C18-Sphingosine 1-phosphate; D-erythro-Sphingosine-1-phosphate (BioDeep_00000175559)

   

human metabolite blood metabolite


代谢物信息卡片


C18-Sphingosine 1-phosphoric acid; D-erythro-sphingosine-1-phosphoric acid

化学式: C18H38NO5P (379.24874680000005)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCCCCCCC=CC(O)C(N)COP(O)(O)=O
InChI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Daniela Küllenberg, Lenka A Taylor, Michael Schneider, Ulrich Massing. Health effects of dietary phospholipids. Lipids in health and disease. 2012 Jan; 11(?):3. doi: 10.1186/1476-511x-11-3. [PMID: 22221489]
  • Marc Freichel, Julia Almering, Volodymyr Tsvilovskyy. The Role of TRP Proteins in Mast Cells. Frontiers in immunology. 2012; 3(?):150. doi: 10.3389/fimmu.2012.00150. [PMID: 22701456]
  • Greg L Harris, Michael B Creason, Greg B Brulte, Deron R Herr. In vitro and in vivo antagonism of a G protein-coupled receptor (S1P3) with a novel blocking monoclonal antibody. PloS one. 2012; 7(4):e35129. doi: 10.1371/journal.pone.0035129. [PMID: 22496900]
  • Giuseppe Danilo Norata, Angela Pirillo, Enrico Ammirati, Alberico Luigi Catapano. Emerging role of high density lipoproteins as a player in the immune system. Atherosclerosis. 2012 Jan; 220(1):11-21. doi: 10.1016/j.atherosclerosis.2011.06.045. [PMID: 21783193]
  • Pranali P Pathare, Alex Lin, Karin E Bornfeldt, Stefan Taubert, Marc R Van Gilst. Coordinate regulation of lipid metabolism by novel nuclear receptor partnerships. PLoS genetics. 2012; 8(4):e1002645. doi: 10.1371/journal.pgen.1002645. [PMID: 22511885]
  • Malgorzata Knapp. Cardioprotective role of sphingosine-1-phosphate. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2011 Dec; 62(6):601-7. doi: . [PMID: 22314562]
  • N Hagen, M Hans, D Hartmann, D Swandulla, G van Echten-Deckert. Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism. Cell death and differentiation. 2011 Aug; 18(8):1356-65. doi: 10.1038/cdd.2011.7. [PMID: 21331079]
  • Alejandro López-Juárez, Sara Morales-Lázaro, Roberto Sánchez-Sánchez, Manjula Sunkara, Hilda Lomelí, Iván Velasco, Andrew J Morris, Diana Escalante-Alcalde. Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development. Glia. 2011 Apr; 59(4):577-89. doi: 10.1002/glia.21126. [PMID: 21319224]
  • Evgeny V Berdyshev, Irina Gorshkova, Peter Usatyuk, Satish Kalari, Yutong Zhao, Nigel J Pyne, Susan Pyne, Roger A Sabbadini, Joe G N Garcia, Viswanathan Natarajan. Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase. PloS one. 2011 Jan; 6(1):e16571. doi: 10.1371/journal.pone.0016571. [PMID: 21304987]
  • Jeanne Adiwinata Pawitan. Potential Agents against Plasma Leakage. ISRN pharmacology. 2011; 2011(?):975048. doi: 10.5402/2011/975048. [PMID: 22084722]
  • Andrea Huwiler, Florence Bourquin, Nataliya Kotelevets, Oleksandr Pastukhov, Guido Capitani, Markus G Grütter, Uwe Zangemeister-Wittke. A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders. PloS one. 2011; 6(8):e22436. doi: 10.1371/journal.pone.0022436. [PMID: 21829623]
  • Fernando Alvarez-Vasquez, Howard Riezman, Yusuf A Hannun, Eberhard O Voit. Mathematical modeling and validation of the ergosterol pathway in Saccharomyces cerevisiae. PloS one. 2011; 6(12):e28344. doi: 10.1371/journal.pone.0028344. [PMID: 22194828]
  • Arundhati Jana, Kalipada Pahan. Sphingolipids in multiple sclerosis. Neuromolecular medicine. 2010 Dec; 12(4):351-61. doi: 10.1007/s12017-010-8128-4. [PMID: 20607622]
  • Dominique P Germain. Fabry disease. Orphanet journal of rare diseases. 2010 Nov; 5(?):30. doi: 10.1186/1750-1172-5-30. [PMID: 21092187]
  • Peter P Toth. Activation of intracellular signaling systems by high-density lipoproteins. Journal of clinical lipidology. 2010 Sep; 4(5):376-81. doi: 10.1016/j.jacl.2010.08.011. [PMID: 21122681]
  • Melissa R Pitman, Stuart M Pitson. Inhibitors of the sphingosine kinase pathway as potential therapeutics. Current cancer drug targets. 2010 Jun; 10(4):354-67. doi: 10.2174/156800910791208599. [PMID: 20370685]
  • Masahide Matsuyama, Kiyoaki Funao, Katsuyuki Kuratsukuri, Tomoaki Tanaka, Yutaka Kawahito, Hajime Sano, Jamel Chargui, Jean-Louis Touraine, Norio Yoshimura, Rikio Yoshimura. Expression of sphingosine-1 phosphate receptor in rat renal ischemia-reperfusion injury. Molecular medicine reports. 2010 Mar; 3(2):233-6. doi: 10.3892/mmr_00000245. [PMID: 21472227]
  • Noureddine Brakch, Olivier Dormond, Soumeya Bekri, Dela Golshayan, Magali Correvon, Lucia Mazzolai, Beat Steinmann, Frédéric Barbey. Evidence for a role of sphingosine-1 phosphate in cardiovascular remodelling in Fabry disease. European heart journal. 2010 Jan; 31(1):67-76. doi: 10.1093/eurheartj/ehp387. [PMID: 19773225]
  • Nicole O'Brien, S Tarran Jones, David G Williams, H Brad Cunningham, Kelli Moreno, Barbara Visentin, Angela Gentile, John Vekich, William Shestowsky, Masao Hiraiwa, Rosalia Matteo, Amy Cavalli, Douglas Grotjahn, Maria Grant, Geneviève Hansen, Mary-Ann Campbell, Roger Sabbadini. Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies. Journal of lipid research. 2009 Nov; 50(11):2245-57. doi: 10.1194/jlr.m900048-jlr200. [PMID: 19509417]
  • Xin Li, Wen Ling, Angela Pennisi, Sharmin Khan, Shmuel Yaccoby. Fenretinide inhibits myeloma cell growth, osteoclastogenesis and osteoclast viability. Cancer letters. 2009 Nov; 284(2):175-81. doi: 10.1016/j.canlet.2009.04.022. [PMID: 19446953]
  • Ashok Kumar, Julie D Saba. Lyase to live by: sphingosine phosphate lyase as a therapeutic target. Expert opinion on therapeutic targets. 2009 Aug; 13(8):1013-25. doi: 10.1517/14728220903039722. [PMID: 19534571]
  • Antonina Kolmakova, Mohanraj Rajesh, David Zang, Roberto Pili, Subroto Chatterjee. VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo. Glycoconjugate journal. 2009 Jul; 26(5):547-58. doi: 10.1007/s10719-008-9206-9. [PMID: 19219548]
  • Arnold von Eckardstein, Lucia Rohrer. Transendothelial lipoprotein transport and regulation of endothelial permeability and integrity by lipoproteins. Current opinion in lipidology. 2009 Jun; 20(3):197-205. doi: 10.1097/mol.0b013e32832afd63. [PMID: 19395962]
  • Subramaniam Ramachandran, Uyen B Chu, Timur A Mavlyutov, Arindam Pal, Susan Pyne, Arnold E Ruoho. The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids. European journal of pharmacology. 2009 May; 609(1-3):19-26. doi: 10.1016/j.ejphar.2009.03.003. [PMID: 19285059]
  • Glória M Direito, Adriana P Almeida, Simone Aquino, Tatiana Alves dos Reis, Claudia Rodrigues Pozzi, Benedito Corrêa. Evaluation of sphingolipids in Wistar rats treated to prolonged and single oral doses of fumonisin b₁. International journal of molecular sciences. 2009 Jan; 10(1):50-61. doi: 10.3390/ijms10010050. [PMID: 19333435]
  • David Wheeler, Veera Venkata Ratnam Bandaru, Peter A Calabresi, Avindra Nath, Norman J Haughey. A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis. Brain : a journal of neurology. 2008 Nov; 131(Pt 11):3092-102. doi: 10.1093/brain/awn190. [PMID: 18772223]
  • Robert W Ledeen, Gusheng Wu. Nuclear sphingolipids: metabolism and signaling. Journal of lipid research. 2008 Jun; 49(6):1176-86. doi: 10.1194/jlr.r800009-jlr200. [PMID: 18326892]
  • Yasumasa Miyazaki, Masakazu Hiraide, Hajime Shibuya. Molecular cloning of functional genes for high growth-temperature and salt tolerance of the basidiomycete Fomitopsis pinicola isolated in a mangrove forest in Micronesia. Bioscience, biotechnology, and biochemistry. 2007 Jan; 71(1):273-8. doi: 10.1271/bbb.60483. [PMID: 17213639]
  • Kevin E Fisher, Andreia Pop, Wonshill Koh, Nicholas J Anthis, W Brian Saunders, George E Davis. Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling. Molecular cancer. 2006 Dec; 5(?):69. doi: 10.1186/1476-4598-5-69. [PMID: 17156449]
  • R A Sabbadini. Targeting sphingosine-1-phosphate for cancer therapy. British journal of cancer. 2006 Nov; 95(9):1131-5. doi: 10.1038/sj.bjc.6603400. [PMID: 17024123]
  • Anne Negre-Salvayre, Nicole Dousset, Gianna Ferretti, Tiziana Bacchetti, Giovanna Curatola, Robert Salvayre. Antioxidant and cytoprotective properties of high-density lipoproteins in vascular cells. Free radical biology & medicine. 2006 Oct; 41(7):1031-40. doi: 10.1016/j.freeradbiomed.2006.07.006. [PMID: 16962927]
  • D Tardieu, S T Tran, A Auvergne, R Babilé, G Benard, J D Bailly, P Guerre. Effects of fumonisins on liver and kidney sphinganine and the sphinganine to sphingosine ratio during chronic exposure in ducks. Chemico-biological interactions. 2006 Mar; 160(1):51-60. doi: 10.1016/j.cbi.2005.11.004. [PMID: 16412405]
  • Shizhong Bu, Masayoshi Yamanaka, Huiping Pei, Alicja Bielawska, Jacek Bielawski, Yusuf A Hannun, Lina Obeid, Maria Trojanowska. Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 Jan; 20(1):184-6. doi: 10.1096/fj.05-4646fje. [PMID: 16278291]
  • Helio Tedesco Silva, Paula Pinheiro Machado, Claudia Rosso Felipe, Jose Osmar Medina Pestana. Immunotherapy for De Novo renal transplantation: what's in the pipeline?. Drugs. 2006; 66(13):1665-84. doi: 10.2165/00003495-200666130-00002. [PMID: 16978033]
  • Puneet S Jolly, Meryem Bektas, Kenneth R Watterson, Heidi Sankala, Shawn G Payne, Sheldon Milstien, Sarah Spiegel. Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors. Blood. 2005 Jun; 105(12):4736-42. doi: 10.1182/blood-2004-12-4686. [PMID: 15741218]
  • Zhong Li, Ji-Hye Paik, Jie-Hye Paik, Zhenglong Wang, Tim Hla, Dianqing Wu. Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. Prostaglandins & other lipid mediators. 2005 May; 76(1-4):95-104. doi: 10.1016/j.prostaglandins.2005.02.002. [PMID: 15967165]
  • Ewa Ninio. Phospholipid mediators in the vessel wall: involvement in atherosclerosis. Current opinion in clinical nutrition and metabolic care. 2005 Mar; 8(2):123-31. doi: 10.1097/00075197-200503000-00004. [PMID: 15716789]
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  • Anthony H Futerman, Yusuf A Hannun. The complex life of simple sphingolipids. EMBO reports. 2004 Aug; 5(8):777-82. doi: 10.1038/sj.embor.7400208. [PMID: 15289826]
  • Robert W Ledeen, Gusheng Wu. Nuclear lipids: key signaling effectors in the nervous system and other tissues. Journal of lipid research. 2004 Jan; 45(1):1-8. doi: 10.1194/jlr.r300015-jlr200. [PMID: 14595003]
  • Kane L Schaphorst, Eddie Chiang, Keri N Jacobs, Ari Zaiman, Viswanathan Natarajan, Frederick Wigley, Joe G N Garcia. Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products. American journal of physiology. Lung cellular and molecular physiology. 2003 Jul; 285(1):L258-67. doi: 10.1152/ajplung.00311.2002. [PMID: 12626332]
  • Flavio Vincenti. What's in the pipeline? New immunosuppressive drugs in transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2002 Nov; 2(10):898-903. doi: 10.1034/j.1600-6143.2002.21005.x. [PMID: 12482141]
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  • D S Im, J Clemens, T L Macdonald, K R Lynch. Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. Biochemistry. 2001 Nov; 40(46):14053-60. doi: 10.1021/bi011606i. [PMID: 11705398]
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  • S Gijsbers, G Van der Hoeven, P P Van Veldhoven. Subcellular study of sphingoid base phosphorylation in rat tissues: evidence for multiple sphingosine kinases. Biochimica et biophysica acta. 2001 May; 1532(1-2):37-50. doi: 10.1016/s1388-1981(01)00111-1. [PMID: 11420172]