Glabrene (BioDeep_00000017587)

   

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


8-(7-hydroxy-2H-1-benzopyran-3-yl)-2,2-dimethyl-1-benzopyran-5-ol

化学式: C20H18O4 (322.1205028)
中文名称: 光甘草素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(C)C=Cc2c(ccc(C3=Cc4ccc(O)cc4OC3)c2O)O1
InChI: InChI=1S/C20H18O4/c1-20(2)8-7-16-17(22)6-5-15(19(16)24-20)13-9-12-3-4-14(21)10-18(12)23-11-13/h3-10,21-22H,11H2,1-2H3

描述信息

Glabrene is an isoflavonoid.
Glabrene is a natural product found in Glycyrrhiza glabra and Glycyrrhiza uralensis with data available.
See also: Glycyrrhiza Glabra (part of).
Glabrene is found in herbs and spices. Glabrene is a constituent of root of Glycyrrhiza glabra (licorice)

同义名列表

13 个代谢物同义名

8-(7-hydroxy-2H-1-benzopyran-3-yl)-2,2-dimethyl-1-benzopyran-5-ol; 8-(7-hydroxy-2H-chromen-3-yl)-2,2-dimethyl-2H-chromen-5-ol; 2,2-dimethyl-8-(7-oxidanyl-2H-chromen-3-yl)chromen-5-ol; 8-(7-hydroxy-2H-chromen-3-yl)-2,2-dimethyl-chromen-5-ol; 8-(7-hydroxy-2H-chromen-3-yl)-2,2-dimethylchromen-5-ol; 2,2-Dimethyl-2H,2H-[3,8]bi[1-benzopyranyl]-7,5-diol; 2,2-Dimethyl-2H,2H-(3,8)bi(1-benzopyranyl)-7,5-diol; 2,2-Dimethyl[3,8-bi-2H-1-benzopyran]-5,7-diol, 9CI; (3,8-BI-2H-1-BENZOPYRAN)-5,7-DIOL, 2,2-DIMETHYL-; 2,2-Dimethyl-2H,2H-3,8-bichromene-5,7-diol; UNII-C6Y321Q75O; C6Y321Q75O; Glabrene



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

30 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jun Liu, Xinchang Deng, Xiao Liang, Longying Li. The phytoestrogen glabrene prevents osteoporosis in ovariectomized rats through upregulation of the canonical Wnt/β-catenin signaling pathway. Journal of biochemical and molecular toxicology. 2021 Feb; 35(2):e22653. doi: 10.1002/jbt.22653. [PMID: 33113278]
  • Kai Li, Shuai Ji, Wei Song, Yi Kuang, Yan Lin, Shunan Tang, Zexu Cui, Xue Qiao, Siwang Yu, Min Ye. Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra. Journal of natural products. 2017 02; 80(2):334-346. doi: 10.1021/acs.jnatprod.6b00783. [PMID: 28140583]
  • Rudy Simons, Jean-Paul Vincken, Loes A M Mol, Susan A M The, Toine F H Bovee, Teus J C Luijendijk, Marian A Verbruggen, Harry Gruppen. Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra). Analytical and bioanalytical chemistry. 2011 Jul; 401(1):305-13. doi: 10.1007/s00216-011-5061-9. [PMID: 21573846]
  • Dalia Somjen, Sara Katzburg, Jacob Vaya, Alvin M Kaye, David Hendel, Gary H Posner, Snait Tamir. Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues. The Journal of steroid biochemistry and molecular biology. 2004 Aug; 91(4-5):241-6. doi: 10.1016/j.jsbmb.2004.04.008. [PMID: 15336701]
  • Dalia Somjen, Esther Knoll, Jacob Vaya, Naftali Stern, Snait Tamir. Estrogen-like activity of licorice root constituents: glabridin and glabrene, in vascular tissues in vitro and in vivo. The Journal of steroid biochemistry and molecular biology. 2004 Jul; 91(3):147-55. doi: 10.1016/j.jsbmb.2004.04.003. [PMID: 15276622]
  • Rivka Ofir, Snait Tamir, Soliman Khatib, Jacob Vaya. Inhibition of serotonin re-uptake by licorice constituents. Journal of molecular neuroscience : MN. 2003 Apr; 20(2):135-40. doi: 10.1385/jmn:20:2:135. [PMID: 12794307]
  • Ohad Nerya, Jacob Vaya, Ramadan Musa, Sarit Izrael, Ruth Ben-Arie, Snait Tamir. Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots. Journal of agricultural and food chemistry. 2003 Feb; 51(5):1201-7. doi: 10.1021/jf020935u. [PMID: 12590456]
  • S Tamir, M Eizenberg, D Somjen, S Izrael, J Vaya. Estrogen-like activity of glabrene and other constituents isolated from licorice root. The Journal of steroid biochemistry and molecular biology. 2001 Sep; 78(3):291-8. doi: 10.1016/s0960-0760(01)00093-0. [PMID: 11595510]