3-[6-[1-(4-Methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridin-2-yl]prop-2-enoic acid (BioDeep_00000175557)
human metabolite blood metabolite
代谢物信息卡片
化学式: C22H24N2O2 (348.18376839999996)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 20%
分子结构信息
SMILES: CC1=CC=C(C=C1)C(=CCN1CCCC1)C1=CC=CC(C=CC(O)=O)=N1
InChI: InChI=1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)
描述信息
同义名列表
7 个代谢物同义名
3-{6-[1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridin-2-yl}prop-2-enoic acid; 3-[6-[1-(4-Methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridin-2-yl]prop-2-enoic acid; 3-[6-[1-(4-Methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridin-2-yl]prop-2-enoate; Acrivastine; BW 825C; BW-825C; Semprex
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- J-C He, E-F Feng, M Liu, H-L Li, M Tian, Q Zhang, L-C Dong, G-L Xu. Development and validation of a liquid chromatography-tandem mass spectrometry method for the simultaneous determination of acrivastine and pseudoephedrine in human plasma and its application in pharmacokinetics.
Arzneimittel-Forschung.
2012 Oct; 62(10):449-56. doi:
10.1055/s-0032-1314877. [PMID: 22936420] - Jussi Kosonen, Leif Kronberg. The occurrence of antihistamines in sewage waters and in recipient rivers.
Environmental science and pollution research international.
2009 Jul; 16(5):555-64. doi:
10.1007/s11356-009-0144-2. [PMID: 19337767] - Benjamin R Collins, Xiaochen Gu. Quantification of antihistamine acrivastine in plasma by solid-phase extraction and high-performance liquid chromatography.
Journal of pharmaceutical and biomedical analysis.
2007 Jan; 43(1):293-7. doi:
10.1016/j.jpba.2006.07.009. [PMID: 16930917] - Yanhong Zhao. Acupuncture plus point-injection for 32 cases of obstinate urticaria.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2006 Mar; 26(1):22-3. doi:
". [PMID: 16705847] - C Gex-Collet, L Imhof, A Brattström, W J Pichler, A Helbling. The butterbur extract petasin has no effect on skin test reactivity induced by different stimuli: a randomized, double-blind crossover study using histamine, codeine, methacholine, and aeroallergen solutions.
Journal of investigational allergology & clinical immunology.
2006; 16(3):156-61. doi:
. [PMID: 16784008] - Kelly M Mahar Doan, Stephen A Wring, Larry J Shampine, Kelly H Jordan, James P Bishop, John Kratz, Eric Yang, Cosette J Serabjit-Singh, Kimberly K Adkison, Joseph W Polli. Steady-state brain concentrations of antihistamines in rats: interplay of membrane permeability, P-glycoprotein efflux and plasma protein binding.
Pharmacology.
2004 Oct; 72(2):92-8. doi:
10.1159/000079137. [PMID: 15331914] - Xiaochen Gu, Daryl J Fediuk, F Estelle R Simons, Keith J Simons. Evaluation and comparison of five matrix excipients for the controlled release of acrivastine and pseudoephedrine.
Drug development and industrial pharmacy.
2004; 30(10):1009-17. doi:
10.1081/ddc-200040237. [PMID: 15595567] - R Fernández Torres, M Callejón Mochón, J C Jiménez Sánchez, M A Bello López, A Guiraúm Perez. Electrochemical behaviour and determination of acrivastine in pharmaceuticals and human urine.
Journal of pharmaceutical and biomedical analysis.
2002 Nov; 30(4):1215-22. doi:
10.1016/s0731-7085(02)00463-6. [PMID: 12408912] - Rut Fernández, Miguel Angel Bello, Manuel Callejón, Juan Carlos Jiménez, Alfonso Guiraúm. Spectrofluorimetric determination of acrivastine in spiked human urine and pharmaceuticals.
Talanta.
2002 Mar; 56(3):571-6. doi:
10.1016/s0039-9140(01)00576-8. [PMID: 18968530] - H Abdine, F Belal. Polarographic behaviour and determination of acrivastine in capsules and human urine.
Talanta.
2002 Jan; 56(1):97-104. doi:
10.1016/s0039-9140(01)00539-2. [PMID: 18968484] - G Plember van Balen, G Caron, G Ermondi, A Pagliara, T Grandi, G Bouchard, R Fruttero, P A Carrupt, B Testa. Lipophilicity behaviour of the Zwitterionic antihistamine cetirizine in phosphatidylcholine liposomes/water systems.
Pharmaceutical research.
2001 May; 18(5):694-701. doi:
10.1023/a:1011049830615. [PMID: 11465428] - R J Dockhorn, B O Williams, R L Sanders. Efficacy of acrivastine with pseudoephedrine in treatment of allergic rhinitis due to ragweed.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
1996 Feb; 76(2):204-8. doi:
10.1016/s1081-1206(10)63423-0. [PMID: 8595542] - J Berlin, A C King, K Tutsch, J W Findlay, P Kohler, M Collier, N J Clendeninn, G Wilding. A phase II study of vinblastine in combination with acrivastine in patients with advanced renal cell carcinoma.
Investigational new drugs.
1994; 12(2):137-41. doi:
10.1007/bf00874444. [PMID: 7860231] - J G Ramaekers, J F O'Hanlon. Acrivastine, terfenadine and diphenhydramine effects on driving performance as a function of dose and time after dosing.
European journal of clinical pharmacology.
1994; 47(3):261-6. doi:
10.1007/bf02570506. [PMID: 7867679] - D G Lang, C M Wang, T L Wenger. Terfenadine alters action potentials in isolated canine Purkinje fibers more than acrivastine.
Journal of cardiovascular pharmacology.
1993 Sep; 22(3):438-42. doi:
10.1097/00005344-199309000-00014. [PMID: 7504135] - M J McNulty, D L Deal, F R Nelson, S Weller, P Chandrasurin, J Shockcor, J W Findlay. Disposition of acrivastine in the male beagle dog.
Drug metabolism and disposition: the biological fate of chemicals.
1992 Sep; 20(5):679-87. doi:
NULL. [PMID: 1358572] - S Y Chang, F R Nelson, J W Findlay, L C Taylor. Quantitative gas chromatographic-mass spectrometric analysis of acrivastine and a metabolite in human plasma.
Journal of chromatography.
1989 Dec; 497(?):288-95. doi:
10.1016/0378-4347(89)80031-3. [PMID: 2576270] - A F Cohen, M J Hamilton, S H Liao, J W Findlay, A W Peck. Pharmacodynamic and pharmacokinetics of BW 825C: a new antihistamine.
European journal of clinical pharmacology.
1985; 28(2):197-204. doi:
10.1007/bf00609692. [PMID: 2859204]