Albifylline (BioDeep_00000175836)

   

human metabolite blood metabolite


代谢物信息卡片


1-(5-hydroxy-5-methylhexyl)-3-methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione

化学式: C13H20N4O3 (280.15353300000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)(CCCCN1C(=O)C2=C(N=CN2)N(C1=O)C)O
InChI: InChI=1S/C13H20N4O3/c1-13(2,20)6-4-5-7-17-11(18)9-10(15-8-14-9)16(3)12(17)19/h8,20H,4-7H2,1-3H3,(H,14,15)

描述信息

D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents

同义名列表

6 个代谢物同义名

1-(5-hydroxy-5-methylhexyl)-3-methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione; 1-(5-hydroxy-5-methylhexyl)-3-methyl-7H-purine-2,6-dione; 1-(5-Hydroxy-5-methylhexyl)-3-methylxanthine; Albifylline; HWA-138; HWA 138



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • P H Jakobsen, C Koch, K Bendtzen. Inhibition of LPS and Plasmodium falciparum induced cytokine secretion by pentoxifylline and two analogues. Scandinavian journal of immunology. 1997 May; 45(5):546-50. doi: 10.1046/j.1365-3083.1997.d01-425.x. [PMID: 9160101]
  • S Bahrami, Y M Yao, H Shiga, G Leichtfried, H Redl, G Schlag. Comparison of the efficacy of pentoxifylline and albifyllin (HWA 138) on endotoxin-induced cytokine production, coagulation disturbances, and mortality. Shock (Augusta, Ga.). 1996 Jun; 5(6):424-8. doi: 10.1097/00024382-199606000-00006. [PMID: 8799954]
  • A Bengtsson, H Redl, G Schlag, T E Mollnes, K Högåsen. Effects on complement activation and cytokine (TNF-alpha and IL-8) release of infusion of anti-TNF-antibodies or a xanthine derivative (HWA 138) in septic baboons. Acta anaesthesiologica Scandinavica. 1996 Feb; 40(2):244-9. doi: 10.1111/j.1399-6576.1996.tb04427.x. [PMID: 8848926]
  • S Bahrami, Y H Yu, H Redl, G Schlag. Acute lung injury by endotoxin-induced mediators: prevention by HWA 138, a new xanthine derivative. The Journal of laboratory and clinical medicine. 1995 Apr; 125(4):487-92. doi: NULL. [PMID: 7706904]
  • A Bunk, F Dapper, H Hata, H Neuhof, F W Hehrlein. Experimental studies of the influence of priming solutions on the systemic activation of complement during cardiopulmonary bypass: comparison between the use of albumin, hydroxyethyl starch and HWA-138. The Journal of cardiovascular surgery. 1993 Apr; 34(2):115-22. doi: NULL. [PMID: 7686550]
  • P Masouyé, K Gunning, J F Pittet, P M Suter, D R Morel. Xanthine derivative HWA 138 attenuates hemodynamic and oxygen uptake dysfunction secondary to severe endotoxin shock in sheep. Circulatory shock. 1992 Feb; 36(2):113-9. doi: NULL. [PMID: 1582002]
  • K L Berens, J D Langston, K M Wasan, D R Luke. Influence of pentoxifylline and related analogues in endotoxemic renal failure. Circulatory shock. 1991 Jul; 34(3):344-8. doi: NULL. [PMID: 1884436]
  • P M Wong, G W Schmid-Schönbein. Attenuation of spontaneous pseudopod formation in human neutrophils by pentoxifylline. Cell biophysics. 1991 Jun; 18(3):203-15. doi: 10.1007/bf02989814. [PMID: 1726532]
  • D R Luke, K L Berens, R R Verani. Benefit of vascular decongestion in glycerol-induced acute renal failure. Renal failure. 1991; 13(2-3):61-9. doi: 10.3109/08860229109022149. [PMID: 1957044]
  • D R Luke, K M Wasan, T J McQueen, G Lopez-Berestein. Enhancement of the treatment of experimental candidiasis with vascular decongestants. The Journal of infectious diseases. 1990 Jul; 162(1):211-4. doi: 10.1093/infdis/162.1.211. [PMID: 2355196]
  • J R Hatherill, M Yonemaru, H Zheng, H Hoffmann, S Fujishima, A Ishizaka, T A Raffin. Attenuation of acute lung injury in septic guinea-pigs by a new xanthine derivative (HWA-138). Pharmatherapeutica. 1989; 5(6):407-15. doi: . [PMID: 2687896]