Infigratinib (BioDeep_00000175341)

   

human metabolite blood metabolite


代谢物信息卡片


N-(2,6-dichloro-3,5-dimethoxyphenyl)-N-(6-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-N-methylcarbamimidic acid

化学式: C26H31Cl2N7O3 (559.1865316)
中文名称: 英非替尼
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CCN1CCN(CC1)C1=CC=C(NC2=CC(=NC=N2)N(C)C(O)=NC2=C(Cl)C(OC)=CC(OC)=C2Cl)C=C1
InChI: InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)

描述信息

L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01E - Protein kinase inhibitors > L01EN - Fibroblast growth factor receptor (fgfr) tyrosine kinase inhibitors
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C164035 - FGFR-targeting Agent
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C155727 - FGFR Inhibitor
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor
D000970 - Antineoplastic Agents

同义名列表

6 个代谢物同义名

N-(2,6-dichloro-3,5-dimethoxyphenyl)-N-(6-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-N-methylcarbamimidic acid; 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea; BGJ398 (NVP-BGJ398); Infigratinib; NVP-BGJ398; BGJ398



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yang Zhang, Ri Wang, He Zhang, Liya Liu, Jianbin An, Jun Hao, Jingxue Ma. Plumbagin Inhibits Proliferation, Migration, and Invasion of Retinal Pigment Epithelial Cells Induced by FGF-2. Tissue & cell. 2021 Oct; 72(?):101547. doi: 10.1016/j.tice.2021.101547. [PMID: 33964605]
  • Ke Li, Xiang Deng, Guangjing Feng, Yi Chen. Knockdown of Bcl-2-Associated Athanogene-3 Can Enhance the Efficacy of BGJ398 via Suppressing Migration and Inducing Apoptosis in Gastric Cancer. Digestive diseases and sciences. 2021 09; 66(9):3036-3044. doi: 10.1007/s10620-020-06640-5. [PMID: 33089486]
  • Kaili Jiang, Xia Tang, Jing Guo, Rui He, Shingpan Chan, Xiaojuan Song, Zhengchao Tu, Yuting Wang, Xiaomei Ren, Ke Ding, Zhang Zhang. GZD824 overcomes FGFR1-V561F/M mutant resistance in vitro and in vivo. Cancer medicine. 2021 07; 10(14):4874-4884. doi: 10.1002/cam4.4041. [PMID: 34114373]
  • Yung Lyou, Petros Grivas, Jonathan E Rosenberg, Jean Hoffman-Censits, David I Quinn, Daniel P Petrylak, Matthew Galsky, Ulka Vaishampayan, Ugo De Giorgi, Sumati Gupta, Howard Burris, Jessica Rearden, Ai Li, Hao Wang, Maribel Reyes, Susan Moran, Siamak Daneshmand, Dean Bajorin, Sumanta K Pal. Hyperphosphatemia Secondary to the Selective Fibroblast Growth Factor Receptor 1-3 Inhibitor Infigratinib (BGJ398) Is Associated with Antitumor Efficacy in Fibroblast Growth Factor Receptor 3-altered Advanced/Metastatic Urothelial Carcinoma. European urology. 2020 12; 78(6):916-924. doi: 10.1016/j.eururo.2020.08.002. [PMID: 32847703]
  • Liang Zhao, Xiaoyun Cao, Lingli Li, Xiaohua Wang, Qin Wang, Shan Jiang, Chun Tang, Suhan Zhou, Nan Xu, Yu Cui, Weipeng Hu, Lingyan Fei, Zhihua Zheng, Limeng Chen, Marcel O Schmidt, Qichun Wei, Jingwei Zhao, Robert Labes, Andreas Patzak, Christopher S Wilcox, Xiaodong Fu, Anton Wellstein, En Yin Lai. Acute Kidney Injury Sensitizes the Brain Vasculature to Ang II (Angiotensin II) Constriction via FGFBP1 (Fibroblast Growth Factor Binding Protein 1). Hypertension (Dallas, Tex. : 1979). 2020 12; 76(6):1924-1934. doi: 10.1161/hypertensionaha.120.15582. [PMID: 33040621]
  • Iris R Hartley, Carole B Miller, Georgios Z Papadakis, Clemens Bergwitz, Jaydira Del Rivero, Jenny E Blau, Pablo Florenzano, Jason A Berglund, Jing Tassone, Kelly L Roszko, Susan Moran, Rachel I Gafni, Randi Isaacs, Michael T Collins. Targeted FGFR Blockade for the Treatment of Tumor-Induced Osteomalacia. The New England journal of medicine. 2020 10; 383(14):1387-1389. doi: 10.1056/nejmc2020399. [PMID: 32905668]
  • Chun-Han Chen, Chun A Changou, Tsung-Han Hsieh, Yu-Ching Lee, Cheng-Ying Chu, Kai-Cheng Hsu, Hao-Ching Wang, Yu-Chen Lin, Yan-Ni Lo, Yun-Ru Liu, Jing-Ping Liou, Yun Yen. Dual Inhibition of PIK3C3 and FGFR as a New Therapeutic Approach to Treat Bladder Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 03; 24(5):1176-1189. doi: 10.1158/1078-0432.ccr-17-2066. [PMID: 29222162]
  • Attaya Suvannasankha, Douglas R Tompkins, Daniel F Edwards, Katarina V Petyaykina, Colin D Crean, Pierrick G Fournier, Jamie M Parker, George E Sandusky, Shoji Ichikawa, Erik A Imel, John M Chirgwin. FGF23 is elevated in multiple myeloma and increases heparanase expression by tumor cells. Oncotarget. 2015 Aug; 6(23):19647-60. doi: 10.18632/oncotarget.3794. [PMID: 25944690]
  • Simon Wöhrle, Christine Henninger, Olivier Bonny, Anne Thuery, Noemie Beluch, Nancy E Hynes, Vito Guagnano, William R Sellers, Francesco Hofmann, Michaela Kneissel, Diana Graus Porta. Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23-mediated hypophosphatemic rickets. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2013 Apr; 28(4):899-911. doi: 10.1002/jbmr.1810. [PMID: 23129509]