Aceclofenac (BioDeep_00000175654)
human metabolite blood metabolite
代谢物信息卡片
2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester
化学式: C16H13Cl2NO4 (353.02215980000005)
中文名称: 醋氯芬酸
谱图信息:
最多检出来源 Homo sapiens(blood) 98.11%
分子结构信息
SMILES: C1=CC=C(C(=C1)CC(=O)OCC(=O)O)NC2=C(C=CC=C2Cl)Cl
InChI: InChI=1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21)
描述信息
M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AB - Acetic acid derivatives and related substances
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
同义名列表
29 个代谢物同义名
2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester; 2-[(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetyl)oxy]acetic acid; 2-[(2,6-Dichlorophenyl)amino]benzeneacetate carboxymethyl ester; Glycolic acid [O-(2,6-dichloroanilino)phenyl]acetic acid ester; Glycolic acid [O-(2,6-dichloroanilino)phenyl]acetate ester; Glycolate [O-(2,6-dichloroanilino)phenyl]acetate ester; 2-[(2,6-Dichlorophenyl)amino]phenylacetoxyacetic acid; 2-((2,6-Dichlorophenyl)amino)phenylacetoxyacetic acid; 2-[(2,6-Dichlorophenyl)amino]phenylacetoxyacetate; Falcol difucrem; Airtal difucrem; Gerbin difucrem; Aceclofenacum; Aceclofenaco; Aceclofenac; Bristaflam; Preservex; Clanza CR; Beofenac; Biofenac; Cincofen; Hifenac; PR-82/3; Sanein; Falcol; Clanza; Airtal; Gerbin; Aital
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:31159
- PubChem: 71771
- HMDB: HMDB0247893
- DrugBank: DB06736
- ChEMBL: CHEMBL93645
- Wikipedia: Aceclofenac
- chemspider: 64809
- CAS: 89796-99-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sushmita Negi, Nikunj Tandel, Neeraj K Garg, Prakriti Sharma, Rajinder Kumar, Praveen Sharma, Reetesh Kumar, Sheetal Saini, Aman Sharma, Rajeev K Tyagi. Co-Delivery of Aceclofenac and Methotrexate Nanoparticles Presents an Effective Treatment for Rheumatoid Arthritis.
International journal of nanomedicine.
2024; 19(?):2149-2177. doi:
10.2147/ijn.s439359. [PMID: 38482519] - Saroj Kumar, Amresh Gupta, Chanchal Kumar Mishra, Satyawan Singh. Novel Aceclofenac-l-Cystine and Aceclofenac-Urea Cocrystals with Enhanced Oral Bioavailability.
Current drug delivery.
2021; 18(8):1174-1181. doi:
10.2174/1567201818666210218103303. [PMID: 33602085] - I N Samartsev, S A Zhivolupov, J S Butakova, M S Parshin. [The open observational study of aceclofenac and vinpocetine effectiveness and tolerability in treatment of patients with chronic cerebrovascular disease after COVID-19 (AQUA study)].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
2021; 121(11):s1-s8. doi:
10.17116/jnevro2021121111s1. [PMID: 34968019] - Narendar Dudhipala, Riyaz Phasha Mohammed, Ahmed Adel Ali Youssef, Nagaraj Banala. Effect of lipid and edge activator concentration on development of aceclofenac-loaded transfersomes gel for transdermal application: in vitro and ex vivo skin permeation.
Drug development and industrial pharmacy.
2020 Aug; 46(8):1334-1344. doi:
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PloS one.
2020; 15(9):e0238951. doi:
10.1371/journal.pone.0238951. [PMID: 32898192] - Chen Jianxian, Kalsoom Saleem, Muhammad Ijaz, Masood Ur-Rehman, Ghulam Murtaza, Mulazim Hussain Asim. Development and in vitro Evaluation of Gastro-protective Aceclofenac-loaded Self-emulsifying Drug Delivery System.
International journal of nanomedicine.
2020; 15(?):5217-5226. doi:
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2018 Sep; 116(?):1074-1081. doi:
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2018 08; 15(8):3101-3110. doi:
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2018 Jul; 32(7):e4232. doi:
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2018 Jun; 2018(?):. doi:
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2018 Mar; 56(3):233-241. doi:
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2017 10; 7(5):709-730. doi:
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Molecular pharmaceutics.
2017 06; 14(6):1883-1897. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2017 May; 102(?):85-93. doi:
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International journal of pharmaceutics.
2017 Jan; 517(1-2):413-431. doi:
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2016 Dec; 31(6):458-463. doi:
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2016 10; 30(5):1122-7. doi:
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2014 Nov; 113(?):138-48. doi:
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2014 Nov; 22(9):805-12. doi:
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2014 Oct; 37(10):1308-16. doi:
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2014; 2014(?):534210. doi:
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2013 Dec; 10(6):656-66. doi:
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Clinical therapeutics.
2013 Oct; 35(10):1528-35. doi:
10.1016/j.clinthera.2013.08.012. [PMID: 24050970] - Praveen Kumar Gaur, Suresh Purohit, Shikha Mishra. Development of aceclofenac nanovesicular system using biomaterial for transdermal delivery: physical characterization, ex vivo, in vivo, and anti-inflammatory studies.
Journal of biomaterials science. Polymer edition.
2013; 24(18):2126-41. doi:
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2012 Sep; 35(17):2219-22. doi:
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Behavioral and brain functions : BBF.
2012 Feb; 8(?):9. doi:
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