5-Chloro-3-ethyl-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-hydroxy-6-methoxybenzamide (BioDeep_00000175640)
human metabolite blood metabolite
代谢物信息卡片
化学式: C17H25ClN2O3 (340.15536099999997)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1=CC(=C(C(=C1O)C(=O)NCC2CCCN2CC)OC)Cl
InChI: InChI=1S/C17H25ClN2O3/c1-4-11-9-13(18)16(23-3)14(15(11)21)17(22)19-10-12-7-6-8-20(12)5-2/h9,12,21H,4-8,10H2,1-3H3,(H,19,22)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Jeffrey B Eells, Josiah Wilcots, Scott Sisk, Shirley X Guo-Ross. NR4A gene expression is dynamically regulated in the ventral tegmental area dopamine neurons and is related to expression of dopamine neurotransmission genes.
Journal of molecular neuroscience : MN.
2012 Mar; 46(3):545-53. doi:
10.1007/s12031-011-9642-z
. [PMID: 21932041] - Andrew B Norman, Mantana K Norman, Michael R Tabet, Vladimir L Tsibulsky, Amadeo J Pesce. Competitive dopamine receptor antagonists increase the equiactive cocaine concentration during self-administration.
Synapse (New York, N.Y.).
2011 May; 65(5):404-11. doi:
10.1002/syn.20858
. [PMID: 20812328] - Ashok Agrawal, Mahalaxmi Mohan, Sanjay Kasture, Caterina Foddis, Maria Assunta Frau, Maria Cecilia Loi, Andrea Maxia. Antidepressant activity of Ceratonia siliqua L. fruit extract, a source of polyphenols.
Natural product research.
2011 Feb; 25(4):450-6. doi:
10.1080/14786419.2010.527447
. [PMID: 21328139] - Gunnar Kleinau, Juliane Pratzka, Daniela Nürnberg, Annette Grüters, Dagmar Führer-Sakel, Heiko Krude, Josef Köhrle, Torsten Schöneberg, Heike Biebermann. Differential modulation of Beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonists.
PloS one.
2011; 6(10):e27073. doi:
10.1371/journal.pone.0027073
. [PMID: 22073124] - Gregory C Hadlock, Pei-Wen Chu, Elliot T Walters, Glen R Hanson, Annette E Fleckenstein. Methamphetamine-induced dopamine transporter complex formation and dopaminergic deficits: the role of D2 receptor activation.
The Journal of pharmacology and experimental therapeutics.
2010 Oct; 335(1):207-12. doi:
10.1124/jpet.110.166660
. [PMID: 20622144] - Xavier Belda, Antonio Armario. Dopamine D1 and D2 dopamine receptors regulate immobilization stress-induced activation of the hypothalamus-pituitary-adrenal axis.
Psychopharmacology.
2009 Oct; 206(3):355-65. doi:
10.1007/s00213-009-1613-5
. [PMID: 19621214] - Yu Shin Kim, Jung Hoon Shin, F Scott Hall, David J Linden. Dopamine signaling is required for depolarization-induced slow current in cerebellar Purkinje cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2009 Jul; 29(26):8530-8. doi:
10.1523/jneurosci.0468-09.2009
. [PMID: 19571144] - Paul J Meyer, Michael M Morgan, Laura B Kozell, Susan L Ingram. Contribution of dopamine receptors to periaqueductal gray-mediated antinociception.
Psychopharmacology.
2009 Jun; 204(3):531-40. doi:
10.1007/s00213-009-1482-y
. [PMID: 19225762] - Gregory C Hadlock, Anthony J Baucum, Jill L King, Kristen A Horner, Glen A Cook, James W Gibb, Diana G Wilkins, Glen R Hanson, Annette E Fleckenstein. Mechanisms underlying methamphetamine-induced dopamine transporter complex formation.
The Journal of pharmacology and experimental therapeutics.
2009 Apr; 329(1):169-74. doi:
10.1124/jpet.108.145631
. [PMID: 19141713] - Scott C Steffensen, Seth R Taylor, Malia L Horton, Elise N Barber, Laura T Lyle, Sarah H Stobbs, David W Allison. Cocaine disinhibits dopamine neurons in the ventral tegmental area via use-dependent blockade of GABA neuron voltage-sensitive sodium channels.
The European journal of neuroscience.
2008 Nov; 28(10):2028-40. doi:
10.1111/j.1460-9568.2008.06479.x
. [PMID: 19046384] - Leigh C P Botly, Christie L Burton, Zoë Rizos, Paul J Fletcher. Characterization of methylphenidate self-administration and reinstatement in the rat.
Psychopharmacology.
2008 Jul; 199(1):55-66. doi:
10.1007/s00213-008-1093-z
. [PMID: 18483809] - Olaf Prante, Rainer Tietze, Carsten Hocke, Stefan Löber, Harald Hübner, Torsten Kuwert, Peter Gmeiner. Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET.
Journal of medicinal chemistry.
2008 Mar; 51(6):1800-10. doi:
10.1021/jm701375u
. [PMID: 18307287] - Emanuela Izzo, Pietro Paolo Sanna, George F Koob. Impairment of dopaminergic system function after chronic treatment with corticotropin-releasing factor.
Pharmacology, biochemistry, and behavior.
2005 Aug; 81(4):701-8. doi:
10.1016/j.pbb.2005.04.017
. [PMID: 16005056] - Tianhong Pan, Wenjie Xie, Joseph Jankovic, Weidong Le. Biological effects of pramipexole on dopaminergic neuron-associated genes: relevance to neuroprotection.
Neuroscience letters.
2005 Mar; 377(2):106-9. doi:
10.1016/j.neulet.2004.11.080
. [PMID: 15740846] - Den'etsu Sutoo, Kayo Akiyama. Music improves dopaminergic neurotransmission: demonstration based on the effect of music on blood pressure regulation.
Brain research.
2004 Aug; 1016(2):255-62. doi:
10.1016/j.brainres.2004.05.018
. [PMID: 15246862] - Sean D Stocker, Matthew F Muldoon, Alan F Sved. Blunted fenfluramine-evoked prolactin secretion in hypertensive rats.
Hypertension (Dallas, Tex. : 1979).
2003 Oct; 42(4):719-24. doi:
10.1161/01.hyp.0000082807.71659.4c
. [PMID: 12885788] - Songbai Zhang, Akihiro Mizutani, Chihiro Hisatsune, Takayasu Higo, Hiroko Bannai, Tomohiro Nakayama, Mitsuharu Hattori, Katsuhiko Mikoshiba. Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells.
The Journal of biological chemistry.
2003 Feb; 278(6):4048-56. doi:
10.1074/jbc.m209960200
. [PMID: 12444087] - Jeffrey M Brown, Evan L Riddle, Verónica Sandoval, Raul K Weston, Jarom E Hanson, Michael J Crosby, Yvette V Ugarte, James W Gibb, Glen R Hanson, Annette E Fleckenstein. A single methamphetamine administration rapidly decreases vesicular dopamine uptake.
The Journal of pharmacology and experimental therapeutics.
2002 Aug; 302(2):497-501. doi:
10.1124/jpet.302.2.497
. [PMID: 12130707] - H L Kimmel, A R Joyce, F I Carroll, M J Kuhar. Dopamine D1 and D2 receptors influence dopamine transporter synthesis and degradation in the rat.
The Journal of pharmacology and experimental therapeutics.
2001 Jul; 298(1):129-40. doi:
NULL
. [PMID: 11408534]