2-(2-Chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione (BioDeep_00000175466)

   

human metabolite blood metabolite


代谢物信息卡片


2-(2-chlorophenyl)-4-methyl-5-[(pyridin-2-yl)methyl]-1H,2H,3H,5H,6H-pyrazolo[4,3-c]pyridine-3,6-dione

化学式: C19H15ClN4O2 (366.088348)
中文名称:
谱图信息: 最多检出来源 Mus musculus(blood) 50%

分子结构信息

SMILES: CC1=C2C(=CC(=O)N1CC3=CC=CC=N3)NN(C2=O)C4=CC=CC=C4Cl
InChI: InChI=1S/C19H15ClN4O2/c1-12-18-15(10-17(25)23(12)11-13-6-4-5-9-21-13)22-24(19(18)26)16-8-3-2-7-14(16)20/h2-10,22H,11H2,1H3

描述信息

GKT136901 is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 is also a selective and direct scavenger of peroxynitrite. GKT136901 can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 also has anti-inflammatory activity[1][2][3].

同义名列表

5 个代谢物同义名

2-(2-chlorophenyl)-4-methyl-5-[(pyridin-2-yl)methyl]-1H,2H,3H,5H,6H-pyrazolo[4,3-c]pyridine-3,6-dione; 2-(2-Chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo(4,3-c)pyridine-3,6(2H,5H)-dione; 2-(2-Chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione; 2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dione; GKT136901



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Nianxin Yang, Agustin Gonzalez-Vicente, Jeffrey L Garvin. Angiotensin II-induced superoxide and decreased glutathione in proximal tubules: effect of dietary fructose. American journal of physiology. Renal physiology. 2020 01; 318(1):F183-F192. doi: 10.1152/ajprenal.00462.2019. [PMID: 31760771]
  • Mona Sedeek, Alex Gutsol, Augusto C Montezano, Dylan Burger, Aurelie Nguyen Dinh Cat, Chris R J Kennedy, Kevin D Burns, Mark E Cooper, Karin Jandeleit-Dahm, Patrick Page, Cedric Szyndralewiez, Freddy Heitz, Richard L Hebert, Rhian M Touyz. Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes. Clinical science (London, England : 1979). 2013 Feb; 124(3):191-202. doi: 10.1042/cs20120330. [PMID: 22920224]
  • M Sedeek, G Callera, A Montezano, A Gutsol, F Heitz, C Szyndralewiez, P Page, C R J Kennedy, K D Burns, R M Touyz, R L Hébert. Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy. American journal of physiology. Renal physiology. 2010 Dec; 299(6):F1348-58. doi: 10.1152/ajprenal.00028.2010. [PMID: 20630933]
  • Benoît Laleu, Francesca Gaggini, Mike Orchard, Laetitia Fioraso-Cartier, Laurène Cagnon, Sophie Houngninou-Molango, Angelo Gradia, Guillaume Duboux, Cédric Merlot, Freddy Heitz, Cédric Szyndralewiez, Patrick Page. First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis. Journal of medicinal chemistry. 2010 Nov; 53(21):7715-30. doi: 10.1021/jm100773e. [PMID: 20942471]