharmacology and experimental therapeutics. 2010 Mar; 332(3):710-9. doi: 10.1124/jpet.109.162701. [PMID: 20016021]
  • Thomas Koch, Dai-Fei Wu, Li-Quan Yang, Lars-Ove Brandenburg, Volker Höllt. Role of phospholipase D2 in the agonist-induced and constitutive endocytosis of G-protein coupled receptors. Journal of neurochemistry. 2006 Apr; 97(2):365-72. doi: 10.1111/j.1471-4159.2006.03736.x. [PMID: 16539674]
  • Christophe Leterrier, Jeanne Lainé, Michèle Darmon, Hélène Boudin, Jean Rossier, Zsolt Lenkei. Constitutive activation drives compartment-selective endocytosis and axonal targeting of type 1 cannabinoid receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 Mar; 26(12):3141-53. doi: 10.1523/jneurosci.5437-05.2006. [PMID: 16554465]
  • C Yang, W Hader, X Zhang. Therapeutic action of cannabinoid on axonal injury induced by peroxynitrite. Brain research. 2006 Mar; 1076(1):238-42. doi: 10.1016/j.brainres.2005.12.101. [PMID: 16473327]
  • Yuko Fukudome, Takako Ohno-Shosaku, Minoru Matsui, Yuko Omori, Masahiro Fukaya, Hiroshi Tsubokawa, Makoto M Taketo, Masahiko Watanabe, Toshiya Manabe, Masanobu Kano. Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling. The European journal of neuroscience. 2004 May; 19(10):2682-92. doi: 10.1111/j.0953-816x.2004.03384.x. [PMID: 15147302]
  • S S Cui, R C Bowen, G B Gu, D K Hannesson, P H Yu, X Zhang. Prevention of cannabinoid withdrawal syndrome by lithium: involvement of oxytocinergic neuronal activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 Dec; 21(24):9867-76. doi: 10.1523/jneurosci.21-24-09867.2001. [PMID: 11739594]
  • K J Chou, L L Tseng, J S Cheng, J L Wang, H C Fang, K C Lee, W Su, Y P Law, C R Jan. CP55,940 increases intracellular Ca2+ levels in Madin-Darby canine kidney cells. Life sciences. 2001 Aug; 69(13):1541-8. doi: 10.1016/s0024-3205(01)01242-5. [PMID: 11554615]