Tyrphostin AG 126 (BioDeep_00000175776)

   

human metabolite blood metabolite


代谢物信息卡片


2-[(3-hydroxy-4-nitrophenyl)methylidene]propanedinitrile

化学式: C10H5N3O3 (215.03309000000002)
中文名称: 酪氨酸磷酸化抑制剂126
谱图信息: 最多检出来源 Homo sapiens(blood) 93.18%

分子结构信息

SMILES: C1=CC(=C(C=C1C=C(C#N)C#N)O)[N+](=O)[O-]
InChI: InChI=1S/C10H5N3O3/c11-5-8(6-12)3-7-1-2-9(13(15)16)10(14)4-7/h1-4,14H

描述信息

D000970 - Antineoplastic Agents > D020032 - Tyrphostins
D004791 - Enzyme Inhibitors
AG126 is a tyrosine kinase inhibitor, can inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM. AG126 can be used in meiosis, mitosis, and postmitotic research[1][2][3][4].

同义名列表

7 个代谢物同义名

2-[(3-hydroxy-4-nitrophenyl)methylidene]propanedinitrile; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile; Tyrphostin AG 126; Tyrphostin ag127; AG-126; Tyrphostin AG126; AG126



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Srinivasan Balachandra, Tiziana Genovese, Emanuela Mazzon, Rosanna Di Paola, Christoph Thiemerman, Ajith K Siriwardena, Salvatore Cuzzocrea. Inhibition of tyrosine-kinase-mediated cellular signaling by tyrphostins AG 126 and AG556 modulates murine experimental acute pancreatitis. Surgery. 2005 Nov; 138(5):913-23. doi: 10.1016/j.surg.2005.05.021. [PMID: 16291393]
  • Alexander A Karakashian, Natalia V Giltiay, George M Smith, Mariana N Nikolova-Karakashian. Expression of neutral sphingomyelinase-2 (NSMase-2) in primary rat hepatocytes modulates IL-beta-induced JNK activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2004 Jun; 18(9):968-70. doi: 10.1096/fj.03-0875fje. [PMID: 15059969]
  • Yong-ming Yao, Ming-hua Cheng, Sheng Yao, Hua-ping Liang, Hong-yun Li, Ning Dong, Yan Yu, Zhi-yong Sheng. [Effects of extracellular signal-regulated kinase inhibition by AG126 on tissue tumor necrosis factor-alpha expression and multiple organ dysfunction in rats with postburn Staphylococcus aureus sepsis]. Zhonghua wai ke za zhi [Chinese journal of surgery]. 2004 Apr; 42(7):391-5. doi: NULL. [PMID: 15144664]
  • Prabal K Chatterjee, Nimesh S A Patel, Espen O Kvale, Paul A J Brown, Keith N Stewart, Domenico Britti, Salvatore Cuzzocrea, Helder Mota-Filipe, Christoph Thiemermann. The tyrosine kinase inhibitor tyrphostin AG126 reduces renal ischemia/reperfusion injury in the rat. Kidney international. 2003 Nov; 64(5):1605-19. doi: 10.1046/j.1523-1755.2003.00254.x. [PMID: 14531792]
  • Tarun K Garg, Jason Y Chang. Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. BMC ophthalmology. 2003 Mar; 3(?):5. doi: 10.1186/1471-2415-3-5. [PMID: 12659653]
  • S Cuzzocrea, M C McDonald, E Mazzon, H Mota-Filipe, V Lepore, A Ciccolo, M L Terranova, D Britti, A P Caputi, C Thiemermann. The tyrosine kinase inhibitor tyrphostin AG 126 reduced the development of colitis in the rat. Laboratory investigation; a journal of technical methods and pathology. 2000 Sep; 80(9):1439-53. doi: 10.1038/labinvest.3780151. [PMID: 11005212]
  • C G Kevil, D K Payne, E Mire, J S Alexander. Vascular permeability factor/vascular endothelial cell growth factor-mediated permeability occurs through disorganization of endothelial junctional proteins. The Journal of biological chemistry. 1998 Jun; 273(24):15099-103. doi: 10.1074/jbc.273.24.15099. [PMID: 9614120]
  • J C López-Talavera, A Levitzki, M Martínez, A Gazit, R Esteban, J Guardia. Tyrosine kinase inhibition ameliorates the hyperdynamic state and decreases nitric oxide production in cirrhotic rats with portal hypertension and ascites. The Journal of clinical investigation. 1997 Aug; 100(3):664-70. doi: 10.1172/jci119578. [PMID: 9239414]
  • J E Sevransky, G Shaked, A Novogrodsky, A Levitzki, A Gazit, A Hoffman, R J Elin, Z M Quezado, B D Freeman, P Q Eichacker, R L Danner, S M Banks, J Bacher, M L Thomas, C Natanson. Tyrphostin AG 556 improves survival and reduces multiorgan failure in canine Escherichia coli peritonitis. The Journal of clinical investigation. 1997 Apr; 99(8):1966-73. doi: 10.1172/jci119364. [PMID: 9109441]