Retinoid 9CUAB30 (BioDeep_00000175482)

   

human metabolite blood metabolite


代谢物信息卡片


3,7-Dimethyl-8-(1,2,3,4-tetrahydro-1-naphthalenyliden)-(2E,4E,6E)-2,4,6-octatrienoate

化学式: C20H22O2 (294.1619712)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 98.73%

分子结构信息

SMILES: CC(C=CC=C(C)C=C1CCCC2=CC=CC=C12)=CC(O)=O
InChI: InChI=1S/C20H22O2/c1-15(7-5-8-16(2)14-20(21)22)13-18-11-6-10-17-9-3-4-12-19(17)18/h3-5,7-9,12-14H,6,10-11H2,1-2H3,(H,21,22)

描述信息

同义名列表

9 个代谢物同义名

3,7-Dimethyl-8-(1,2,3,4-tetrahydro-1-naphthalenyliden)-(2E,4E,6E)-2,4,6-octatrienoate; 8-(3,4-Dihydro-1(2H)-naphthalen-1-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid; 3,7-dimethyl-8-(1,2,3,4-tetrahydronaphthalen-1-ylidene)octa-2,4,6-trienoic acid; 8-(3,4-dihydro-2H-naphthalen-1-ylidene)-3,7-dimethylocta-2,4,6-trienoic acid; Retinoid 9CUAB30; (9Z)-UAB30; 9CUAB30; UAB-30; UAB 30



数据库引用编号

2 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jill M Kolesar, Shannon Andrews, Heather Green, Tom C Havighurst, Barbara W Wollmer, Katina DeShong, Douglas E Laux, Helen Krontiras, Donald D Muccio, KyungMann Kim, Clinton J Grubbs, Margaret G House, Howard L Parnes, Brandy M Heckman-Stoddard, Howard H Bailey. A Randomized, Placebo-Controlled, Double-Blind, Dose Escalation, Single Dose, and Steady-State Pharmacokinetic Study of 9cUAB30 in Healthy Volunteers. Cancer prevention research (Philadelphia, Pa.). 2019 12; 12(12):903-912. doi: 10.1158/1940-6207.capr-19-0310. [PMID: 31484659]
  • Chu-Fang Chou, Yu-Hua Hsieh, Clinton J Grubbs, Venkatram R Atigadda, James A Mobley, Reinhard Dummer, Donald D Muccio, Isao Eto, Craig A Elmets, W Timothy Garvey, Pi-Ling Chang. The retinoid X receptor agonist, 9-cis UAB30, inhibits cutaneous T-cell lymphoma proliferation through the SKP2-p27kip1 axis. Journal of dermatological science. 2018 Jun; 90(3):343-356. doi: 10.1016/j.jdermsci.2018.03.006. [PMID: 29599065]
  • Alicia M Waters, Jerry E Stewart, Venkatram R Atigadda, Elizabeth Mroczek-Musulman, Donald D Muccio, Clinton J Grubbs, Elizabeth A Beierle. Preclinical Evaluation of UAB30 in Pediatric Renal and Hepatic Malignancies. Molecular cancer therapeutics. 2016 05; 15(5):911-21. doi: 10.1158/1535-7163.mct-15-0521. [PMID: 26873726]
  • Matthew Lindeblad, Izet M Kapetanovic, Kasim K Kabirov, Nancy Dinger, Irina Mankovskaya, Robert Morrisey, Tomas Martín-Jiménez, Alexander Lyubimov. Assessment of oral toxicity and safety of 9-cis-UAB30, a potential chemopreventive agent, in rat and dog studies. Drug and chemical toxicology. 2011 Jul; 34(3):300-10. doi: 10.3109/01480545.2010.536771. [PMID: 21649485]
  • Jill M Kolesar, Ryan Hoel, Marcia Pomplun, Tom Havighurst, Jeanne Stublaski, Barbara Wollmer, Helen Krontiras, Wayne Brouillette, Donald Muccio, Kyungmann Kim, Clinton J Grubbs, Howard E Bailey. A pilot, first-in-human, pharmacokinetic study of 9cUAB30 in healthy volunteers. Cancer prevention research (Philadelphia, Pa.). 2010 Dec; 3(12):1565-70. doi: 10.1158/1940-6207.capr-10-0149. [PMID: 21149332]
  • Izet M Kapetanovic, Thomas L Horn, William D Johnson, Michael J Cwik, Carol J Detrisac, David L McCormick. Murine oncogenicity and pharmacokinetics studies of 9-cis-UAB30, an RXR agonist, for breast cancer chemoprevention. International journal of toxicology. 2010 Mar; 29(2):157-64. doi: 10.1177/1091581809360070. [PMID: 20335511]
  • Clinton J Grubbs, Donald L Hill, Kirby I Bland, Samuel W Beenken, Tsu-Han Lin, Isao Eto, Venkatram R Atigadda, Kimberly K Vines, Wayne J Brouillette, Donald D Muccio. 9cUAB30, an RXR specific retinoid, and/or tamoxifen in the prevention of methylnitrosourea-induced mammary cancers. Cancer letters. 2003 Nov; 201(1):17-24. doi: 10.1016/s0304-3835(03)00461-0. [PMID: 14580682]