N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine (BioDeep_00000175781)

   

human metabolite blood metabolite


代谢物信息卡片


N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine

化学式: C16H14ClN3O2 (315.0774494)
中文名称: 酪氨酸激酶抑制剂AG 1478, 酪氨酸磷酸化抑制剂AG1478
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC
InChI: InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)

描述信息

C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor
D000970 - Antineoplastic Agents > D020032 - Tyrphostins
D004791 - Enzyme Inhibitors

同义名列表

10 个代谢物同义名

N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine; 4-(3-Chloroanilino)-6,7-dimethoxyquinazoline; Tyrphostin ag 1478 monohydrochloride; Tyrphostin ag 1478-mesylate; Tyrphostin ag-1478; Tyrphostin AG 1478; Tyrphostin-ag1478; RTKI CPD; AG-1478; AG 1478



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Yandong Yi, Yuejin Zhang, Yuanlong Song, Yisheng Lu. Treadmill Running Regulates Adult Neurogenesis, Spatial and Non-spatial Learning, Parvalbumin Neuron Activity by ErbB4 Signaling. Cellular and molecular neurobiology. 2024 Jan; 44(1):17. doi: 10.1007/s10571-023-01439-0. [PMID: 38285192]
  • Kangchen Li, Xiaofeng Mei, Kexin Xu, Lidan Jia, Peng Zhao, Yange Tian, Jiansheng Li. Comparative study of cigarette smoke, Klebsiella pneumoniae, and their combination on airway epithelial barrier function in mice. Environmental toxicology. 2023 May; 38(5):1133-1142. doi: 10.1002/tox.23753. [PMID: 36757011]
  • Danielle Kamato, Mai Gabr, Hirushi Kumarapperuma, Zheng J Chia, Wenhua Zheng, Suowen Xu, Narin Osman, Peter J Little. Gαq Is the Specific Mediator of PAR-1 Transactivation of Kinase Receptors in Vascular Smooth Muscle Cells. International journal of molecular sciences. 2022 Nov; 23(22):. doi: 10.3390/ijms232214425. [PMID: 36430902]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Rie Marunaka, Akiyuki Taruno, Toshiro Yamamoto, Narisato Kanamura, Yoshinori Marunaka. Action of Protein Tyrosine Kinase Inhibitors on the Hypotonicity-Stimulated Trafficking Kinetics of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells: Analysis Using a Mathematical Model. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 50(1):363-377. doi: 10.1159/000494012. [PMID: 30308504]
  • Dandan Liang, Hongjin Chen, Leping Zhao, Wenxin Zhang, Jie Hu, Zhiguo Liu, Peng Zhong, Wei Wang, Jingying Wang, Guang Liang. Inhibition of EGFR attenuates fibrosis and stellate cell activation in diet-induced model of nonalcoholic fatty liver disease. Biochimica et biophysica acta. Molecular basis of disease. 2018 Jan; 1864(1):133-142. doi: 10.1016/j.bbadis.2017.10.016. [PMID: 29038049]
  • Xiaona Zhang, Longmei Cai, Jingcai He, Xiaoyan Li, Libo Li, Xiaohua Chen, Ping Lan. Influence and mechanism of 5-aminolevulinic acid-photodynamic therapy on the metastasis of esophageal carcinoma. Photodiagnosis and photodynamic therapy. 2017 Dec; 20(?):78-85. doi: 10.1016/j.pdpdt.2017.08.004. [PMID: 28811223]
  • Wanida Cholpraipimolrat, Tawit Suriyo, Nuchanart Rangkadilok, Sumontha Nookabkaew, Jutamaad Satayavivad. Hijiki and sodium arsenite stimulate growth of human colorectal adenocarcinoma cells through ERK1/2 activation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 Dec; 110(?):33-41. doi: 10.1016/j.fct.2017.09.052. [PMID: 28974440]
  • Zheng Xu, Yunjie Zhao, Peng Zhong, Jingying Wang, Qiaoyou Weng, Yuanyuan Qian, Jibo Han, Chunpeng Zou, Guang Liang. EGFR inhibition attenuates diabetic nephropathy through decreasing ROS and endoplasmic reticulum stress. Oncotarget. 2017 May; 8(20):32655-32667. doi: 10.18632/oncotarget.15948. [PMID: 28427241]
  • Rong Gao, Mu-Huo Ji, Da-Peng Gao, Run-Hua Yang, Shao-Gang Zhang, Jian-Jun Yang, Jin-Chun Shen. Neuroinflammation-Induced Downregulation of Hippocampacal Neuregulin 1-ErbB4 Signaling in the Parvalbumin Interneurons Might Contribute to Cognitive Impairment in a Mouse Model of Sepsis-Associated Encephalopathy. Inflammation. 2017 Apr; 40(2):387-400. doi: 10.1007/s10753-016-0484-2. [PMID: 27913953]
  • Yuh Baba, Toyonobu Maeda, Atsuko Suzuki, Satoshi Takada, Masato Fujii, Yasumasa Kato. Deguelin Potentiates Apoptotic Activity of an EGFR Tyrosine Kinase Inhibitor (AG1478) in PIK3CA-Mutated Head and Neck Squamous Cell Carcinoma. International journal of molecular sciences. 2017 Jan; 18(2):. doi: 10.3390/ijms18020262. [PMID: 28134774]
  • Saghir Akhtar, Bashayer Al-Zaid, Ahmed Z El-Hashim, Bindu Chandrasekhar, Sreeja Attur, Ibrahim F Benter. Impact of PAMAM delivery systems on signal transduction pathways in vivo: Modulation of ERK1/2 and p38 MAP kinase signaling in the normal and diabetic kidney. International journal of pharmaceutics. 2016 Dec; 514(2):353-363. doi: 10.1016/j.ijpharm.2016.03.039. [PMID: 27032566]
  • Xiao-Pei Yang, Ji-Yang Fu, Rui-Cheng Yang, Wen-Tong Liu, Tao Zhang, Bo Yang, Ling Miao, Bei-Bei Dou, Chen Tan, Huan-Chun Chen, Xiang-Ru Wang. EGFR transactivation contributes to neuroinflammation in Streptococcus suis meningitis. Journal of neuroinflammation. 2016 10; 13(1):274. doi: 10.1186/s12974-016-0734-0. [PMID: 27756321]
  • Melissa Skibba, Yuanyuan Qian, Yuyan Bao, Junjie Lan, Kesong Peng, Yunjie Zhao, Peng Zhong, Jie Hu, Xiaokun Li, Guang Liang. New EGFR inhibitor, 453, prevents renal fibrosis in angiotensin II-stimulated mice. European journal of pharmacology. 2016 Oct; 789(?):421-430. doi: 10.1016/j.ejphar.2016.08.009. [PMID: 27497883]
  • Gursev S Dhaunsi, Mayra Alsaeid, Saghir Akhtar. Phytanic acid activates NADPH oxidase through transactivation of epidermal growth factor receptor in vascular smooth muscle cells. Lipids in health and disease. 2016 Jun; 15(?):105. doi: 10.1186/s12944-016-0273-9. [PMID: 27287039]
  • Aby Joiakim, Patricia A Mathieu, Catherine Shelp, Julie Boerner, John J Reiners. Epidermal Growth Factor Receptor Kinase Inhibitors Synergize with TCDD to Induce CYP1A1/1A2 in Human Breast Epithelial MCF10A Cells. Drug metabolism and disposition: the biological fate of chemicals. 2016 May; 44(5):665-71. doi: 10.1124/dmd.115.066274. [PMID: 26953171]
  • Qilu Fang, Chunpeng Zou, Peng Zhong, Feng Lin, Weixin Li, Lintao Wang, Yali Zhang, Chao Zheng, Yi Wang, Xiaokun Li, Guang Liang. EGFR mediates hyperlipidemia-induced renal injury via regulating inflammation and oxidative stress: the detrimental role and mechanism of EGFR activation. Oncotarget. 2016 Apr; 7(17):24361-73. doi: 10.18632/oncotarget.8222. [PMID: 27014908]
  • Dariusz Wodziak, Aiwen Dong, Michael F Basin, Anson W Lowe. Anterior Gradient 2 (AGR2) Induced Epidermal Growth Factor Receptor (EGFR) Signaling Is Essential for Murine Pancreatitis-Associated Tissue Regeneration. PloS one. 2016; 11(10):e0164968. doi: 10.1371/journal.pone.0164968. [PMID: 27764193]
  • I-Hua Chen, Hsin-Chu Shih, Pei-Wen Hsieh, Fang-Rong Chang, Yang-Chang Wu, Chin-Chung Wu. HPW-RX40 restores anoikis sensitivity of human breast cancer cells by inhibiting integrin/FAK signaling. Toxicology and applied pharmacology. 2015 Dec; 289(2):330-40. doi: 10.1016/j.taap.2015.09.011. [PMID: 26386190]
  • C Thomas G Appleton, Shirine E Usmani, Michael A Pest, Vasek Pitelka, John S Mort, Frank Beier. Reduction in disease progression by inhibition of transforming growth factor α-CCL2 signaling in experimental posttraumatic osteoarthritis. Arthritis & rheumatology (Hoboken, N.J.). 2015 Oct; 67(10):2691-701. doi: 10.1002/art.39255. [PMID: 26138996]
  • Tony N Wang, Xing Chen, Renzhong Li, Bo Gao, Zahraa Mohammed-Ali, Chao Lu, Victoria Yum, Jeffrey G Dickhout, Joan C Krepinsky. SREBP-1 Mediates Angiotensin II-Induced TGF-β1 Upregulation and Glomerular Fibrosis. Journal of the American Society of Nephrology : JASN. 2015 Aug; 26(8):1839-54. doi: 10.1681/asn.2013121332. [PMID: 25398788]
  • Hui-Chun Wang, Fang-Rong Chang, Tzu-Jung Huang, Ching-Ying Kuo, Yu-Chi Tsai, Chin-Chung Wu. (-)-Liriopein B Suppresses Breast Cancer Progression via Inhibition of Multiple Kinases. Chemical research in toxicology. 2015 May; 28(5):897-906. doi: 10.1021/tx500518j. [PMID: 25856345]
  • Aiwen Dong, Dariusz Wodziak, Anson W Lowe. Epidermal growth factor receptor (EGFR) signaling requires a specific endoplasmic reticulum thioredoxin for the post-translational control of receptor presentation to the cell surface. The Journal of biological chemistry. 2015 Mar; 290(13):8016-27. doi: 10.1074/jbc.m114.623207. [PMID: 25666625]
  • Mary Taub, Robert Parker, Paremala Mathivanan, Muhamad Asnawi Mohd Ariff, Trina Rudra. Antagonism of the prostaglandin E2 EP1 receptor in MDCK cells increases growth through activation of Akt and the epidermal growth factor receptor. American journal of physiology. Renal physiology. 2014 Sep; 307(5):F539-50. doi: 10.1152/ajprenal.00510.2013. [PMID: 25007872]
  • Yuke Zhang, Maoxiang Zhu, Zhihua Yang, Xiujie Pan, Yuanyuan Jiang, Congcong Sun, Qin Wang, Wei Xiao. The human Cathelicidin LL-37 induces MUC5AC mucin production by airway epithelial cells via TACE-TGF-α-EGFR pathway. Experimental lung research. 2014 Sep; 40(7):333-42. doi: 10.3109/01902148.2014.926434. [PMID: 24901072]
  • K Fujiki, H Inamura, M Matsuoka. Detrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells. Cell death & disease. 2014 Aug; 5(?):e1378. doi: 10.1038/cddis.2014.339. [PMID: 25118938]
  • Yuichi Ohnishi, Yuki Minamino, Kenji Kakudo, Masami Nozaki. Resistance of oral squamous cell carcinoma cells to cetuximab is associated with EGFR insensitivity and enhanced stem cell-like potency. Oncology reports. 2014 Aug; 32(2):780-6. doi: 10.3892/or.2014.3258. [PMID: 24926885]
  • Laurel A Grisanti, Jennifer A Talarico, Rhonda L Carter, Justine E Yu, Ashley A Repas, Scott W Radcliffe, Hoang-Ai Tang, Catherine A Makarewich, Steven R Houser, Douglas G Tilley. β-Adrenergic receptor-mediated transactivation of epidermal growth factor receptor decreases cardiomyocyte apoptosis through differential subcellular activation of ERK1/2 and Akt. Journal of molecular and cellular cardiology. 2014 Jul; 72(?):39-51. doi: 10.1016/j.yjmcc.2014.02.009. [PMID: 24566221]
  • Pauline Larroque-Cardoso, Elodie Mucher, Marie-Hélène Grazide, Gwendal Josse, Anne-Marie Schmitt, Florence Nadal-Wolbold, Kamelija Zarkovic, Robert Salvayre, Anne Nègre-Salvayre. 4-Hydroxynonenal impairs transforming growth factor-β1-induced elastin synthesis via epidermal growth factor receptor activation in human and murine fibroblasts. Free radical biology & medicine. 2014 Jun; 71(?):427-436. doi: 10.1016/j.freeradbiomed.2014.02.015. [PMID: 24561579]
  • Maria Luisa Bondì, Antonina Azzolina, Emanuela Fabiola Craparo, Chiara Botto, Erika Amore, Gaetano Giammona, Melchiorre Cervello. Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells. Journal of nanobiotechnology. 2014 May; 12(?):21. doi: 10.1186/1477-3155-12-21. [PMID: 24886097]
  • Anas H A Abu-Humaidan, Nageshwar Ananthoju, Tirthankar Mohanty, Andreas Sonesson, Per Alberius, Artur Schmidtchen, Peter Garred, Ole E Sørensen. The epidermal growth factor receptor is a regulator of epidermal complement component expression and complement activation. Journal of immunology (Baltimore, Md. : 1950). 2014 Apr; 192(7):3355-64. doi: 10.4049/jimmunol.1302305. [PMID: 24591374]
  • Zhengyu Lu, Mei Cui, Hong Zhao, Tao Wang, Yan Shen, Qiang Dong. Tissue kallikrein mediates neurite outgrowth through epidermal growth factor receptor and flotillin-2 pathway in vitro. Cellular signalling. 2014 Feb; 26(2):220-32. doi: 10.1016/j.cellsig.2013.10.010. [PMID: 24211626]
  • Kota Fujiki, Hisako Inamura, Masato Matsuoka. Phosphorylation of FOXO3a by PI3K/Akt pathway in HK-2 renal proximal tubular epithelial cells exposed to cadmium. Archives of toxicology. 2013 Dec; 87(12):2119-27. doi: 10.1007/s00204-013-1077-6. [PMID: 23673518]
  • Rohan Samarakoon, Amy D Dobberfuhl, Catherine Cooley, Jessica M Overstreet, Samik Patel, Roel Goldschmeding, Kirstan K Meldrum, Paul J Higgins. Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species. Cellular signalling. 2013 Nov; 25(11):2198-209. doi: 10.1016/j.cellsig.2013.07.007. [PMID: 23872073]
  • Mariko Murata, Kaoru Midorikawa, Shosuke Kawanishi. Oxidative DNA damage and mammary cell proliferation by alcohol-derived salsolinol. Chemical research in toxicology. 2013 Oct; 26(10):1455-63. doi: 10.1021/tx400182n. [PMID: 24020587]
  • Ana B Fernández-Martínez, Francisco J Lucio Cazaña. Epidermal growth factor receptor transactivation by intracellular prostaglandin E2-activated prostaglandin E2 receptors. Role in retinoic acid receptor-β up-regulation. Biochimica et biophysica acta. 2013 Sep; 1833(9):2029-38. doi: 10.1016/j.bbamcr.2013.04.013. [PMID: 23644172]
  • Dane D Jensen, Cody B Godfrey, Christian Niklas, Meritxell Canals, Martina Kocan, Daniel P Poole, Jane E Murphy, Farzad Alemi, Graeme S Cottrell, Christoph Korbmacher, Nevin A Lambert, Nigel W Bunnett, Carlos U Corvera. The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts. The Journal of biological chemistry. 2013 Aug; 288(32):22942-60. doi: 10.1074/jbc.m113.455774. [PMID: 23818521]
  • C Slattery, Y Jang, W A Kruger, D H Hryciw, A Lee, P Poronnik. γ-Secretase inhibition promotes fibrotic effects of albumin in proximal tubular epithelial cells. British journal of pharmacology. 2013 Jul; 169(6):1239-51. doi: 10.1111/bph.12214. [PMID: 23594166]
  • Saghir Akhtar, Bindu Chandrasekhar, Sreeja Attur, Mariam H M Yousif, Ibrahim F Benter. On the nanotoxicity of PAMAM dendrimers: Superfect® stimulates the EGFR-ERK1/2 signal transduction pathway via an oxidative stress-dependent mechanism in HEK 293 cells. International journal of pharmaceutics. 2013 May; 448(1):239-46. doi: 10.1016/j.ijpharm.2013.03.039. [PMID: 23538097]
  • A H Kurt, R N Tiftik, I Un, S Ulker, K Buyukafsar. G protein-coupled estrogen receptor1 (GPER1) may mediate Rho-kinase (ROCK-2) up-regulation in coronary endothelial cells. Endocrine regulations. 2013 Apr; 47(2):75-84. doi: 10.4149/endo_2013_02_75. [PMID: 23641788]
  • William H Chappell, Stephen L Abrams, Richard A Franklin, Michelle M LaHair, Giuseppe Montalto, Melchiorre Cervello, Alberto M Martelli, Ferdinando Nicoletti, Saverio Candido, Massimo Libra, Jerry Polesel, Renato Talamini, Michele Milella, Agostino Tafuri, Linda S Steelman, James A McCubrey. Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine. Cell cycle (Georgetown, Tex.). 2012 Dec; 11(23):4447-61. doi: 10.4161/cc.22786. [PMID: 23159854]
  • Hidehisa Shimizu, Yuichi Hirose, Sumie Goto, Fuyuhiko Nishijima, Houda Zrelli, Nahla Zghonda, Toshimitsu Niwa, Hitoshi Miyazaki. Indoxyl sulfate enhances angiotensin II signaling through upregulation of epidermal growth factor receptor expression in vascular smooth muscle cells. Life sciences. 2012 Sep; 91(5-6):172-7. doi: 10.1016/j.lfs.2012.06.033. [PMID: 22781707]
  • William B Weglicki, Jay H Kramer, Christopher F Spurney, Joanna J Chmielinska, I Tong Mak. The EGFR tyrosine kinase inhibitor tyrphostin AG-1478 causes hypomagnesemia and cardiac dysfunction. Canadian journal of physiology and pharmacology. 2012 Aug; 90(8):1145-9. doi: 10.1139/y2012-023. [PMID: 22646904]
  • Shakeel U R Mir, Ling Jin, Rolf J Craven. Neutrophil gelatinase-associated lipocalin (NGAL) expression is dependent on the tumor-associated sigma-2 receptor S2RPgrmc1. The Journal of biological chemistry. 2012 Apr; 287(18):14494-501. doi: 10.1074/jbc.m111.324921. [PMID: 22418433]
  • A Martínez-Palacián, G Del Castillo, B Herrera, M Fernández, C Roncero, I Fabregat, A Sánchez. EGFR is dispensable for c-Met-mediated proliferation and survival activities in mouse adult liver oval cells. Cellular signalling. 2012 Feb; 24(2):505-513. doi: 10.1016/j.cellsig.2011.09.031. [PMID: 22001397]
  • Hui-Ping Lin, Li-Kuo Kuo, Chih-Pin Chuu. Combined treatment of curcumin and small molecule inhibitors suppresses proliferation of A549 and H1299 human non-small-cell lung cancer cells. Phytotherapy research : PTR. 2012 Jan; 26(1):122-6. doi: 10.1002/ptr.3523. [PMID: 21567511]
  • Anush Oganesian, Vladimir Yarov-Yarovoy, William C Parks, Debra A Schwinn. Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathway. Proceedings of the National Academy of Sciences of the United States of America. 2011 Dec; 108(49):19796-801. doi: 10.1073/pnas.1116271108. [PMID: 22089237]
  • Kaname Uno, Katsuaki Kato, Gen Kusaka, Naoki Asano, Katsunori Iijima, Tooru Shimosegawa. The balance between 4-hydroxynonenal and intrinsic glutathione/glutathione S-transferase A4 system may be critical for the epidermal growth factor receptor phosphorylation of human esophageal squamous cell carcinomas. Molecular carcinogenesis. 2011 Oct; 50(10):781-90. doi: 10.1002/mc.20699. [PMID: 21751261]
  • Anh-Nguyet T Nguyen, Kyle Jansson, Gladis Sánchez, Madhulika Sharma, Gail A Reif, Darren P Wallace, Gustavo Blanco. Ouabain activates the Na-K-ATPase signalosome to induce autosomal dominant polycystic kidney disease cell proliferation. American journal of physiology. Renal physiology. 2011 Oct; 301(4):F897-906. doi: 10.1152/ajprenal.00095.2011. [PMID: 21697238]
  • Guillaume Bollée, Martin Flamant, Sandra Schordan, Cécile Fligny, Elisabeth Rumpel, Marine Milon, Eric Schordan, Nathalie Sabaa, Sophie Vandermeersch, Ariane Galaup, Anita Rodenas, Ibrahim Casal, Susan W Sunnarborg, David J Salant, Jeffrey B Kopp, David W Threadgill, Susan E Quaggin, Jean-Claude Dussaule, Stéphane Germain, Laurent Mesnard, Karlhans Endlich, Claude Boucheix, Xavier Belenfant, Patrice Callard, Nicole Endlich, Pierre-Louis Tharaux. Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nature medicine. 2011 Sep; 17(10):1242-50. doi: 10.1038/nm.2491. [PMID: 21946538]
  • Bachir W El Debs, Ulrich Tschulena, Andrew D Griffiths, Christoph A Merten. A competitive co-cultivation assay for cancer drug specificity evaluation. Journal of biomolecular screening. 2011 Sep; 16(8):818-24. doi: 10.1177/1087057111414898. [PMID: 21788393]
  • Geetanjali Kharmate, Padmesh S Rajput, Heather L Watt, Rishi K Somvanshi, Nicole Chaudhari, Xiaofan Qiu, Ujendra Kumar. Role of somatostatin receptor 1 and 5 on epidermal growth factor receptor mediated signaling. Biochimica et biophysica acta. 2011 Jun; 1813(6):1172-89. doi: 10.1016/j.bbamcr.2011.03.006. [PMID: 21419811]
  • Eva Nagyova, Antonella Camaioni, Sona Scsukova, Alzbeta Mlynarcikova, Radek Prochazka, Lucie Nemcova, Antonietta Salustri. Activation of cumulus cell SMAD2/3 and epidermal growth factor receptor pathways are involved in porcine oocyte-cumulus cell expansion and steroidogenesis. Molecular reproduction and development. 2011 Jun; 78(6):391-402. doi: 10.1002/mrd.21312. [PMID: 21520325]
  • András Balla, László Sándor Erdélyi, Eszter Soltész-Katona, Tamas Balla, Péter Várnai, László Hunyady. Demonstration of angiotensin II-induced Ras activation in the trans-Golgi network and endoplasmic reticulum using bioluminescence resonance energy transfer-based biosensors. The Journal of biological chemistry. 2011 Feb; 286(7):5319-27. doi: 10.1074/jbc.m110.176933. [PMID: 21062747]
  • Daniela A Eisinger, Hermann Ammer. Epidermal growth factor treatment switches δ-opioid receptor-stimulated extracellular signal-regulated kinases 1 and 2 signaling from an epidermal growth factor to an insulin-like growth factor-1 receptor-dependent mechanism. Molecular pharmacology. 2011 Feb; 79(2):326-35. doi: 10.1124/mol.110.064956. [PMID: 21078885]
  • Wei-Chiao Chang, Chen-Chia Chang, Yung-Song Wang, Yu-Shiuan Wang, Wei-Teng Weng, Tohru Yoshioka, Suh-Hang Hank Juo. Involvement of the epidermal growth factor receptor in Pb²+-induced activation of cPLA₂/COX-2 genes and PGE₂ production in vascular smooth muscle cells. Toxicology. 2011 Jan; 279(1-3):45-53. doi: 10.1016/j.tox.2010.09.004. [PMID: 20850495]
  • William Weidong Du, Burton B Yang, Bing L Yang, Zhaoqun Deng, Ling Fang, Sze Wan Shan, Zina Jeyapalan, Yaou Zhang, Arun Seth, Albert J Yee. Versican G3 domain modulates breast cancer cell apoptosis: a mechanism for breast cancer cell response to chemotherapy and EGFR therapy. PloS one. 2011; 6(11):e26396. doi: 10.1371/journal.pone.0026396. [PMID: 22096483]
  • N Ulu, H Gurdal, S W Landheer, M Duin, M O Guc, H Buikema, R H Henning. α1-Adrenoceptor-mediated contraction of rat aorta is partly mediated via transactivation of the epidermal growth factor receptor. British journal of pharmacology. 2010 Nov; 161(6):1301-10. doi: 10.1111/j.1476-5381.2010.00829.x. [PMID: 20977469]
  • Bin Xiao, Xuguang Li, Jiangtao Yan, Xuefeng Yu, Guangtian Yang, Xiao Xiao, James W Voltz, Darryl C Zeldin, Dao Wen Wang. Overexpression of cytochrome P450 epoxygenases prevents development of hypertension in spontaneously hypertensive rats by enhancing atrial natriuretic peptide. The Journal of pharmacology and experimental therapeutics. 2010 Sep; 334(3):784-94. doi: 10.1124/jpet.110.167510. [PMID: 20501636]
  • S J Uhm, M K Gupta, J H Yang, H-J Chung, T S Min, H T Lee. Epidermal growth factor can be used in lieu of follicle-stimulating hormone for nuclear maturation of porcine oocytes in vitro. Theriogenology. 2010 May; 73(8):1024-36. doi: 10.1016/j.theriogenology.2009.11.029. [PMID: 20106515]
  • Abedelnasser Abulrob, Zhengfang Lu, Ewa Baumann, Dusan Vobornik, Rod Taylor, Danica Stanimirovic, Linda J Johnston. Nanoscale imaging of epidermal growth factor receptor clustering: effects of inhibitors. The Journal of biological chemistry. 2010 Jan; 285(5):3145-56. doi: 10.1074/jbc.m109.073338. [PMID: 19959837]
  • Victoria McEneaney, Ruth Dooley, Brian J Harvey, Warren Thomas. Protein kinase D stabilizes aldosterone-induced ERK1/2 MAP kinase activation in M1 renal cortical collecting duct cells to promote cell proliferation. The Journal of steroid biochemistry and molecular biology. 2010 Jan; 118(1-2):18-28. doi: 10.1016/j.jsbmb.2009.09.014. [PMID: 19804826]
  • Ting Wang, Youxue Wang, Hitoshi Yamashita. Evodiamine inhibits adipogenesis via the EGFR-PKCalpha-ERK signaling pathway. FEBS letters. 2009 Nov; 583(22):3655-9. doi: 10.1016/j.febslet.2009.10.046. [PMID: 19854188]
  • Baoman Li, Shiquen Zhang, Min Li, Leif Hertz, Liang Peng. Chronic treatment of astrocytes with therapeutically relevant fluoxetine concentrations enhances cPLA2 expression secondary to 5-HT2B-induced, transactivation-mediated ERK1/2 phosphorylation. Psychopharmacology. 2009 Nov; 207(1):1-12. doi: 10.1007/s00213-009-1631-3. [PMID: 19662385]
  • David E Joyner, Sylvia H Trang, Timothy A Damron, Albert J Aboulafia, Judd E Cummings, R Lor Randall. Desmoid cell motility is induced in vitro by rhEGF. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2009 Sep; 27(9):1258-62. doi: 10.1002/jor.20865. [PMID: 19242968]
  • Guiying Li, Chang Han, Lihong Xu, Kyu Lim, Kumiko Isse, Tong Wu. Cyclooxygenase-2 prevents fas-induced liver injury through up-regulation of epidermal growth factor receptor. Hepatology (Baltimore, Md.). 2009 Sep; 50(3):834-43. doi: 10.1002/hep.23052. [PMID: 19585617]
  • Ibrahim F Benter, Halit Canatan, Mustapha Benboubetra, Mariam H M Yousif, Saghir Akhtar. Global upregulation of gene expression associated with renal dysfunction in DOCA-salt-induced hypertensive rats occurs via signaling cascades involving epidermal growth factor receptor: a microarray analysis. Vascular pharmacology. 2009 Aug; 51(2-3):101-9. doi: 10.1016/j.vph.2009.04.004. [PMID: 19410658]
  • Y Liu, R Pixley, M Fusaro, G Godoy, E Kim, M E Bromberg, R W Colman. Cleaved high-molecular-weight kininogen and its domain 5 inhibit migration and invasion of human prostate cancer cells through the epidermal growth factor receptor pathway. Oncogene. 2009 Jul; 28(30):2756-65. doi: 10.1038/onc.2009.132. [PMID: 19483730]
  • Hideki Kimura, Xuan Li, Kunio Torii, Toshiharu Okada, Kazuko Kamiyama, Daisuke Mikami, Naoki Takahashi, Haruyoshi Yoshida. Dexamethasone enhances basal and TNF-alpha-stimulated production of PAI-1 via the glucocorticoid receptor regardless of 11beta-hydroxysteroid dehydrogenase 2 status in human proximal renal tubular cells. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2009 Jun; 24(6):1759-65. doi: 10.1093/ndt/gfn756. [PMID: 19153071]
  • Meryem Güller, Kahina Toualbi-Abed, Agnès Legrand, Laurence Michel, Alain Mauviel, Dominique Bernuau, Fanny Daniel. c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1. World journal of gastroenterology. 2008 Nov; 14(41):6339-46. doi: 10.3748/wjg.14.6339. [PMID: 19009649]
  • Jet Phey Lim, Jack T H Wang, Markus C Kerr, Rohan D Teasdale, Paul A Gleeson. A role for SNX5 in the regulation of macropinocytosis. BMC cell biology. 2008 Oct; 9(?):58. doi: 10.1186/1471-2121-9-58. [PMID: 18854019]
  • Anette Weyergang, Olav Kaalhus, Kristian Berg. Photodynamic targeting of EGFR does not predict the treatment outcome in combination with the EGFR tyrosine kinase inhibitor Tyrphostin AG1478. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2008 Sep; 7(9):1032-40. doi: 10.1039/b806209a. [PMID: 18754049]
  • Tushar B Deb, Christine M Coticchia, Robert Barndt, Hong Zuo, Robert B Dickson, Michael D Johnson. Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation. American journal of physiology. Cell physiology. 2008 Aug; 295(2):C365-77. doi: 10.1152/ajpcell.00449.2007. [PMID: 18562482]
  • Conrad Ortiz, Laia Caja, Patricia Sancho, Esther Bertran, Isabel Fabregat. Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells: role of reactive oxygen species production and glutathione depletion. Biochemical pharmacology. 2008 May; 75(10):1935-45. doi: 10.1016/j.bcp.2008.02.015. [PMID: 18371937]
  • Michael P Sanderson, Sascha Keller, Angel Alonso, Svenja Riedle, Peter J Dempsey, Peter Altevogt. Generation of novel, secreted epidermal growth factor receptor (EGFR/ErbB1) isoforms via metalloprotease-dependent ectodomain shedding and exosome secretion. Journal of cellular biochemistry. 2008 Apr; 103(6):1783-97. doi: 10.1002/jcb.21569. [PMID: 17910038]
  • Lilach Tencer, Elke Burgermeister, Matthias P Ebert, Mordechai Liscovitch. Rosiglitazone induces caveolin-1 by PPARgamma-dependent and PPRE-independent mechanisms: the role of EGF receptor signaling and its effect on cancer cell drug resistance. Anticancer research. 2008 Mar; 28(2A):895-906. doi: NULL. [PMID: 18507034]
  • Shougang Zhuang, Gilbert R Kinsey, Kyle Rasbach, Rick G Schnellmann. Heparin-binding epidermal growth factor and Src family kinases in proliferation of renal epithelial cells. American journal of physiology. Renal physiology. 2008 Mar; 294(3):F459-68. doi: 10.1152/ajprenal.00473.2007. [PMID: 18171996]
  • Crisanto S Escano, Lindsay B Keever, Alexander A Gutweiler, Bradley T Andresen. Angiotensin II activates extracellular signal-regulated kinase independently of receptor tyrosine kinases in renal smooth muscle cells: implications for blood pressure regulation. The Journal of pharmacology and experimental therapeutics. 2008 Jan; 324(1):34-42. doi: 10.1124/jpet.107.126300. [PMID: 17911376]
  • Babu V Bassa, Jung W Noh, Shobha H Ganji, Mi-Kyung Shin, Daeyoung D Roh, Vaijinath S Kamanna. Lysophosphatidylcholine stimulates EGF receptor activation and mesangial cell proliferation: regulatory role of Src and PKC. Biochimica et biophysica acta. 2007 Nov; 1771(11):1364-71. doi: 10.1016/j.bbalip.2007.09.004. [PMID: 17950662]
  • Sandra Bien, Alexander Riad, Christoph A Ritter, Matthias Gratz, Florian Olshausen, Dirk Westermann, Markus Grube, Thomas Krieg, Sabine Ciecholewski, Stephan B Felix, Alexander Staudt, Heinz-Peter Schultheiss, Ralf Ewert, Uwe Völker, Carsten Tschöpe, Heyo K Kroemer. The endothelin receptor blocker bosentan inhibits doxorubicin-induced cardiomyopathy. Cancer research. 2007 Nov; 67(21):10428-35. doi: 10.1158/0008-5472.can-07-1344. [PMID: 17974986]
  • Victoria McEneaney, Brian J Harvey, Warren Thomas. Aldosterone rapidly activates protein kinase D via a mineralocorticoid receptor/EGFR trans-activation pathway in the M1 kidney CCD cell line. The Journal of steroid biochemistry and molecular biology. 2007 Nov; 107(3-5):180-90. doi: 10.1016/j.jsbmb.2007.03.043. [PMID: 17681751]
  • Karina Zitta, Martin Albrecht, Stephan Weidinger, Artur Mayerhofer, Frank Köhn. Protease activated receptor 2 and epidermal growth factor receptor are involved in the regulation of human sperm motility. Asian journal of andrology. 2007 Sep; 9(5):690-6. doi: 10.1111/j.1745-7262.2007.00289.x. [PMID: 17712488]
  • Jun Konishi, Keiko S Kawaguchi, Huan Vo, Nobuhiro Haruki, Adriana Gonzalez, David P Carbone, Thao P Dang. Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers. Cancer research. 2007 Sep; 67(17):8051-7. doi: 10.1158/0008-5472.can-07-1022. [PMID: 17804716]
  • Shougang Zhuang, Yan Yan, Rebecca A Daubert, Rick G Schnellmann. Epiregulin promotes proliferation and migration of renal proximal tubular cells. American journal of physiology. Renal physiology. 2007 Jul; 293(1):F219-26. doi: 10.1152/ajprenal.00082.2007. [PMID: 17389679]
  • Jing Cheng, Simon C Watkins, William H Walker. Testosterone activates mitogen-activated protein kinase via Src kinase and the epidermal growth factor receptor in sertoli cells. Endocrinology. 2007 May; 148(5):2066-74. doi: 10.1210/en.2006-1465. [PMID: 17272394]
  • W Bruce Sneddon, Yanmei Yang, Jianming Ba, Lisa M Harinstein, Peter A Friedman. Extracellular signal-regulated kinase activation by parathyroid hormone in distal tubule cells. American journal of physiology. Renal physiology. 2007 Mar; 292(3):F1028-34. doi: 10.1152/ajprenal.00288.2006. [PMID: 17107942]
  • Kyle A Rasbach, Rick G Schnellmann. Signaling of mitochondrial biogenesis following oxidant injury. The Journal of biological chemistry. 2007 Jan; 282(4):2355-62. doi: 10.1074/jbc.m608009200. [PMID: 17116659]
  • Yurii V Mukhin, Monika Gooz, John R Raymond, Maria N Garnovskaya. Collagenase-2 and -3 mediate epidermal growth factor receptor transactivation by bradykinin B2 receptor in kidney cells. The Journal of pharmacology and experimental therapeutics. 2006 Sep; 318(3):1033-43. doi: 10.1124/jpet.106.104000. [PMID: 16717107]
  • Rola Barhoumi, Igbal Awooda, Youssef Mouneimne, Stephen Safe, Robert C Burghardt. Effects of benzo-a-pyrene on oxytocin-induced Ca2+ oscillations in myometrial cells. Toxicology letters. 2006 Aug; 165(2):133-41. doi: 10.1016/j.toxlet.2006.02.005. [PMID: 16567066]
  • I Arany, J K Megyesi, B D Nelkin, R L Safirstein. STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells. Kidney international. 2006 Aug; 70(4):669-74. doi: 10.1038/sj.ki.5001604. [PMID: 16788692]
  • Atsuyoshi Nishina, Hirokazu Kimura, Akihiro Sekiguchi, Ryo-hei Fukumoto, Satoshi Nakajima, Shoei Furukawa. Lysophosphatidylethanolamine in Grifola frondosa as a neurotrophic activator via activation of MAPK. Journal of lipid research. 2006 Jul; 47(7):1434-43. doi: 10.1194/jlr.m600045-jlr200. [PMID: 16614393]
  • Veronique Picihard, Yolande Berthois, Monique Roccabianca, Charles Prévôt, Marcel Sarrazin, Henri Portugal, Shant Kumar, Pat Kumar, Jean-Baptiste Rognoni. Concomitant cell growth and differentiation are dependent on erbB1 and integrin activation in an autonomously surviving colon adenocarcinoma: involvement of autocrine amphiregulin secretion. Anticancer research. 2006 Jul; 26(4B):2769-83. doi: NULL. [PMID: 16886596]
  • Hirohisa Ogawa, Shizuka Inoue, Fumitaka Ogushi, Hideo Ogura, Yoichi Nakamura. Toluene diisocyanate (TDI) induces production of inflammatory cytokines and chemokines by bronchial epithelial cells via the epidermal growth factor receptor and p38 mitogen-activated protein kinase pathways. Experimental lung research. 2006 Jun; 32(6):245-62. doi: 10.1080/01902140600817515. [PMID: 16908450]
  • Ju Suk Lee, Su Yung Kim, Chae Hwa Kwon, Yong Keun Kim. EGFR-dependent ERK activation triggers hydrogen peroxide-induced apoptosis in OK renal epithelial cells. Archives of toxicology. 2006 Jun; 80(6):337-46. doi: 10.1007/s00204-005-0052-2. [PMID: 16341693]
  • A G Ellis, M M Doherty, F Walker, J Weinstock, M Nerrie, A Vitali, R Murphy, T G Johns, A M Scott, A Levitzki, G McLachlan, L K Webster, A W Burgess, E C Nice. Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase. Biochemical pharmacology. 2006 May; 71(10):1422-34. doi: 10.1016/j.bcp.2006.01.020. [PMID: 16522318]
  • L D Alexander, Y Ding, S Alagarsamy, X-L Cui, J G Douglas. Arachidonic acid induces ERK activation via Src SH2 domain association with the epidermal growth factor receptor. Kidney international. 2006 May; 69(10):1823-32. doi: 10.1038/sj.ki.5000363. [PMID: 16598196]
  • Ken Mori, Joji Kitayama, Dai Shida, Hiroharu Yamashita, Toshiaki Watanabe, Hirokazu Nagawa. Lysophosphatidic acid-induced effects in human colon carcinoma DLD1 cells are partially dependent on transactivation of epidermal growth factor receptor. The Journal of surgical research. 2006 May; 132(1):56-61. doi: 10.1016/j.jss.2005.07.040. [PMID: 16289596]
  • Sebastian Bergmann, Kerstin Junker, Peter Henklein, Morley D Hollenberg, Utz Settmacher, Roland Kaufmann. PAR-type thrombin receptors in renal carcinoma cells: PAR1-mediated EGFR activation promotes cell migration. Oncology reports. 2006 Apr; 15(4):889-93. doi: 10.3892/or.15.4.889. [PMID: 16525676]