3-((5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl)methyl)pyridine (BioDeep_00000175494)
human metabolite blood metabolite
代谢物信息卡片
3-{[5-(2,3-dichlorophenyl)-1H-1,2,3,4-tetrazol-1-yl]methyl}pyridine
化学式: C13H9Cl2N5 (305.0234974)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C(=C1)Cl)Cl)C2=NN=NN2CC3=CN=CC=C3
InChI: InChI=1S/C13H9Cl2N5/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9/h1-7H,8H2
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相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Seckin Ozkanlar, Nergis Ulas, Ozgur Kaynar, Emine Satici. P2X7 receptor antagonist A-438079 alleviates oxidative stress of lung in LPS-induced septic rats.
Purinergic signalling.
2023 Mar; ?(?):. doi:
10.1007/s11302-023-09936-z. [PMID: 36959434] - Zijun Zou, Qin Wang, Minggen Zhou, Weichao Li, Yikai Zheng, Fanyi Li, Shengcai Zheng, Zhijie He. Protective effects of P2X7R antagonist in sepsis-induced acute lung injury in mice via regulation of circ_0001679 and circ_0001212 and downstream Pln, Cdh2, and Nprl3 expression.
The journal of gene medicine.
2020 12; 22(12):e3261. doi:
10.1002/jgm.3261. [PMID: 32783373] - Min Jiang, Ben-Wen Cui, Yan-Ling Wu, Yu Zhang, Yue Shang, Jian Liu, Hong-Xu Yang, Chun-Ying Qiao, Zi-Ying Zhan, Huan Ye, Quan Jin, Ji-Xing Nan, Li-Hua Lian. P2X7R orchestrates the progression of murine hepatic fibrosis by making a feedback loop from macrophage to hepatic stellate cells.
Toxicology letters.
2020 Oct; 333(?):22-32. doi:
10.1016/j.toxlet.2020.07.023. [PMID: 32721574] - Muhammad Tahir Khan, Jan Deussing, Yong Tang, Peter Illes. Astrocytic rather than neuronal P2X7 receptors modulate the function of the tri-synaptic network in the rodent hippocampus.
Brain research bulletin.
2019 09; 151(?):164-173. doi:
10.1016/j.brainresbull.2018.07.016. [PMID: 30098388] - Yanji Zhu, Qian Li, Wenlong Xun, Yuan Chen, Caihui Zhang, Shuzhen Sun. Blocking P2X7 receptor ameliorates oxidized LDL-mediated podocyte apoptosis.
Molecular biology reports.
2019 Aug; 46(4):3809-3816. doi:
10.1007/s11033-019-04823-6. [PMID: 31004300] - Gokhan Arslan, Bahattin Avci, Süleyman Emre Kocacan, Emil Rzayev, Mustafa Ayyildiz, Erdal Agar. The interaction between P2X7Rs and T-type calcium ion channels in penicillin-induced epileptiform activity.
Neuropharmacology.
2019 05; 149(?):1-12. doi:
10.1016/j.neuropharm.2019.01.027. [PMID: 30695710] - Qian-Qian Su, Yang-Yang Tian, Zhen-Ni Liu, Lei-Lei Ci, Xiong-Wen Lv. Purinergic P2X7 receptor blockade mitigates alcohol-induced steatohepatitis and intestinal injury by regulating MEK1/2-ERK1/2 signaling and egr-1 activity.
International immunopharmacology.
2019 Jan; 66(?):52-61. doi:
10.1016/j.intimp.2018.11.012. [PMID: 30445307] - Nishkantha Arulkumaran, Marije L Sixma, Sean Pollen, Elias Ceravola, Elisa Jentho, Maria Prendecki, Paul S Bass, Frederick W K Tam, Robert J Unwin, Mervyn Singer. P2X7 receptor antagonism ameliorates renal dysfunction in a rat model of sepsis.
Physiological reports.
2018 03; 6(5):. doi:
10.14814/phy2.13622. [PMID: 29488356] - Robert I Menzies, John W R Booth, John J Mullins, Matthew A Bailey, Frederick W K Tam, Jill T Norman, Robert J Unwin. Hyperglycemia-induced Renal P2X7 Receptor Activation Enhances Diabetes-related Injury.
EBioMedicine.
2017 May; 19(?):73-83. doi:
10.1016/j.ebiom.2017.04.011. [PMID: 28434946] - A R Barros-Barbosa, M G Lobo, F Ferreirinha, P Correia-de-Sá, J M Cordeiro. P2X7 receptor activation downmodulates Na(+)-dependent high-affinity GABA and glutamate transport into rat brain cortex synaptosomes.
Neuroscience.
2015 Oct; 306(?):74-90. doi:
10.1016/j.neuroscience.2015.08.026. [PMID: 26299340] - Yanli Yan, Jianwen Bai, Xiaoxu Zhou, Jinhua Tang, Chunming Jiang, Evelyn Tolbert, George Bayliss, Rujun Gong, Ting C Zhao, Shougang Zhuang. P2X7 receptor inhibition protects against ischemic acute kidney injury in mice.
American journal of physiology. Cell physiology.
2015 Mar; 308(6):C463-72. doi:
10.1152/ajpcell.00245.2014. [PMID: 25588875] - Yuanyuan Zhang, Fahuan Yuan, Xuejiao Cao, Zhifang Zhai, GangHuang, Xiang Du, Yiqin Wang, Jingbo Zhang, Yunjian Huang, Jinghong Zhao, Weiping Hou. P2X7 receptor blockade protects against cisplatin-induced nephrotoxicity in mice by decreasing the activities of inflammasome components, oxidative stress and caspase-3.
Toxicology and applied pharmacology.
2014 11; 281(1):1-10. doi:
10.1016/j.taap.2014.09.016. [PMID: 25308879] - Liam E Browne, R Alan North. P2X receptor intermediate activation states have altered nucleotide selectivity.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2013 Sep; 33(37):14801-8. doi:
10.1523/jneurosci.2022-13.2013. [PMID: 24027280] - Alberto Baroja-Mazo, Maria Barberà-Cremades, Pablo Pelegrín. P2X7 receptor activation impairs exogenous MHC class I oligopeptides presentation in antigen presenting cells.
PloS one.
2013; 8(8):e70577. doi:
10.1371/journal.pone.0070577. [PMID: 23940597] - Karin N Westlund, Liping Zhang, Fei Ma, Helieh S Oz. Chronic inflammation and pain in a tumor necrosis factor receptor (TNFR) (p55/p75-/-) dual deficient murine model.
Translational research : the journal of laboratory and clinical medicine.
2012 Jul; 160(1):84-94. doi:
10.1016/j.trsl.2011.10.003. [PMID: 22687964] - Rafaz Hoque, Muhammed Adnan Sohail, Steven Salhanick, Ahsan F Malik, Ayaz Ghani, Simon C Robson, Wajahat Z Mehal. P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice.
American journal of physiology. Gastrointestinal and liver physiology.
2012 May; 302(10):G1171-9. doi:
10.1152/ajpgi.00352.2011. [PMID: 22383490] - Xu Ji, Yukiko Naito, Go Hirokawa, Huachun Weng, Yumiko Hiura, Rie Takahashi, Naoharu Iwai. P2X(7) receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2012 Feb; 35(2):173-9. doi:
10.1038/hr.2011.153. [PMID: 21918525] - Ming-Yang Chang, Jenn-Kan Lu, Ya-Chung Tian, Yung-Chang Chen, Cheng-Chieh Hung, Yi-Hui Huang, Yau-Hung Chen, Mai-Szu Wu, Chih-Wei Yang, Yi-Chuan Cheng. Inhibition of the P2X7 receptor reduces cystogenesis in PKD.
Journal of the American Society of Nephrology : JASN.
2011 Sep; 22(9):1696-706. doi:
10.1681/asn.2010070728. [PMID: 21636640] - Murugavel Ponnusamy, Li Ma, Rujun Gong, Maoyin Pang, Y Eugene Chin, Shougang Zhuang. P2X7 receptors mediate deleterious renal epithelial-fibroblast cross talk.
American journal of physiology. Renal physiology.
2011 Jan; 300(1):F62-70. doi:
10.1152/ajprenal.00473.2010. [PMID: 20861083] - D L Donnelly-Roberts, M F Jarvis. Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states.
British journal of pharmacology.
2007 Jul; 151(5):571-9. doi:
10.1038/sj.bjp.0707265. [PMID: 17471177]