4-Butyl-5-hydroxy-1,2-diphenylpyrazol-3-one (BioDeep_00000175561)
human metabolite blood metabolite
代谢物信息卡片
4-butyl-5-hydroxy-1,2-diphenyl-2,3-dihydro-1H-pyrazol-3-one
化学式: C19H20N2O2 (308.15247)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 98.11%
分子结构信息
SMILES: CCCCC1=C(N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3)O
InChI: InChI=1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,22H,2-3,14H2,1H3
数据库引用编号
分类词条
相关代谢途径
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BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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American journal of veterinary research.
2008 Feb; 69(2):167-73. doi:
10.2460/ajvr.69.2.167. [PMID: 18241011] - Yukihiro Kuroda, Madoka Saito, Harumi Sakai, Takashi Yamaoka. Rapid characterization of drug-drug interaction in plasma protein binding using a surface plasmon resonance biosensor.
Drug metabolism and pharmacokinetics.
2008; 23(2):120-7. doi:
10.2133/dmpk.23.120. [PMID: 18445992] - P Z Vroon, B van der Wagt, J M Koornneef, G R Davies. Problems in obtaining precise and accurate Sr isotope analysis from geological materials using laser ablation MC-ICPMS.
Analytical and bioanalytical chemistry.
2008 Jan; 390(2):465-76. doi:
10.1007/s00216-007-1742-9. [PMID: 18080118] - Brian Kornblit, Lea Munthe-Fog, Hans O Madsen, Jens Strøm, Lars Vindeløv, Peter Garred. Association of HMGB1 polymorphisms with outcome in patients with systemic inflammatory response syndrome.
Critical care (London, England).
2008; 12(3):R83. doi:
10.1186/cc6935. [PMID: 18577209] - Heiko Vogel, Juergen Kroymann, Thomas Mitchell-Olds. Different transcript patterns in response to specialist and generalist herbivores in the wild Arabidopsis relative Boechera divaricarpa.
PloS one.
2007 Oct; 2(10):e1081. doi:
10.1371/journal.pone.0001081. [PMID: 17957263] - Yoshitane Nozaki, Hiroyuki Kusuhara, Tsunenori Kondo, Masahiro Iwaki, Yoshiyuki Shiroyanagi, Hideki Nakayama, Shigeru Horita, Hayakazu Nakazawa, Teruo Okano, Yuichi Sugiyama. Species difference in the inhibitory effect of nonsteroidal anti-inflammatory drugs on the uptake of methotrexate by human kidney slices.
The Journal of pharmacology and experimental therapeutics.
2007 Sep; 322(3):1162-70. doi:
10.1124/jpet.107.121491. [PMID: 17578901] - Atli Thorarensen, Ronald W Sarver, Fang Tian, Andrea Ho, Donna L Romero, Keith R Marotti. Human serum albumin binding assay based on displacement of a non selective fluorescent inhibitor.
Bioorganic & medicinal chemistry letters.
2007 Aug; 17(16):4646-9. doi:
10.1016/j.bmcl.2007.05.077. [PMID: 17560104] - Ulf Mathias, Manfred Jung. Determination of drug-serum protein interactions via fluorescence polarization measurements.
Analytical and bioanalytical chemistry.
2007 Jul; 388(5-6):1147-56. doi:
10.1007/s00216-007-1351-7. [PMID: 17554529] - Hossam Ebaid, Mohamed A Dkhil, Mohamed A Danfour, Amany Tohamy, Mohamed S Gabry. Piroxicam-induced hepatic and renal histopathological changes in mice.
The Libyan journal of medicine.
2007 Jun; 2(2):82-9. doi:
10.4176/070130. [PMID: 21503258] - Shawn M R Stanley, Wei Khee Wee, Boon Huat Lim, Hsiao Ching Foo. Direct-injection screening for acidic drugs in plasma and neutral drugs in equine urine by differential-gradient LC-LC coupled MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Apr; 848(2):292-302. doi:
10.1016/j.jchromb.2006.10.041. [PMID: 17101303] - Cheryl Lans, Nancy Turner, Tonya Khan, Gerhard Brauer, Willi Boepple. Ethnoveterinary medicines used for ruminants in British Columbia, Canada.
Journal of ethnobiology and ethnomedicine.
2007 Feb; 3(?):11. doi:
10.1186/1746-4269-3-11. [PMID: 17324258] - Marie-Eve Fradette, Christophe Céleste, Hèléne Richard, Guy Beauchamp, Sheila Laverty. Effects of continuous oral administration of phenylbutazone on biomarkers of cartilage and bone metabolism in horses.
American journal of veterinary research.
2007 Feb; 68(2):128-33. doi:
10.2460/ajvr.68.2.128. [PMID: 17269876] - Bela M Arosalo, Marja Raekallio, Minna Rajamäki, Elina Holopainen, Tuulia Kastevaara, Hanna Salonen, Satu Sankari. Detecting early kidney damage in horses with colic by measuring matrix metalloproteinase -9 and -2, other enzymes, urinary glucose and total proteins.
Acta veterinaria Scandinavica.
2007 Jan; 49(?):4. doi:
10.1186/1751-0147-49-4. [PMID: 17244354] - Vijay L Kumar, Sanjeev Roy. Calotropis procera latex extract affords protection against inflammation and oxidative stress in Freund's complete adjuvant-induced monoarthritis in rats.
Mediators of inflammation.
2007; 2007(?):47523. doi:
10.1155/2007/47523. [PMID: 17497032] - Azza A K El-Sheikh, Jeroen J M W van den Heuvel, Jan B Koenderink, Frans G M Russel. Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport.
The Journal of pharmacology and experimental therapeutics.
2007 Jan; 320(1):229-35. doi:
10.1124/jpet.106.110379. [PMID: 17005917] - Harold Bays, Peter H Jones. Colesevelam hydrochloride: reducing atherosclerotic coronary heart disease risk factors.
Vascular health and risk management.
2007; 3(5):733-42. doi:
". [PMID: 18078024] - Pasquale Gallo, Serena Fabbrocino, Floriana Vinci, Maurizio Fiori, Vincenzo Danese, Antonella Nasi, Luigi Serpe. Multi-residue determination of non-steroidal anti-inflammatory drug residues in animal serum and plasma by HPLC and photo-diode array detection.
Journal of chromatographic science.
2006 Nov; 44(10):585-90. doi:
10.1093/chromsci/44.10.585. [PMID: 17254366] - Takahito Nishiyama, Tomihiro Kobori, Kouji Arai, Kenichiro Ogura, Tomokazu Ohnuma, Kazuo Ishii, Kenichiro Hayashi, Akira Hiratsuka. Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the C-glucuronidation of phenylbutazone.
Archives of biochemistry and biophysics.
2006 Oct; 454(1):72-9. doi:
10.1016/j.abb.2006.07.010. [PMID: 16949544] - Vishal R Tandon, R K Gupta. Vitex negundo Linn (VN) leaf extract as an adjuvant therapy to standard anti-inflammatory drugs.
The Indian journal of medical research.
2006 Oct; 124(4):447-50. doi:
". [PMID: 17159267] - Manoranjan Adak, Joyanta Kumar Gupta. Evaluation of anti-inflammatory activity of Calotropis gigantea (AKANDA) in various biological system.
Nepal Medical College journal : NMCJ.
2006 Sep; 8(3):156-61. doi:
". [PMID: 17203820] - Jeffrey R Simard, Patricia A Zunszain, James A Hamilton, Stephen Curry. Location of high and low affinity fatty acid binding sites on human serum albumin revealed by NMR drug-competition analysis.
Journal of molecular biology.
2006 Aug; 361(2):336-51. doi:
10.1016/j.jmb.2006.06.028. [PMID: 16844140] - Cheryl Lans, Nancy Turner, Gerhard Brauer, Grant Lourenco, Karla Georges. Ethnoveterinary medicines used for horses in Trinidad and in British Columbia, Canada.
Journal of ethnobiology and ethnomedicine.
2006 Aug; 2(?):31. doi:
10.1186/1746-4269-2-31. [PMID: 16893454] - P J Ferre, V Laroute, J P Braun, J Cazaux, P L Toutain, H P Lefebvre. Simultaneous and minimally invasive assessment of muscle tolerance and bioavailability of different volumes of an intramuscular formulation in the same animals.
Journal of animal science.
2006 May; 84(5):1295-301. doi:
10.2527/2006.8451295x. [PMID: 16612034] - Shannon K Reed, Nathaniel T Messer, Ronald K Tessman, Kevin G Keegan. Effects of phenylbutazone alone or in combination with flunixin meglumine on blood protein concentrations in horses.
American journal of veterinary research.
2006 Mar; 67(3):398-402. doi:
10.2460/ajvr.67.3.398. [PMID: 16506899] - Floriana Vinci, Serena Fabbrocino, Maurizio Fiori, Luigi Serpe, Pasquale Gallo. Determination of fourteen non-steroidal anti-inflammatory drugs in animal serum and plasma by liquid chromatography/mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2006; 20(22):3412-20. doi:
10.1002/rcm.2748. [PMID: 17066368] - George Nuki, Peter A Simkin. A concise history of gout and hyperuricemia and their treatment.
Arthritis research & therapy.
2006; 8 Suppl 1(?):S1. doi:
10.1186/ar1906. [PMID: 16820040] - Anna M Hawrot-Kawecka, Grzegorz P Kawecki, Jan Duława. [Hyperammonemia type II as an example of urea cycle disorder].
Wiadomosci lekarskie (Warsaw, Poland : 1960).
2006; 59(7-8):512-5. doi:
NULL. [PMID: 17209350]