Allisartan isoproxil (BioDeep_00000175868)

   

human metabolite blood metabolite


代谢物信息卡片


{[(propan-2-yloxy)carbonyl]oxy}methyl 2-butyl-4-chloro-1-{[2-(2H-1,2,3,4-tetrazol-5-yl)-[1,1-biphenyl]-4-yl]methyl}-1H-imidazole-5-carboxylate

化学式: C27H29ClN6O5 (552.1888)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 87.5%

分子结构信息

SMILES: CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)OCOC(=O)OC(C)C)Cl
InChI: InChI=1S/C27H29ClN6O5/c1-4-5-10-22-29-24(28)23(26(35)37-16-38-27(36)39-17(2)3)34(22)15-18-11-13-19(14-12-18)20-8-6-7-9-21(20)25-30-32-33-31-25/h6-9,11-14,17H,4-5,10,15-16H2,1-3H3,(H,30,31,32,33)

描述信息

Allisartan isoproxil (ALS-3) is an orally potent, selective, non-peptide inhibitor of Angiotensin II Type 1. Allisartan isoproxil is also an antihypertensive agent. Allisartan isoproxil may inhibit angiotensin-aldosterone system and oxidative stress. Allisartan isoproxil lowers blood pressure and protects the organs, preventing cerebrovascular damage. Allisartan isoproxil (80-320 mg/kg/d) has shown toxicity in rat models by targeting liver organs[1][2].

同义名列表

4 个代谢物同义名

{[(propan-2-yloxy)carbonyl]oxy}methyl 2-butyl-4-chloro-1-{[2-(2H-1,2,3,4-tetrazol-5-yl)-[1,1-biphenyl]-4-yl]methyl}-1H-imidazole-5-carboxylate; [(isopropoxycarbonyl)oxy]methyl 2-butyl-5-chloro-3-{[2-(2H-1,2,3,4-tetrazol-5-yl)-[1,1-biphenyl]-4-yl]methyl}imidazole-4-carboxylate; Allisartan isoproxil; ALS-3 compound



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表


文献列表

  • Wu Yi, Peiyuan Yan, Sisi Lin, Rui Hao, Yannan Wang, Jin Yu, Lu Fang, Jingjing Zhu, Di Zhao, Shengjia Tong, Yongkai Si, Tiantian Ye, Zeyu Wu, Zhiquan Qin, Hua Huang, Chongyang Deng, Jingchao Sun, Ying Wang. Pharmacokinetics and Safety of a Single Dose and Multiple Doses of Allisartan Isoproxil, an Angiotensin II Receptor Blocker, in Healthy Chinese People. Clinical pharmacology in drug development. 2022 01; 11(1):43-50. doi: 10.1002/cpdd.995. [PMID: 34240572]
  • Qi-Sheng Ling, Sai-Long Zhang, Jia-Sheng Tian, Ming-He Cheng, Ai-Jun Liu, Feng-Hua Fu, Jian-Guo Liu, Chao-Yu Miao. Allisartan isoproxil reduces mortality of stroke-prone rats and protects against cerebrovascular, cardiac, and aortic damage. Acta pharmacologica Sinica. 2021 Jun; 42(6):871-884. doi: 10.1038/s41401-021-00684-7. [PMID: 34002042]
  • Qinyang Jin, Qin Zhu, Kai Wang, Mengli Chen, Xinli Li. Allisartan isoproxil attenuates oxidative stress and inflammation through the SIRT1/Nrf2/NF‑κB signalling pathway in diabetic cardiomyopathy rats. Molecular medicine reports. 2021 03; 23(3):. doi: 10.3892/mmr.2021.11854. [PMID: 33495841]
  • Xiuli Li, Jingchao Sun, Zitao Guo, Dafang Zhong, Xiaoyan Chen. Carboxylesterase 2 and Intestine Transporters Contribute to the Low Bioavailability of Allisartan, a Prodrug of Exp3174 for Hypertension Treatment in Humans. Drug metabolism and disposition: the biological fate of chemicals. 2019 08; 47(8):843-853. doi: 10.1124/dmd.118.085092. [PMID: 31076412]
  • Jian-Qi Zhang, Guo-Hong Yang, Xin Zhou, Jun-Xiang Liu, Rui Shi, Yan Dong, Shao-Bo Chen, Yu-Ming Li. Effects of allisartan isoproxil on blood pressure and target organ injury in patients with mild to moderate essential hypertension. Medicine. 2019 Mar; 98(12):e14907. doi: 10.1097/md.0000000000014907. [PMID: 30896643]
  • Yongzhen Liu, Hao Wang, Yumei Cheng, Jingjun Sun, Junwen Qiao, Henglei Lu, Liang Zhu, Likun Gong, Jin Ren. A 26-week repeated-dose toxicity study of allisartan isoproxil in Sprague-Dawley rats. Drug and chemical toxicology. 2013 Oct; 36(4):443-50. doi: 10.3109/01480545.2013.776580. [PMID: 23534454]