1-(2,4-Dichlorobenzyl)-1H-indazole-3-carbohydrazide (BioDeep_00000175752)

   

human metabolite blood metabolite


代谢物信息卡片


1-[(2,4-dichlorophenyl)methyl]-1H-indazole-3-carbohydrazide

化学式: C15H12Cl2N4O (334.0388)
中文名称: 男用口服避孕药
谱图信息: 最多检出来源 Homo sapiens(blood) 100%

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=NN2CC3=C(C=C(C=C3)Cl)Cl)C(=O)NN
InChI: InChI=1S/C15H12Cl2N4O/c16-10-6-5-9(12(17)7-10)8-21-13-4-2-1-3-11(13)14(20-21)15(22)19-18/h1-7H,8,18H2,(H,19,22)

描述信息

Adjudin is an extensively studied male contraceptive with a superior mitochondria-inhibitory effect. Adjudin is also a potent Cl- channel blocker.

同义名列表

5 个代谢物同义名

1-[(2,4-dichlorophenyl)methyl]-1H-indazole-3-carbohydrazide; 1-(2,4-Dichlorobenzyl)-1H-indazole-3-carbohydrazide; 1-(2,4-Dichlorobenzyl)indazole-3-carbohydrazide; Adjudin; AF-2364



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Qiong Wang, Chenming Zou, Lingying Wang, Xueqin Gao, Jindan Wu, Songwei Tan, Gang Wu. Doxorubicin and adjudin co-loaded pH-sensitive nanoparticles for the treatment of drug-resistant cancer. Acta biomaterialia. 2019 08; 94(?):469-481. doi: 10.1016/j.actbio.2019.05.061. [PMID: 31141733]
  • Xiaojing Qian, Dolores D Mruk, Elissa W P Wong, Pearl P Y Lie, C Yan Cheng. Palladin is a regulator of actin filament bundles at the ectoplasmic specialization in adult rat testes. Endocrinology. 2013 May; 154(5):1907-20. doi: 10.1210/en.2012-2269. [PMID: 23546604]
  • Ka-Wai Mok, Dolores D Mruk, Bruno Silvestrini, C Yan Cheng. rpS6 Regulates blood-testis barrier dynamics by affecting F-actin organization and protein recruitment. Endocrinology. 2012 Oct; 153(10):5036-48. doi: 10.1210/en.2012-1665. [PMID: 22948214]
  • Hui Wang, Xiang-Xiang Chen, Li-Rong Wang, Yun-Dong Mao, Zuo-Min Zhou, Jia-Hao Sha. AF-2364 is a prospective spermicide candidate. Asian journal of andrology. 2010 May; 12(3):322-35. doi: 10.1038/aja.2010.11. [PMID: 20418891]
  • Guo-Xin Hu, Lu-Feng Hu, Dai-Zheng Yang, Jun-Wei Li, Guo-Rong Chen, Bing-Bing Chen, Dolores D Mruk, Michele Bonanomi, Bruno Silvestrini, C Yan Cheng, Ren-Shan Ge. Adjudin targeting rabbit germ cell adhesion as a male contraceptive: a pharmacokinetics study. Journal of andrology. 2009 Jan; 30(1):87-93. doi: 10.2164/jandrol.108.004994. [PMID: 18802200]
  • Oli Sarkar, P P Mathur. Adjudin-mediated germ cell depletion alters the anti-oxidant status of adult rat testis. Molecular reproduction and development. 2009 Jan; 76(1):31-7. doi: 10.1002/mrd.20928. [PMID: 18449895]
  • Nikki P Y Lee, Dolores D Mruk, Weiliang Xia, C Yan Cheng. Cellular localization of sphingomyelin synthase 2 in the seminiferous epithelium of adult rat testes. The Journal of endocrinology. 2007 Jan; 192(1):17-32. doi: 10.1677/joe-06-0002. [PMID: 17210739]
  • Wing-yee Lui, Will M Lee, C Yan Cheng. Sertoli-germ cell adherens junction dynamics in the testis are regulated by RhoB GTPase via the ROCK/LIMK signaling pathway. Biology of reproduction. 2003 Jun; 68(6):2189-206. doi: 10.1095/biolreprod.102.011379. [PMID: 12606349]
  • Ann S N Lau, Dolores D Mruk. Rab8B GTPase and junction dynamics in the testis. Endocrinology. 2003 Apr; 144(4):1549-63. doi: 10.1210/en.2002-220893. [PMID: 12639940]
  • C Y Cheng, B Silvestrini, J Grima, M Y Mo , L J Zhu , E Johansson, L Saso, M G Leone, M Palmery, D Mruk. Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis. Biology of reproduction. 2001 Aug; 65(2):449-61. doi: 10.1095/biolreprod65.2.449. [PMID: 11466213]
  • J Grima, B Silvestrini, C Y Cheng. Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-(2,4-dichlorobenzyl)-indazole-3-carbohydrazide. Biology of reproduction. 2001 May; 64(5):1500-8. doi: 10.1095/biolreprod64.5.1500. [PMID: 11319158]