3-[2-(6-Methyl-2-pyridinyl)ethynyl]-2-cyclohexene-1-one O-methyloxime (BioDeep_00000175530)
human metabolite blood metabolite
代谢物信息卡片
化学式: C15H16N2O (240.1263)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: CON=C1CCCC(=C1)C#CC1=NC(C)=CC=C1
InChI: InChI=1S/C15H16N2O/c1-12-5-3-7-14(16-12)10-9-13-6-4-8-15(11-13)17-18-2/h3,5,7,11H,4,6,8H2,1-2H3
描述信息
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Kelly Smart, Sylvia M L Cox, Atsuko Nagano-Saito, Pedro Rosa-Neto, Marco Leyton, Chawki Benkelfat. Test-retest variability of [11 C]ABP688 estimates of metabotropic glutamate receptor subtype 5 availability in humans.
Synapse (New York, N.Y.).
2018 09; 72(9):e22041. doi:
10.1002/syn.22041. [PMID: 29935121] - Geoffrey Warnock, Michael Sommerauer, Linjing Mu, Gloria Pla Gonzalez, Susanne Geistlich, Valerie Treyer, Roger Schibli, Alfred Buck, Stefanie D Krämer, Simon M Ametamey. A first-in-man PET study of [18F]PSS232, a fluorinated ABP688 derivative for imaging metabotropic glutamate receptor subtype 5.
European journal of nuclear medicine and molecular imaging.
2018 06; 45(6):1041-1051. doi:
10.1007/s00259-017-3879-x. [PMID: 29177707] - Matts Kågedal, Zsolt Cselényi, Svante Nyberg, Patrick Raboisson, Lars Ståhle, Per Stenkrona, Katarina Varnäs, Christer Halldin, Andrew C Hooker, Mats O Karlsson. A positron emission tomography study in healthy volunteers to estimate mGluR5 receptor occupancy of AZD2066 - estimating occupancy in the absence of a reference region.
NeuroImage.
2013 Nov; 82(?):160-9. doi:
10.1016/j.neuroimage.2013.05.006. [PMID: 23668965] - Nicolas Morin, Laurent Grégoire, Marc Morissette, Sandrine Desrayaud, Baltazar Gomez-Mancilla, Fabrizio Gasparini, Thérèse Di Paolo. MPEP, an mGlu5 receptor antagonist, reduces the development of L-DOPA-induced motor complications in de novo parkinsonian monkeys: biochemical correlates.
Neuropharmacology.
2013 Mar; 66(?):355-64. doi:
10.1016/j.neuropharm.2012.07.036. [PMID: 22884464] - Selena Milicevic Sephton, Linjing Mu, W Bernd Schweizer, Roger Schibli, Stefanie D Krämer, Simon M Ametamey. Synthesis and evaluation of novel α-fluorinated (E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-enone-O-methyl oxime (ABP688) derivatives as metabotropic glutamate receptor subtype 5 PET radiotracers.
Journal of medicinal chemistry.
2012 Aug; 55(16):7154-62. doi:
10.1021/jm300648b. [PMID: 22822714] - Bazoumana Ouattara, Fabrizio Gasparini, Marc Morissette, Laurent Grégoire, Pershia Samadi, Baltazar Gomez-Mancilla, Thérèse Di Paolo. Effect of L-Dopa on metabotropic glutamate receptor 5 in the brain of parkinsonian monkeys.
Journal of neurochemistry.
2010 May; 113(3):715-24. doi:
10.1111/j.1471-4159.2010.06635.x. [PMID: 20132464] - Matthias T Wyss, Simon M Ametamey, Valerie Treyer, Andrea Bettio, Milen Blagoev, Lea J Kessler, Cyrill Burger, Bruno Weber, Mark Schmidt, Fabrizio Gasparini, Alfred Buck. Quantitative evaluation of 11C-ABP688 as PET ligand for the measurement of the metabotropic glutamate receptor subtype 5 using autoradiographic studies and a beta-scintillator.
NeuroImage.
2007 Apr; 35(3):1086-92. doi:
10.1016/j.neuroimage.2007.01.005. [PMID: 17320417] - Simon M Ametamey, Valerie Treyer, Johannes Streffer, Matthias T Wyss, Mark Schmidt, Milen Blagoev, Samuel Hintermann, Yves Auberson, Fabrizio Gasparini, Uta C Fischer, Alfred Buck. Human PET studies of metabotropic glutamate receptor subtype 5 with 11C-ABP688.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2007 Feb; 48(2):247-52. doi:
NULL. [PMID: 17268022]
