Alamethicin from Trichoderma viride (BioDeep_00000175818)
human metabolite blood metabolite
代谢物信息卡片
4-({3-carbamoyl-1-[(1-hydroxy-3-phenylpropan-2-yl)carbamoyl]propyl}carbamoyl)-4-(2-{2-[2-({1-[2-(2-{2-[2-(2-{2-[4-carbamoyl-2-(2-{2-[2-(2-{[1-(2-acetamido-2-methylpropanoyl)pyrrolidin-2-yl]formamido}-2-methylpropanamido)propanamido]-2-methylpropanamido}propanamido)butanamido]-2-methylpropanamido}-3-methylbutanamido)-2-methylpropanamido]acetamido}-4-methylpentanamido)-2-methylpropanoyl]pyrrolidin-2-yl}formamido)-3-methylbutanamido]-2-methylpropanamido}-2-methylpropanamido)butanoic acid
化学式: C92H150N22O25 (1963.1141930000001)
中文名称: 丙甲菌素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC(C(=O)NC(C)(C)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CC2=CC=CC=C2)CO)NC(=O)CNC(=O)C(C)(C)NC(=O)C(C(C)C)NC(=O)C(C)(C)NC(=O)C(CCC(=O)N)NC(=O)C(C)NC(=O)C(C)(C)NC(=O)C(C)NC(=O)C(C)(C)NC(=O)C3CCCN3C(=O)C(C)(C)NC(=O)C
InChI: InChI=1S/C92H150N22O25/c1-47(2)43-58(72(127)108-92(24,25)84(139)113-41-29-33-59(113)73(128)103-65(48(3)4)75(130)111-90(20,21)82(137)112-89(18,19)80(135)102-56(37-40-64(120)121)70(125)101-55(35-38-61(93)117)69(124)98-54(46-115)44-53-31-27-26-28-32-53)99-63(119)45-95-77(132)85(10,11)110-76(131)66(49(5)6)104-81(136)88(16,17)107-71(126)57(36-39-62(94)118)100-67(122)50(7)96-78(133)86(12,13)106-68(123)51(8)97-79(134)87(14,15)109-74(129)60-34-30-42-114(60)83(138)91(22,23)105-52(9)116/h26-28,31-32,47-51,54-60,65-66,115H,29-30,33-46H2,1-25H3,(H2,93,117)(H2,94,118)(H,95,132)(H,96,133)(H,97,134)(H,98,124)(H,99,119)(H,100,122)(H,101,125)(H,102,135)(H,103,128)(H,104,136)(H,105,116)(H,106,123)(H,107,126)(H,108,127)(H,109,129)(H,110,131)(H,111,130)(H,112,137)(H,120,121)
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D004791 - Enzyme Inhibitors > D014475 - Uncoupling Agents
D049990 - Membrane Transport Modulators
D007476 - Ionophores
Alamethicin, isolated from Trichoderma viride, is a channel-forming peptide antibiotic and induces voltage-gated conductance in model and cell membranes[1][2].
同义名列表
3 个代谢物同义名
4-({3-carbamoyl-1-[(1-hydroxy-3-phenylpropan-2-yl)carbamoyl]propyl}carbamoyl)-4-(2-{2-[2-({1-[2-(2-{2-[2-(2-{2-[4-carbamoyl-2-(2-{2-[2-(2-{[1-(2-acetamido-2-methylpropanoyl)pyrrolidin-2-yl]formamido}-2-methylpropanamido)propanamido]-2-methylpropanamido}propanamido)butanamido]-2-methylpropanamido}-3-methylbutanamido)-2-methylpropanamido]acetamido}-4-methylpentanamido)-2-methylpropanoyl]pyrrolidin-2-yl}formamido)-3-methylbutanamido]-2-methylpropanamido}-2-methylpropanamido)butanoic acid; Alamethicin from Trichoderma viride; alamethicin
数据库引用编号
7 个数据库交叉引用编号
- PubChem: 16132684
- HMDB: HMDB0248098
- MeSH: Alamethicin
- KNApSAcK: C00015052
- chemspider: 17289333
- CAS: 27061-78-5
- medchemexpress: HY-N6708
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Vladimir I Novoderezhkin, Tatyana I Rokitskaya, Elena A Kotova, Yuri N Antonenko. Synchronization of opening and closing of two gramicidin A channels pulled together by a linker: possible relevance to channel clustering.
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10.1039/d2cp04884a. [PMID: 36644888] - Masato Kondoh, Arisa Sano, Izuru Kawamura, Taka-Aki Ishibashi. Total Internal Reflection Raman Spectra of Alamethicin Interacting with Supported Lipid Bilayers at a Silica/Water Interface.
The journal of physical chemistry. B.
2022 12; 126(50):10712-10720. doi:
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2022 10; 1864(10):183997. doi:
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10.1016/j.bbamem.2022.184001. [PMID: 35817122] - ZhangFei Su, J Jay Leitch, Jacek Lipkowski. Effect of Lipid Composition on the Inhibition Mechanism of Amiloride on Alamethicin Ion Channels in Supported Phospholipid Bilayers.
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10.1021/acs.langmuir.2c00953. [PMID: 35749587] - Allan G Rasmusson, Ian Max Møller, Susanne Widell. Assessment of Respiratory Enzymes in Intact Cells by Permeabilization with Alamethicin.
Methods in molecular biology (Clifton, N.J.).
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Nature communications.
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Current microbiology.
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Biophysical journal.
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Biochemistry.
2012 Dec; 51(51):10124-6. doi:
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The journal of physical chemistry. B.
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IEEE transactions on nanobioscience.
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2012 Apr; 134(14):6237-43. doi:
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Physical chemistry chemical physics : PCCP.
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BMC plant biology.
2010 Dec; 10(?):274. doi:
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Plant signaling & behavior.
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Journal of the American Chemical Society.
2010 May; 132(20):7086-93. doi:
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Nanotechnology.
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Analytical chemistry.
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Proceedings of the National Academy of Sciences of the United States of America.
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Journal of bioenergetics and biomembranes.
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