Lysyl-aspartyl-glutamyl-leucine (BioDeep_00000175610)

   

human metabolite blood metabolite


代谢物信息卡片


2-{[4-carboxy-2-({3-carboxy-2-[(2,6-diamino-1-hydroxyhexylidene)amino]-1-hydroxypropylidene}amino)-1-hydroxybutylidene]amino}-4-methylpentanoate

化学式: C21H37N5O9 (503.2591152)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 96.3%

分子结构信息

SMILES: CC(C)CC(C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCCCN)N
InChI: InChI=1S/C21H37N5O9/c1-11(2)9-15(21(34)35)26-19(32)13(6-7-16(27)28)24-20(33)14(10-17(29)30)25-18(31)12(23)5-3-4-8-22/h11-15H,3-10,22-23H2,1-2H3,(H,24,33)(H,25,31)(H,26,32)(H,27,28)(H,29,30)(H,34,35)



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Katsuhiro Nakanishi, Shota Morikane, Nao Hosokawa, Yuka Kajihara, Kohta Kurohane, Yasuo Niwa, Hirokazu Kobayashi, Yasuyuki Imai. Plant-derived secretory component forms secretory IgA with shiga toxin 1-specific dimeric IgA produced by mouse cells and whole plants. Plant cell reports. 2019 Feb; 38(2):161-172. doi: 10.1007/s00299-018-2358-6. [PMID: 30506369]
  • Yuan-Yuan Fu, Jin Zhao, Jong-Hwa Park, Geun-Won Choi, Kong Young Park, Youn Hyung Lee, In Sik Chung. Human colorectal cancer antigen GA733-2-Fc fused to endoplasmic reticulum retention motif KDEL enhances its immunotherapeutic effects. Journal of cancer research and therapeutics. 2018 Sep; 14(Supplement):S748-S757. doi: 10.4103/0973-1482.199445. [PMID: 30249898]
  • Georg Hierl, Timo Höwing, Erika Isono, Friedrich Lottspeich, Christine Gietl. Ex vivo processing for maturation of Arabidopsis KDEL-tailed cysteine endopeptidase 2 (AtCEP2) pro-enzyme and its storage in endoplasmic reticulum derived organelles. Plant molecular biology. 2014 Apr; 84(6):605-20. doi: 10.1007/s11103-013-0157-6. [PMID: 24287716]
  • Riccardo Battelli, Lara Lombardi, Piero Picciarelli, Roberto Lorenzi, Lorenzo Frigerio, Hilary J Rogers. Expression and localisation of a senescence-associated KDEL-cysteine protease from Lilium longiflorum tepals. Plant science : an international journal of experimental plant biology. 2014 Jan; 214(?):38-46. doi: 10.1016/j.plantsci.2013.09.011. [PMID: 24268162]
  • Antônio J Rocha, Emanoella L Soares, José H Costa, Washington L G Costa, Arlete A Soares, Fábio C S Nogueira, Gilberto B Domont, Francisco A P Campos. Differential expression of cysteine peptidase genes in the inner integument and endosperm of developing seeds of Jatropha curcas L. (Euphorbiaceae). Plant science : an international journal of experimental plant biology. 2013 Dec; 213(?):30-7. doi: 10.1016/j.plantsci.2013.08.009. [PMID: 24157205]
  • François-Xavier Campbell-Valois, Matthias Trost, Magali Chemali, Brian D Dill, Annie Laplante, Sophie Duclos, Shayan Sadeghi, Christiane Rondeau, Isabel C Morrow, Christina Bell, Etienne Gagnon, Kiyokata Hatsuzawa, Pierre Thibault, Michel Desjardins. Quantitative proteomics reveals that only a subset of the endoplasmic reticulum contributes to the phagosome. Molecular & cellular proteomics : MCP. 2012 Jul; 11(7):M111.016378. doi: 10.1074/mcp.m111.016378. [PMID: 22427703]
  • Shinichi Takahashi, Yoshikane Izawa, Norihiro Suzuki. Astroglial pentose phosphate pathway rates in response to high-glucose environments. ASN neuro. 2012 Mar; 4(2):. doi: 10.1042/an20120002. [PMID: 22300409]
  • Zhe Lu, Kyung-Jin Lee, Yingxue Shao, Jeong-Hwan Lee, Yangkang So, Young-Kug Choo, Doo-Byoung Oh, Kyung-A Hwang, Seung Han Oh, Yeon Soo Han, Kisung Ko. Expression of GA733-Fc fusion protein as a vaccine candidate for colorectal cancer in transgenic plants. Journal of biomedicine & biotechnology. 2012; 2012(?):364240. doi: 10.1155/2012/364240. [PMID: 22675251]
  • Shinya Matsukawa, Yuki Moriyama, Tadayoshi Hayata, Haruka Sasaki, Yuzuru Ito, Makoto Asashima, Hiroki Kuroda. KDEL tagging: a method for generating dominant-negative inhibitors of the secretion of TGF-beta superfamily proteins. The International journal of developmental biology. 2012; 56(5):351-6. doi: 10.1387/ijdb.123514sm. [PMID: 22811269]
  • Stanley Ck Cheung, Li-Zhong Liu, Lin-Lin Lan, Qiao-Quan Liu, Samuel Sm Sun, Juliana Cn Chan, Peter Cy Tong. Glucose lowering effect of transgenic human insulin-like growth factor-I from rice: in vitro and in vivo studies. BMC biotechnology. 2011 Apr; 11(?):37. doi: 10.1186/1472-6750-11-37. [PMID: 21486461]
  • Pierre-Emmanuel Rautou, Dominique Cazals-Hatem, Richard Moreau, Claire Francoz, Gérard Feldmann, Didier Lebrec, Eric Ogier-Denis, Pierre Bedossa, Dominique Valla, François Durand. Acute liver cell damage in patients with anorexia nervosa: a possible role of starvation-induced hepatocyte autophagy. Gastroenterology. 2008 Sep; 135(3):840-8, 848.e1. doi: 10.1053/j.gastro.2008.05.055. [PMID: 18644371]
  • Sergio Medina-Godoy, Angel Valdez-Ortiz, María Elena Valverde, Octavio Paredes-López. Endoplasmic reticulum-retention C-terminal sequence enhances production of an 11S seed globulin from Amaranthus hypochondriacus in Pichia pastoris. Biotechnology journal. 2006 Oct; 1(10):1085-92. doi: 10.1002/biot.200600126. [PMID: 17004299]
  • Dean Gilham, Mustafa Alam, Wenhui Gao, Dennis E Vance, Richard Lehner. Triacylglycerol hydrolase is localized to the endoplasmic reticulum by an unusual retrieval sequence where it participates in VLDL assembly without utilizing VLDL lipids as substrates. Molecular biology of the cell. 2005 Feb; 16(2):984-96. doi: 10.1091/mbc.e04-03-0224. [PMID: 15601899]
  • Giles P Saville, Alexandra L Patmanidi, Robert D Possee, Linda A King. Deletion of the Autographa californica nucleopolyhedrovirus chitinase KDEL motif and in vitro and in vivo analysis of the modified virus. The Journal of general virology. 2004 Apr; 85(Pt 4):821-831. doi: 10.1099/vir.0.19732-0. [PMID: 15039525]
  • Takashi Okamoto, Tomoo Shimada, Ikuko Hara-Nishimura, Mikio Nishimura, Takao Minamikawa. C-terminal KDEL sequence of a KDEL-tailed cysteine proteinase (sulfhydryl-endopeptidase) is involved in formation of KDEL vesicle and in efficient vacuolar transport of sulfhydryl-endopeptidase. Plant physiology. 2003 Aug; 132(4):1892-900. doi: 10.1104/pp.103.021147. [PMID: 12913146]
  • Ming Ying, Ragna Sannerud, Torgeir Flatmark, Jaakko Saraste. Colocalization of Ca2+-ATPase and GRP94 with p58 and the effects of thapsigargin on protein recycling suggest the participation of the pre-Golgi intermediate compartment in intracellular Ca2+ storage. European journal of cell biology. 2002 Sep; 81(9):469-83. doi: 10.1078/0171-9335-00266. [PMID: 12416724]
  • Christopher M Cabral, Yan Liu, Kelley W Moremen, Richard N Sifers. Organizational diversity among distinct glycoprotein endoplasmic reticulum-associated degradation programs. Molecular biology of the cell. 2002 Aug; 13(8):2639-50. doi: 10.1091/mbc.e02-02-0068. [PMID: 12181335]
  • E Torres, P Gonzalez-Melendi, E Stöger, P Shaw, R M Twyman, L Nicholson, C Vaquero, R Fischer, P Christou, Y Perrin. Native and artificial reticuloplasmins co-accumulate in distinct domains of the endoplasmic reticulum and in post-endoplasmic reticulum compartments. Plant physiology. 2001 Nov; 127(3):1212-23. doi: 10.1104/pp.010260. [PMID: 11706200]
  • L Frigerio, A Pastres, A Prada, A Vitale. Influence of KDEL on the fate of trimeric or assembly-defective phaseolin: selective use of an alternative route to vacuoles. The Plant cell. 2001 May; 13(5):1109-26. doi: 10.1105/tpc.13.5.1109. [PMID: 11340185]
  • M Schmid, D J Simpson, H Sarioglu, F Lottspeich, C Gietl. The ricinosomes of senescing plant tissue bud from the endoplasmic reticulum. Proceedings of the National Academy of Sciences of the United States of America. 2001 Apr; 98(9):5353-8. doi: 10.1073/pnas.061038298. [PMID: 11296243]
  • A Sepp, C A Farrar, T Dorling, T Cairns, A J George, R I Lechler. Inhibition of expression of the Galalpha1-3Gal epitope on porcine cells using an intracellular single-chain antibody directed against alpha1,3galactosyltransferase. Journal of immunological methods. 1999 Dec; 231(1-2):191-205. doi: 10.1016/s0022-1759(99)00134-9. [PMID: 10648938]
  • L Meunier, S Bourgerie, R Mayer, A C Roche, M Monsigny. Optimized conditions to couple two water-soluble biomolecules through alkylamine thiolation and thioetherification. Bioconjugate chemistry. 1999 Mar; 10(2):206-12. doi: 10.1021/bc980069k. [PMID: 10077469]
  • F Mallard, C Antony, D Tenza, J Salamero, B Goud, L Johannes. Direct pathway from early/recycling endosomes to the Golgi apparatus revealed through the study of shiga toxin B-fragment transport. The Journal of cell biology. 1998 Nov; 143(4):973-90. doi: 10.1083/jcb.143.4.973. [PMID: 9817755]
  • M Schmid, D Simpson, F Kalousek, C Gietl. A cysteine endopeptidase with a C-terminal KDEL motif isolated from castor bean endosperm is a marker enzyme for the ricinosome, a putative lytic compartment. Planta. 1998 Oct; 206(3):466-75. doi: 10.1007/s004250050423. [PMID: 9763713]
  • A Schouten, J Roosien, J M de Boer, A Wilmink, M N Rosso, D Bosch, W J Stiekema, F J Gommers, J Bakker, A Schots. Improving scFv antibody expression levels in the plant cytosol. FEBS letters. 1997 Sep; 415(2):235-41. doi: 10.1016/s0014-5793(97)01129-0. [PMID: 9351003]
  • L Johannes, D Tenza, C Antony, B Goud. Retrograde transport of KDEL-bearing B-fragment of Shiga toxin. The Journal of biological chemistry. 1997 Aug; 272(31):19554-61. doi: 10.1074/jbc.272.31.19554. [PMID: 9235960]
  • A Altmeyer, R G Maki, A M Feldweg, M Heike, V P Protopopov, S K Masur, P K Srivastava. Tumor-specific cell surface expression of the-KDEL containing, endoplasmic reticular heat shock protein gp96. International journal of cancer. 1996 Aug; 69(4):340-9. doi: 10.1002/(sici)1097-0215(19960822)69:4<340::aid-ijc18>3.0.co;2-9. [PMID: 8797880]
  • A A Scheel, H R Pelham. Purification and characterization of the human KDEL receptor. Biochemistry. 1996 Aug; 35(31):10203-9. doi: 10.1021/bi960807x. [PMID: 8756485]
  • S B Patel, S M Grundy. Interactions between microsomal triglyceride transfer protein and apolipoprotein B within the endoplasmic reticulum in a heterologous expression system. The Journal of biological chemistry. 1996 Aug; 271(31):18686-94. doi: 10.1074/jbc.271.31.18686. [PMID: 8702523]
  • I V Majoul, P I Bastiaens, H D Söling. Transport of an external Lys-Asp-Glu-Leu (KDEL) protein from the plasma membrane to the endoplasmic reticulum: studies with cholera toxin in Vero cells. The Journal of cell biology. 1996 May; 133(4):777-89. doi: 10.1083/jcb.133.4.777. [PMID: 8666663]
  • V Natarajan, K B Holven, S Reppe, R Blomhoff, J O Moskaug. The C-terminal RNLL sequence of the plasma retinol-binding protein is not responsible for its intracellular retention. Biochemical and biophysical research communications. 1996 Apr; 221(2):374-9. doi: 10.1006/bbrc.1996.0603. [PMID: 8619863]
  • M N Rosso, A Schouten, J Roosien, T Borst-Vrenssen, R S Hussey, F J Gommers, J Bakker, A Schots, P Abad. Expression and functional characterization of a single chain Fv antibody directed against secretions involved in plant nematode infection process. Biochemical and biophysical research communications. 1996 Mar; 220(2):255-63. doi: 10.1006/bbrc.1996.0428. [PMID: 8645292]
  • G Martire, G Mottola, M C Pascale, N Malagolini, I Turrini, F Serafini-Cessi, M R Jackson, S Bonatti. Different fate of a single reporter protein containing KDEL or KKXX targeting signals stably expressed in mammalian cells. The Journal of biological chemistry. 1996 Feb; 271(7):3541-7. doi: 10.1074/jbc.271.7.3541. [PMID: 8631959]
  • A Schouten, J Roosien, F A van Engelen, G A de Jong, A W Borst-Vrenssen, J F Zilverentant, D Bosch, W J Stiekema, F J Gommers, A Schots, J Bakker. The C-terminal KDEL sequence increases the expression level of a single-chain antibody designed to be targeted to both the cytosol and the secretory pathway in transgenic tobacco. Plant molecular biology. 1996 Feb; 30(4):781-93. doi: 10.1007/bf00019011. [PMID: 8624409]
  • E Tagge, J Chandler, B L Tang, W Hong, M C Willingham, A Frankel. Cytotoxicity of KDEL-terminated ricin toxins correlates with distribution of the KDEL receptor in the Golgi. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 1996 Feb; 44(2):159-65. doi: 10.1177/44.2.8609372. [PMID: 8609372]
  • S Munro. An investigation of the role of transmembrane domains in Golgi protein retention. The EMBO journal. 1995 Oct; 14(19):4695-704. doi: 10.1002/j.1460-2075.1995.tb00151.x. [PMID: 7588599]
  • H Y Yun, B A Eipper. Addition of an endoplasmic reticulum retention/retrieval signal does not block maturation of enzymatically active peptidylglycine alpha-amidating monooxygenase. The Journal of biological chemistry. 1995 Jun; 270(25):15412-6. doi: 10.1074/jbc.270.25.15412. [PMID: 7797530]
  • T Okamoto, H Nakayama, K Seta, T Isobe, T Minamikawa. Posttranslational processing of a carboxy-terminal propeptide containing a KDEL sequence of plant vacuolar cysteine endopeptidase (SH-EP). FEBS letters. 1994 Aug; 351(1):31-4. doi: 10.1016/0014-5793(94)00809-4. [PMID: 8076688]
  • R M Napier, L C Fowke, C Hawes, M Lewis, H R Pelham. Immunological evidence that plants use both HDEL and KDEL for targeting proteins to the endoplasmic reticulum. Journal of cell science. 1992 Jun; 102 ( Pt 2)(?):261-71. doi: 10.1242/jcs.102.2.261. [PMID: 1383243]
  • F Peter, P Nguyen Van, H D Söling. Different sorting of Lys-Asp-Glu-Leu proteins in rat liver. The Journal of biological chemistry. 1992 May; 267(15):10631-7. doi: 10.1016/s0021-9258(19)50064-3. [PMID: 1316906]
  • B L Tang, S H Wong, S H Low, W Hong. Retention of a type II surface membrane protein in the endoplasmic reticulum by the Lys-Asp-Glu-Leu sequence. The Journal of biological chemistry. 1992 Apr; 267(10):7072-6. doi: NULL. [PMID: 1348058]