Isoangustone A (BioDeep_00000017588)

 

Secondary id: BioDeep_00000270343

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


4H-1-Benzopyran-4-one, 3-(3,4-dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl)-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-

化学式: C25H26O6 (422.1729)
中文名称:
谱图信息: 最多检出来源 Escherichia coli(natural_products) 13.27%

分子结构信息

SMILES: c1(c(c(c2c(c1)occ(c2=O)c1cc(c(c(c1)CC=C(C)C)O)O)O)CC=C(C)C)O
InChI: InChI=1S/C25H26O6/c1-13(2)5-7-15-9-16(10-20(27)23(15)28)18-12-31-21-11-19(26)17(8-6-14(3)4)24(29)22(21)25(18)30/h5-6,9-12,26-29H,7-8H2,1-4H3

描述信息

Isoangustone A is a member of isoflavanones.
Isoangustone A is a natural product found in Glycyrrhiza glabra, Glycyrrhiza uralensis, and Glycyrrhiza inflata with data available.
Isoangustone A is found in herbs and spices. Isoangustone A is isolated from the roots of Glycyrrhiza uralensis (Chinese licorice).
Isolated from the roots of Glycyrrhiza uralensis (Chinese licorice). Isoangustone A is found in herbs and spices.

同义名列表

12 个代谢物同义名

4H-1-Benzopyran-4-one, 3-(3,4-dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl)-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-; 3-(3,4-Dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl)-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one; 3-[3,4-Dihydroxy-5-(3-methyl-2-butenyl)phenyl]-5,7-dihydroxy-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one, 9CI; 4H-1-Benzopyran-4-one, 3-(3,4-dihydroxy-5-(3-methyl-2-butenyl)phenyl)-5,7-dihydroxy-6-(3-methyl-2-butenyl)-; 3-[3,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl]-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one; 3-[3,4-dihydroxy-5-(3-methylbut-2-enyl)phenyl]-5,7-dihydroxy-6-(3-methylbut-2-enyl)chromen-4-one; 5,7,3,4-Tetrahydroxy-6,5-diprenylisoflavone; Flavone base + 4O, 2Prenyl; UNII-58NM254N9T; Isoangustone A; IsoangustoneA; 58NM254N9T



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Jing-Ran Fan, Yi Kuang, Ze-Yuan Dong, Yang Yi, Yan-Xia Zhou, Bin Li, Xue Qiao, Min Ye. Prenylated Phenolic Compounds from the Aerial Parts of Glycyrrhiza uralensis as PTP1B and α-Glucosidase Inhibitors. Journal of natural products. 2020 04; 83(4):814-824. doi: 10.1021/acs.jnatprod.9b00262. [PMID: 32196343]
  • Yi Kuang, Bin Li, Jingran Fan, Xue Qiao, Min Ye. Antitussive and expectorant activities of licorice and its major compounds. Bioorganic & medicinal chemistry. 2018 01; 26(1):278-284. doi: 10.1016/j.bmc.2017.11.046. [PMID: 29224994]
  • Shuai Ji, Ziwei Li, Wei Song, Yongrui Wang, Wenfei Liang, Kai Li, Shunan Tang, Qi Wang, Xue Qiao, Demin Zhou, Siwang Yu, Min Ye. Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine. Journal of natural products. 2016 Feb; 79(2):281-92. doi: 10.1021/acs.jnatprod.5b00877. [PMID: 26841168]
  • Wei Huang, Shunan Tang, Xue Qiao, Wanwan Ma, Shuai Ji, Kui Wang, Min Ye, Siwang Yu. Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupting mitochondrial functions. Fitoterapia. 2014 Apr; 94(?):36-47. doi: 10.1016/j.fitote.2014.01.016. [PMID: 24486984]
  • Mi Ra Seon, So Young Park, Soo Jin Kwon, Soon Sung Lim, Hyun Ju Choi, Heesook Park, Do Young Lim, Jong-Sang Kim, Choong Hwan Lee, Jongdai Kim, Jung Han Yoon Park. Hexane/ethanol extract of Glycyrrhiza uralensis and its active compound isoangustone A induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells. The Journal of nutritional biochemistry. 2012 Jan; 23(1):85-92. doi: 10.1016/j.jnutbio.2010.11.010. [PMID: 21429724]
  • Mi Ra Seon, Soon Sung Lim, Hyun Ju Choi, So Young Park, Han Jin Cho, Jin-Kyu Kim, Jongdai Kim, Dae Young Kwon, Jung Han Yoon Park. Isoangustone A present in hexane/ethanol extract of Glycyrrhiza uralensis induces apoptosis in DU145 human prostate cancer cells via the activation of DR4 and intrinsic apoptosis pathway. Molecular nutrition & food research. 2010 Sep; 54(9):1329-39. doi: 10.1002/mnfr.200900260. [PMID: 20229524]