Chiniofon (BioDeep_00000175251)
human metabolite blood metabolite
代谢物信息卡片
8-Hydroxy-7-iodoquinoline-5-sulphonic acid
化学式: C9H6INO4S (350.9062306)
中文名称: 喹碘方
谱图信息:
最多检出来源 Homo sapiens(blood) 97.73%
分子结构信息
SMILES: C1=CC2=C(C(=C(C=C2S(=O)(=O)O)I)O)N=C1
InChI: InChI=1S/C9H6INO4S/c10-6-4-7(16(13,14)15)5-2-1-3-11-8(5)9(6)12/h1-4,12H,(H,13,14,15)
描述信息
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01A - Agents against amoebiasis and other protozoal diseases
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:135481
- PubChem: 11043
- HMDB: HMDB0247438
- ChEMBL: CHEMBL1788402
- Wikipedia: Chiniofon
- MeSH: Hydroxyquinolines
- chemspider: 10575
- CAS: 8002-90-2
- CAS: 547-91-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rahsan Erdem, Gwen Ambler, Mohamed Al-Ibrahim, Katarzyna Fraczek, Steven D Dong, Christopher Gast, Laina D Mercer, Michael Raine, Sharon M Tennant, Wilbur H Chen, Eugenio L de Hostos, Robert K M Choy. A Phase 2a randomized, single-center, double-blind, placebo-controlled study to evaluate the safety and preliminary efficacy of oral iOWH032 against cholera diarrhea in a controlled human infection model.
PLoS neglected tropical diseases.
2021 11; 15(11):e0009969. doi:
10.1371/journal.pntd.0009969. [PMID: 34793441] - Waralee Ruankham, Kamonrat Phopin, Ratchanok Pingaew, Supaluk Prachayasittikul, Virapong Prachayasittikul, Tanawut Tantimongcolwat. In silico and multi-spectroscopic analyses on the interaction of 5-amino-8-hydroxyquinoline and bovine serum albumin as a potential anticancer agent.
Scientific reports.
2021 10; 11(1):20187. doi:
10.1038/s41598-021-99690-2. [PMID: 34642420] - Woo Shik Shin, Megin E Nguyen, Alexander Bergstrom, Isabella R Jennings, Michael W Crowder, Ramaiah Muthyala, Yuk Yin Sham. Fragment-based screening and hit-based substructure search: Rapid discovery of 8-hydroxyquinoline-7-carboxylic acid as a low-cytotoxic, nanomolar metallo β-lactamase inhibitor.
Chemical biology & drug design.
2021 10; 98(4):481-492. doi:
10.1111/cbdd.13912. [PMID: 34148302] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Yukiko Karuo, Riona Shiraki, Ayaka Yoshida, Ryo Tsunokawa, Mayuko Nakahara-Yamada, Atsushi Tarui, Kazuyuki Sato, Kentaro Kawai, Masaaki Omote, Hitoshi Nishimura. Identification and Synthesis of DDI-6, a Quinolinol Analog Capable of Activating Both Caenorhabditis elegans and Mouse Spermatozoa.
Chemical & pharmaceutical bulletin.
2021; 69(6):557-563. doi:
10.1248/cpb.c21-00127. [PMID: 34078802] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Cristina P Matos, Yasemin Yildizhan, Zelal Adiguzel, Fernando R Pavan, Débora L Campos, João Costa Pessoa, Liliana P Ferreira, Ana Isabel Tomaz, Isabel Correia, Ceyda Acilan. New ternary iron(iii) aminobisphenolate hydroxyquinoline complexes as potential therapeutic agents.
Dalton transactions (Cambridge, England : 2003).
2019 Jun; 48(24):8702-8716. doi:
10.1039/c9dt01193e. [PMID: 31123737] - Gang Xing, Li Pan, Ce Yi, Xiaoran Li, Xinyue Ge, Ying Zhao, Yichuang Liu, Jinyan Li, Anthony Woo, Bin Lin, Yuyang Zhang, Maosheng Cheng. Design, synthesis and biological evaluation of 5-(2-amino-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one derivatives as potent β2-adrenoceptor agonists.
Bioorganic & medicinal chemistry.
2019 06; 27(12):2306-2314. doi:
10.1016/j.bmc.2018.10.043. [PMID: 30392952] - Jing Zhu, Mu Zhang, Tingli Han, Hua Wu, Zhibo Xiao, Shihui Lin, Chuanjiang Wang, Fang Xu. Exploring the Biomarkers of Sepsis-Associated Encephalopathy (SAE): Metabolomics Evidence from Gas Chromatography-Mass Spectrometry.
BioMed research international.
2019; 2019(?):2612849. doi:
10.1155/2019/2612849. [PMID: 31781604] - Jayme P Coyle, Robert J Rinaldi, Giffe T Johnson, Marie M Bourgeois, James McCluskey, Raymond D Harbison. Acrolein measurement and degradation in Dulbecco's Modified Eagle Medium: an examination of in-vitro exposure metrics.
Toxicology mechanisms and methods.
2018 Feb; 28(2):115-121. doi:
10.1080/15376516.2017.1370755. [PMID: 28826359] - Nishikant Wase, Boqiang Tu, James W Allen, Paul N Black, Concetta C DiRusso. Identification and Metabolite Profiling of Chemical Activators of Lipid Accumulation in Green Algae.
Plant physiology.
2017 Aug; 174(4):2146-2165. doi:
10.1104/pp.17.00433. [PMID: 28652262] - Seung-Yong Seo, Wonku Kang. Quantitative determination of a synthetic amide derivative of gallic acid, SG-HQ2, using liquid chromatography tandem mass spectrometry, and its pharmacokinetics in rats.
Journal of pharmaceutical and biomedical analysis.
2016 Nov; 131(?):103-106. doi:
10.1016/j.jpba.2016.08.015. [PMID: 27568342] - P Sun, G Esteban, T Inokuchi, J Marco-Contelles, B B Weksler, I A Romero, P O Couraud, M Unzeta, M Solé. Protective effect of the multitarget compound DPH-4 on human SSAO/VAP-1-expressing hCMEC/D3 cells under oxygen-glucose deprivation conditions: an in vitro experimental model of cerebral ischaemia.
British journal of pharmacology.
2015 Nov; 172(22):5390-402. doi:
10.1111/bph.13328. [PMID: 26362823] - Ha Won Lee, Samia Q Khan, Mohd Hafeez Faridi, Changli Wei, Nicholas J Tardi, Mehmet M Altintas, Hatem A Elshabrawy, Steve Mangos, Kevin L Quick, Sanja Sever, Jochen Reiser, Vineet Gupta. A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules.
Journal of the American Society of Nephrology : JASN.
2015 Nov; 26(11):2741-52. doi:
10.1681/asn.2014090859. [PMID: 25858967] - Helen L Barr, Nigel Halliday, Miguel Cámara, David A Barrett, Paul Williams, Douglas L Forrester, Rebecca Simms, Alan R Smyth, David Honeybourne, Joanna L Whitehouse, Edward F Nash, Jane Dewar, Andrew Clayton, Alan J Knox, Andrew W Fogarty. Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis.
The European respiratory journal.
2015 Oct; 46(4):1046-54. doi:
10.1183/09031936.00225214. [PMID: 26022946] - Sonali M Shiriskar, Neeraj Agarwal, Raghuvir R S Pissurlenkar, Basir Ahmad. Effects of 2-amino-8-hydroxyquinoline interaction on the conformation of physiological isomers of human serum albumin.
European biophysics journal : EBJ.
2015 May; 44(4):193-205. doi:
10.1007/s00249-015-1014-0. [PMID: 25761396] - Sedat Caner, Akif Altınbaş, Müyesser Saykı, Fatih Büyükcam, Barış Yılmaz, Erman Çakal, Şahin Çoban, Tuncay Delibaşı. M30 does not predict the severity of hepatosteatosis, whereas adiponectin level declined with increase of ALT and the severity of hepatic steatosis.
Journal of clinical laboratory analysis.
2014 Sep; 28(5):381-5. doi:
10.1002/jcla.21697. [PMID: 24648300] - Reza Karimi Shervedani, Zeinab Rezvaninia, Hassan Sabzyan, Hassan Zali Boeini. Characterization of gold-thiol-8-hydroxyquinoline self-assembled monolayers for selective recognition of aluminum ion using voltammetry and electrochemical impedance spectroscopy.
Analytica chimica acta.
2014 May; 825(?):34-41. doi:
10.1016/j.aca.2014.03.041. [PMID: 24767148] - Yukari Totsuka, Tetsushi Watanabe, Souleymane Coulibaly, Sae Kobayashi, Marina Nishizaki, Miho Okazaki, Tomohiro Hasei, Keiji Wakabayashi, Hitoshi Nakagama. In vivo genotoxicity of a novel heterocyclic amine, aminobenzoazepinoquinolinone-derivative (ABAQ), produced by the Maillard reaction between glucose and l-tryptophan.
Mutation research. Genetic toxicology and environmental mutagenesis.
2014 Jan; 760(?):48-55. doi:
10.1016/j.mrgentox.2013.12.002. [PMID: 24333690] - Osama K Abou-Zied, John Husband, Najla Al-Lawatia, Thomas B Steinbrecher. Ground state spectroscopy of hydroxyquinolines: evidence for the formation of protonated species in water-rich dioxane-water mixtures.
Physical chemistry chemical physics : PCCP.
2014 Jan; 16(1):61-70. doi:
10.1039/c3cp52811a. [PMID: 24158492] - Osama K Abou-Zied, Najla Al-Lawatia, Marcus Elstner, Thomas B Steinbrecher. Binding of hydroxyquinoline probes to human serum albumin: combining molecular modeling and Förster's resonance energy transfer spectroscopy to understand flexible ligand binding.
The journal of physical chemistry. B.
2013 Jan; 117(4):1062-74. doi:
10.1021/jp311238n. [PMID: 23297700] - Alan G Japp, Raj Chelliah, Laura Tattersall, Ninian N Lang, Xu Meng, Kathleen Weisel, Arie Katz, David Burt, Keith A A Fox, Giora Z Feuerstein, Thomas M Connolly, David E Newby. Effect of PSI-697, a novel P-selectin inhibitor, on platelet-monocyte aggregate formation in humans.
Journal of the American Heart Association.
2013 Jan; 2(1):e006007. doi:
10.1161/jaha.112.006007. [PMID: 23525448] - Zhi-Yong Xiao, Shao-Hui Chen, Jun-Ping Cheng, Wen-Xia Zhou, Yong-Xiang Zhang, Ri-Fang Yang, Liu-Hong Yun. Y27, a novel derivative of 4-hydroxyquinoline-3-formamide, prevents the development of murine systemic lupus erythematosus-like diseases in MRL/lpr autoimmune mice and BDF1 hybrid mice.
Arthritis research & therapy.
2012 Nov; 14(6):R235. doi:
10.1186/ar4078. [PMID: 23116248] - Amy R Cameron, Katherine Wallace, Lisa Logie, Alan R Prescott, Terry G Unterman, Jean Harthill, Graham Rena. The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a.
The Biochemical journal.
2012 Apr; 443(1):57-64. doi:
10.1042/bj20112124. [PMID: 22248233] - Olaf Weber, Stefan Willmann, Hilmar Bischoff, Volkhart Li, Alexandros Vakalopoulos, Klemens Lustig, Frank-Thorsten Hafner, Roland Heinig, Carsten Schmeck, Klaus Buehner. Prediction of a potentially effective dose in humans for BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein (CETP) by allometric species scaling and combined pharmacodynamic and physiologically-based pharmacokinetic modelling.
British journal of clinical pharmacology.
2012 Feb; 73(2):219-31. doi:
10.1111/j.1365-2125.2011.04064.x. [PMID: 21762205] - Michael-Friedrich Boettcher, Roland Heinig, Carsten Schmeck, Christian Kohlsdorfer, Matthias Ludwig, Anja Schaefer, Sabine Gelfert-Peukert, Georg Wensing, Olaf Weber. Single dose pharmacokinetics, pharmacodynamics, tolerability and safety of BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein.
British journal of clinical pharmacology.
2012 Feb; 73(2):210-8. doi:
10.1111/j.1365-2125.2011.04083.x. [PMID: 21838789] - Ramón Rodrigo. Prevention of postoperative atrial fibrillation: novel and safe strategy based on the modulation of the antioxidant system.
Frontiers in physiology.
2012; 3(?):93. doi:
10.3389/fphys.2012.00093. [PMID: 22518106] - Shiang Yong Lim, Derek John Hausenloy. Remote ischemic conditioning: from bench to bedside.
Frontiers in physiology.
2012; 3(?):27. doi:
10.3389/fphys.2012.00027. [PMID: 22363297] - Abdolkarim Mahrooz, Mohammad-Reza Rashidi, Mohammad Nouri. Naringenin is an inhibitor of human serum paraoxonase (PON1): an in vitro study.
Journal of clinical laboratory analysis.
2011 Nov; 25(6):395-401. doi:
10.1002/jcla.20490. [PMID: 22086792] - Cyrille B Confavreux. Bone: from a reservoir of minerals to a regulator of energy metabolism.
Kidney international. Supplement.
2011 Apr; ?(121):S14-9. doi:
NULL. [PMID: 21346725] - Enrique C Morales-Villegas, Germano Di Sciascio, Carlo Briguori. Statins: cardiovascular risk reduction in percutaneous coronary intervention-basic and clinical evidence of hyperacute use of statins.
International journal of hypertension.
2011 Mar; 2011(?):904742. doi:
10.4061/2011/904742. [PMID: 21461336] - Marlieke Visser, Mariska Davids, Hein J Verberne, Wouter E M Kok, Hans W M Niessen, Lenny M W van Venrooij, Riccardo Cocchieri, Willem Wisselink, Bas A J M de Mol, Paul A M van Leeuwen. Rationale and design of a proof-of-concept trial investigating the effect of uninterrupted perioperative (par)enteral nutrition on amino acid profile, cardiomyocytes structure, and cardiac perfusion and metabolism of patients undergoing coronary artery bypass grafting.
Journal of cardiothoracic surgery.
2011 Mar; 6(?):36. doi:
10.1186/1749-8090-6-36. [PMID: 21439030] - Bei Zheng, Tao Li, Xiao-peng Ge, Jin Lin, Dong-sheng Wang. [Comparative study on the coagulation of PACl with different contents of aluminum polymeric species].
Huan jing ke xue= Huanjing kexue.
2010 Aug; 31(8):1813-8. doi:
". [PMID: 21090298] - Frédérique Renault, Tiffany Carus, Cécile Cléry-Barraud, Mikael Elias, Eric Chabrière, Patrick Masson, Daniel Rochu. Integrative analytical approach by capillary electrophoresis and kinetics under high pressure optimized for deciphering intrinsic and extrinsic cofactors that modulate activity and stability of human paraoxonase (PON1).
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 May; 878(17-18):1346-55. doi:
10.1016/j.jchromb.2009.11.027. [PMID: 19945920] - Syed Ahmad, Jade J Carter, John E Scott. A homogeneous cell-based assay for measurement of endogenous paraoxonase 1 activity.
Analytical biochemistry.
2010 May; 400(1):1-9. doi:
10.1016/j.ab.2010.01.023. [PMID: 20096260] - Sean M Watts, Melissa M Uhl, Stephen P Maurano, Erin E Nuccio. Using small-scale studies to prioritize threats and guide recovery of a rare hemiparasitic plant: Cordylanthus rigidus ssp. littoralis.
PloS one.
2010 Jan; 5(1):e8892. doi:
10.1371/journal.pone.0008892. [PMID: 20126657] - Teresa L Micotto, Adrienne S Brown, James N Wilson. Fluorescent mimics of 5-hydroxytryptamine based on N-alkylated derivatives of 6-hydroxycarbostyril.
Chemical communications (Cambridge, England).
2009 Dec; ?(48):7548-50. doi:
10.1039/b917578d. [PMID: 20024275] - Dick Pluim, Jos H Beijnen, Jan H M Schellens, Olaf van Tellingen. Simultaneous determination of AZD1152 (prodrug) and AZD1152-hydroxyquinazoline pyrazol anilide by reversed phase liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Nov; 877(29):3549-55. doi:
10.1016/j.jchromb.2009.08.035. [PMID: 19744901] - Fong-Fu Hsu, Vijaya M Lakshmi, Terry V Zenser. Characterization of new metabolites from in vivo biotransformation of 2-amino-3-methylimidazo[4,5-f]quinoline in mouse by mass spectrometry.
Journal of mass spectrometry : JMS.
2009 Sep; 44(9):1359-68. doi:
10.1002/jms.1620. [PMID: 19629964] - Makiko Yoshida, Paul F Jacques, James B Meigs, Edward Saltzman, M Kyla Shea, Caren Gundberg, Bess Dawson-Hughes, Gerard Dallal, Sarah L Booth. Effect of vitamin K supplementation on insulin resistance in older men and women.
Diabetes care.
2008 Nov; 31(11):2092-6. doi:
10.2337/dc08-1204. [PMID: 18697901] - C J Zuurbier, H B Van Wezel. Glucose-insulin therapy, plasma substrate levels and cardiac recovery after cardiac ischemic events.
Cardiovascular drugs and therapy.
2008 Apr; 22(2):125-31. doi:
10.1007/s10557-008-6087-x. [PMID: 18266096] - Zhi-Yong Xiao, Wen-Xia Zhou, Yong-Xiang Zhang, Jun-Ping Cheng, Jun-Feng He, Ri-Fang Yang, Liu-Hong Yun. Roquinimex-mediated protection effect on the development of chronic graft-versus-host disease in mice is associated with induction of Th1 cytokine production and inhibition of proinflammatory cytokine production.
Life sciences.
2007 Oct; 81(19-20):1403-10. doi:
10.1016/j.lfs.2007.08.044. [PMID: 17950363] - Hong-Cheng Pan, Fu-Pei Liang, Chang-Jie Mao, Jun-Jie Zhu, Hong-Yuan Chen. Highly luminescent zinc(II)-bis(8-hydroxyquinoline) complex nanorods: sonochemical synthesis, characterizations, and protein sensing.
The journal of physical chemistry. B.
2007 May; 111(20):5767-72. doi:
10.1021/jp0703049. [PMID: 17461570] - Daniel D Myers, Shirley K Wrobleski, Chris Longo, Patricia W Bedard, Neelu Kaila, George D Shaw, Frank J Londy, Suzan E Rohrer, Beverly A Fex, Paul J Zajkowski, Thomas R Meier, Angela E Hawley, Diana M Farris, Nicole E Ballard, Peter K Henke, Robert G Schaub, Thomas W Wakefield. Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation.
Thrombosis and haemostasis.
2007 Mar; 97(3):400-7. doi:
10.1160/th06-11-0658. [PMID: 17334507] - M Lutfi Firdaus, Kazuhiro Norisuye, Taishi Sato, Shouhei Urushihara, Yusuke Nakagawa, Shigeo Umetani, Yoshiki Sohrin. Preconcentration of Zr, Hf, Nb, Ta and W in seawater using solid-phase extraction on TSK-8-hydroxyquinoline resin and determination by inductively coupled plasma-mass spectrometry.
Analytica chimica acta.
2007 Feb; 583(2):296-302. doi:
10.1016/j.aca.2006.10.033. [PMID: 17386559] - Amal M El-Shennawy, Amira H Mohamed, Mohamed Abass. Studies on parasitologic and haematologic activities of an enaminone derivative of 4-hydroxyquinolin-2(1H)-one against murine schistosomiasis mansoni.
MedGenMed : Medscape general medicine.
2007 Jan; 9(1):15. doi:
. [PMID: 17435624] - Tanmoy Bera, Nilay Nandi, D Sudhahar, Md Ali Akbar, Abhik Sen, Pradeep Das. Preliminary evidence on existence of transplasma membrane electron transport in Entamoeba histolytica trophozoites: a key mechanism for maintaining optimal redox balance.
Journal of bioenergetics and biomembranes.
2006 Dec; 38(5-6):299-308. doi:
10.1007/s10863-006-9047-9. [PMID: 17039394] - Cornelis J Van der Schyf, Shunit Gal, Werner J Geldenhuys, Moussa B H Youdim. Multifunctional neuroprotective drugs targeting monoamine oxidase inhibition, iron chelation, adenosine receptors, and cholinergic and glutamatergic action for neurodegenerative diseases.
Expert opinion on investigational drugs.
2006 Aug; 15(8):873-86. doi:
10.1517/13543784.15.8.873. [PMID: 16859391] - Tsuyoshi Sugio, Tomohiro Hisazumi, Tadayoshi Kanao, Kazuo Kamimura, Fumiaki Takeuchi, Atsunori Negishi. Existence of aa3-type ubiquinol oxidase as a terminal oxidase in sulfite oxidation of Acidithiobacillus thiooxidans.
Bioscience, biotechnology, and biochemistry.
2006 Jul; 70(7):1584-91. doi:
10.1271/bbb.50623. [PMID: 16861791] - Peter Tobin, Stephen Clarke, J Paul Seale, Soon Lee, Michael Solomon, Sally Aulds, Michael Crawford, James Gallagher, Tony Eyers, Laurent Rivory. The in vitro metabolism of irinotecan (CPT-11) by carboxylesterase and beta-glucuronidase in human colorectal tumours.
British journal of clinical pharmacology.
2006 Jul; 62(1):122-9. doi:
10.1111/j.1365-2125.2005.02477.x. [PMID: 16842384] - Hailin Zheng, Moussa B H Youdim, Lev M Weiner, Mati Fridkin. Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons.
Biochemical pharmacology.
2005 Nov; 70(11):1642-52. doi:
10.1016/j.bcp.2005.09.003. [PMID: 16226724] - Hailin Zheng, Shunit Gal, Lev M Weiner, Orit Bar-Am, Abraham Warshawsky, Mati Fridkin, Moussa B H Youdim. Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition.
Journal of neurochemistry.
2005 Oct; 95(1):68-78. doi:
10.1111/j.1471-4159.2005.03340.x. [PMID: 16181413] - Terushi Haradahira, Takashi Okauchi, Jun Maeda, Ming-Rong Zhang, Toru Nishikawa, Ryouichi Konno, Kazutoshi Suzuki, Tetsuya Suhara. Effects of endogenous agonists, glycine and D-serine, on in vivo specific binding of [11C]L-703,717, a PET radioligand for the glycine-binding site of NMDA receptors.
Synapse (New York, N.Y.).
2003 Nov; 50(2):130-6. doi:
10.1002/syn.10254. [PMID: 12923815] - Kirsten E Tollefson, James Kroczynski, Michael V Cutaia. Time-dependent interactions of oxidant-sensitive fluoroprobes with inhibitors of cellular metabolism.
Laboratory investigation; a journal of technical methods and pathology.
2003 Mar; 83(3):367-75. doi:
10.1097/01.lab.0000059934.53602.4f. [PMID: 12649337] - M H Ralphs, D R Gardner, D L Turner, J A Pfister, E Thacker. Predicting toxicity of tall larkspur (Delphinium barbeyi): measurement of the variation in alkaloid concentration among plants and among years.
Journal of chemical ecology.
2002 Nov; 28(11):2327-41. doi:
10.1023/a:1021013719206. [PMID: 12523572] - Johanna Osterberg, Ulf Haglund. Effect of linomide on gut immune cell distribution and on TNF-alpha in plasma and ascites: an experimental study in the septic rat.
Shock (Augusta, Ga.).
2002 Nov; 18(5):471-5. doi:
10.1097/00024382-200211000-00015. [PMID: 12412629] - M Jamaluddin Ahmed, M Enamul Haque. A rapid spectrophotometric method for the determination of molybdenum in industrial, environmental, biological and soil samples using 5,7-dibromo-8-hydroxyquinoline.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2002 Apr; 18(4):433-9. doi:
10.2116/analsci.18.433. [PMID: 11999518] - A Katz, U Pick. Plasma membrane electron transport coupled to Na(+) extrusion in the halotolerant alga Dunaliella.
Biochimica et biophysica acta.
2001 Apr; 1504(2-3):423-31. doi:
10.1016/s0005-2728(01)00157-8. [PMID: 11245805] - J N Whitaker, J S Wolinsky, P A Narayana, A A Bartolucci, J H Noseworthy, F D Lublin, A Linde, P Gjörstrup, H C Sullivan. Relationship of urinary myelin basic protein-like material with cranial magnetic resonance imaging in advanced multiple sclerosis.
Archives of neurology.
2001 Jan; 58(1):49-54. doi:
10.1001/archneur.58.1.49. [PMID: 11176936] - R D Reinders, P G Bijker, J H Huis In't Veld, F Van Knapen. Use of 8-hydroxyquinoline-beta-D-glucuronide for presumptive identification of Shiga toxin-producing Escherichia coli O157.
Letters in applied microbiology.
2000 May; 30(5):411-4. doi:
10.1046/j.1472-765x.2000.00640.x. [PMID: 10792673] - T Haradahira, M Zhang, J Maeda, T Okauchi, K Kawabe, T Kida, K Suzuki, T Suhara1. A strategy for increasing the brain uptake of a radioligand in animals: use of a drug that inhibits plasma protein binding.
Nuclear medicine and biology.
2000 May; 27(4):357-60. doi:
10.1016/s0969-8051(00)00096-2. [PMID: 10938470] - K Strandgården, P Höglund, L Grönquist, L Svensson, P O Gunnarsson. Absorption and disposition including enterohepatic circulation of (14C) roquinimex after oral administration to healthy volunteers.
Biopharmaceutics & drug disposition.
2000 Mar; 21(2):53-67. doi:
10.1002/1099-081x(200003)21:2<53::aid-bdd214>3.0.co;2-f. [PMID: 11100907] - M Shalev, A Ko, M P Gelderman, E Fortin, G Reed, S Slavin, I Gery. Multiformic modulation of endotoxin effects by linomide.
Clinical immunology (Orlando, Fla.).
1999 Dec; 93(3):250-5. doi:
10.1006/clim.1999.4800. [PMID: 10600336] - K Strandgârden, P Höglund, O Nordle, J Polacek, H Wännman, P O Gunnarsson. Dissolution rate-limited absorption and complete bioavailability of roquinimex in man.
Biopharmaceutics & drug disposition.
1999 Oct; 20(7):347-54. doi:
10.1002/(sici)1099-081x(199910)20:7<347::aid-bdd194>3.0.co;2-0. [PMID: 10760843] - S C Chena, J K Liu. The respiratory responses to cyanide of a cyanide-resistant Klebsiella oxytoca bacterial strain.
FEMS microbiology letters.
1999 Jun; 175(1):37-43. doi:
10.1111/j.1574-6968.1999.tb13599.x. [PMID: 10361707] - B Zbar, W Kaelin, E Maher, S Richard. Third International Meeting on von Hippel-Lindau disease.
Cancer research.
1999 May; 59(9):2251-3. doi:
NULL. [PMID: 10232616] - F Lin, P G Geiger, W Korytowski, A W Girotti. Protoporphyrin IX-sensitized photoinactivation of 5-aminolevulinate-treated leukemia cells: effects of exogenous iron.
Photochemistry and photobiology.
1999 Mar; 69(3):375-81. doi:
10.1562/0031-8655(1999)069<0375:pispoa>2.3.co;2. [PMID: 10089831] - M Olausson, D Lukes, J Norrby, Z Qi, H Ekberg, G Gannedahl, G Tufveson, L Mjörnstedt. Antithymocyte globulin and cyclosporin A are synergistic in an experimental transplantation tolerance model in the rat.
Scandinavian journal of immunology.
1999 Jan; 49(1):38-44. doi:
10.1046/j.1365-3083.1999.00453.x. [PMID: 10023855] - M J Mackean, D Kerr, M Lesko, A Svedberg, F Hansson, D Jodrell, J Cassidy. A feasibility study of roquinimex (Linomide) and alpha interferon in patients with advanced malignant melanoma or renal carcinoma.
British journal of cancer.
1998 Dec; 78(12):1620-3. doi:
10.1038/bjc.1998.732. [PMID: 9862573] - R A Zager, D S Conrad, K Burkhart. Ceramide accumulation during oxidant renal tubular injury: mechanisms and potential consequences.
Journal of the American Society of Nephrology : JASN.
1998 Sep; 9(9):1670-80. doi:
10.1681/asn.v991670. [PMID: 9727376] - M Matsukawa, K Takeda, H Shima, K Tagawa, K Banno, T Sato. Enzyme-linked immunosorbent assay for TA-2005-glucuronide in human plasma.
Journal of pharmaceutical and biomedical analysis.
1998 Jun; 17(2):245-54. doi:
10.1016/s0731-7085(97)00186-6. [PMID: 9638577] - G del Real, M Llorente, L Boscá, S Hortelano, A Serrano, P Lucas, L Gómez, J L Torán, C Redondo, C Martínez. Suppression of HIV-1 infection in linomide-treated SCID-hu-PBL mice.
AIDS (London, England).
1998 May; 12(8):865-72. doi:
10.1097/00002030-199808000-00008. [PMID: 9631139] - O Pekarski, J Björk, G Hedlund, G Andersson. The inhibitory effect in experimental autoimmune encephalomyelitis by the immunomodulatory drug Linomide (PNU-212616) is not mediated via release of endogenous glucocorticoids.
Autoimmunity.
1998; 28(4):235-41. doi:
10.3109/08916939808995371. [PMID: 9892505] - D Lehmann, D Karussis, R Mizrachi-Koll, A S Linde, O Abramsky. Inhibition of the progression of multiple sclerosis by linomide is associated with upregulation of CD4+/CD45RA+ cells and downregulation of CD4+/CD45RO+ cells.
Clinical immunology and immunopathology.
1997 Nov; 85(2):202-9. doi:
10.1006/clin.1997.4444. [PMID: 9344704] - A C Harring, Z Xu, G Andersson, G Hedlund. Linomide enhances apoptosis in CD4+CD8+ thymocytes.
Scandinavian journal of immunology.
1997 Nov; 46(5):488-94. doi:
10.1046/j.1365-3083.1997.d01-155.x. [PMID: 9393631] - J Weidenfeld, D Karussis, O Abramsky, D Lehmann, I Arbell, H Ovadia. Linomide activates the adrenocortical axis in the rat: inhibition of experimental autoimmune encephalomyelitis by linomide is not related to the increase of corticosterone.
Journal of neuroimmunology.
1997 Oct; 79(1):49-53. doi:
10.1016/s0165-5728(97)00121-5. [PMID: 9357446] - A Pawinski, A T van Oosterom, R de Wit, S Fosså, J Croles, A Svedberg, M A Lentz, P H de Mulder. An EORTC phase II study of the efficacy and safety of linomide in the treatment of advanced renal cell carcinoma.
European journal of cancer (Oxford, England : 1990).
1997 Mar; 33(3):496-9. doi:
10.1016/s0959-8049(97)89028-4. [PMID: 9155538] - R de Wit, A Pawinsky, G Stoter, A T van Oosterom, S D Fosså, R Paridaens, A Svedberg, P H de Mulder. EORTC phase II study of daily oral linomide in metastatic renal cell carcinoma patients with good prognostic factors.
European journal of cancer (Oxford, England : 1990).
1997 Mar; 33(3):493-5. doi:
10.1016/s0959-8049(97)89027-2. [PMID: 9155537] - S Hortelano, M J Díaz-Guerra, A Gonzalez-García, E Leonardo, C Gamallo, L Boscá, C Martínez-A. Linomide administration to mice attenuates the induction of nitric oxide synthase elicited by lipopolysaccharide-activated macrophages and prevents nephritis in MRL/Mp-lpr/lpr mice.
Journal of immunology (Baltimore, Md. : 1950).
1997 Feb; 158(3):1402-8. doi:
NULL. [PMID: 9013985] - S Morecki, C Nabet, P Falk, M Fridkis-Hareli, I Pecht, J J Mond, S Slavin. The effect of linomide, an immunoregulator in experimental autoimmune diseases, on humoral antibody responses in mice.
Autoimmunity.
1997; 25(4):223-32. doi:
10.3109/08916939708994731. [PMID: 9344330] - J C Bergh, T H Tötterman, B C Termander, K A Strandgarden, P O Gunnarsson, B I Nilsson. The first clinical pilot study of roquinimex (Linomide) in cancer patients with special focus on immunological effects.
Cancer investigation.
1997; 15(3):204-11. doi:
10.3109/07357909709039716. [PMID: 9171853] - S Slavin, L Weiss, W Xia, D J Gross. Successful treatment of diabetes in NOD mice with advanced disease by islet isografts following immunoregulation with Linomide (quinoline-3-carboxamide).
Cell transplantation.
1996 Nov; 5(6):627-30. doi:
10.1016/s0963-6897(96)00085-1. [PMID: 8951220] - M Deckert, A Franzke, J Buer, M Probst, S Duensing, E Lopez-Haenninen, H Kirchner, H Poliwoda, J Atzpodien. Linomide and interleukin-2 in patients with advanced renal cell carcinoma.
Cancer biotherapy & radiopharmaceuticals.
1996 Oct; 11(5):319-24. doi:
10.1089/cbr.1996.11.319. [PMID: 10851512] - K Sogabe, N F Roeser, M A Venkatachalam, J M Weinberg. Differential cytoprotection by glycine against oxidant damage to proximal tubule cells.
Kidney international.
1996 Sep; 50(3):845-54. doi:
10.1038/ki.1996.384. [PMID: 8872959] - I B Joseph, J T Isaacs. The antiangiogenic agent linomide inhibits tumor necrosis factor-alpha secretion via inhibition of its synthesis.
The Prostate.
1996 Sep; 29(3):183-90. doi:
10.1002/(sici)1097-0045(199609)29:3<183::aid-pros4>3.0.co;2-f. [PMID: 8827087] - G Zandman-Goddard, J George, Y Levy, M Blank, S Slavin, Y Shoenfeld. Modulation of experimental systemic lupus erythematosus with linomide.
Lupus.
1996 Aug; 5(4):328-33. doi:
10.1177/096120339600500415. [PMID: 8869907] - T Unak, P Unak. Direct radioiodination of metabolic 8-hydroxy-quinolyl-glucuronide, as a potential anti-cancer drug.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
1996 Jul; 47(7):645-7. doi:
10.1016/0969-8043(95)00333-9. [PMID: 8759157] - U B Christensen, D Mauricio, J I Reimers, H U Andersen, T Kalland, J Nerup, T Mandrup-Poulsen. Linomide increases plasma corticosterone in normal rats, but does not prevent the inhibitory action of IL-1 on beta-cells in vivo or ex vivo.
Autoimmunity.
1996; 23(4):257-68. doi:
10.3109/08916939608995348. [PMID: 8915032] - M Olausson, N Arvidsson, D Lukes, L Mjörnstedt, Z Qi, H Ekberg, G Gannedahl, G Tufveson. Inhibition of ATG-induced experimental transplantation tolerance with LS2616.
Transplantation proceedings.
1995 Dec; 27(6):3541-3. doi:
NULL. [PMID: 8540092] - F Lin, A W Girotti. Stimulatory and inhibitory effects of iron on photodynamic inactivation of leukemia cells.
Photochemistry and photobiology.
1995 Sep; 62(3):528-34. doi:
10.1111/j.1751-1097.1995.tb02379.x. [PMID: 8570708] - F Dalet, T Segovia. Evaluation of a new agar in Uricult-Trio for rapid detection of Escherichia coli in urine.
Journal of clinical microbiology.
1995 May; 33(5):1395-8. doi:
10.1128/jcm.33.5.1395-1398.1995. [PMID: 7615766] - J Vukanovic, B Hartley-Asp, J T Isaacs. Inhibition of tumor angiogenesis and the therapeutic ability of linomide against rat prostatic cancers.
The Prostate.
1995 May; 26(5):235-46. doi:
10.1002/pros.2990260503. [PMID: 7538663] - J Vukanovic, J T Isaacs. Linomide inhibits angiogenesis, growth, metastasis, and macrophage infiltration within rat prostatic cancers.
Cancer research.
1995 Apr; 55(7):1499-504. doi:
NULL. [PMID: 7533663] - N Zeraidi, A A Zeggwagh, R Abouqal, A Zekraoui, O Kerkeb. [Kidney insufficiency: toxicity factor of methyl-bromo-hydroxyquinoline].
Annales de medecine interne.
1995; 146(8):593-5. doi:
NULL. [PMID: 8734090] - D M Karussis, D Lehmann, T Brenner, I Wirguin, R Mizrachi-Koll, C Sicsic, O Abramsky. Immunomodulation of experimental autoimmune myasthenia gravis with linomide.
Journal of neuroimmunology.
1994 Dec; 55(2):187-93. doi:
10.1016/0165-5728(94)90009-4. [PMID: 7829669] - I Mahmood, S H Neau, W D Mason. An enzymatic assay for the MAO-B inhibitor selegiline in plasma.
Journal of pharmaceutical and biomedical analysis.
1994 Jul; 12(7):895-9. doi:
10.1016/0731-7085(93)e0021-e. [PMID: 7981318] - P Borgström, I P Torres Filho, P Vajkoczy, K Strandgården, J Polaçek, B Hartley-Asp. The quinoline-3-carboxamide linomide inhibits angiogenesis in vivo.
Cancer chemotherapy and pharmacology.
1994; 34(4):280-6. doi:
10.1007/bf00686033. [PMID: 7518359] - N G Ilbäck, L Wesslén, K Pauksen, T Stålhandske, G Friman, J Fohlman. Effects of the antiviral WIN 54954 and the immune modulator LS 2616 on cachectin/TNF and gamma-interferon responses during viral heart disease.
Scandinavian journal of infectious diseases. Supplementum.
1993; 88(?):117-23. doi:
. [PMID: 8390714] - A Wanders, P Vogt, A Karlsson-Parra, K Wonigkeit, B Gerdin, G Tufveson. Evidence that LS-2616 (linomide) causes acute rejection of rat allografts protected by cyclosporine but not of long-term surviving allografts.
Transplantation.
1991 Aug; 52(2):234-8. doi:
10.1097/00007890-199108000-00010. [PMID: 1871795]