AdipoRon (BioDeep_00000175750)
human metabolite blood metabolite
代谢物信息卡片
2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide
化学式: C27H28N2O3 (428.21)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 92.65%
分子结构信息
SMILES: C1CN(CCC1NC(=O)COC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)CC4=CC=CC=C4
InChI: InChI=1S/C27H28N2O3/c30-26(28-24-15-17-29(18-16-24)19-21-7-3-1-4-8-21)20-32-25-13-11-23(12-14-25)27(31)22-9-5-2-6-10-22/h1-14,24H,15-20H2,(H,28,30)
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 16307093
- HMDB: HMDB0248016
- ChEMBL: CHEMBL3393145
- Wikipedia: AdipoRon
- chemspider: 11029953
- CAS: 924416-43-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Robert B Shultz, Nan Hai, Yinghui Zhong. Local delivery of AdipoRon from self-assembled microparticles to inhibit myelin lipid uptake and to promote lipid efflux from rat macrophages.
Journal of neural engineering.
2024 02; 21(1):. doi:
10.1088/1741-2552/ad29d5. [PMID: 38359460] - I A Pobozheva, K V Dracheva, S N Pchelina, V V Miroshnikova. [AdipoRon Effect on Expression of Lipid Metabolism Genes in Cultured Human Primary Macrophages].
Molekuliarnaia biologiia.
2023 Jul; 57(4):623-631. doi:
10.31857/s0026898423040183, edn: qlxhwk. [PMID: 37528782] - Chenchen Zhao, Bing Wu, Jinxia Li, Qianming Jiang, Juan J Loor, Menglin Liu, Linfang Chen, Yiwei Zhu, Wenwen Gao, Xiliang Du, Yuxiang Song, Guowen Liu, Lin Lei, Xinwei Li. AdipoRon alleviates fatty acid-induced lipid accumulation and mitochondrial dysfunction in bovine hepatocytes by promoting autophagy.
Journal of dairy science.
2023 May; ?(?):. doi:
10.3168/jds.2022-22723. [PMID: 37268562] - Camille M Selvais, María A Davis-López de Carrizosa, Maxime Nachit, Romain Versele, Nicolas Dubuisson, Laurence Noel, Justine Gillard, Isabelle A Leclercq, Sonia M Brichard, Michel Abou-Samra. AdipoRon enhances healthspan in middle-aged obese mice: striking alleviation of myosteatosis and muscle degenerative markers.
Journal of cachexia, sarcopenia and muscle.
2023 02; 14(1):464-478. doi:
10.1002/jcsm.13148. [PMID: 36513619] - Chong Li, Yanfang Cao, Yangguang Ren, Yudian Zhao, Xing Wu, Sujin Si, Jing Li, Qi Li, Na Zhang, Donghua Li, Guoxi Li, Xiaojun Liu, Xiangtao Kang, Ruirui Jiang, Yadong Tian. The adiponectin receptor agonist, AdipoRon, promotes reproductive hormone secretion and gonadal development via the hypothalamic-pituitary-gonadal axis in chickens.
Poultry science.
2023 Feb; 102(2):102319. doi:
10.1016/j.psj.2022.102319. [PMID: 36512870] - Liang Dai, Qian Wang, Pengfei Wang, Shangran Zhang, Luyang Tai, Xiangrui Xu, Gang Sun, Mengyu Duan, Haoliang Yuan, Zhiqi Feng. Discovery of novel AdipoRon analogues as potent anti-inflammatory agents against nonalcoholic steatohepatitis.
European journal of medicinal chemistry.
2022 Dec; 244(?):114800. doi:
10.1016/j.ejmech.2022.114800. [PMID: 36215862] - Zhongzan Cao, Ben Ma, Chengyu Cui, Jiahui Zhao, Sidi Liu, Yunqiao Qiu, Yan Zheng, Ming Gao, Xinhong Luan. Protective effects of AdipoRon on the liver of Huoyan goose fed a high-fat diet.
Poultry science.
2022 Apr; 101(4):101708. doi:
10.1016/j.psj.2022.101708. [PMID: 35150940] - Yongliang Wang, Huan Liu, Ruixin Zhang, Yuyao Xiang, Junfeng Lu, Bo Xia, Liang Peng, Jiangwei Wu. AdipoRon exerts opposing effects on insulin sensitivity via fibroblast growth factor 21-mediated time-dependent mechanisms.
The Journal of biological chemistry.
2022 03; 298(3):101641. doi:
10.1016/j.jbc.2022.101641. [PMID: 35090894] - Mahmoud M Samaha, Manar G Helal, Mohamed El-Sherbiny, Eman Said, Hatem A Salem. Diacerein versus adipoRon as adiponectin modulators in experimentally-induced end-stage type 2 diabetes mellitus in rats.
Environmental toxicology and pharmacology.
2022 Feb; 90(?):103806. doi:
10.1016/j.etap.2021.103806. [PMID: 34974166] - Yachun Han, Shan Xiong, Hao Zhao, Shikun Yang, Ming Yang, Xuejing Zhu, Na Jiang, Xiaofen Xiong, Peng Gao, Ling Wei, Ying Xiao, Lin Sun. Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy.
Cell death & disease.
2021 10; 12(11):1031. doi:
10.1038/s41419-021-04326-y. [PMID: 34718329] - Sonja Lindfors, Zydrune Polianskyte-Prause, Rim Bouslama, Eero Lehtonen, Miia Mannerla, Harry Nisen, Jukka Tienari, Hanne Salmenkari, Richard Forsgård, Tuomas Mirtti, Markku Lehto, Per-Henrik Groop, Sanna Lehtonen. Adiponectin receptor agonist AdipoRon ameliorates renal inflammation in diet-induced obese mice and endotoxin-treated human glomeruli ex vivo.
Diabetologia.
2021 08; 64(8):1866-1879. doi:
10.1007/s00125-021-05473-9. [PMID: 33987714] - Antonio Gázquez, Francisca Rodríguez, María Sánchez-Campillo, Lidia E Martínez-Gascón, Marino B Arnao, Pedro Saura-Garre, María D Albaladejo-Otón, Elvira Larqué. Adiponectin agonist treatment in diabetic pregnant rats.
The Journal of endocrinology.
2021 07; 251(1):1-13. doi:
10.1530/joe-20-0617. [PMID: 34156347] - Yan Li, Bei Song, Chengchao Ruan, WenJie Xue, Jianrong Zhao. AdipoRon Attenuates Hypertension-Induced Epithelial-Mesenchymal Transition and Renal Fibrosis via Promoting Epithelial Autophagy.
Journal of cardiovascular translational research.
2021 06; 14(3):538-545. doi:
10.1007/s12265-020-10075-8. [PMID: 33025271] - Alexander Jenke, Mariam Yazdanyar, Shunsuke Miyahara, Agunda Chekhoeva, Moritz Benjamin Immohr, Julia Kistner, Udo Boeken, Artur Lichtenberg, Payam Akhyari. AdipoRon Attenuates Inflammation and Impairment of Cardiac Function Associated With Cardiopulmonary Bypass-Induced Systemic Inflammatory Response Syndrome.
Journal of the American Heart Association.
2021 03; 10(6):e018097. doi:
10.1161/jaha.120.018097. [PMID: 33666100] - Thomas H Lee, Brian R Christie, Henriette van Praag, Kangguang Lin, Parco Ming-Fai Siu, Aimin Xu, Kwok-Fai So, Suk-Yu Yau. AdipoRon Treatment Induces a Dose-Dependent Response in Adult Hippocampal Neurogenesis.
International journal of molecular sciences.
2021 Feb; 22(4):. doi:
10.3390/ijms22042068. [PMID: 33669795] - Nina Graffmann, Audrey Ncube, Soraia Martins, Aurelian Robert Fiszl, Philipp Reuther, Martina Bohndorf, Wasco Wruck, Mathias Beller, Constantin Czekelius, James Adjaye. A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference.
Biology open.
2021 01; 10(1):. doi:
10.1242/bio.054189. [PMID: 33372064] - Toshiharu Onodera, Ebrahim Ghazvini Zadeh, Peng Xu, Ruth Gordillo, Zheng Guo, Nolwenn Joffin, Biao Yu, Philipp E Scherer, Wen-Hong Li. PEGylated AdipoRon derivatives improve glucose and lipid metabolism under insulinopenic and high-fat diet conditions.
Journal of lipid research.
2021; 62(?):100095. doi:
10.1016/j.jlr.2021.100095. [PMID: 34214600] - Daqian Gu, Yu Shi, Zhengfan Gong, Tianyang Xia, Hongmei Ren, Duofen He, Jian Yang, Yu Han, Chunyu Zeng. AdipoRon, an adiponectin receptor agonist, protects contrast-induced nephropathy by suppressing oxidative stress and inflammation via activation of the AMPK pathway.
Clinical and experimental nephrology.
2020 Nov; 24(11):989-998. doi:
10.1007/s10157-020-01944-2. [PMID: 32734507] - Zhi-Xi Duan, Chao Tu, Qing Liu, Shuang-Qing Li, Yi-Han Li, Peng Xie, Zhi-Hong Li. Adiponectin receptor agonist AdipoRon attenuates calcification of osteoarthritis chondrocytes by promoting autophagy.
Journal of cellular biochemistry.
2020 06; 121(5-6):3333-3344. doi:
10.1002/jcb.29605. [PMID: 31898335] - Michel Abou-Samra, Camille M Selvais, Raphael Boursereau, Sophie Lecompte, Laurence Noel, Sonia M Brichard. AdipoRon, a new therapeutic prospect for Duchenne muscular dystrophy.
Journal of cachexia, sarcopenia and muscle.
2020 04; 11(2):518-533. doi:
10.1002/jcsm.12531. [PMID: 31965757] - Michael L Salinas, Natividad R Fuentes, Rachel Choate, Rachel C Wright, David N McMurray, Robert S Chapkin. AdipoRon Attenuates Wnt Signaling by Reducing Cholesterol-Dependent Plasma Membrane Rigidity.
Biophysical journal.
2020 02; 118(4):885-897. doi:
10.1016/j.bpj.2019.09.009. [PMID: 31630812] - Sarah Nicolas, Nathalie Rochet, Nadine Gautier, Joëlle Chabry, Didier F Pisani. The adiponectin receptor agonist AdipoRon normalizes glucose metabolism and prevents obesity but not growth retardation induced by glucocorticoids in young mice.
Metabolism: clinical and experimental.
2020 02; 103(?):154027. doi:
10.1016/j.metabol.2019.154027. [PMID: 31778708] - Min Sha, Yaru Gao, Can Deng, Yuemeng Wan, Yuan Zhuang, Xiaochuan Hu, Ying Wang. Therapeutic effects of AdipoRon on liver inflammation and fibrosis induced by CCl4 in mice.
International immunopharmacology.
2020 Feb; 79(?):106157. doi:
10.1016/j.intimp.2019.106157. [PMID: 31911372] - Wen-Ze Xiao, Li Zhang. Adiponectin receptor agonist AdipoRon relieves endotoxin-induced acute hepatitis in mice.
Chinese medical journal.
2019 Oct; 132(20):2438-2445. doi:
10.1097/cm9.0000000000000488. [PMID: 31651516] - Xin-Hua Liu, Jiang Ping Pan, William A Bauman, Christopher P Cardozo. AdipoRon prevents myostatin-induced upregulation of fatty acid synthesis and downregulation of insulin activity in a mouse hepatocyte line.
Physiological reports.
2019 08; 7(13):e14152. doi:
10.14814/phy2.14152. [PMID: 31250564] - Yaeni Kim, Cheol Whee Park. Mechanisms of Adiponectin Action: Implication of Adiponectin Receptor Agonism in Diabetic Kidney Disease.
International journal of molecular sciences.
2019 Apr; 20(7):. doi:
10.3390/ijms20071782. [PMID: 30974901] - Qishuang Zhou, Hongkai Xiang, Ang Li, Wu Lin, Zhaoshui Huang, Junxiu Guo, Pingjie Wang, Yijie Chi, Ke Xiang, Yunsheng Xu, Libing Zhou, Kwok-Fai So, Xiaoming Chen, Xin Sun, Yi Ren. Activating Adiponectin Signaling with Exogenous AdipoRon Reduces Myelin Lipid Accumulation and Suppresses Macrophage Recruitment after Spinal Cord Injury.
Journal of neurotrauma.
2019 03; 36(6):903-918. doi:
10.1089/neu.2018.5783. [PMID: 30221582] - Xinlei Hu, Qiong Ou-Yang, Lanlan Wang, Tingting Li, Xiaoxue Xie, Jun Liu. AdipoRon prevents l-thyroxine or isoproterenol-induced cardiac hypertrophy through regulating the AMPK-related pathway.
Acta biochimica et biophysica Sinica.
2019 Jan; 51(1):20-30. doi:
10.1093/abbs/gmy152. [PMID: 30566571] - Sarah Nicolas, Delphine Debayle, Catherine Béchade, Luc Maroteaux, Anne-Sophie Gay, Pascale Bayer, Catherine Heurteaux, Alice Guyon, Joëlle Chabry. Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression.
Translational psychiatry.
2018 08; 8(1):159. doi:
10.1038/s41398-018-0210-y. [PMID: 30115912] - Sun Ryoung Choi, Ji Hee Lim, Min Young Kim, Eun Nim Kim, Yaeni Kim, Beom Soon Choi, Yong-Soo Kim, Hye Won Kim, Kyung-Min Lim, Min Jeong Kim, Cheol Whee Park. Adiponectin receptor agonist AdipoRon decreased ceramide, and lipotoxicity, and ameliorated diabetic nephropathy.
Metabolism: clinical and experimental.
2018 08; 85(?):348-360. doi:
10.1016/j.metabol.2018.02.004. [PMID: 29462574] - Panhu Zhu, Weijun Huang, Jiaming Li, Xiaodong Ma, Mengqi Hu, Yujun Wang, Qinlong Xu, Xianna Wang. Design, synthesis chalcone derivatives as AdipoR agonist for type 2 diabetes.
Chemical biology & drug design.
2018 08; 92(2):1525-1536. doi:
10.1111/cbdd.13319. [PMID: 29704399] - Ling Huang, Xiao-Hu Qu, Hui Chen, Ke-Jian Xie, Min Xiao. [The intervention effects of AdipoRon on renal injury in type 2 diabetic mice].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2018 Jun; 34(6):568-571. doi:
10.12047/j.cjap.5587.2018.127. [PMID: 31032594] - Yaeni Kim, Ji Hee Lim, Min Young Kim, Eun Nim Kim, Hye Eun Yoon, Seok Joon Shin, Bum Soon Choi, Yong-Soo Kim, Yoon Sik Chang, Cheol Whee Park. The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes.
Journal of the American Society of Nephrology : JASN.
2018 04; 29(4):1108-1127. doi:
10.1681/asn.2017060627. [PMID: 29330340] - Shu-Juan Wang, Wen-Yi Lu, Kai-Yan Liu. Adiponectin receptor agonist AdipoRon suppresses adipogenesis in C3H10T1/2 cells through the adenosine monophosphate‑activated protein kinase signaling pathway.
Molecular medicine reports.
2017 Nov; 16(5):7163-7169. doi:
10.3892/mmr.2017.7450. [PMID: 28901521] - Lei Sun, Xiaoxiao Yang, Qi Li, Peng Zeng, Ying Liu, Lipei Liu, Yuanli Chen, Miao Yu, Chuanrui Ma, Xiaoju Li, Yan Li, Rongxin Zhang, Yan Zhu, Qing Robert Miao, Jihong Han, Yajun Duan. Activation of Adiponectin Receptor Regulates Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Inhibits Lesions in ApoE-Deficient Mice.
Arteriosclerosis, thrombosis, and vascular biology.
2017 07; 37(7):1290-1300. doi:
10.1161/atvbaha.117.309630. [PMID: 28546220] - Filippo Weisz, Sonia Piccinin, Dalila Mango, Richard Teke Ngomba, Nicola B Mercuri, Ferdinando Nicoletti, Robert Nisticò. The role of adiponectin receptors in the regulation of synaptic transmission in the hippocampus.
Synapse (New York, N.Y.).
2017 05; 71(5):. doi:
10.1002/syn.21964. [PMID: 28187508] - Min Xiao, Xiao-Hu Qu, Hui Chen, Li-Qin Jin. [The effect of AdipoRon on insulin sensitivity of mouse skeletal muscle cells and its mechanism].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2017 Apr; 33(4):319-322. doi:
10.12047/j.cjap.5533.2017.078. [PMID: 29926636] - William L Holland, Jonathan Y Xia, Joshua A Johnson, Kai Sun, Mackenzie J Pearson, Ankit X Sharma, Ezekiel Quittner-Strom, Trevor S Tippetts, Ruth Gordillo, Philipp E Scherer. Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis.
Molecular metabolism.
2017 03; 6(3):267-275. doi:
10.1016/j.molmet.2017.01.002. [PMID: 28271033] - Min Xiao, Xiao-Hu Qu, Chang-Xi Li, Ju-Ping Lv, Yang Shi, Ke-Jian Xie. [AdipoRon for the treatment of type 2 diabetes in mice and its possible mechanism of the liver].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2016 Mar; 32(3):198-201. doi:
10.13459/j.cnki.cjap.2016.03.002. [PMID: 29931876] - Miki Okada-Iwabu, Toshimasa Yamauchi, Masato Iwabu, Teruki Honma, Ken-ichi Hamagami, Koichi Matsuda, Mamiko Yamaguchi, Hiroaki Tanabe, Tomomi Kimura-Someya, Mikako Shirouzu, Hitomi Ogata, Kumpei Tokuyama, Kohjiro Ueki, Tetsuo Nagano, Akiko Tanaka, Shigeyuki Yokoyama, Takashi Kadowaki. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity.
Nature.
2013 Nov; 503(7477):493-9. doi:
10.1038/nature12656. [PMID: 24172895]
