Adenosine dialdehyde (BioDeep_00000175744)
human metabolite blood metabolite
代谢物信息卡片
化学式: C10H11N5O4 (265.0811006)
中文名称: 氧化高碘酸腺苷
谱图信息:
最多检出来源 Mus musculus(blood) 33.33%
分子结构信息
SMILES: C1=NC(=C2C(=N1)N(C=N2)C(C=O)OC(CO)C=O)N
InChI: InChI=1S/C10H11N5O4/c11-9-8-10(13-4-12-9)15(5-14-8)7(3-18)19-6(1-16)2-17/h1,3-7,17H,2H2,(H2,11,12,13)
描述信息
Adenosine dialdehyde, a purine nucleoside analogue, is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM)[1]. Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo and can be used for the cancer research[1][2].
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- PubChem: 99920
- HMDB: HMDB0248007
- ChEMBL: CHEMBL281476
- chemspider: 90277
- CAS: 39798-19-1
- CAS: 34240-05-6
- medchemexpress: HY-123055
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ying Xie, Sui Ke, Jingshu Chen, Nengtai Ouyang, Yanan Tian. Epigenetic sensitization of pregnane X receptor-regulated gene expression by dimethyl sulfoxide.
Toxicology letters.
2020 Mar; 321(?):131-137. doi:
10.1016/j.toxlet.2019.12.029. [PMID: 31877331] - Yunjun Xiao, Junjie Xia, Jinquan Cheng, Haiyan Huang, Yani Zhou, Xifei Yang, Xuefen Su, Yuebin Ke, Wenhua Ling. Inhibition of S-Adenosylhomocysteine Hydrolase Induces Endothelial Dysfunction via Epigenetic Regulation of p66shc-Mediated Oxidative Stress Pathway.
Circulation.
2019 05; 139(19):2260-2277. doi:
10.1161/circulationaha.118.036336. [PMID: 30773021] - Yunjun Xiao, Wei Huang, Jinzhou Zhang, Chaoqiong Peng, Min Xia, Wenhua Ling. Increased plasma S-adenosylhomocysteine-accelerated atherosclerosis is associated with epigenetic regulation of endoplasmic reticulum stress in apoE-/- mice.
Arteriosclerosis, thrombosis, and vascular biology.
2015 Jan; 35(1):60-70. doi:
10.1161/atvbaha.114.303817. [PMID: 25359864] - Matthew I Jackson, Kristoffer Lunøe, Charlotte Gabel-Jensen, Bente Gammelgaard, Gerald F Combs. Metabolism of selenite to selenosugar and trimethylselenonium in vivo: tissue dependency and requirement for S-adenosylmethionine-dependent methylation.
The Journal of nutritional biochemistry.
2013 Dec; 24(12):2023-30. doi:
10.1016/j.jnutbio.2013.04.007. [PMID: 24139672] - Jessica A Sipkens, Paul A J Krijnen, Nynke E Hahn, Melissa Wassink, Christof Meischl, Desirée E C Smith, René J P Musters, Coen D A Stehouwer, Jan A Rauwerda, Victor W M van Hinsbergh, Hans W M Niessen. Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47(phox).
Molecular and cellular biochemistry.
2011 Dec; 358(1-2):229-39. doi:
10.1007/s11010-011-0973-4. [PMID: 21739151] - Malin Hultberg, Anders Isaksson, Anders Andersson, Björn Hultberg. The polyphenol quercetin strongly increases homocysteine production in a human hepatoma (Hep G2) cell line.
Clinical biochemistry.
2006 Feb; 39(2):160-3. doi:
10.1016/j.clinbiochem.2005.11.002. [PMID: 16330015] - Carol A Lammon, X Chris Le, Ronald D Hood. Pretreatment with periodate-oxidized adenosine enhances developmental toxicity of inorganic arsenic in mice.
Birth defects research. Part B, Developmental and reproductive toxicology.
2003 Aug; 68(4):335-43. doi:
10.1002/bdrb.10029. [PMID: 14666996] - Iván Csanaky, Zoltán Gregus. Effect of selenite on the disposition of arsenate and arsenite in rats.
Toxicology.
2003 Apr; 186(1-2):33-50. doi:
10.1016/s0300-483x(02)00604-2. [PMID: 12604169] - F Bontemps, G Van Den Berghe. Metabolism of exogenous S-adenosylmethionine in isolated rat hepatocyte suspensions: methylation of plasma-membrane phospholipids without intracellular uptake.
The Biochemical journal.
1997 Oct; 327 ( Pt 2)(?):383-9. doi:
10.1042/bj3270383. [PMID: 9359405] - R Loncar, C W Flesche, A Deussen. Determinants of the S-adenosylhomocysteine (SAH) technique for the local assessment of cardiac free cytosolic adenosine.
Journal of molecular and cellular cardiology.
1997 May; 29(5):1289-305. doi:
10.1006/jmcc.1996.0351. [PMID: 9201616] - T Hasegawa, M Mihara, K Nakamuro, Y Sayato. Mechanisms of selenium methylation and toxicity in mice treated with selenocystine.
Archives of toxicology.
1996; 71(1-2):31-8. doi:
10.1007/s002040050355. [PMID: 9010583] - J L Hoffman, K P McConnell. Periodate-oxidized adenosine inhibits the formation of dimethylselenide and trimethylselenonium ion in mice treated with selenite.
Archives of biochemistry and biophysics.
1987 May; 254(2):534-40. doi:
10.1016/0003-9861(87)90134-2. [PMID: 3579317] - R L Bartel, R T Borchardt. Effects of adenosine dialdehyde on S-adenosylhomocysteine hydrolase and S-adenosylmethionine-dependent transmethylations in mouse L929 cells.
Molecular pharmacology.
1984 May; 25(3):418-24. doi:
". [PMID: 6727864] - D M Boyle, W L Dean. Alteration of phospholipid composition of mouse liver microsomes in vivo and the effect on membrane properties.
Biochimica et biophysica acta.
1982 Jun; 688(2):667-70. doi:
10.1016/0005-2736(82)90378-9. [PMID: 7104343] - T Dobrzański, D Pieschl. Plasma immunoreactive insulin and somatotropin in delirium tremens and alcoholic hallucinosis.
Journal of studies on alcohol.
1976 Mar; 37(3):327-33. doi:
10.15288/jsa.1976.37.327. [PMID: 4667]