1,3-Benzenedicarbonitrile, 2-[[4-[[2-(acetyloxy)ethyl]butylamino]-2-methylphenyl]azo]-5-nitro- (BioDeep_00000175417)

   

human metabolite blood metabolite


代谢物信息卡片


1,3-Benzenedicarbonitrile, 2-[[4-[[2-(acetyloxy)ethyl]butylamino]-2-methylphenyl]azo]-5-nitro-

化学式: C23H24N6O4 (448.1858944)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCN(CCOC(=O)C)C1=CC(=C(C=C1)N=NC2=C(C=C(C=C2C#N)[N+](=O)[O-])C#N)C
InChI: InChI=1S/C23H24N6O4/c1-4-5-8-28(9-10-33-17(3)30)20-6-7-22(16(2)11-20)26-27-23-18(14-24)12-21(29(31)32)13-19(23)15-25/h6-7,11-13H,4-5,8-10H2,1-3H3

描述信息

同义名列表

2 个代谢物同义名

1,3-Benzenedicarbonitrile, 2-[[4-[[2-(acetyloxy)ethyl]butylamino]-2-methylphenyl]azo]-5-nitro-; 2-[butyl({4-[2-(2,6-dicyano-4-nitrophenyl)diazen-1-yl]-3-methylphenyl})amino]ethyl acetate



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jin Meng, Marina Levina, Ali R Rajabi-Siahboomi, Andrew N Round, Mike Reading, Duncan Q M Craig. The development of thermal nanoprobe methods as a means of characterizing and mapping plasticizer incorporation into ethylcellulose films. Pharmaceutical research. 2012 Aug; 29(8):2128-38. doi: 10.1007/s11095-012-0742-4. [PMID: 22528979]
  • Alexander K Zetzl, Alejandro G Marangoni, Shai Barbut. Mechanical properties of ethylcellulose oleogels and their potential for saturated fat reduction in frankfurters. Food & function. 2012 Mar; 3(3):327-37. doi: 10.1039/c2fo10202a. [PMID: 22377795]
  • Kovanya Moodley, Viness Pillay, Yahya E Choonara, Lisa C du Toit, Valence M K Ndesendo, Pradeep Kumar, Shivaan Cooppan, Priya Bawa. Oral drug delivery systems comprising altered geometric configurations for controlled drug delivery. International journal of molecular sciences. 2012; 13(1):18-43. doi: 10.3390/ijms13010018. [PMID: 22312236]
  • Nikhil Kasliwal, Jeetendra Singh Negi, Vandana Jugran, Rahul Jain. Formulation, development, and performance evaluation of metoclopramide HCl oro-dispersible sustained release tablet. Archives of pharmacal research. 2011 Oct; 34(10):1691-700. doi: 10.1007/s12272-011-1013-3. [PMID: 22076769]
  • K J Wadher, R B Kakde, M J Umekar. Formulation and evaluation of a sustained-release tablets of metformin hydrochloride using hydrophilic synthetic and hydrophobic natural polymers. Indian journal of pharmaceutical sciences. 2011 Mar; 73(2):208-15. doi: 10.4103/0250-474x.91579. [PMID: 22303065]
  • Keizo Fukushima, Thangavelu Prabha, Yukako Ito, Nobuyuki Sugioka, Kanji Takada. Polymeric three-layered particles for the delivery of prednisolone to the lower gastrointestinal tract in rats. Drug development and industrial pharmacy. 2011 Mar; 37(3):335-41. doi: 10.3109/03639045.2010.513010. [PMID: 21244236]
  • Chang-jun Li, Yan-ling Yu, Qing-min Yang, Ying Li, Yu-hong Zhang, Jing-yi Wang. [Optimization of the formulation of ranolazine hydrochloride sustained-release tablet and its pharmacokinetics in dogs]. Yao xue xue bao = Acta pharmaceutica Sinica. 2010 Sep; 45(9):1170-6. doi: NULL. [PMID: 21351575]
  • Xiao-Xiang Zhang, Ke Cheng. [Effect of different coating materials on hygroscopicity of compound Luhui granules]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2010 Jun; 33(6):979-83. doi: ". [PMID: 21049624]
  • M Trotta, R Cavalli, C Trotta, R Bussano, L Costa. Electrospray technique for solid lipid-based particle production. Drug development and industrial pharmacy. 2010 Apr; 36(4):431-8. doi: 10.3109/03639040903241817. [PMID: 19788405]
  • Cristina Freire, Fridrun Podczeck, Dinora Ferreira, Francisco Veiga, João Sousa, Angelina Pena. Assessment of the in-vivo drug release from pellets film-coated with a dispersion of high amylose starch and ethylcellulose for potential colon delivery. The Journal of pharmacy and pharmacology. 2010 Jan; 62(1):55-61. doi: 10.1211/jpp.62.01.0005. [PMID: 20722999]
  • Wei Zhang, Hongtao Song, Qian Zhang. [Preparation of gastric floating sustained-release capsules of Tripterygium wilfordii by using multiparticulate time-controlled release technology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 Nov; 34(22):2867-71. doi: ". [PMID: 20209947]
  • Ehab R Bendas. Two different approaches for the prediction of in vivo plasma concentration-time profile from in vitro release data of once daily formulations of diltiazem hydrochloride. Archives of pharmacal research. 2009 Sep; 32(9):1317-29. doi: 10.1007/s12272-009-1918-2. [PMID: 19784589]
  • Yunying Tao, Yifan Lu, Yinjing Sun, Bing Gu, Weiyue Lu, Jun Pan. Development of mucoadhesive microspheres of acyclovir with enhanced bioavailability. International journal of pharmaceutics. 2009 Aug; 378(1-2):30-6. doi: 10.1016/j.ijpharm.2009.05.025. [PMID: 19465102]
  • J Scala-Bertola, M Rabiskova, T Lecompte, F Bonneaux, P Maincent. Granules in the improvement of oral heparin bioavailability. International journal of pharmaceutics. 2009 Jun; 374(1-2):12-6. doi: 10.1016/j.ijpharm.2009.02.020. [PMID: 19446753]
  • Mahmood Ahmad, Khalid Pervaiz, Ghulam Murtaza, Munaza Ramzan. Pharmacokinetic modelling of microencapsulated metronidazole. Yao xue xue bao = Acta pharmaceutica Sinica. 2009 Jun; 44(6):674-9. doi: NULL. [PMID: 19806902]
  • Stuart L Cantor, Stephen W Hoag, Larry L Augsburger. Formulation and characterization of a compacted multiparticulate system for modified release of water-soluble drugs--Part II theophylline and cimetidine. Drug development and industrial pharmacy. 2009 May; 35(5):568-82. doi: 10.1080/03639040802459460. [PMID: 18979306]
  • Kesavan Bhaskar, Jayaraman Anbu, Velayutham Ravichandiran, Vobalaboina Venkateswarlu, Yamsani Madhusudan Rao. Lipid nanoparticles for transdermal delivery of flurbiprofen: formulation, in vitro, ex vivo and in vivo studies. Lipids in health and disease. 2009 Feb; 8(?):6. doi: 10.1186/1476-511x-8-6. [PMID: 19243632]
  • Akira Fujii, Norio Yasui-Furukori, Taku Nakagami, Takenori Niioka, Manabu Saito, Yasushi Sato, Sunao Kaneko. Comparative in vivo bioequivalence and in vitro dissolution of two valproic acid sustained-release formulations. Drug design, development and therapy. 2009 Feb; 2(?):139-44. doi: 10.2147/dddt.s3556. [PMID: 19920901]
  • Hong-Liang Lin, Shyr-Yi Lin, Ying-Ku Lin, Hsiu-O Ho, Yo-Wen Lo, Ming-Thau Sheu. Release characteristics and in vitro-in vivo correlation of pulsatile pattern for a pulsatile drug delivery system activated by membrane rupture via osmotic pressure and swelling. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2008 Sep; 70(1):289-301. doi: 10.1016/j.ejpb.2008.03.021. [PMID: 18539015]
  • Jolly M Sankalia, Mayur G Sankalia, Rajashree C Mashru. Drug release and swelling kinetics of directly compressed glipizide sustained-release matrices: establishment of level A IVIVC. Journal of controlled release : official journal of the Controlled Release Society. 2008 Jul; 129(1):49-58. doi: 10.1016/j.jconrel.2008.03.016. [PMID: 18456362]
  • Munish Ahuja, Avinash S Dhake, Surendra K Sharma, Dipak K Majumdar. Topical ocular delivery of NSAIDs. The AAPS journal. 2008 Jun; 10(2):229-41. doi: 10.1208/s12248-008-9024-9. [PMID: 18437583]
  • Valérie Hoffart, Philippe Maincent, Alf Lamprecht, Véronique Latger-Cannard, Véronique Regnault, Christian Merle, Valérie Jouan-Hureaux, Thomas Lecompte, Claude Vigneron, Nathalie Ubrich. Immunoadsorption of alloantibodies onto erythroid membrane antigens encapsulated into polymeric microparticles. Pharmaceutical research. 2007 Nov; 24(11):2055-62. doi: 10.1007/s11095-007-9340-2. [PMID: 17566853]
  • Atsuko Fukui, Ryuta Fujii, Yorinobu Yonezawa, Hisakazu Sunada. Analysis of the release process of phenylpropanolamine hydrochloride from ethylcellulose matrix granules IV.(1)) Evaluation of the controlled release properties for in vivo and in vitro release systems. Chemical & pharmaceutical bulletin. 2007 Nov; 55(11):1569-73. doi: 10.1248/cpb.55.1569. [PMID: 17978513]
  • Huan-Xiang Zeng, Gang Cheng, Wei-San Pan, Guo-Ping Zhong, Min Huang. Preparation of codeine-resinate and chlorpheniramine-resinate sustained-release suspension and its pharmacokinetic evaluation in beagle dogs. Drug development and industrial pharmacy. 2007 Jun; 33(6):649-65. doi: 10.1080/03639040601050221. [PMID: 17613029]
  • Chong-Min Ji, Hui-Nan Xu, Ning-Yun Sun, Yan-Ping Lu, Wei Wu. Guar gum/ethylcellulose coated pellets for colon-specific drug delivery. Yao xue xue bao = Acta pharmaceutica Sinica. 2007 Jun; 42(6):656-62. doi: ". [PMID: 17702405]
  • Hong-Tao Song, Qian Zhang, Hui-Juan Wang, Xin-Jin Guo, Da-Wei Chen, Zhong-Gui He. Preparation of the traditional Chinese medicine compound recipe Shuxiong sustained-release capsules by multiparticulate time-controlled explosion technology. Die Pharmazie. 2007 May; 62(5):372-7. doi: ". [PMID: 17557747]
  • He Wei, Du Qing, Cao De-Ying, Xiang Bai, Fanli-Fang. Pectin/Ethylcellulose as film coatings for colon-specific drug delivery: preparation and in vitro evaluation using 5-fluorouracil pellets. PDA journal of pharmaceutical science and technology. 2007 Mar; 61(2):121-30. doi: NULL. [PMID: 17479720]
  • S P Gupta, S K Jain. Transdermal atenolol releasing system: an approach towards its development. Journal of drug targeting. 2006 Nov; 14(9):607-13. doi: 10.1080/10611860600866591. [PMID: 17090396]
  • Ashish K Jain, Sunil K Jain, Awesh Yadav, Govind P Agrawal. Controlled release calcium silicate based floating granular delivery system of ranitidine hydrochloride. Current drug delivery. 2006 Oct; 3(4):367-72. doi: 10.2174/156720106778559083. [PMID: 17076638]
  • E Mehuys, J P Remon, A Korst, L Van Bortel, R Mols, P Augustijns, C Porter, C Vervaet. Human bioavailability of propranolol from a matrix-in-cylinder system with a HPMC-Gelucire core. Journal of controlled release : official journal of the Controlled Release Society. 2005 Oct; 107(3):523-36. doi: 10.1016/j.jconrel.2005.06.019. [PMID: 16055224]
  • Kenneth D R Setchell, Amnon Brzezinski, Nadine M Brown, Pankaj B Desai, Murad Melhem, Trevor Meredith, Linda Zimmer-Nechimias, Brian Wolfe, Yoram Cohen, Yoav Blatt. Pharmacokinetics of a slow-release formulation of soybean isoflavones in healthy postmenopausal women. Journal of agricultural and food chemistry. 2005 Mar; 53(6):1938-44. doi: 10.1021/jf0488099. [PMID: 15769117]
  • E Mehuys, C Vervaet, I Gielen, H Van Bree, J P Remon. In vitro and in vivo evaluation of a matrix-in-cylinder system for sustained drug delivery. Journal of controlled release : official journal of the Controlled Release Society. 2004 Apr; 96(2):261-71. doi: 10.1016/j.jconrel.2004.01.023. [PMID: 15081217]
  • Lee F Siew, Sit-Ming Man, J Michael Newton, Abdul W Basit. Amylose formulations for drug delivery to the colon: a comparison of two fermentation models to assess colonic targeting performance in vitro. International journal of pharmaceutics. 2004 Apr; 273(1-2):129-34. doi: 10.1016/j.ijpharm.2003.12.015. [PMID: 15010137]
  • A N Assimopoulou, V P Papageorgiou. Preparation and release studies of alkannin-containing microcapsules. Journal of microencapsulation. 2004 Mar; 21(2):161-73. doi: 10.1080/02652040310001637839. [PMID: 15198428]
  • Nantharat Pearnchob, Roland Bodmeier. Dry polymer powder coating and comparison with conventional liquid-based coatings for Eudragit) RS, ethylcellulose and shellac. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2003 Nov; 56(3):363-9. doi: 10.1016/s0939-6411(03)00121-8. [PMID: 14602178]
  • A N Assimopoulou, V P Papageorgiou, C Kiparissides. Synthesis and release studies of shikonin-containing microcapsules prepared by the solvent evaporation method. Journal of microencapsulation. 2003 Sep; 20(5):581-96. doi: 10.1080/0265204031000148031. [PMID: 12909543]
  • Eva Melzer, Jörg Kreuter, Rolf Daniels. Ethylcellulose: a new type of emulsion stabilizer. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2003 Jul; 56(1):23-7. doi: 10.1016/s0939-6411(03)00025-0. [PMID: 12837477]
  • Yoshifumi Murata, Kyoko Kofuji, Susumu Kawashima. Preparation of floating alginate gel beads for drug delivery to the gastric mucosa. Journal of biomaterials science. Polymer edition. 2003; 14(6):581-8. doi: 10.1163/15685620360674263. [PMID: 12901439]
  • Saleh A al-Suwayeh, Abdel-Rehim M el-Helw, Abdullah F al-Mesned, Mohsen A Bayomi, Abobakr S el-Gorashi. In vitro--in vivo evaluation of tableted caseinchitosan microspheres containing diltiazem hydrochloride. Bollettino chimico farmaceutico. 2003 Jan; 142(1):14-20. doi: NULL. [PMID: 12680034]
  • Junko Takishima, Hiraku Onishi, Yoshiharu Machida. Prolonged intestinal absorption of cephradine with chitosan-coated ethylcellulose microparticles in rats. Biological & pharmaceutical bulletin. 2002 Nov; 25(11):1498-502. doi: 10.1248/bpb.25.1498. [PMID: 12419970]
  • T Y Fan, S L Wei, W W Yan, D B Chen, J Li. An investigation of pulsatile release tablets with ethylcellulose and Eudragit L as film coating materials and cross-linked polyvinylpyrrolidone in the core tablets. Journal of controlled release : official journal of the Controlled Release Society. 2001 Dec; 77(3):245-51. doi: 10.1016/s0168-3659(01)00508-9. [PMID: 11733092]
  • B Sreenivasa Rao, A Seshasayana, S V Pardha Saradhi, N Ravi Kumar, C P Narayan, K V Ramana Murthy. Correlation of 'in vitro' release and 'in vivo' absorption characteristics of rifampicin from ethylcellulose coated nonpareil beads. International journal of pharmaceutics. 2001 Nov; 230(1-2):1-9. doi: 10.1016/s0378-5173(01)00835-3. [PMID: 11672951]
  • T Yamada, H Onishi, Y Machida. Sustained release ketoprofen microparticles with ethylcellulose and carboxymethylethylcellulose. Journal of controlled release : official journal of the Controlled Release Society. 2001 Aug; 75(3):271-82. doi: 10.1016/s0168-3659(01)00399-6. [PMID: 11489315]
  • C W Liao, I C Cheng, K S Yeh, F Y Lin, C N Weng. Release characteristics of microspheres prepared by co-spray drying Actinobacillus pleuropneumoniae antigens and aqueous ethyl-cellulose dispersion. Journal of microencapsulation. 2001 May; 18(3):285-97. doi: 10.1080/02652040010019442. [PMID: 11308220]
  • Y I Jeong, T Ohno, Z Hu, Y Yoshikawa, N Shibata, S Nagata, K Takada. Evaluation of an intestinal pressure-controlled colon delivery capsules prepared by a dipping method. Journal of controlled release : official journal of the Controlled Release Society. 2001 Apr; 71(2):175-82. doi: 10.1016/s0168-3659(01)00211-5. [PMID: 11274749]
  • T Yamada, H Onishi, Y Machida. In vitro and in vivo evaluation of sustained release chitosan-coated ketoprofen microparticles. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2001 Mar; 121(3):239-45. doi: 10.1248/yakushi.121.239. [PMID: 11265119]
  • A Ainaoui, J Siepmann, R Bodmeier, J M Vergnaud. Calculation of the dimensions of dosage forms with release controlled by diffusion for in vivo use. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2001 Jan; 51(1):17-24. doi: 10.1016/s0939-6411(00)00139-9. [PMID: 11154899]