3-(2-Chlorophenyl)-N-(1-(3-methoxyphenyl)ethyl)propan-1-amine (BioDeep_00000175632)
human metabolite blood metabolite
代谢物信息卡片
3-(2-Chlorophenyl)-N-(1-(3-methoxyphenyl)ethyl)propan-1-amine
化学式: C18H22ClNO (303.139)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C1=CC(=CC=C1)OC)NCCCC2=CC=CC=C2Cl
InChI: InChI=1S/C18H22ClNO/c1-14(16-8-5-10-17(13-16)21-2)20-12-6-9-15-7-3-4-11-18(15)19/h3-5,7-8,10-11,13-14,20H,6,9,12H2,1-2H3
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相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Anna E Davey, Katie Leach, Celine Valant, Arthur D Conigrave, Patrick M Sexton, Arthur Christopoulos. Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor.
Endocrinology.
2012 Mar; 153(3):1232-41. doi:
10.1210/en.2011-1426. [PMID: 22210744] - Osvaldo Rey, Wenhan Chang, Daniel Bikle, Nora Rozengurt, Steven H Young, Enrique Rozengurt. Negative cross-talk between calcium-sensing receptor and β-catenin signaling systems in colonic epithelium.
The Journal of biological chemistry.
2012 Jan; 287(2):1158-67. doi:
10.1074/jbc.m111.274589. [PMID: 22094462] - Mario Bonomini, Annalisa Giardinelli, Caterina Morabito, Sara Di Silvestre, Moreno Di Cesare, Natalia Di Pietro, Vittorio Sirolli, Gloria Formoso, Luigi Amoroso, Maria Addolorata Mariggiò, Assunta Pandolfi. Calcimimetic R-568 and its enantiomer S-568 increase nitric oxide release in human endothelial cells.
PloS one.
2012; 7(1):e30682. doi:
10.1371/journal.pone.0030682. [PMID: 22295103] - Jun Oh, Julia Beckmann, Jacek Bloch, Verena Hettgen, Julian Mueller, Li Li, Meike Hoemme, Marie-Luise Gross, Roland Penzel, Peter Mundel, Franz Schaefer, Claus P Schmitt. Stimulation of the calcium-sensing receptor stabilizes the podocyte cytoskeleton, improves cell survival, and reduces toxin-induced glomerulosclerosis.
Kidney international.
2011 Sep; 80(5):483-92. doi:
10.1038/ki.2011.105. [PMID: 21508926] - Neal X Chen, Sharon M Moe, Tracy Eggleston-Gulyas, Xianming Chen, William D Hoffmeyer, Robert L Bacallao, Brittney S Herbert, Vincent H Gattone. Calcimimetics inhibit renal pathology in rodent nephronophthisis.
Kidney international.
2011 Sep; 80(6):612-9. doi:
10.1038/ki.2011.139. [PMID: 21633408] - Charles Henley, Yuhua Yang, James Davis, Jenny Ying Lin Lu, Sean Morony, Wei Fan, Monica Florio, Banghua Sun, Edward Shatzen, James K Pretorius, William G Richards, David J St Jean, Christopher Fotsch, Jeff D Reagan. Discovery of a calcimimetic with differential effects on parathyroid hormone and calcitonin secretion.
The Journal of pharmacology and experimental therapeutics.
2011 Jun; 337(3):681-91. doi:
10.1124/jpet.110.178681. [PMID: 21422163] - Alice Cavanaugh, Jennifer McKenna, Ann Stepanchick, Gerda E Breitwieser. Calcium-sensing receptor biosynthesis includes a cotranslational conformational checkpoint and endoplasmic reticulum retention.
The Journal of biological chemistry.
2010 Jun; 285(26):19854-64. doi:
10.1074/jbc.m110.124792. [PMID: 20421307] - Daniel Alvarez-Hernández, Ignacio González-Suárez, José L Fernández-Martín, Isabel Rodríguez, Iñigo Santamaría, Eliecer Coto, Jorge B Cannata-Andía. Residue 826 in the calcium-sensing receptor is implicated in the response to calcium and to R-568 calcimimetic compound.
Calcified tissue international.
2010 Mar; 86(3):227-33. doi:
10.1007/s00223-009-9298-7. [PMID: 20130845] - Giovanna Valenti, Annalisa Mira, Lisa Mastrofrancesco, Domenica Rita Lasorsa, Marianna Ranieri, Maria Svelto. Differential modulation of intracellular Ca2+ responses associated with calcium-sensing receptor activation in renal collecting duct cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2010; 26(6):901-12. doi:
10.1159/000323999. [PMID: 21220921] - Jenny Ying Lin Lu, Yuhua Yang, Gilles Gnacadja, Arthur Christopoulos, Jeff D Reagan. Effect of the calcimimetic R-568 [3-(2-chlorophenyl)-N-((1R)-1-(3-methoxyphenyl)ethyl)-1-propanamine] on correcting inactivating mutations in the human calcium-sensing receptor.
The Journal of pharmacology and experimental therapeutics.
2009 Dec; 331(3):775-86. doi:
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Journal of hypertension.
2009 Oct; 27(10):1980-7. doi:
10.1097/hjh.0b013e32832f0d22. [PMID: 19593209] - Vardit Lavi-Moshayoff, Justin Silver, Tally Naveh-Many. Human PTH gene regulation in vivo using transgenic mice.
American journal of physiology. Renal physiology.
2009 Sep; 297(3):F713-9. doi:
10.1152/ajprenal.00161.2009. [PMID: 19570881] - Sharon M Moe, Mark F Seifert, Neal X Chen, Rachel M Sinders, Xianming Chen, Dana Duan, Charles Henley, Dave Martin, Vincent H Gattone. R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD).
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2009 Aug; 24(8):2371-7. doi:
10.1093/ndt/gfp078. [PMID: 19258382] - Michael P Greenwood, Gert Flik, Graham F Wagner, Richard J Balment. The corpuscles of Stannius, calcium-sensing receptor, and stanniocalcin: responses to calcimimetics and physiological challenges.
Endocrinology.
2009 Jul; 150(7):3002-10. doi:
10.1210/en.2008-1758. [PMID: 19299449] - Vincent H Gattone, Neal X Chen, Rachel M Sinders, Mark F Seifert, Danxia Duan, David Martin, Charles Henley, Sharon M Moe. Calcimimetic inhibits late-stage cyst growth in ADPKD.
Journal of the American Society of Nephrology : JASN.
2009 Jul; 20(7):1527-32. doi:
10.1681/asn.2008090927. [PMID: 19423689] - Vicente E Torres. Type II calcimimetics and polycystic kidney disease: unanswered questions.
Journal of the American Society of Nephrology : JASN.
2009 Jul; 20(7):1421-5. doi:
10.1681/asn.2009050501. [PMID: 19520753] - Kumiko Nakagawa, Niru Parekh, Nadezda Koleganova, Eberhard Ritz, Franz Schaefer, Claus Peter Schmitt. Acute cardiovascular effects of the calcimimetic R-568 and its enantiomer S-568 in rats.
Pediatric nephrology (Berlin, Germany).
2009 Jul; 24(7):1385-9. doi:
10.1007/s00467-009-1153-6. [PMID: 19280225] - Ognen Ivanovski, Igor G Nikolov, Nobuhiko Joki, Axelle Caudrillier, Olivier Phan, Romuald Mentaverri, Julien Maizel, Yasuhiro Hamada, Thao Nguyen-Khoa, Masafumi Fukagawa, Said Kamel, Bernard Lacour, Tilman B Drüeke, Ziad A Massy. The calcimimetic R-568 retards uremia-enhanced vascular calcification and atherosclerosis in apolipoprotein E deficient (apoE-/-) mice.
Atherosclerosis.
2009 Jul; 205(1):55-62. doi:
10.1016/j.atherosclerosis.2008.10.043. [PMID: 19118829] - Morris Nechama, Iddo Z Ben-Dov, Justin Silver, Tally Naveh-Many. Regulation of PTH mRNA stability by the calcimimetic R568 and the phosphorus binder lanthanum carbonate in CKD.
American journal of physiology. Renal physiology.
2009 Apr; 296(4):F795-800. doi:
10.1152/ajprenal.90625.2008. [PMID: 19129257] - Xiaofang Wang, Peter C Harris, Stefan Somlo, Daniel Batlle, Vicente E Torres. Effect of calcium-sensing receptor activation in models of autosomal recessive or dominant polycystic kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2009 Feb; 24(2):526-34. doi:
10.1093/ndt/gfn527. [PMID: 18826972] - Masih-ul Alam, John Paul Kirton, Fiona L Wilkinson, Emily Towers, Smeeta Sinha, Mansour Rouhi, Thomas N Vizard, Andrew P Sage, David Martin, Donald T Ward, Marie Yvonne Alexander, Daniela Riccardi, Ann E Canfield. Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells.
Cardiovascular research.
2009 Feb; 81(2):260-8. doi:
10.1093/cvr/cvn279. [PMID: 18852253] - Nadezda Koleganova, Grzegorz Piecha, Eberhard Ritz, Claus Peter Schmitt, Marie-Luise Gross. A calcimimetic (R-568), but not calcitriol, prevents vascular remodeling in uremia.
Kidney international.
2009 Jan; 75(1):60-71. doi:
10.1038/ki.2008.490. [PMID: 19092814] - Ziyad Al-Aly. The new role of calcimimetics as vasculotropic agents.
Kidney international.
2009 Jan; 75(1):9-12. doi:
10.1038/ki.2008.563. [PMID: 19092812] - Brenda A Finney, Pierre M del Moral, William J Wilkinson, Sebastien Cayzac, Martin Cole, David Warburton, Paul J Kemp, Daniela Riccardi. Regulation of mouse lung development by the extracellular calcium-sensing receptor, CaR.
The Journal of physiology.
2008 Dec; 586(24):6007-19. doi:
10.1113/jphysiol.2008.161687. [PMID: 18955379] - Ramona Rus, Christine Haag, Christiane Bumke-Vogt, Volker Bähr, Bernhard Mayr, Matthias Möhlig, Egbert Schulze, Karin Frank-Raue, Friedhelm Raue, Christof Schöfl. Novel inactivating mutations of the calcium-sensing receptor: the calcimimetic NPS R-568 improves signal transduction of mutant receptors.
The Journal of clinical endocrinology and metabolism.
2008 Dec; 93(12):4797-803. doi:
10.1210/jc.2008-1076. [PMID: 18796518] - Grzegorz Piecha, Gabor Kokeny, Kumiko Nakagawa, Nadezda Koleganova, Aman Geldyyev, Irina Berger, Eberhard Ritz, Claus Peter Schmitt, Marie-Luise Gross. Calcimimetic R-568 or calcitriol: equally beneficial on progression of renal damage in subtotally nephrectomized rats.
American journal of physiology. Renal physiology.
2008 Apr; 294(4):F748-57. doi:
10.1152/ajprenal.00220.2007. [PMID: 18199601] - Hiroaki Ogata, Fumihiko Koiwa, Eriko Kinugasa, Tadao Akizawa. CKD-MBD: impact on management of kidney disease.
Clinical and experimental nephrology.
2007 Dec; 11(4):261-268. doi:
10.1007/s10157-007-0492-5. [PMID: 18085385] - Paul E Harrington, Christopher Fotsch. Calcium sensing receptor activators: calcimimetics.
Current medicinal chemistry.
2007; 14(28):3027-34. doi:
10.2174/092986707782794096. [PMID: 18220738] - V Shalhoub, E Shatzen, C Henley, M Boedigheimer, J McNinch, R Manoukian, M Damore, D Fitzpatrick, K Haas, B Twomey, P Kiaei, S Ward, D L Lacey, D Martin. Calcification inhibitors and Wnt signaling proteins are implicated in bovine artery smooth muscle cell calcification in the presence of phosphate and vitamin D sterols.
Calcified tissue international.
2006 Dec; 79(6):431-42. doi:
10.1007/s00223-006-0126-z. [PMID: 17171500] - Nobuo Nagano. [Calcium receptor/calcium-sensing receptor].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
2006 Sep; 128(3):188-90. doi:
NULL. [PMID: 17139821] - Apolonia Rybczyńska, Konrad Boblewski, Artur Lehmann, Czesława Orlewska, Henryk Foks. Pharmacological activity of calcimimetic NPS R-568 administered intravenously in rats: dose dependency.
Pharmacological reports : PR.
2006 Jul; 58(4):533-9. doi:
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American journal of kidney diseases : the official journal of the National Kidney Foundation.
2006 May; 47(5):715-26. doi:
10.1053/j.ajkd.2006.01.015. [PMID: 16632010] - Nobuo Nagano. Pharmacological and clinical properties of calcimimetics: calcium receptor activators that afford an innovative approach to controlling hyperparathyroidism.
Pharmacology & therapeutics.
2006 Mar; 109(3):339-65. doi:
10.1016/j.pharmthera.2005.06.019. [PMID: 16102839] - Tobias Odenwald, Kumiko Nakagawa, Charlotte Hadtstein, Frank Roesch, Peter Gohlke, Eberhard Ritz, Franz Schaefer, Claus Peter Schmitt. Acute blood pressure effects and chronic hypotensive action of calcimimetics in uremic rats.
Journal of the American Society of Nephrology : JASN.
2006 Mar; 17(3):655-62. doi:
10.1681/asn.2005090914. [PMID: 16421225] - Ignacio Lopez, Escolastico Aguilera-Tejero, Francisco J Mendoza, Yolanda Almaden, Jose Perez, David Martin, Mariano Rodriguez. Calcimimetic R-568 decreases extraosseous calcifications in uremic rats treated with calcitriol.
Journal of the American Society of Nephrology : JASN.
2006 Mar; 17(3):795-804. doi:
10.1681/asn.2005040342. [PMID: 16467452] - Ronen Levi, Iddo Z Ben-Dov, Vardit Lavi-Moshayoff, Maya Dinur, David Martin, Tally Naveh-Many, Justin Silver. Increased parathyroid hormone gene expression in secondary hyperparathyroidism of experimental uremia is reversed by calcimimetics: correlation with posttranslational modification of the trans acting factor AUF1.
Journal of the American Society of Nephrology : JASN.
2006 Jan; 17(1):107-12. doi:
10.1681/asn.2005070679. [PMID: 16291838] - Eberhard Ritz, Marie-Luise Gross, Ralf Dikow. Role of calcium-phosphorous disorders in the progression of renal failure.
Kidney international. Supplement.
2005 Dec; ?(99):S66-70. doi:
10.1111/j.1523-1755.2005.09912.x. [PMID: 16336579] - Kausik Ray, Justin Tisdale, Robert H Dodd, Philippe Dauban, Martial Ruat, John K Northup. Calindol, a positive allosteric modulator of the human Ca(2+) receptor, activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca(2+).
The Journal of biological chemistry.
2005 Nov; 280(44):37013-20. doi:
10.1074/jbc.m506681200. [PMID: 16135510] - P Ureña, N Legoupil, M C de Vernejoul. [Calcimimetics, mechanisms of action and therapeutic applications].
Presse medicale (Paris, France : 1983).
2005 Sep; 34(15):1095-100. doi:
10.1016/s0755-4982(05)84125-9. [PMID: 16334889] - John Cunningham. [Management of secondary hyperparathyroidism].
Clinical calcium.
2005 Sep; 15 Suppl 1(?):217-24. doi:
NULL. [PMID: 16279027] - Jill S Lindberg. Calcimimetics: a new tool for management of hyperparathyroidism and renal osteodystrophy in patients with chronic kidney disease.
Kidney international. Supplement.
2005 Jun; ?(95):S33-6. doi:
10.1111/j.1523-1755.2005.09505.x. [PMID: 15882311] - Grzegorz Piecha, Jerzy Chudek, Andrzej Wiecek. [Calcimimetics--a new treatment for hyperparathyroidism?].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
2005 May; 18(107):581-4. doi:
NULL. [PMID: 16161961] - Nobuo Nagano, Edward F Nemeth. Functional proteins involved in regulation of intracellular Ca(2+) for drug development: the extracellular calcium receptor and an innovative medical approach to control secondary hyperparathyroidism by calcimimetics.
Journal of pharmacological sciences.
2005 Mar; 97(3):355-60. doi:
10.1254/jphs.fmj04007x6. [PMID: 15781990] - Apolonia Rybczyńska, Konrad Boblewski, Artur Lehmann, Czeslawa Orlewska, Henryk Foks, Krystyna Drewnowska, Anzelm Hoppe. Calcimimetic NPS R-568 induces hypotensive effect in spontaneously hypertensive rats.
American journal of hypertension.
2005 Mar; 18(3):364-71. doi:
10.1016/j.amjhyper.2004.10.019. [PMID: 15797655] - Masahide Mizobuchi, Ikuji Hatamura, Hiroaki Ogata, Fumie Saji, Susumu Uda, Kazuhiro Shiizaki, Toshifumi Sakaguchi, Shigeo Negi, Eriko Kinugasa, Shozo Koshikawa, Tadao Akizawa. Calcimimetic compound upregulates decreased calcium-sensing receptor expression level in parathyroid glands of rats with chronic renal insufficiency.
Journal of the American Society of Nephrology : JASN.
2004 Oct; 15(10):2579-87. doi:
10.1097/01.asn.0000141016.20133.33. [PMID: 15466262] - William G Goodman. Calcimimetic agents for the treatment of secondary hyperparathyroidism.
Seminars in nephrology.
2004 Sep; 24(5):460-3. doi:
10.1016/j.semnephrol.2004.06.006. [PMID: 15490411] - Tilman B Drüeke. Modulation and action of the calcium-sensing receptor.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2004 Aug; 19 Suppl 5(?):V20-26. doi:
10.1093/ndt/gfh1052. [PMID: 15284356] - Min Pi, L Darryl Quarles. A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2004 May; 19(5):862-9. doi:
10.1359/jbmr.040114. [PMID: 15068510] - William G Goodman. Calcimimetic agents and secondary hyperparathyroidism: rationale for use and results from clinical trials.
Pediatric nephrology (Berlin, Germany).
2003 Dec; 18(12):1206-10. doi:
10.1007/s00467-003-1290-2. [PMID: 14586685] - Qisheng Tu, Min Pi, L Darryl Quarles. Calcyclin mediates serum response element (SRE) activation by an osteoblastic extracellular cation-sensing mechanism.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2003 Oct; 18(10):1825-33. doi:
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Kidney international. Supplement.
2003 Jun; ?(85):S91-6. doi:
10.1046/j.1523-1755.63.s85.22.x. [PMID: 12753275] - Hiroaki Ogata, Eberhard Ritz, Giulio Odoni, Kerstin Amann, Stephan R Orth. Beneficial effects of calcimimetics on progression of renal failure and cardiovascular risk factors.
Journal of the American Society of Nephrology : JASN.
2003 Apr; 14(4):959-67. doi:
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Medicina.
2003; 63(2):165-71. doi:
NULL. [PMID: 12793088] - Apolonia Rybczyńska, Anzelm Hoppe. [Calcimimmetic and calcilytics: new perspectives of correction of abnormal parathormone (PTH) secretion].
Przeglad lekarski.
2003; 60(6):418-24. doi:
NULL. [PMID: 14974181] - Min Pi, Robert F Spurney, Qisheng Tu, Todd Hinson, L Darryl Quarles. Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor.
Endocrinology.
2002 Oct; 143(10):3830-8. doi:
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European journal of pharmacology.
2002 Jul; 447(2-3):271-8. doi:
10.1016/s0014-2999(02)01849-6. [PMID: 12151018] - William G Goodman, Stewart A Turner. Future role of calcimimetics in end-stage renal disease.
Advances in renal replacement therapy.
2002 Jul; 9(3):200-8. doi:
10.1053/jarr.2002.34841. [PMID: 12203202] - Kausik Ray, John Northup. Evidence for distinct cation and calcimimetic compound (NPS 568) recognition domains in the transmembrane regions of the human Ca2+ receptor.
The Journal of biological chemistry.
2002 May; 277(21):18908-13. doi:
10.1074/jbc.m202113200. [PMID: 11880385] - Tilman B Drüeke. Treatment of secondary hyperparathyroidism with vitamin D derivatives and calcimimetics before and after start of dialysis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2002; 17 Suppl 11(?):20-2. doi:
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Annual review of medicine.
2001; 52(?):203-20. doi:
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Kidney international.
2001 Jan; 59(1):386-7. doi:
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