Alexidine (BioDeep_00000175848)

   

human metabolite blood metabolite


代谢物信息卡片


1-{N-[6-(N-{amino[N-(2-ethylhexyl)carbamimidamido]methylidene}amino)hexyl]carbamimidamido}-N-(2-ethylhexyl)methanimidamide

化学式: C26H56N10 (508.46891760000005)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 87.5%

分子结构信息

SMILES: CCCCC(CC)CN=C(N)NC(=NCCCCCCN=C(N)NC(=NCC(CC)CCCC)N)N
InChI: InChI=1S/C26H56N10/c1-5-9-15-21(7-3)19-33-25(29)35-23(27)31-17-13-11-12-14-18-32-24(28)36-26(30)34-20-22(8-4)16-10-6-2/h21-22H,5-20H2,1-4H3,(H5,27,29,31,33,35)(H5,28,30,32,34,36)

描述信息

C254 - Anti-Infective Agent > C28394 - Topical Anti-Infective Agent
D007004 - Hypoglycemic Agents > D001645 - Biguanides

同义名列表

11 个代谢物同义名

1-{N-[6-(N-{amino[N-(2-ethylhexyl)carbamimidamido]methylidene}amino)hexyl]carbamimidamido}-N-(2-ethylhexyl)methanimidamide; N,N-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide; 1,1-Hexamethylenebis(5-(2-ethylhexyl)biguanide); Alexidine dihydrofluoride; Alexidine dihydrchloride; Alexidine diacetate; Alexidinum; Bisguadine; alexidine; Rotersept; Alexidina



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ryan Houston, Yusuke Sekine, Mads B Larsen, Kei Murakami, Steven J Mullett, Stacy G Wendell, Derek P Narendra, Bill B Chen, Shiori Sekine. Discovery of bactericides as an acute mitochondrial membrane damage inducer. Molecular biology of the cell. 2021 11; 32(21):ar32. doi: 10.1091/mbc.e21-04-0191. [PMID: 34495738]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Emily K Pugach, McKenna Feltes, Randal J Kaufman, Daniel S Ory, Anne G Bang. High-content screen for modifiers of Niemann-Pick type C disease in patient cells. Human molecular genetics. 2018 06; 27(12):2101-2112. doi: 10.1093/hmg/ddy117. [PMID: 29659804]
  • Chensu Wang, Hanspeter Niederstrasser, Peter M Douglas, Rueyling Lin, Juan Jaramillo, Yang Li, Nathaniel W Oswald, Anwu Zhou, Elizabeth A McMillan, Saurabh Mendiratta, Zhaohui Wang, Tian Zhao, Zhiqaing Lin, Min Luo, Gang Huang, Rolf A Brekken, Bruce A Posner, John B MacMillan, Jinming Gao, Michael A White. Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan. Nature communications. 2017 12; 8(1):2270. doi: 10.1038/s41467-017-02332-3. [PMID: 29273768]
  • Satya Sree N Kolar, Joseph C Manarang, Alan R Burns, William L Miller, Alison M McDermott, Jan P G Bergmanson. Contact lens care solution killing efficacy against Acanthamoeba castellanii by in vitro testing and live-imaging. Contact lens & anterior eye : the journal of the British Contact Lens Association. 2015 Dec; 38(6):442-50. doi: 10.1016/j.clae.2015.06.006. [PMID: 26208952]
  • J A Chawner, P Gilbert. Interaction of the bisbiguanides chlorhexidine and alexidine with phospholipid vesicles: evidence for separate modes of action. The Journal of applied bacteriology. 1989 Mar; 66(3):253-8. doi: 10.1111/j.1365-2672.1989.tb02476.x. [PMID: 2663802]
  • T E Balanyk, H J Sandham. Development of sustained-release antimicrobial dental varnishes effective against Streptococcus mutans in vitro. Journal of dental research. 1985 Dec; 64(12):1356-60. doi: 10.1177/00220345850640120501. [PMID: 3865945]
  • T F Tsao, M G Newman, Y Y Kwok, A K Horikoshi. Effect of Chinese and western antimicrobial agents on selected oral bacteria. Journal of dental research. 1982 Sep; 61(9):1103-6. doi: 10.1177/00220345820610091501. [PMID: 6963285]
  • W R Roberts, M Addy. Comparison of the in vivo and in vitro antibacterial properties of antiseptic mouthrinses containing chlorhexidine, alexidine, cetyl pyridinium chloride and hexetidine. Relevance to mode of action. Journal of clinical periodontology. 1981 Aug; 8(4):295-310. doi: 10.1111/j.1600-051x.1981.tb02040.x. [PMID: 6947993]
  • H C Carlson, K Porter, T H Alms. The effect of an alexidine mouthwash on dental plaque and gingivitis. Journal of periodontology. 1977 Apr; 48(4):216-8. doi: 10.1902/jop.1977.48.4.216. [PMID: 265389]