2-[5-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylidene]-4-methoxy-2-pyrrolylidene]indole (BioDeep_00000175282)
human metabolite blood metabolite
代谢物信息卡片
化学式: C20H19N3O (317.15280440000004)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 81.82%
分子结构信息
SMILES: COC1=CC(NC1=CC1=C(C)C=C(C)N1)=C1C=C2C=CC=CC2=N1
InChI: InChI=1S/C20H19N3O/c1-12-8-13(2)21-16(12)10-19-20(24-3)11-18(23-19)17-9-14-6-4-5-7-15(14)22-17/h4-11,21,23H,1-3H3
描述信息
同义名列表
7 个代谢物同义名
2-((2Z)-2-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole methanesulfonate (1:1); 2-{5-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-4-methoxy-2,5-dihydro-1H-pyrrol-2-ylidene}-2H-indole; 2-(2-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole methanesulfonate; 2-(2-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole; 2-[5-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylidene]-4-methoxy-2-pyrrolylidene]indole; Obatoclax Mesylate; obatoclax
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Binli Mao, Vu Thuy Khanh Le-Trilling, Kai Wang, Denise Mennerich, Jie Hu, Zhenyu Zhao, Jiaxin Zheng, Yingying Deng, Benjamin Katschinski, Shilei Xu, Guiji Zhang, Xuefei Cai, Yuan Hu, Jianwei Wang, Mengji Lu, Ailong Huang, Ni Tang, Mirko Trilling, Yong Lin. Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro.
Emerging microbes & infections.
2022 Dec; 11(1):483-497. doi:
10.1080/22221751.2022.2026739. [PMID: 34989664] - Yu-Jin Kim, Haydar Witwit, Beatrice Cubitt, Juan C de la Torre. Inhibitors of Anti-apoptotic Bcl-2 Family Proteins Exhibit Potent and Broad-Spectrum Anti-mammarenavirus Activity via Cell Cycle Arrest at G0/G1 Phase.
Journal of virology.
2021 11; 95(24):e0139921. doi:
10.1128/jvi.01399-21. [PMID: 34586865] - Finny S Varghese, Esther van Woudenbergh, Gijs J Overheul, Marc J Eleveld, Lisa Kurver, Niels van Heerbeek, Arjan van Laarhoven, Pascal Miesen, Gerco den Hartog, Marien I de Jonge, Ronald P van Rij. Berberine and Obatoclax Inhibit SARS-Cov-2 Replication in Primary Human Nasal Epithelial Cells In Vitro.
Viruses.
2021 02; 13(2):. doi:
10.3390/v13020282. [PMID: 33670363] - Aleksandr Ianevski, Rouan Yao, Mona Høysæter Fenstad, Svetlana Biza, Eva Zusinaite, Tuuli Reisberg, Hilde Lysvand, Kirsti Løseth, Veslemøy Malm Landsem, Janne Fossum Malmring, Valentyn Oksenych, Sten Even Erlandsen, Per Arne Aas, Lars Hagen, Caroline H Pettersen, Tanel Tenson, Jan Egil Afset, Svein Arne Nordbø, Magnar Bjørås, Denis E Kainov. Potential Antiviral Options against SARS-CoV-2 Infection.
Viruses.
2020 06; 12(6):. doi:
10.3390/v12060642. [PMID: 32545799] - Shalini Pandey, Sohan Patil, Nirmalya Ballav, Sudipta Basu. Spatial targeting of Bcl-2 on endoplasmic reticulum and mitochondria in cancer cells by lipid nanoparticles.
Journal of materials chemistry. B.
2020 05; 8(19):4259-4266. doi:
10.1039/d0tb00408a. [PMID: 32285907] - Petter I Andersen, Klara Krpina, Aleksandr Ianevski, Nastassia Shtaida, Eunji Jo, Jaewon Yang, Sandra Koit, Tanel Tenson, Veijo Hukkanen, Marit W Anthonsen, Magnar Bjoras, Magnus Evander, Marc P Windisch, Eva Zusinaite, Denis E Kainov. Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine.
Viruses.
2019 10; 11(10):. doi:
10.3390/v11100964. [PMID: 31635418] - Mohamad Norisham Mohamad Rosdi, Shahkila Mohd Arif, Mohamad Hafizi Abu Bakar, Siti Aisyah Razali, Razauden Mohamed Zulkifli, Harisun Ya'akob. Molecular docking studies of bioactive compounds from Annona muricata Linn as potential inhibitors for Bcl-2, Bcl-w and Mcl-1 antiapoptotic proteins.
Apoptosis : an international journal on programmed cell death.
2018 01; 23(1):27-40. doi:
10.1007/s10495-017-1434-7. [PMID: 29204721] - Dirk Theile, David Allendorf, Bruno Christian Köhler, Adam Jassowicz, Johanna Weiss. Obatoclax as a perpetrator in drug-drug interactions and its efficacy in multidrug resistance cell lines.
The Journal of pharmacy and pharmacology.
2015 Nov; 67(11):1575-84. doi:
10.1111/jphp.12455. [PMID: 26255619] - Mai Nguyen, Regina Cencic, Franziska Ertel, Cynthia Bernier, Jerry Pelletier, Anne Roulston, John R Silvius, Gordon C Shore. Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim.
BMC cancer.
2015 Aug; 15(?):568. doi:
10.1186/s12885-015-1582-5. [PMID: 26231047] - Ganesh S Moorthy, Robin E Norris, Peter C Adamson, Elizabeth Fox. A liquid chromatography/tandem mass spectrometry method for determination of obatoclax in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Nov; 971(?):30-4. doi:
10.1016/j.jchromb.2014.09.005. [PMID: 25261914] - Lydia Scarfò, Paolo Ghia. Reprogramming cell death: BCL2 family inhibition in hematological malignancies.
Immunology letters.
2013 Sep; 155(1-2):36-9. doi:
10.1016/j.imlet.2013.09.015. [PMID: 24095849] - Karen A Urtishak, Alena Y Z Edwards, Li-San Wang, Amanda Hudome, Blaine W Robinson, Jeffrey S Barrett, Kajia Cao, Lori Cory, Jonni S Moore, Andrew D Bantly, Qian-Chun Yu, I-Ming L Chen, Susan R Atlas, Cheryl L Willman, Mondira Kundu, Andrew J Carroll, Nyla A Heerema, Meenakshi Devidas, Joanne M Hilden, ZoAnn E Dreyer, Stephen P Hunger, Gregory H Reaman, Carolyn A Felix. Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia.
Blood.
2013 Apr; 121(14):2689-703. doi:
10.1182/blood-2012-04-425033. [PMID: 23393050] - Robert C Jackson. Pharmacodynamic modelling of biomarker data in oncology.
ISRN pharmacology.
2012; 2012(?):590626. doi:
10.5402/2012/590626. [PMID: 22523699] - Borja Díaz de Greñu, Paulina Iglesias Hernández, Margarita Espona, David Quiñonero, Mark E Light, Tomás Torroba, Ricardo Pérez-Tomás, Roberto Quesada. Synthetic prodiginine obatoclax (GX15-070) and related analogues: anion binding, transmembrane transport, and cytotoxicity properties.
Chemistry (Weinheim an der Bergstrasse, Germany).
2011 Dec; 17(50):14074-83. doi:
10.1002/chem.201101547. [PMID: 22069220] - E P Booy, E S Henson, S B Gibson. Epidermal growth factor regulates Mcl-1 expression through the MAPK-Elk-1 signalling pathway contributing to cell survival in breast cancer.
Oncogene.
2011 May; 30(20):2367-78. doi:
10.1038/onc.2010.616. [PMID: 21258408] - Guillaume Poiroux, Marguerite Pitié, Raphaël Culerrier, Elodie Lafont, Bruno Ségui, Els J M Van Damme, Willy J Peumans, Jean Bernadou, Thierry Levade, Pierre Rougé, Annick Barre, Hervé Benoist. Targeting of T/Tn antigens with a plant lectin to kill human leukemia cells by photochemotherapy.
PloS one.
2011; 6(8):e23315. doi:
10.1371/journal.pone.0023315. [PMID: 21858067] - F McCoy, J Hurwitz, N McTavish, I Paul, C Barnes, B O'Hagan, K Odrzywol, J Murray, D Longley, G McKerr, D A Fennell. Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK.
Cell death & disease.
2010 Dec; 1(?):e108. doi:
10.1038/cddis.2010.86. [PMID: 21368880] - Susan M O'Brien, David F Claxton, Michael Crump, Stefan Faderl, Thomas Kipps, Michael J Keating, Jean Viallet, Bruce D Cheson. Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia.
Blood.
2009 Jan; 113(2):299-305. doi:
10.1182/blood-2008-02-137943. [PMID: 18931344]